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Effects of fluid balance on prognosis of acute respiratory distress syndrome patients secondary to sepsis

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World Journal of Emergency Medicine 2020年第4期11卷 216-222页

作者： Yu-ming Wang Yan-jun Zheng Ying Chen Yun-chuan Huang Wei-wei Chen Ran Ji Li-li Xu Zhi-tao yang Hui-qiu Sheng Hong-ping Qu En-qiang Mao er-zhen Chen Department of Emergency Ruijin Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Critical Care Medicine Ruijin Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghaiChina

BACKGROUND:Fluid management is crucial to acute respiratory distress syndrome(ARDS)secondary to ***,choices of fluid resuscitation strategies and fluid input volumes remain a thorny *** study aimed to elucidate the relationship between fluid balance and prognosis of ARDS patients secondary to ***:Our study included 322 sepsis patients from Ruijin Hospital between 2014 and 2018,and 84 patients were diagnosed as ARDS within 72 hours after onset of sepsis according to Berlin ARDS Defi ***:Among the 322 sepsis patients,84(26.1%)were complicated with ARDS within 72 *** patients had a lower oxygenation index(PaO2/FiO2166.4±71.0 vs.255.0±91.2,Per duration of mechanical ventilation(11[6-24]days vs.0[0-0]days,Pere much lower in survivors than in non-survivors(43.2±16.7 mL/kg vs.51.0±25.2 mL/kg,Pere much higher in survivors(45.2±19.8 mL/kg vs.40.2±22.7 mL/kg,Per prognosis of sepsis patients complicated with ARDS.

关键词： Sepsis Acute respiratory distress syndrome Fluid balance Prognosis

新工科背景下地方性院校本硕博贯通培养模式探究

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教育教学论坛 2024年第17期 9-12页

作者：程强张彩霞杨聪彬北京工业大学机械与能源工程学院北京100124

国家发展战略对创新型人才提出了新的需求,新工科推进驱动着高校人才培养模式的不断革新。本硕博贯通的创新人才培养模式正是适应高层次人才培养工作新要求而提出的。分析了国内现有本硕博贯通培养的现状,阐述了目前存在的问题,针对地... 详细信息

国家发展战略对创新型人才提出了新的需求,新工科推进驱动着高校人才培养模式的不断革新。本硕博贯通的创新人才培养模式正是适应高层次人才培养工作新要求而提出的。分析了国内现有本硕博贯通培养的现状,阐述了目前存在的问题,针对地方性院校进一步提出了如何做好本硕博教育贯通培养,从明确培养目标、优化培养机制与课程管理、加大科研引导、关注国际视野等方面提出了改进措施。

关键词：新工科本硕博贯通地方性院校创新人才培养

Ultrasound-guided co-axial introducer needle biopsy in the diagnosis of eosinophilic cystitis in children

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Chinese Medical Journal 2021年第15期134卷 1872-1873页

作者： Yan-Bing Luo qiang Gao Jing Guo Yong Zhang Jian Sun Wei-Yu Li er-Long Xiao Department of Urology Surgery Qingdao Women and Children's HospitalQingdaoShandong 266034China

characterized by transmural eosinophilic inflammation of the bladder wall,accompanied by increased urine frequency,hematuria,dysuria,and suprapubic pain.[1]It has rarely been reported in *** median age at diagnosis in the pediatric population is 6.5 *** is no standard treatment for EC in childhood,and most patients receive non-steroidal anti-inflammatory agents or steroids as adjuvant therapy.121 Most cases in children are self-limiting and do not require more invasive treatments,but serious complications can occur and relapsing forms have been ***,there may be a need for long-term monitoring with relevant blood and urine tests and imaging.13,41 Biopsy is essential for the diagnosis of ***,cystoscopy with biopsy is recommended by international *** biopsy is invasive,*** the disease is confined to the bladder submucosa,without the involvement of the mucosal layer,it is tricky to perform the cystoscopic biopsy,because the whole layer bladder biopsy is not chosen by cystoscopy *** biopsy is an unpleasant and costly procedure.

