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Laser-Treated Surfaces for VADs:From Inert Titanium to Potential Biofunctional Materials

Biomedical Engineering Frontiers 2022年第1期3卷 399-406页

作者： Eduardo Bock Wilhelm Pfleging Dayane Tada erenilda macedo Nathalia Premazzi Rosa Sá Juliana Solheid Heino Besser Aron Andrade Laboratory of Bioengineering and Biomaterials Federal Institute of Technology in Sao Paulo(IFSP)Sao PauloBrazil Center of Engineering in Circulatory Assistance Institute Dante Pazzanese of Cardiology(IDPC)Sao PauloBrazil Institute for Applied Materials-Applied Materials Physics Karlsruhe Institute of Technology(KIT)KarlsruheGermany Federal University of Sao Paulo(UNIFESP) Sao Jose dos CamposBrazil National Institute for Space Research(INPE) Sao Jose dos CamposBrazil

***-treated surfaces for ventricular assist *** *** work has scientific impact since it proposes a biofunctional surface created with laser processing in bioinert *** diseases are the world’s leading cause of *** especially debilitating heart disease is congestive heart *** the possible therapies,heart transplantation and mechanical circulatory assistance are the main treatments for its severe form at a more advanced *** development of biomaterials for ventricular assist devices is still being carried *** polished titanium is currently employed in several devices,its performance could be improved by enhancing the bioactivity of its *** to improve the titanium without using coatings that can be detached,this work presents the formation of laser-induced periodic surface structures with a topology suitable for cell adhesion and neointimal tissue *** surface was modified by femtosecond laser ablation and cell adhesion was evaluated in vitro by using fibroblast *** results indicate the formation of the desired topology,since the cells showed the appropriate adhesion compared to the control *** electron microscopy showed several positive characteristics in the cells shape and their surface *** in vitro results obtained with different topologies point that the proposed LIPSS would provide enhanced cell adhesion and *** laser processes studied can create new interactions in biomaterials already known and improve the performance of biomaterials for use in ventricular assist devices.

关键词： titanium biomaterials Titanium

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Alpha-1 antitrypsin deficiency and Pi*Z allele as important co-factors in the development of liver fibrosis

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World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： Ana Isabel Ferreira Catarina Guimarães Vitor macedo Silva Sofia Xavier Joana Magalhães JoséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health Sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosis<77 mg/dL predicted a nonalcoholic fatty liver disease fibrosis score(NFS)not excluding advanced fibrosis[area under the curve(AUC)=0.840,P<0.001;AUC=0.836,P<0.001;AUC=0.681,P=0.025].An age≥50 years and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,P<0.001;AUC=0.795,P<0.001).Patients with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFS not excluding advanced fibrosis(P<0.001,P=0.002,P=0.008,P<0.001,P=0.033).Patients with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUSION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosis<77 mg/*** created an algorithm for liver disease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Dipole (hyper)polarizabilities of neutral silver clusters

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Chinese Physics B 2016年第12期25卷 217-222页

作者： Francisco E Jorge Luiz G M de macedo Departarnento de Fisica Universidade Fedoral do Espirito Santo 29060-900 Vitoria Brazil Unidade Academica de Fisica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Faculdade de Biotecnologia ICB Universidade Federal do Para 66075-110 Belem Brazil

At the Douglas-Kroll-Hess （DKI4） level, the B3PW91 functional along with the all-eleclron relativistic basis sets of valence triple and quadruple zeta qualities are used to determine the structure, stability, and electronic properties of the small silver clusters （Agn, n ≤ 7）. The results presented in this study are in good agreement with the experimental data and theoretical values obtained at a higher level of theory from the literature. Static polarizability and hyperpolarizability are also reported. It is verified that the mean dipole polarizability per atom exhibits an odd-even oscillation and that the polarizability anisotropy is directly related to the cluster shape. In this article, the first study of hyperpolarizabilities of small silver clusters is presented. Except for the monomer, the second hyperpolarizabilities of the silver clusters are significantly larger than those of the copper clusters.

关键词： B3PW91 functional all-electron basis sets non-relativistic and DKH2 calculations silver clusters,dipole (hyper)polarizabilities

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Leaf water potential and gas exchange of eucalypt clonal seedlings to leaf solar protectant

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Journal of Forestry Research 2019年第1期30卷 57-64页

作者： Talita Miranda Teixeira Xavier José Eduardo macedo Pezzopane Ricardo Miguel Penchel José Ricardo macedo Pezzopane Departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito Santo Fibria Celulose S.A Rodovia General Euryale Jesus Zerbini Embrapa Pecuária Sudeste

This experiment was carried out in acclimatized greenhouses with seedlings of two hybrid clones of Eucalyptus urophylla×Eucalyptus grandis. A sunscreen protector consisting of 62.5% calcium carbonate was sprayed on the seedlings at weekly intervals. Water stress was induced by suspending irrigation until the soil reached 30% available water and water was then replaced so that it returned to field capacity. Gas exchange and leaf water status were measured after 50 days. The experiment was set up in a 4×2 factorial randomized block design in four distinct environments:(1) temperatures less than 21.2℃ and vapor pressure deficit of 0.15 kPa;(2) intermediate temperatures of 24.2℃ and vapor pressure deficit of 0.69 kPa;(3) high temperatures of 27.0℃ and high vapor pressure deficit of 1.4 kPa; and,(4) high temperature of 27.0℃ and vapor pressure deficit below 1.10 kPa. Two leaf sun protector treatments were used, with five replications each. High atmospheric demand acted as a stress factor for the seedlings during the initial growth *** of leaf sunscreen protector provided beneficial effects in maintaining optimum water status and gas exchanges of the plants under water stress.

