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The Role of TNF Related Apoptosis-Inducing Ligand in Neurodegenerative Diseases

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Cellular & Molecular Immunology 2005年第2期2卷 113-122页

作者： Y.Huang N.erdmann H.Peng Y.Zhao ThelaboratoryofNeurotoxicologyattheCenterforNeurovirology＆NeurodegenerativeDisorders ／／Dept.Pharmacology Dept.ofSurgery UniversityofNebraskaMedicalCenterOmahaNE68198-5880USA／／InstituteofAnimalResearchChineseAcademyofScienceChina

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions,and in many cases neuronal cell *** the etiology of neurodegenerative diseases may be distinct,different diseases display a similar pathogenesis,for example abnormal immunity within the central nervous system(CNS),activation of macrophage/microglia and the involvement of proinflammatory *** studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death,also called ***-related apoptosis-inducing ligand(TRAIL),a member of the TNF family,has been shown to be involved in apoptosis during many *** one member of a death ligand family,TRAIL was originally thought to target only tumor cells and was not present in ***,recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages,a major disease inducing cell during HIV-1-assoeiated dementia(HAD).TRAIL is also induced on neuron by β-amyloid protein,an important pathogen for Alzheimer's *** this review,we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases,TRAIL induced apoptosis signaling in the CNS cells,and specific role of TRAIL in individual *** & Molecular Immunology.2005;2(2):113-122.

关键词： Alzheimer's disease HⅣ-1 associated dementia multiple sclerosis apoptosis TRAIL macrophage

Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

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World Journal of Gastroenterology 2009年第35期15卷 4392-4401页

作者： Stephanie Schulz-Geske Kati erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser Department of Pharmacology and Toxicology School of PharmacyMartin Luther University Halle-Wittenberg06099 HalleGermany Department of Pediatrics Stanford University School of MedicineStanfordCA 94305 United States Department of Pharmaceutics College of PharmacyUniversity of MinnesotaMinneapolisMN 55455 United States

AIM： To investigate the molecular mechanism and functional consequences of heme oxygenase-1 （HO-1） activation by lansoprazole in endothelial cells and macrophages. MeTHODS： expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species （ROS） formation was measured with lucigenin-enhanced chemiluminescence. HO-1 promoter activity in mouse fibroblasts, stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed usingin vivo bioluminescence imaging. ReSULTS： Lansoprazole levels in endothelial cells increased HO-1 mRNA and HO-1 protein levels in macrophages. In addition, lansoprazole-induced ferritin protein levels in both cell systems. Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation. The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor, chromium mesoporphyrin IX. Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However, the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter ***： Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.

关键词： Antioxidants Ferritin Heme oxygenase-1 Lansoprazole Reactive oxygen species

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临床心脏病学研究的教益

德国医学 2000年第5期17卷 252-253页

作者： e.erdmann 王琳 Medizinische Klinik der Medizinischen einrichtungen der Universitt zu Kln Joseph-Stelzmann-Straβe 9D-50924 KlnGermany 同济医科大学附属同济医院

10年来心血管领域的发展速度是最快的。通过超声可以使以前很难诊断的某些疾病如心包积液、瓣膜病、心房粘液瘤、复杂的先天性心脏病、肺动脉栓塞、主动脉夹层等在数分钟内得以明确。MRI应用于心血管疾病中,提供了心脏和大血管的精确影... 详细信息

10年来心血管领域的发展速度是最快的。通过超声可以使以前很难诊断的某些疾病如心包积液、瓣膜病、心房粘液瘤、复杂的先天性心脏病、肺动脉栓塞、主动脉夹层等在数分钟内得以明确。MRI应用于心血管疾病中,提供了心脏和大血管的精确影像。仅去年就有53万余人接受了冠状动脉造影,而且病例数还会增加。肌钙蛋白T的测定有助于心肌梗死的快速诊断。这一系列有价值的检查方法得到了广泛的应用。治疗方面的进展:介入性心脏病学获得很大成功(每年15万以上的病人从中受益！),冠状动脉再通术,房间隔缺损封闭术。

关键词：心脏病治疗高血压预后

Occurrence of seeding metastases in resectable perihilar cholangiocarcinoma and the role of low-dose radiotherapy to prevent this

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World Journal of Hepatology 2020年第11期12卷 1089-1097页

作者： Lotte C Franken eva Roos Job Saris Jeanin e van Hooft Otto M van Delden Joanne Verheij Joris I erdmann Marc G Besselink Olivier R Busch Geertjan van Tienhoven Thomas M van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Pathology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Gastroenterology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Interventional Radiology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiation Oncology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands

