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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

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Determination of Scaling Parameter and Dynamical Resonances in Complex-Rotated Hamiltonian Ⅰ:Theory

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Communications in Theoretical Physics 2008年第3期49卷 599-606页

作者： ZHAO fang ZHAO Mei-shan Department of Mathematics and Department of Chemistry The University of Chicago Chicago Illinois 60637 USA The James Pranck Institute and Department of Chemistry The University of Chicago Chicago Illinois 60637 USA

In this paper we present a theoretical analysis on the determination of the scaling parameter in the complex-rotated Hamiltonian, which has served as a basis for successful applications of the rigged Hilbert space theory for resonances. Based on the complex energy eigenvalue, E（θ） = er（θ） - iГ（θ）/2, as a function of the scaling parameter θ, we find that for potential barrier scattering, the condition dГ（θI）/dθ = 0 uniquely determines the scaling parameter 8. The condition d er （θR）/ dθ = 0 is merely a consequence of the Virial theorem and θI =θR is not a necessary condition for a resonance state. We also provide a harmonic approximation formMism for resonances in scattering over a potential barrier.

关键词： complex-rotated Hamiltonian potential scattering resonances rigged Hilbert space

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Boundedness of Some Marcinkiewicz Integral Operators Related to Higher Order Commutators on Hardy Spaces

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Acta Mathematica Sinica,English Series 2006年第1期22卷 105-114页

作者： shan Zhen LU Li fang XU Department of Mathematics Beijing Normal University Beijing 100875 P. R. China

In this paper, the authors study the boundedness properties of μΩ↑m,b generated by the function b ∈Lipβ（R^n）（0 〈β≤ 1/m） and the Marcinkiewicz integrals operator μΩ. The boundednesses are established on t... 详细信息

关键词： Marcinkiewicz integral Higher order commutator Lipshcitz space Hardy type space Herz space

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Development of a Non-Pollution Orange Fruit Expert System Software Based on ***

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Agricultural Sciences in China 2011年第5期10卷 805-812页

作者： LI Yi-shan HONG Li-fang Institute of Network Technology Beijing University of Posts and Telecommunications Beijing 100876 P.R.China Agricultural Environment and Resource Institute Yunnan Academy of Agricultural Sciences Kunming 650205 P.R.China

Based on ***,a orange fruit tree fertilizer expert system software was *** system could simulate and decide an annual fertilization plan for young and mature trees in terms of geographical position and *** paper introduced the design conditions,framework,production,and deployment of the *** exhibited characters of orange specialty and was a typical online agriculture expert *** use of the system for orange fruit management could decrease production cost,guarantee orange quality and improve economical benefit at the same *** using the system saved N input by 41-238 g/plant,P2O5 input 3-24 g/plant,and K2O input 1-36 g/plant,and got higher yield by 6-17 kg/plant.

关键词： rational fertilization expert system orange fruit tree ***

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Encapsulating manganese oxide nanoparticles within conducting polypyrrole via in situ redox reaction and oxidative polymerization for long-life lithium-ion batteries

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Rare Metals 2021年第9期40卷 2415-2423页

作者： He-Liang Yao shan-shan Gao Zheng-Qian Fu Wei-Chao Bao Zhong-Hui Cui Yi-Qiu Li fang-fang Xu State Key Laboratory of High Performance Ceramics and Superﬁne Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Manganese oxides(MnO_(x)) have been extensively investigated due to their extremely high theoretical capacities for application as conversion anodes in lithiumion batteries. However, fully performing their theoretical performance still faces poor electric conductivity and serious volume change upon lithium insertion/***, we demonstrate encapsulating manganese oxide nanoparticles within a conducting polymer polypyrrole(PPy) shell as a facile strategy to overcome such flaws through in situ redox reaction and oxidative polymerization process. Such an in situ method combines the redox reaction between potassium permanganate and tetrahydrofuran to form MnO_(x)nanoparticles and the subsequent oxidative polymerization of pyrrole to form a conductive polypyrrole coating shell by the oxidant KMnO_(4) into one step. For the as-fabricated products(MnO_(x)@PPy), this tenderly introduced conductive PPy shell highly favors the fast electron transfer and preserves the electrode structure integrity upon repeated cycling. As the anode for LIBs, MnO_(x)@PPy exhibits superior lithium storage performance with a high reversible capacity(1538 mAh·g^(-1)), long-life cyclability(747 mAh·g^(-1) after 1000 cycles at 1.0 C) and durable ratability(574 mAh·g^(-1) at 2.0 C). This work demonstrates that the convenient in situ strategy to form conductive polymer coating shell is effective to improve the performance of conversion anodes and can be extended to other materials for energy storage applications.

