Pancreatic cancer: treatment approaches and trends
Pancreatic cancer: treatment approaches and trends作者机构：Laboratory of Microscopy and MicroanalysesGroup of Applied Chemotherapy and Fluorescent ProbesDepartment of Cellular BiologyInstitute of Biological ScienceUniversity of BrasiliaBrasiliaDF 70910-900Brazil
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2018年第4卷第1期
页 面：351-364页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pancreatic cancer chemotherapy gemcitabine immunotherapy
摘 要：Pancreatic cancer is one of the most challenging diseases due to its often late diagnose which results in limited therapeutic options and poor *** date,the only curative treatment is complete tumor removal surgery but only a few patients are eligible to do *** median survival period after surgery followed by chemotherapy adjuvant treatment is about 2 *** its approval by the FDA,Gemcitabine has become the first-line chemotherapy agent for treatment of advanced pancreatic *** FOLFIRINOX regimen is also used as a treatment scheme for pancreatic cancer;however,this regimen has resulted in small improvements in overall patient’s *** is appropriated to clarify that the FOLFIRINOX regimen can only be administered in patients with good performance *** to the absence of outstanding result after patient’s treatment with diverse chemotherapeutic agents combinations or unsuccessful administration of single-agent drugs to treat pancreatic cancer,the immunotherapy has become a new hope.A more comprehensive understanding of cancer microenvironment and the chemical communication between cancer cells and immune cells can result in new therapeutic approaches that will improve the elimination of pancreatic cancer cells,enhancing life quality for these patients and increasing the overall survival.
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