关键词： Eucalyptus urophylla×Eucalyptus grandis Calcium carbonate Water stress Atmospheric demand

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Discontinuation of antiviral therapy in chronic hepatitis B patients

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World Journal of Clinical Cases 2021年第24期9卷 6979-6986页

作者： Renato Medas Rodrigo Liberal Guilherme macedo Department of Gastroenterology and Hepatology Centro Hospitalar Universitario de São JoãoPorto 4200-319Portugal

Nucleos(t)ide analogs(NUC)are the first-line therapy for patients with chronic hepatitis B(CHB)recommended by most current *** therapy decreases progression of liver disease,reduces the risk of liver-related complications,and improves the quality of life of patients with *** indefinite or long-term NUC therapy is usually recommended,this strategy raises several concerns,such as side-effects,adherence,costs,and patient willingness to stop *** data showed the feasibility,efficacy,and safety of stopping antiviral therapy in carefully selected CHB patients,leading to its incorporation in international *** who discontinue NUC have a higher likelihood of hepatitis B surface antigen(HBsAg)loss compared to patients who continue on *** pertaining endpoints allowing safety discontinuation of NUC therapy differ among international *** hepatitis B e antigen(HBeAg)-positive patients,durable HBeAg seroconversion is considered an acceptable treatment *** HBeAg-negative patients,some guidelines propose undetectability hepatitis B virus DNA for at least 2 or 3 years,while others consider HBsAg loss as the only acceptable *** patients who stop therapy should remain under strict clinical and laboratorial follow-up protocols to detect and manage relapses in a timely *** reliable predictor of relapse has been consistently identified to date,although quantitative HBsAg has been increasingly studied as a reliable biomarker to predict safe NUC discontinuation.

关键词： Chronic hepatitis B Finite therapy Hepatitis B surface antigen loss Relapse Retreatment

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Conscience imperative of providing information and knowledge in hepatology:The Portuguese approach

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World Journal of Clinical Cases 2017年第1期5卷 24-26页

作者： Guilherme macedo Marco Silva Department of Gastroenterology the Centro Hospitalar São JoãoWGO Training CenterFaculty of MedicineUniversity of Porto4200-319 PortoPortugal

The last 25 years have been a thrilling time for the Portuguese hepatologists. Our national meetings have been providing the forum for the exchange of scientific ideas and the presentation of clinical research in clinical Hepatology, a growing world of knowledge in medical care. Bridging the gaps between technology and clinical daily practice, the latest development and the almost humble bedside care, has been a challenge for the increasing numbers of doctors devoted to the diagnostic and treatment of liver disease. We have been trying to be very persuasive among the Portuguese medical community in demonstrating that cultural vectors may influence the origin and pattern of liver disease among us. Viral hepatitis and alcoholic liver disease are paradigms of this assumption. Chronic liver disease is responsible for 3% of the deaths in Portugal, which accounts for the top ten causes of death in our country. The recognition by public health authorities of this fact along with the national net of hepatology outpatient consultation in public hospitals, has brought liver diseases under the lights of doctors concerns and an increased public awareness of its dimension.

关键词： Alcohol Cirrhosis Hepatology Liver Public health

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Coronavirus disease 2019 severity in obesity:Metabolic dysfunctionassociated fatty liver disease in the spotlight

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World Journal of Gastroenterology 2021年第16期27卷 1738-1750页

作者： Isabela macedo Lopes Vasques-Monteiro Vanessa Souza-Mello Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Food Science and Technology Federal University of the State of Rio de JaneiroRio de Janeiro 22290250Brazil Laboratory of Morphometry Metabolismand Cardiovascular DiseasesBiomedical CenterInstitute of BiologyAnatomy DepartmentRio de Janeiro State UniversityRio de Janeiro 20551030Brazil

The coronavirus disease 2019(COVID-19)outbreak has drawn the scientific community's attention to pre-existing metabolic conditions that could aggravate the infection,causing extended viral shedding,prolonged hospitalization,and high death *** dysfunction-associated fatty liver disease(MAFLD)emerges as a surrogate for COVID-19 severity due to the constellation of metabolic alterations it *** review outlines the impact MAFLD exerts on COVID-19 severity in obese subjects,besides the possible mechanistic links to the poor *** data collected showed that MAFLD patients had poorer COVID-19 outcomes than non-MAFLD obese *** is generally accompanied by impaired glycemic control and systemic arterial hypertension,both of which can decompensate during the COVID-19 clinical ***,MAFLD subjects had higher plasma inflammatory marker concentrations than non-MAFLD subjects,which might be related to an intensified cytokine storm syndrome frequently associated with the need for mechanical ventilation and *** conclusion,MAFLD represents a higher risk than obesity for COVID-19 severity,resulting in poor outcomes and even progression to non-alcoholic *** should include MAFLD subjects in the high-risk group,intensify preventive measurements,and prioritize their vaccination.

