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Va.cula. Ca.cifica.ion： Current Genetics Underlying This Complex Phenomenon

Chinese Medica. Journa. 2017年第9期130卷 1113-1121页

作者： Nona.zit perez-Herna.dez Ga. a.tilon-Duque Ruben Bla.hma.-Bra.n Gilberto Va.ga.-a.a.con a.ria. a.a.l Rodriguez-Cortes Shely a.ra.-Da.iez Rosa.inda.Posa.a.-sanchez Jose Ma.uel Rodriguez-perez Depa.tment of Molecula. Biology National Institute of Cardiology "lgnacio Chavez" Mexico Mexico City 14080 Mexico 2Depa.tment of Endocrinology National Institute of Cardiology "Ignacio Chavez" Mexico Mexico City 14080 Mexico

Objective： Va.cula. ca.cifica.ion is the consequence of the complex intera.tion between genetic, environmenta., a.d va.cula. fa.tors, which ultima.ely lea. to the deposition of ca.cium in the tunica.intima.（a.herosclerotic ca.cifica.ion） or tunica.media.（M6nckenberg＇s sclerosis）. Va.cula. ca.cifica.ion is a.so closely rela.ed to other pa.hologies, such a. dia.etes mellitus, dyslipidemia. a.d chronic kidney disea.e. It ha. been concluded tha. the degree of va.cula. ca.cifica.ion ma. va.y from person to person, even if the a.socia.ed pa.hologies a.d environmenta. fa.tors a.e the sa.e. Therefore, this suggests a. importa.t genetic contribution to the development of va.cula. ca.cifica.ion. This review a.med to find the most recent evidence a.out va.cula. ca.cifica.ion pa.hophysiology rega.ding the genetic a.pects a.d molecula. pa.hwa.s. Da.a.Sources： We conducted a. exha.stive sea.ch in Scopus, EBSCO, a.d PubMed with the keywords ＂genetics a.d va.cula. ca.cifica.ion＂, ＂molecula. pa.hwa.s, genetic a.d va.cula. ca.cifica.ion＂ a.d included the ma.n a.ticles from Ja.ua.y 1995 up to a.gust 2016. We focused on the most recent evidence a.out va.cula. ca.cifica.ion pa.hophysiology rega.ding the genetic a.pects a.d molecula. pa.hwa.s. Study Selection： The most va.ua.le published origina. a.d review a.ticles rela.ed to our objective were selected. Results： Va.cula. ca.cifica.ion is a.multifa.toria. disea.e; thus, its pa.hophysiology ca.not be expla.ned by a.single specific fa.tor, ra.her tha. by the result of the a.socia.ion of severa. genetic va.ia.ts, molecula. pa.hwa. intera.tions, a.d environmenta. fa.tors tha. promote its development. Conclusion： a.though severa. molecula. a.pects of this mecha.ism ha.e been elucida.ed, there is still a.need for a.better understa.ding of the fa.tors tha. predispose to this disea.e.

关键词： a.herosclerosis Ca.diova.cula. Risk Genetics Polymorphisms Va.cula. Ca.cifica.ion

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Highly efficient multi-meta. ca.a.ysts for ca.bon dioxide reduction prepa.ed from a.omica.ly sequenced meta. orga.ic fra.eworks

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Na.o Resea.ch 2021年第2期14卷 493-500页

作者： Celia.Ca.tillo-Bla. Consuelo a.va.ez-Ga.va. Ines Puente-Orench a.ba.Ga.cia.sanchez Freddy E.Oropeza.enrique Gutirrez-Puebla.a.geles Monge Victor a.de la.Pena.O'hea.Felipe Ga.da.a Ma.eria.s Science Institute of Ma.rid(CSIC) C/Sor Juana Ines de la Cruz 3Madrid 28049Spain Instituto de Ca.a.isis y Petroleoquimica.CSIC) dM arie Curie 2Madrid 28049Spain Instituto de Ciencia.de Ma.eria.es de a.a.on Pedro Cerbuna 12Zaragoza 50009Spain Institut La.e La.gevin 71 Avenue des Martyrs38042 GrenobleFrance Photoa.tiva.ed Processes Unit IMDEa.Energy Institute Mostoles Technology ParkAvenida Ramdn de la Sagra 3MostolesMadrid 28935Spain Depa.tment of Inorga.ic Chemistry University Autonomous of MadridC/Frandsco Tomdsy Valiente 7Madrid 28049Spain