关键词： Manganese oxide Polypyrrole High cycling performance Lithium-ion battery

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A Novel Model of the H Radical in Hot-Filament Chemical Vapor Deposition

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Chinese Physics Letters 2011年第2期28卷 216-219页

作者： GUO Xiao-Song BAO Zhong ZHANG shan-shan XIE er-Qing Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Physical Science and Technology SchoolLanzhou UniversityLanzhou 730000

Amorphous hydrogenated and crystalline silicon thin films were prepared by hot-filament chemical vapor deposition.A structural transformation from amorphous phase to crystalline phase by increasing the filament temperature Tfil from 1600℃ to 1650℃ was *** phenomenon may result from the associated abundance of H radicals participating in the growth of the Silms.A probability distribution model of the H radical is proposed to elucidate this *** to this model,the phase transition is due to a distinct difference in the probability distribution of the H radicals,which seems to be dependent upon Tfil.

关键词： deposition transformation crystalline

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Pancreatic panniculitis as the first presentation of pancreatic ductaladenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 106-108页

作者： Wei-fang Zhu shan fang Jian-Jun Qiao Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Pancreatic panniculitis,also known as pancreatic fat necrosis or enzymatic panniculitis,is a rare type of panniculitis that occurs in 0.3%−3%of patients with pancreatic disease such as acute or chronic pancreatitis and pancreatic carcinoma,especially acinar cell carcinoma[1,2].The clinical manifestations are nonspecific erythema tender nodules.

关键词： Pancreatic acute adenocarcinoma

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Bioleaching of two different types of chalcopyrite by Acidithiobacillus ferrooxidans

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International Journal of Minerals,Metallurgy and Materials 2013年第2期20卷 119-124页

作者： Ying-bo Dong Hai Lin Kai-bin Fu Xiao-fang Xu shan-shan Zhou Key Laboratory of High-Efficient Mining and Safety of Metal Mines (Ministry of Education) University of Science and Technology Beijing School of Civil and Environmental Engineering University of Science and Technology Beijing

Two different types of chalcopyrite （pyritic chalcopyrite and porphyry chalcopyrite） were bioleached with AcidithiobaciUus ferrooxidans ATF6. The bioleaching of the pyritic chalcopyrite and porphyry chalcopyrite is quite different. The copper extraction reaches 46.96% for the pyritic chalcopyrite after 48-d leaching, but it is only 14.50% for the porphyry chalcopyrite. Proper amounts of initial ferrous ions can improve the efficiency of copper extraction for the two different types of chalcopyrite. The optimum dosage of ferrous ions for the pyritic chalcopyrite and porphyry chalcopyrite is different. The adsorption of ATF6 on the pyritic chalcopyrite and porphyry chalcopyrite was also studied in this paper. It is found that ATF6 is selectively adsorbed by the two different types of chalcopyrite; the higher adsorption onto the pyritic chalcopyrite than the porphyry chalcopyrite leads to the higher copper dissolution rate of the pyritic chalcopyrite. In addition, the zeta-potential of chalcopyrite before and after bioleaching further confirms that ATF6 is more easily adsorbed onto the pyritic chalcopyrite.

关键词： chalcopyrite bioleaching adsorption functional groups

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Theoretical Study on the Confluence of Debris Flow and the Main River

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四川大学学报（工程科学版） 2005年第S1期37卷 138-142页

作者： Guo, Zhixue Huang, er Cao, Shuyou Liu, Xingnian fang, Duo Lab. of Hydraulic and Mountain River Eng. Sichuan Univ. Chengdu 610065 China

Because of the high momentum of debris flow,when it confluences with the Main River,the water level in the upstream of the conjunction point will increase and a portion of sediment will deposit in the con- junction *** discharge of downstream will be less then the summation discharge of main river and side channel,and the density of downstream will be difference from both the density of the fluid of main river and *** on momentum theory,and with the transport coefficient and deposit coef...

关键词： debris flow transport coefficient deposit coeffieient water rising discharge ratio density ratio

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