关键词： Metabolic dysfunction-associated fatty liver disease Obesity COVID-19 Severity Cytokine storm syndrome

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Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding:A systematic review

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World Journal of Gastroenterology 2020年第45期26卷 7242-7257页

作者： Jose Cotter Cilenia Baldaia Manuela Ferreira Guilherme macedo Isabel Pedroto Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Department of Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBraga 4710-057Portugal Department of Life and Health Sciences Research Institute(ICVS)/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Gastroenterology Hospital de Santa MariaCentro Hospitalar Lisboa NorteLisbon 1649-035Portugal Department of University Clinic of Medicine II Faculty of MedicineUniversity of LisbonLisbon 1649-028Portugal Department of Gastroenterology Centro Hospitalar e Universitário de CoimbraCoimbra 3000-075Portugal Department of Faculty of Medicine University of CoimbraCoimbra 3004-504Portugal Department of Gastroenterology Centro Hospitalar de São JoãoPorto 4200-319Portugal Department of Gastroenterology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Department of Gastroenterology and Hepatology Training Center World Gastroenterology OrganizationPorto 4200-319Portugal Department of Gastroenterology Centro Hospitalar do PortoPorto 4099-001Portugal Department of Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal

BACKGROUND Anemia is considered a public health issue and is often caused by iron ***-deficiency anemia(IDA)often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women,and its prevalence among patients with gastrointestinal bleeding has been estimated to be 61%.However,few guidelines regarding the appropriate investigation of patients with IDA due to gastrointestinal bleeding have been *** To review current evidence and guidelines concerning IDA management in gastrointestinal bleeding patients to develop recommendations for its diagnosis and *** Five gastroenterology experts formed the Digestive Bleeding and Anemia Workgroup and conducted a systematic literature search in PubMed and professional association ***(via PubMed)searches combined medical subject headings(MeSH)terms and the keywords“gastrointestinal bleeding”with“iron-deficiency anemia”and“diagnosis”or“treatment”or“management”or“prognosis”or“prevalence”or“safety”or“iron”or“transfusion”or“quality of life”,or other terms to identify relevant articles reporting the management of IDA in patients over the age of 18 years with gastrointestinal bleeding;retrieved studies were published in English between January 2003 and April *** professional association websites were searched for clinical practice *** lists from guidelines were reviewed to identify additional relevant *** recommendations were developed by consensus during two meetings and were supported by the published literature identified during the systematic *** From 494 Literature citations found during the initial literature search,17 original articles,one meta-analysis,and 13 clinical practice guidelines were *** on the published evidence and clinical experience,the workgroup developed the following ten recommendations for the management of IDA in patients with gastrointestinal bleeding:(1)Evaluation of

关键词： Anemia iron-deficiency Erythrocyte transfusion Ferric carboxymaltose Gastrointestinal hemorrhage Iron Practice guidelines as topic

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Cadmium sorption by sodium and thiourea-modified zeolite-rich tuffs

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Journal of Environmental Sciences 2017年第2期29卷 39-48页

作者： Perfecto Barragán P M.Guadalupe macedo M Maria T.Olguín Instituto Tecnologico de Toluca Laboratorio de Investigacion en Ingenieria Ambiental.Av.Tecnologico S/NColonia Ex-Rancho La VirgenMetepecEstado de Meico CP.52140Mexico Instituto National de Investigaciones Nucleares Departamento de QuimicaA.P.18-1027Col.EseandonDelegacion Miguel Hidalgo C.P.11801Mexico

In the present investigation, two zeolite-rich tuffs from Guaymas and El Cajon（State of Sonora）, which were conditioned with a sodium chloride solution and subsequently modified with a thiourea solution, were chosen to evaluate the removal of Cd from aqueous systems. The zeolitic materials were characterized by scanning electron microscopy and X-ray diffraction. The surface area was also determined. The experiments were performed in a batch system, and the influences of p H, contact time between phases, and the concentration of Cd in the solution on the adsorption by sodium or thiourea-modified zeolite-rich tuff were investigated. It was found that the efficiency of Cd ion removal from aqueous solutions is influenced by the p H of the aqueous systems. The Cd adsorption kinetic data were well fitted to a pseudo-second-order model in all cases. The Langmuir and Langmuir–Freundlich isotherms adequately described the Cd sorption behavior by the zeolite from El Cajon pretreated with Na Cl and the zeolite from Guaymas modified with thiourea, respectively.

关键词： Cadmium Zeolite-rich-tuff Sorption Kinetics Isotherms

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