The precise control on the combina.ion of multiple meta. a.oms in the structure of meta.-orga.ic fra.eworks(MOFs)endowed by reticula. chemistry,a.lows the obta.ning of ma.eria.s with compositions tha. a.e progra.med for a.hieving enha.ced *** present work illustra.es how through the tra.sforma.ion of MOFs with desired a.ra.gements of meta. ca.ions,multi-meta. spinel oxides with precise compositions ca. be obta.ned,a.d used a. ca.a.yst precursor for the reverse wa.er-ga. shift *** differences in the spinel initia. composition a.d structure,determined by neutron powder diffra.tion,influence the overa.l ca.a.ytic a.tivity with cha.ges in the process of in s itu forma.ion of a.tive,meta.-oxide supported meta. na.opa.ticles,which ha.e been monitored a.d cha.a.terized with in situ X-ra. diffra.tion a.d photoelectron spectroscopy studies.

关键词： reticula. chemistry multi-meta. meta.-orga.ic fra.eworks(MOFs) ca.bon dioxide reduction heterogeneous ca.a.ysis reverse wa.er-ga. shift in-situ X-ra. photoelectron spectroscopy(XPS)

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Compa.ison between type-2 a.d type-1 myoca.dia. infa.ction：clinica. fea.ures, trea.ment stra.egies a.d outcomes

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Journa. of Geria.ric Ca.diology 2016年第1期13卷 15-22页

作者： a.gel Lopez-Cuenca.Miria. Gomez-Molina.Pedro J Flores-Bla.co Ma.ia.ela.sanchez-Ma.tinez a.drea.Ga.cia.Na.bon Igna.io De La. Hera.-Gomez Ma.ia.J Sa.nchez-Ga.ia. Esther Guerrero-perez Ma.ia.o Va.des Sergio Ma.za.o-Fema.dez Depa.tment of Interna. Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Division of Ca.diology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Depa.tment of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Depa.tment of lnterna. Medicine University of Murcia Murcia Spain

ObjectiveTo 与尖锐心肌的梗塞(a.I ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 a.I 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被... 详细信息

ObjectiveTo 与尖锐心肌的梗塞(a.I ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 a.I 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被收集。在 1 年的后续，死亡，击，流血的非致命的心肌的梗塞和专业是 ***-1 a.I 在 707 是在场的(86%) 盒子当(14%) 117 作为 type-2 被分类时。有 type-2 a.I 的病人更经常是象糖尿病那样的女、有的更高的合作病态，以前的非圣片断举起急性冠的症候群，损害肾的功能，贫血症， a.ria. 纤维性颤动和恶意。然而，保存了左室的喷射部分，正常冠的动脉是经常看见的更多，侵略治疗是不太普通的，并且反血小板药， sta.ins 和 beta.blockers 是在有 type-2 a.I 的病人规定的更少。在 1 年的后续， type-2 a.I 与更高粗略的死亡风险被联系(HR：1.75， 95% CI：1.14-2.68；P = 0.001 ) ，但是这个协会没在 multiva.ia.le 调整以后仍然保持重要(P = 0.785 ) 。而且，我们没发现 type-2 a.I 与另外的临床的 *** 被联系这张真实人口与 type-1 相比， type-2 a.I 是主要女人们并且有更多的合作病态。侵略治疗策略和 ca.dioprotective 药是在 type-2 使用的更少，当 1 年的临床的结果是类似的时。

关键词：冠的容器后续学习心肌的梗塞

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Review of the El Sopla. a.ber Outcrop,Ea.ly Creta.eous of Ca.ta.ria.Spa.n

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a.ta.Geologica.Sinica.English Edition) 2010年第4期84卷 959-976页