BACKGROUND Preoperative biliary drainage in patients with presumed resectable perihilar cholangiocarcinoma(PHC)is hypothesized to promote the occurrence of seeding *** metastases can occur at the surgical scars or at the site of postoperative drains,and in case of percutaneous biliary drainage,at the catheter *** prevent seeding metastases after resection,we routinely treated PHC patients with preoperative radiotherapy(RT)for over 25 years until January *** To investigate the incidence of seeding metastases following resection of *** All patients who underwent resection for pathology proven PHC between January 2000 and March 2019 were included in this retrospective *** 2000-January 2018,patients received preoperative RT(3×3.5 Gray).RT was omitted in patients treated after January *** A total of 171 patients underwent resection for PHC between January 2000 and March *** 171 patients undergoing resection,111 patients(65%)were treated with preoperative *** bile cytology showed no difference in the presence of viable tumor cells in bile of patients undergoing preoperative RT or ***,two patients(1.2%)with seeding metastases were identified,both in the laparotomy scar and both after preoperative RT(one patient with endoscopic and the other with percutaneous and endoscopic biliary drainage).CONCLUSION The incidence of seeding metastases in patients with resected PHC in our series was low(1.2%).This low incidence and the inability of providing evidence that preoperative low-dose RT prevents seeding metastases,has led us to discontinue preoperative RT in patients with resectable PHC in our center.

关键词： Perihilar cholangiocarcinoma Seeding metastases Preventive radiotherapy

可去除染料--N-聚糖多方法深入分析中的缺失环节

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engineering 2023年第7期26卷 132-150,I0006页

作者： Samanta Cajic RenéHennig Valerian Grote Udo Reichl erdmann Rapp Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg 39106Germany glyXera GmbH Magdeburg 39120Germany Otto-von-Guericke University Chair of Bioprocess EngineeringMagdeburg 39106Germany

As the roles of glycans in health and disease continue to be unraveled,it is becoming apparent that glycans’immense complexity cannot be *** fully delineate glycan structures,we developed an integrative approach combining a set of cost-effective,widespread,and easy-to-handle analytical *** key feature of our workflow is the exploitation of a removable fluorescent label—exemplified by 9-fluorenylmethyl chloroformate(Fmoc)—to bridge the gap between diverse glycoanalytical methods,especially multiplexed capillary gel electrophoresis with laser-induced fluorescence detection(xCGeLIF)and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOFMS).Through the detailed structural analysis of selected,dauntingly complex N-glycans from chicken ovalbumin,horse serum,and bovine transferrin,we illustrate the capabilities of the presented ***,this approach“visualizes”N-glycans that have been difficult to identify thus far—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycan structures,potentially providing useful new targets for biomarker discovery.

关键词： Glycoproteins N-glycans Reversible labeling Hydrophilic interaction liquid chromatography Capillary gel electrophoresis Mass spectrometry

Preliminary age-based life history characteristics of the dogtooth tuna,Gymnosarda unicolor(Ruppell,1838),in the southwest Pacific Ocean

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Aquaculture and Fisheries 2023年第3期8卷 323-331页

作者： David J.Welch Adam K.Smith Kyne Krusic-Golub Sandra erdmann Stephen J.Newman C_(2)O Fisheries PO Box 3041CairnsQueensland4870Australia Centre for Sustainable Tropical Fisheries and Aquaculture College of Science and EngineeringJames Cook UniversityTownsville4811Australia Reef ecologic TownsvilleQueensland4811Australia Fish Ageing Services Pty.Ltd. QueenscliffVictoria3225Australia Western Australian Fisheries and Marine Research Laboratories Department of Primary Industries and Regional DevelopmentGovernment of Western AustraliaNorth BeachWestern Australia6020Australia

Dogtooth tuna,Gymnosarda unicolor were sampled off the east coast of Australia(southwest Pacific Ocean)from 2007 to *** were determined by examining thin transverse sections of their sagittal otoliths and were based on counts of alternating opaque and translucent zones(annual growth increments).Growth was rapid during the first year of life,after which growth in length was much *** of the constrained von Bertalanffy growth function(fork length-at-age)were L∞=1164.77(mm,FL)and K=0.44 year^(-1).Preliminary estimates of longevity indicate a maximum observed age of at least 20 *** was a high degree of variation in the observed length and age of sexual maturity for *** this variation,the size at 50%maturity for female *** estimated in this study was 713 mm FL(ears of age).The diet of *** is very broad and covers a range of fish *** life history characteristics of *** overall,indicate that this species may be somewhat resilient to ***,reports of localised depletions,in association with heavy targeting by sports fishers,low effective population sizes and patchy recruitment indicate that this species is particularly vulnerable to overfishing.

