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PhaseⅠ/Ⅱtrial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

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Chinese journal of Cancer 2016年第12期35卷 743-753页

作者： Lin Kong jing Gao jiyi hu Weixu hu Xiyin Guan Rong Lu jiade j.Lu Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Shanghai Cancer HospitalShanghai 200321P.R.China. Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. Department of Outpatient Clinic Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. Shanghai Proton and Heavy Ion Center 4365 Kangxin RoadPudongShanghai 201315P.R.China.

Background: After deinitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma(NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present signiicant challenges for locally recurrent NPC. Surgery, stereotactic ablative body radiotherapy, and brachytherapy have been used to treat locally recurrent NPC. However, only patients with small-volume tumors can beneit from these treatments. Re-irradiation with X-ray—based intensity-modulated radiotherapy(IMXT) has been more widely used for salvage treatment of locally recurrent NPC with a large tumor burden, but over-irradiation to the surrounding normal tissues has been shown to cause frequent and severe toxicities. Furthermore, locally recurrent NPC represents a clinical entity that is more radioresistant than its primary counterpart. Due to the inherent physical advantages of heavy-particle therapy, precise dose delivery to the target volume(s), without exposing the surrounding organs at risk to extra doses, is highly feasible with carbon-ion radiotherapy(CIRT). In addition, CIRT is a high linear energy transfer(LET) radiation and provides an increased relative biological efectiveness compared with photon and proton radiotherapy. Our prior work showed that CIRT alone to 57.5 Gy E(gray equivalent), at 2.5 Gy E per daily fraction, was well tolerated in patients who were previously treated for NPC with a deinitive dose of IMXT. The short-term response rates at 3–6 months were also acceptable. However, no patients were treated with concurrent chemotherapy. Whether the addition of concurrent chemotherapy to CIRT can beneit locally recurrent NPC patients over CIRT alone has never been addressed. It is possible that the beneits of high-LET CIRT may make radiosensitizing chemotherapy unnecessary. We therefore implemented a phase I/II clinical trial to address these questions and present our methodology and *** and design: The maximal tolerated dose(MTD) of re-treatment usi

关键词： Recurrent nasopharyngeal cancer Carbon ion radiotherapy Re-irradiation Salvage therapy Chemotherapy

信息化时代基于微课的翻转课堂在研究生英语教学中的应用研究

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科教文汇 2025年第1期 124-128页

作者：胡奇军江西中医药大学人文学院江西南昌330004

研究生教育对学生的英语能力要求较高,传统的学习方式难以满足学生的学习需求,互联网的普及和信息技术的发展为研究生英语教学改革指明了新的方向。基于微课的翻转课堂深度学习模式实现了以信息化带动教育现代化,引导学生主动探索学习... 详细信息

研究生教育对学生的英语能力要求较高,传统的学习方式难以满足学生的学习需求,互联网的普及和信息技术的发展为研究生英语教学改革指明了新的方向。基于微课的翻转课堂深度学习模式实现了以信息化带动教育现代化,引导学生主动探索学习中的问题,让学生更多地参与深入思考,提高研究生的自主学习能力和英语综合应用能力,提升研究生教育的整体质量。

关键词：信息技术研究生英语翻转课堂微课应用研究

ON THE ZEROS OF QUOTIENTS OF BESSEL FUNCTIONS

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Chinese Annals of Mathematics,Series B 2000年第3期21卷 285-296页

作者： A.FRIEDMAN B.hu j.j.L.VELAZQUEZ DepartmentofMathematics UniversityofMinnesotaMinneapolisMN55455USA. DepartmentofMathematics UniversityofNotreDameNotreDameIN46556USA. DepartamentodeMatematicaAplicada FacultaddeMatematicasUniversidadComplutense28040MadridSpain.

The paper studies the zeros of 2mIm/Im-1- (m+1)I1 /I0, where Im are the Bessel functions.