作者： Ma.ía.Na.a.RO enrique PENa.VER Rica.do perez-DE La.FUENTE Ja.me ORTEGa.BLa.CO Cesa. MENOR-Sa.Va. Edua.do Ba.RON Ca.men SORIa.O Idoia.ROSa.ES Ra.a.l LOPEZ DEL Va.LE Fra.cisco VELa.CO Ferna.do TORNOS Véronique Da.IERO-GOMEZ Berna.d GOMEZ Xa.ier DELCLOS Instituto Geologico y Minero de Espa.a E-28003MadridSpain Depa.ta.ent d'Estra.igra.ia Paleontologia i Geociencies MarinesFacultat de GeologiaUniversitat de BarcelonaE-08071BarcelonaSpain Centro de a.trobiologia.CSIC-INTa. E-28850Torrejon de ArdozSpain Europea. Synchrotron Ra.ia.ion Fa.ilities F-38000 GrenobleFrance/Geosciences Rennes-Universite de Rennes 1F-35042 RennesFrance El Sopla. S.L. Prao El CollaoE-39553CantabriaSpain Universida. del Pa.s Va.co Dpto.Mineralogia y PetrologiaE-48080 BilbaoSpain CNRS-UMR 5125 PEPS Universite Lyon 1GeodeF-69622 VilleurbanneFrance

El Sopla. outcrop, a. Ea.ly Creta.eous a.ber deposit recently discovered in northern Spa.n （Ca.ta.ria., ha. been shown to be the la.gest site of a.ber with a.thropod inclusions tha. ha. been found in Spa.n so fa.. Releva.t da.a.provided herein for biogeochemistry of the a.ber, pa.ynology, ta.honomy a.d a.thropod bioinclusions complement those previously published. This set of da.a.suggests a. lea.t two bota.ica. sources for the a.ber of El Sopla. deposit. The first （type a.a.ber） strongly supports a.source rela.ed to Cheirolepidia.ea., a.d the second （type B a.ber） shows non-specific conifer bioma.kers. Compa.ison of molecula. composition of type a.a.ber with Frenelopsis lea.es （Cheirolepidia.ea.） strongly suggests a.biochemica. a.finity a.d a.common bota.ica. origin. a.prelimina.y pa.ynologica. study indica.es a.regiona. high ta.onomica. diversity, ma.nly of pteridophyte spores a.d gymnosperm pollen gra.ns. a.cording to the prelimina.y pa.ynologica. da.a. the region wa. inha.ited by conifer forests a.a.ted to a.dry sea.on under a.subtropica. clima.e. The a.unda.t cha.coa.ified wood a.socia.ed with the a.ber in the sa.e beds is evidence of pa.eofires tha. most likely promoted both the resin production a.d a. intensive erosion of the litter, a.d subsequent grea. a.cumula.ion of a.ber plus pla.t cuticles. In a.dition, for the first time in the fossil record, cha.coa.ified pla.t fibers a. bioinclnsions in a.ber a.e reported. Other releva.t ta.honomic da.a.a.e the exceptiona. presence of serpulids a.d bryozoa.s on the surfa.es of some a.ber pieces indica.ing both a.long exposure on ma.ine or bra.kish-wa.er a.d a.mixed a.sembla.e of a.ber. La.tly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing rema.ka.le a.a.ta.ions, a.e reported. In conclusion, a.documented scena.io for the origin of the El Sopla. a.ber outcrop is provided.

关键词： fossil resin chemota.onomy pa.eobota.y cha.coa. a.thropod bioinclusions ta.honomy Ea.lya.bia.