关键词： diagnosis urine needle

A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant,PPlase to Suppress Endoplasmic Reticulum-Mediated Immunity

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Molecular Plant 2018年第8期11卷 1067-1083页

作者： Guangjin Fan yang yang Tingting Li Wenqin Lu Yu DU Xiaoyu qiang Qujiang Wen Weixing Shan State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F University Yangling Shaanxi 712100 China State Key Laboratory of Crop Stress Biology for Add Areas and College of Agronomy Northwest A&F University Yangling Shaanxi 712100 China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture Northwest A&F University Yangling Shaanxi 712100 China

Phytophthora pathogens secrete a large arsenal of effectors that manipulate host processes to create an environment conducive to pathogen colonization. However, the underlying mechanisms by which Phytophthora effectors manipulate host plant cells still remain largely unclear. In this study, we report that PcAvr3a12, a Phytophthera capsici RXLR effector and a member of the Avr3a effector family, suppresses plant immunity by targeting and inhibiting host plant peptidyl-prolyl cis-trans isomerase （PPlase）. Overexpression of PcAvr3a 12 in Arabidopsis thaliana enhanced plant susceptibility to P. capsici. FKBP15-2, an endoplasmic reticulum （er）-Iocalized protein, was identified as a host target of PcAvr3a12 during early P. capsici infection. Analyses of A. thaliana T-DNA insertion mutant （fkbp15-2）, RNAi, and overexpression lines consistently showed that FKBP15-2 positively regulates plant immunity in response to Phytophthora infection. FKBP15-2 possesses PPlase activity essential for its contribution to immunity but is directly suppressed by PcAvr3a12. Interestingly, we found that FKBP15-2 is involved in er stress sensing and is required for er stress-mediated plant immunity. Taken together, these results suggest that P. capsici deploys an RXLR effector, PcAvr3a12, to facilitate infection by targeting and suppressing a novel er-Iocalized PPlase, FKBP15-2, which is required for er stress-mediated plant immunity.

关键词： RXLR effector Avr3a FKBP er stress immunity Phytophthora capsici

Hemiphasmid Side-Chain Liquid Crystalline Polynorbornene: Phase Structure and Strain-Hardening Based on “Multi-Chain Column” Physical Crosslinks

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Hemiphasmid Side-Chain Liquid Crystalline Polynorbornene: Ph...

2016年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十四届全国高分子液晶态与超分子有序结构学术论文报告会）

作者： Ruiying Zhao Shuang yang er-qiang Chen Beijing National Laboratory for Molecular Sciences Department of Polymer Science and Engineering and Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular Engineering Peking University

Hemiphasmid mesogen is composed of two parts with different shapes,a rod-like and a fan-like moieties that are linked together.1 Due to the special shape matching mechanism,side-chain liquid crystalline polymers(SCLCPs)with side groups containing hemiphasmid mesogens have fantastic ability of *** diversity of side groups provides abundant manners for designing ordered

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多温度条件沥青混合料水稳定性评价指标阈值

吉林大学学报（工学版） 2024年第7期54卷 1966-1977页

作者：罗蓉梁宇牛茏昌黄婷婷苗强武汉理工大学交通与物流工程学院武汉430063 湖北省公路工程技术研究中心武汉430063 广州市高速公路有限公司广州510289

为预防与减少沥青路面水损害的发生,以表面能理论为基础、全国六大区域主要城市月平均气温为依据,结合表面能试验和宏观水稳定性试验两种评价方法来准确评价多温度条件下沥青混合料的水稳定性。首先,测试−20~50℃区间内原材料表面能,确... 详细信息

为预防与减少沥青路面水损害的发生,以表面能理论为基础、全国六大区域主要城市月平均气温为依据,结合表面能试验和宏观水稳定性试验两种评价方法来准确评价多温度条件下沥青混合料的水稳定性。首先,测试−20~50℃区间内原材料表面能,确定各温度条件下黏附性评价指标er值;选用4种沥青混合料进行−20℃的5次冻融循环劈裂试验、10℃和30℃的浸水马歇尔试验以及50℃的浸水汉堡车辙试验,并借助以上3种宏观试验指标及其技术要求,依次确定对应于各温度点的指标er阈值。试验结果表明:在−20、10、30、50℃条件下,基质沥青混合料的指标er阈值分别为0.992、1.693、0.994和0.512;改性沥青混合料的指标er阈值分别为1.562、1.944、1.144和0.512。进而以多温度条件下沥青混合料水稳定性评价指标阈值为基础,建立基质沥青混合料阈值与温度的关系模型为y=-0.0006x2+0.0097x+1.4726;改性沥青混合料阈值与温度的关系模型为y=-0.0006x2+0.0004x+1.8341,其中x为温度,y为对应温度条件下的指标阈值。

关键词：沥青混合料水稳定性表面能阈值温度

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Cloning and Characterization of Porcine TSARG7 Gene and Analysis of Its Tissue-Specific Expression

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Agricultural Sciences in China 2009年第11期8卷 1384-1391页

作者： LI Mei-li LI Gui-qiang FANG Wei WANG Wei SONG Xiao-guang LI er-lin JIA Chao XU Yin-xue College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 P.R.China