关键词： Zeros Quotient Bessel function

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小煤柱沿空掘进瓦斯综合防治技术研究

煤炭技术 2025年第1期44卷 198-201页

作者：胡乐天山西保利平山煤业股份有限公司山西沁水048200

以某矿31018回风顺槽小煤柱沿空掘进为工程背景,对采空区侧煤体卸压范围考察,确定采空区侧煤体卸压范围,并在卸压范围进行残余瓦斯含量测试,划定无突出危险性范围;采用对小煤柱进行注浆加固和巷道全断面喷浆措施防止采空区瓦斯溢出;使... 详细信息

以某矿31018回风顺槽小煤柱沿空掘进为工程背景,对采空区侧煤体卸压范围考察,确定采空区侧煤体卸压范围,并在卸压范围进行残余瓦斯含量测试,划定无突出危险性范围;采用对小煤柱进行注浆加固和巷道全断面喷浆措施防止采空区瓦斯溢出;使用钻屑指标法对掘进工作面进行预测和验证。统计表明:31018回风顺槽小煤柱沿空掘巷过程中,预测指标K_(1max)=0.24,S_(max)=3.4,平均进尺5.8 m/d,回风流平均瓦斯浓度为0.15%,单日绝对瓦斯涌出量平均为1.04 m^(3)/min,实现了巷道安全掘进。

关键词：沿空掘进瓦斯治理小煤柱卸压范围注浆加固

Recent applications of isotope analysis to forensic anthropology

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Forensic Sciences Research 2019年第1期4卷 29-44页

作者： eric j.Bartelink Lesley A.Chesson Department of Anthropology California State UniversityChicoCAUSA Contractor at Defense POW/MIA Accounting Agency(DPAA)Laboratory Pacific Architects and Engineers(PAE)HIUSA

Isotope analysis has become an increasingly valuable tool in forensic anthropology case-work over the past decade. Modern-day isotopic investigations on human remains have integrated the use of multi-isotope profiles (e.g. C, N, O, H, S, Sr, and Pb) as well as iso-topic landscapes ("isoscapes") from multiple body tissues (e.g. teeth, bone, hair, and nails) to predict possible region-of-origin of unidentified human remains. Together, data from various isotope analyses provide additional lines of evidence for human identification, including a decedent's possible region-of-birth, long-term adult residence, recent travel history, and dietary choices. Here, we present the basic principles of isotope analysis and provide a brief overview of instrumentation, analytical standards, sample selection, and sample quality measures. Finally, we present case studies that reflect the diverse applications of isotope analysis to the medicolegal system before describing some future research directions. As shown herein, isotope analysis is a flexible and powerful geolocation tool that can provide new investigative leads for unidentified human remains cases.

关键词： Forensic sciences forensic anthropology stable isotope analysis isoscapes provenancing

Effect of Strain Path Reversal on Austenite Grain Subdivision and Deformation Induced Ferrite Transformation Studied by Hot Torsion

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journal of Iron and Steel Research International 2011年第S1期18卷 233-237页

作者： Muszka Krzysztof Wynne Bradley P Palmiere eric j Institute for Microstructural and Mechanical Process Engineering The University of SheffieldMappin StreetSheffield S1 3JDUK

The effects of large strain and strain path reversal on the deformation microstructure evolution in austenite below the recrystallisation temperature were studied by hot torsion using a non-transforming Fe-30wt%Ni model austenitic *** show that the high angle boundaries (HABs) can be generated by both microstructure mechanism through dislocation accumulation and texture mechanism via subgrain ***,multiple strain path reversals lead to less well-developed HABs in the original grains compared to single reversal deformed to the same amount of total accumulative *** effect is attributed to the subgrain rotation mechanism being less effective at small *** comparison,the same hot torsion tests were conducted using a microalloyed steel at a temperature between Ae 3 and Ar *** single strain path reversal,substantial deformation-induced austenite-to-ferrite phase transformation was ***,a test with multiple strain path reversals but with the same total strain produces much lower levels of strain-induced ferrite *** difference is correlated to the observations made in the Fe-30wt%Ni model *** is believed that the different amount of strain-induced ferrite originated from the different levels of strain-induced HABs within the austenite which act as ferrite nucleation sites.