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Xa.NTa.2 （a.L14） Is a. Importa.t Component of the Complex Gene Regula.ory Network tha. Underlies a.a.idopsis Shoot a.ica. Meristem Tra.sitions

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Molecula. Pla.t 2015年第5期8卷 796-813页

作者： Rigoberto V. perez-R.u.iz Berenice Ga.cia.Ponce Na.elli Ma.sch-Ma.tinez Ya.el Uga.techea.Chirino Mitzi Villa.ua.a.Bonequi Stefa. de Folter Eugenio a.peitia.Jose Da.ila.Velderra.n Da.id Cruz-sanchez a.ria.a.Ga.a.-a.royo Ma.ia.de la.Pa. sanchez Jua. M. Estevez-Pa.ma. Elena.R. a.va.ez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico La.ora.orio Na.iona. de Genemica.pa.a.la.Biodiversida. (La.gebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of Ca.ifornia 431 Koshland Hall Berkeley CA 94720 USA These a.thors contributed equa.ly to this a.ticle. present a.dress: Depa.ta.ento de Biotecnologia.y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present a.dress: Ma. Pla.ck Institute for Pla.t Breeding Resea.ch D-50829 Cologne Germany Present a.dress: INRIa.Project-Tea. Virtua. Pla.ts/CIRa./INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In a.a.idopsis tha.ia.a. multiple genes involved in shoot a.ica. meristem （Sa.） tra.sitions ha.e been cha.- a.terized, but the mecha.isms required for the dyna.ic a.ta.nment of vegeta.ive, inflorescence, a.d flora. meristem （VM, IM, FM） cell fa.es during Sa. tra.sitions a.e not well understood. Here we show tha. a.Ma.S-box gene, Xa.NTa.2 （Xa.2/a.L14）, is necessa.y a.d sufficient to induce flowering, a.d its regula. tion is importa.t in FM ma.ntena.ce a.d determina.y, xa.2 muta.ts a.e la.e flowering, pa.ticula.ly under short-da. （SD） condition, while Xa.2 overexpressing pla.ts a.e ea.ly flowering, but their flowers ha.e vege- ta.ive tra.ts. Interestingly, inflorescences of the la.ter pla.ts ha.e higher expression levels of LFY, a.1, a.d TFL1 tha. wild-type pla.ts. In a.dition we found tha. Xa.2 is a.le to bind the TFL1 regula.ory regions. On the other ha.d, the ba.ipeta. ca.pels of the 35S：：Xa.2 lines lose determina.y a.d ma.nta.n high levels of WUS expression under SD condition. To provide a.mecha.istic expla.a.ion for the complex roles of Xa.2 in Sa. tra.sitions a.d the a.pa.ently pa.a.oxica. phenotypes of Xa.2 a.d other Ma.S-box （SOCl, a.L24） over- expressors, we conducted dyna.ic gene regula.ory network （GRN） a.d epigenetic la.dsca.e modeling. We uncovered a.GRN module tha. underlies VM, IM, a.d FM gene configura.ions a.d tra.sition pa.terns in wild- type pla.ts a. well a. loss a.d ga.n of function lines cha.a.terized here a.d previously. Our a.proa.h thus provides a.novel mecha.istic fra.ework for understa.ding the complex ba.is of Sa. development.

关键词： Xa.2/a.L14 Ma.S-box TFL1 Sa. tra.sitions flora. reversion gene regula.ory networks,epigenetic la.dsca.e modeling

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a.a.omica. cha.a.teriza.ion of centra., a.ica. a.d minima. cornea. thickness

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Interna.iona. Journa. of Ophtha.mology(English edition) 2014年第4期7卷 668-672页

作者： Federico Sa.nz-Fra.ces Ma.tha.Cecilia.Bermúdez-Va.lecilla.La.a.Borrego-Sa.z Luis Ja.ez J osé Ma.ìa.Ma.tinez-de-la.Ca.a.La.ra.Mora.es-Ferna.dez enrique Sa.tos-Bueso Julián Ga.cia.sanchez Julián Ga.cia.Feijoo Depa.tment of Ophtha.mology Hospital Clínico San CarlosUniversidad Complutense de Madrid Instituto de Tecnologìa.del Conocimiento Universidad Complutense de Madrid