关键词： Otoliths Age Life history Pacific ocean Diet Fisheries management

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主动脉夹层动脉瘤的影像学检查

德国医学 1995年第3期12卷 155-156页

作者： D.J.Beuckelmann e.erdmann 刘启功 Klinik Ⅲ für Innere Medizin Universitat zu KolnJoseph-Stelzmann-Straβe 9D-50924 KolnGermany 同济医科大学附属同济医院

急性主动脉夹层动脉瘤危及生命,及时准确的诊断和治疗对挽救生命起决定性作用。未治疗者每小时死亡率为1％,而早期治疗可明显降低病人死亡率。Stanford将主动脉夹层动脉瘤分两型:A型:夹层累及升主动脉。B型:不累及升主动脉。A型相当于De... 详细信息

急性主动脉夹层动脉瘤危及生命,及时准确的诊断和治疗对挽救生命起决定性作用。未治疗者每小时死亡率为1％,而早期治疗可明显降低病人死亡率。Stanford将主动脉夹层动脉瘤分两型:A型:夹层累及升主动脉。B型:不累及升主动脉。A型相当于DeBakeyⅠ、Ⅱ型,B型相当于Ⅲ型。手术可改善A型病人的预后,而无并发症的B型患者用药物治疗也可获得良效。

关键词：主动脉瘤超声心动图核磁共振成像 CT 血管造影

心血管学的分子生物学心功能不全和心肌肥大的表型改变

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德国医学 1994年第3期11卷 127-129页

作者： M.Bhm M.Wankerl e.erdmann 王来 Medizinisehe Klinik Ⅲ für Innere Medizin der Universitt zu Kn Josef-Stelzmann-Str.9D-50924 KlnGermany Medizinisehe Klinik Ⅲ für Innere Medizin der Universitt zu Kln Josef-Stelzmann-Str.9D-50924 KlnGermany 同济医科大学附属同济医院

各种真核细胞的表型及功能取决于其蛋白质的功能状态(离子通道、酶)、转录和翻译过程,以及基本的基因密码有无变异。每个环节的变化均可影响细胞的功能状态和结构;心功能不全及心肌肥大的进程中,上述每一环节均有相应的质与量变化,影响... 详细信息

各种真核细胞的表型及功能取决于其蛋白质的功能状态(离子通道、酶)、转录和翻译过程,以及基本的基因密码有无变异。每个环节的变化均可影响细胞的功能状态和结构;心功能不全及心肌肥大的进程中,上述每一环节均有相应的质与量变化,影响着病程发展。

关键词：心血管学分子生物学心功能不全心肌肥大

Modified MMT Clay Using Species of Different Chemical Nature for Preparation HDPe Composites： effect on Transport and Thermal Properties

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材料科学与工程（中英文A版） 2011年第6期1卷 778-789页

作者： erdmann e.e.nora Monasterio Femanda Toro Maria Antonia Destefanis Hugo Instituto de Investigaciones para la Industria Quimica - INIQUI-CONICeT lngenieria Universidad National de Salta C.P. 4400 Salta Argentina Instituto de Investigaciones para la lndustria Quimica - INIQULCONICeT Consejo de lnvestigaciones- CIUNSa Facultad deCiencias Exactas Universidad Nacional de Salta C.P. 4400 Salta Argentina

Sodium montmorillonite (MMT) was modified with three cyclic species, and high density polyethylene (HDPe) was used as polymeric matrix. The cyclic species used for modifying the MMT were: ε-caprolactam (ε-CLa), ε-caprolactone (ε-CLo) and octamethylcyclotetrasiloxane (OMCTS). They were introduced into silicate interlamellar spaces using different ways. Clays were characterized by X-ray diffraction (XRD), infrared spectra (FTIR) and thermal gravimetric analysis (TG-DTG). Melt processing was used to prepare the HDPe/clay composites. The composites were studied by XRD and scanning electron microscopy (SeM), TG-DTG, differential scanning calorimetry (DSC) and pervaporation techniques. The results show the feasibility of obtaining MMT modified with different organic molecules, the addition of modified clays in the polymeric matrix affected the thermal and transport properties of the composites.

关键词：聚乙烯复合材料高密度聚乙烯改性蒙脱土改性粘土化学性质热性能八甲基环四硅氧烷 TG-DTG