TSARG7 is a novel member of the acyltransferase family since its sequence possesses the highly conserved phosphate acyltransferase （PlsC） domain existing in all acyltransferase-like proteins. The porcine TSARG7 had been identified by cloning in silico but had not been confirmed experimentally. The full-length mRNA of porcine TSARG7 gene was sequenced and two splice variants were discovered. The full-length cDNA of TSARG7 variant 1 was 2 513 bp and variant 2 was 2 634 bp. The putative porcine TSARG7 proteins, which were located in the cytoplasm, encoded 458 and 456 amino acids, respectively. Real-time PCR analysis showed that TSARG7 gene was expressed in various tissues, but at different levels. The expression levels of this gene were higher in the skeletal muscle, heart, and testis than that in other tissues, suggesting that the TSARG7 gene played a role in procine skeletal muscle, heart, and testis functions.

关键词： TSARG7 cDNA cloning pig bioinformatic analysis gene expression

羟氯扎胺盐酸左旋咪唑复方混悬液对靶动物牛的安全性试验

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动物医学进展 2024年第2期45卷 84-89页

作者：高馨儿陈玲玲姚学强周凯仁王娟周绪正朱晓鹏张继瑜甘肃农业大学动物医学院甘肃兰州730070 中国农业科学院兰州畜牧与兽药研究所甘肃兰州730050 万禾草畜产业科技开发有限责任公司甘肃张掖734312

为评价羟氯扎胺盐酸左旋咪唑复方混悬液的安全性,确定该药对靶动物牛的毒性风险,选用32头健康西门塔尔肉牛(10~12月龄),随机分为4组,每组8头,分别以推荐剂量的0、1、3、5倍剂量连续口服给药3 d,给药后观察14 d。在试验开始前(第0天)、... 详细信息

为评价羟氯扎胺盐酸左旋咪唑复方混悬液的安全性,确定该药对靶动物牛的毒性风险,选用32头健康西门塔尔肉牛(10~12月龄),随机分为4组,每组8头,分别以推荐剂量的0、1、3、5倍剂量连续口服给药3 d,给药后观察14 d。在试验开始前(第0天)、给药结束后(第4天)及试验结束后(第18天)抽取试验牛血液进行血液学检查及血清生化检查。试验第4天,于0剂量组和5倍剂量组内随机选择4头牛进行安乐死(雌雄各半),试验结束后安乐死0剂量组及5倍剂量组剩余牛,进行组织病理学观察。综合体重、临床毒性观察、血液学检查、血清生化检查和组织病理学观察结果,评估药物的安全性。试验结果显示,1、3、5倍剂量组给药后12 h内多数牛均出现腹泻反应,5倍剂量组个别牛有短暂的表现呆滞、食欲减退,停药后副作用逐渐减弱或消失,试验第5天时临床各项观测结果均正常;其他剂量组未出现采食、饮水及精神状态异常,未观测到明显临床病理表现。试验结束后,0剂量组及1倍剂量组试验牛体重均有增加,但3倍剂量组及5倍剂量组试验牛体重下降;血液学检查及血清生化分析结果显示,与0剂量组相比,3倍剂量组及5倍剂量组试验牛部分指标存在显著差异(P<0.05);对试验牛剖检,组织病理学观察未发现肉眼可见明显病变。综上所述,连续3 d每天口服5倍推荐剂量的羟氯扎胺盐酸左旋咪唑复方混悬液靶动物牛仍可耐受,故临床按推荐剂量为0.25 mL/kg口服羟氯扎胺盐酸左旋咪唑复方混悬液具有安全性。

关键词：羟氯扎胺盐酸左旋咪唑牛靶动物安全

Magneto-Optical Trapping of 88Sr atoms with 689 nm Laser

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Chinese Physics Letters 2011年第3期28卷 51-54页

作者： WANG qiang LIN Bai-Ke ZHAO yang LI Ye WANG Shao-Kai WANG Min-Ming ZANG er-Jun LI Tian-Chu FANG Zhan-Jun Division of Electricity and Quantum Metrology National Institute of MetrologyBeijing 100013 Department of Precision Instruments and Mechanology Tsinghua UniversityBeijing 100084

We report the experimental realization of strontium magneto-optical trap(MOT)operating on the intercombination transition lSo-3 P1 at 689nm,namely red MOT.A 689nm laser used for cooling and trapping is injection locked to a master laser,whose linewidth is narrowed to 150 Hz by locking to a high finesse optical reference cavity.88 Sr atoms pre-cooled and trapped by the broad^(1)S_(O)-^(1)P_(l)transition at 461 nm are transferred to the red MOT with the help of a time sequence *** transfer ratio is about 20%and the red MOT's temperature is estimated to be less than 20μK by the time-of-flight(TOF)image analysis.

关键词： optical realization narrow