关键词： strain induced transformation ultra fine ferrite dislocation boundaries EBSD

Predicting the strut forces of the steel supporting structure of deep excavation considering various factors by machine learning methods

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Underground Space 2024年第5期18卷 114-129页

作者： Haibo hu Xunjian hu Xiaonan Gong Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou 310058China

The application of steel strut force servo systems in deep excavation engineering is not widespread,and there is a notable scarcity of in-situ measured *** presents a significant research gap in the *** this,our study introduces a valuable dataset and application scenarios,serving as a reference point for future *** main objective of this study is to use machine learning(ML)methods for accurately predicting strut forces in steel supporting structures,a crucial aspect for the safety and stability of deep excavation *** employed five different ML methods:radial basis function neural network(RBFNN),back propagation neural network(BPNN),K-Nearest Neighbor(KNN),support vector machine(SVM),and random forest(RF),utilizing a dataset of 2208 measured *** points included one output parameter(strut forces)and seven input parameters(vertical position of strut,plane position of strut,time,temperature,unit weight,cohesion,and internal frictional angle).The effectiveness of these methods was assessed using root mean square error(RMSE),correlation coefficient(R),and mean absolute error(MAE).Our findings indicate that the BPNN method outperforms others,with RMSE,R,and MAE values of 72.1 kN,0.9931,and 57.4 kN,respectively,on the testing *** study underscores the potential of ML methods in precisely predicting strut forces in deep excavation engineering,contributing to enhanced safety measures and project planning.

关键词： Deep excavation Steel supporting structure Strut forces Machine learning Time Temperature

Binding of transition metals to S100 proteins

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Science China(Life Sciences) 2016年第8期59卷 792-801页

作者： Benjamin A.Gilston eric P.Skaar Walter j.Chazin Departments of Biochemistry and Chemistry and Center for Structural BiologyVanderbilt UniversityNashville TN 37232-9717USA Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashville TN 37232-2561USA

The S100 proteins are a unique class of EF-hand Ca^(2+) binding proteins distributed in a cell-specific, tissue-specific, and cell cycle-specific manner in humans and other vertebrates. These proteins are distinguished by their distinctive homodimeric structure, both intracellular and extracellular functions, and the ability to bind transition metals at the dimer interface. Here we summarize current knowledge of S100 protein binding of Zn^(2+), Cu^(2+) and Mn^(2+) ions, focusing on binding affinities, conformational changes that arise from metal binding, and the roles of transition metal binding in S100 protein function.

关键词： S100 Proteins Zinc Manganese Copper

Theoretical potential for low energy consumption phase change memory utilizing electrostatically-induced structural phase transitions in 2D materials

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npj Computational Materials 2018年第1期4卷 653-661页

作者： Daniel A.Rehn Yao Li eric Pop Evan j.Reed Department of Mechanical Engineering Stanford UniversityStanfordCA 94305USA Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Structural phase-change materials are of great importance for applications in information storage *** driven structural phase transitions are employed in phase-change memory to achieve lower programming voltages and potentially lower energy consumption than mainstream nonvolatile memory ***,the waste heat generated by such thermal mechanisms is often not optimized,and could present a limiting factor to widespread *** potential for electrostatically driven structural phase transitions has recently been predicted and subsequently reported in some two-dimensional materials,providing an athermal mechanism to dynamically control properties of these materials in a nonvolatile fashion while achieving potentially lower energy *** this work,we employ DFT-based calculations to make theoretical comparisons of the energy required to drive electrostatically-induced and thermally-induced phase *** theoretical limits in monolayer MoTe2 and thin films of Ge_(2)Sb_(2)Te_(5),we find that the energy consumption per unit volume of the electrostatically driven phase transition in monolayer MoTe2 at room temperature is 9% of the adiabatic lower limit of the thermally driven phase transition in Ge_(2)Sb_(2)Te_(5).Furthermore,experimentally reported phase change energy consumption of Ge_(2)Sb_(2)Te_(5) is 100–10,000 times larger than the adiabatic lower limit due to waste heat flow out of the material,leaving the possibility for energy consumption in monolayer MoTe2-based devices to be orders of magnitude smaller than Ge_(2)Sb_(2)Te_(5)-based devices.

关键词： transitions phase structural