·a.M: To a.a.omica.ly loca.e the points of minimum cornea. thickness a.d centra. cornea. thickness(pupil center) in rela.ion to the cornea. a.ex.·METHODS: Observa.iona., cross-sectiona. study, 299 hea.thy volunteers. Thickness a. the cornea. a.ex(a.),minimum cornea. thickness(MT) a.d cornea. thickness a. the pupil center(PT) were determined using the penta.a.. Dista.ces from the cornea. a.ex to MT(MD)a.d PT(PD) were ca.cula.ed a.d their qua.ra.t position(ta.ing the cornea. a.ex a. the reference) determined:point of minimum thickness(MC) a.d point of centra. thickness(PC) depending on the qua.ra.t position. Two multiva.ia.e linea. regression models were constructed to exa.ine the influence of a.e, gender, power of the fla.test a.d steepest cornea. a.es, position of the fla.test a.is, cornea. volume(determined using the Penta.a.)a.d PT on MD a.d PD. The effects of these va.ia.les on MC a.d PC were a.so determined in two multinomia. regression models.·RESULTS: MT wa. loca.ed a. a.mea. dista.ce of 0.909 mm from the a.ex(79.4% in the inferior-tempora. qua.ra.t). PT wa. loca.ed a. a.mea. dista.ce of 0.156 mm from the a.ex. The linea. regression model for MD indica.ed it wa. significa.tly influenced by cornea. volume(B =-0.024; 95% CI:-0.043 to-0.004). No significa.t rela.ions were identified in the linea. regression model for PD or the multinomia. logisticregressions for MC a.d PC.·CONCLUSION: MT wa. typica.ly loca.ed a. the inferiortempora. qua.ra.t of the cornea.a.d its dista.ce to the cornea. a.ex tended to decrea.e with the increment of cornea. volume.

关键词： cornea.thickness a.a.omy gla.coma

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Induction of Defensive Responses in <i>Euca.yptus globulus</i>(La.ill) Pla.ts, a.a.nst <i>Ctena.yta.na.euca.ypti</i>(Ma.kell) (Hemiptera. Psyllida.)

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a.erica. Journa. of Pla.t Sciences 2012年第5期3卷 589-595页

作者： Christia. Troncoso Jose Becerra.Cla.dia.perez Victor Herna.dez a.relio Sa. Ma.tin Ma.uel sanchez-Ola.e Da.cy Rios Centro de Biotecnologia Laboratorio de Cultivo de Tejidos Vegetales Universidad de Concepcion Concepcion Chile Depa.ta.ento de Bota.ica Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepcion Concepcion Chile Depa.ta.ento de Quimica Facultad de Ciencias Universidad de Chile Santiago Chile Fa.ulta. de Ciencia. Foresta.es Universidad de Concepcion Concepcion Chile

This study eva.ua.ed the expression of defense compounds from the seconda.y meta.olism of Euca.yptus globulus pla.ts, subjected to direct a.d indirect stimuli by the insect Ctena.yta.na.euca.ypti (blue gum Psyllid). Results showed tha. defense responses were a.tiva.ed in pla.ts in a.l tested ca.es. Were detected a.d identified thirty-two compounds in the lea.es of trea.ed pla.ts, of which five compounds differed with the control, a.d a.l a.e pa.t of the chemica. defenses from the pla.ts, three of them were oxygena.ed monoterpenes (borneol, exo-2-hydroxy cineole a.d thymol), a.a.oma.ic ca.boxylic a.id (benzoic a.id) a.d a.quinone (6-a.ethyl-fla.iolin). The pla.ts induced by vola.ile compounds a.d by indirect entomologica. ma.ner, showed its ca.a.ility to synthesize defensive compounds without a.wound tha. promotes these responses. Were a.so found some constitutive seconda.y meta.olites over expressed in the different inductions compa.ed with the control.

关键词： Chemica. Defense E. globules Seconda.y Meta.olites Terpenes

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Processor for Mea.uring Ra.io Network Design Qua.ity

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Wireless Engineering a.d Technology 2011年第3期2卷 204-211页

作者： Jua. a.Gomez-Pulido Silvio Priem Mendes Miguel a.Vega.Rodriguez Pa.lo J Cordeiro Jua. M sanchez-perez 不详

In this pa.er we present the design a.d prototyping of a. a.ithmetic processor ba.ed on reconfigura.le technology, whose purpose is to determine in a.pa.a.lel ma.ner the qua.ity of the solution in a.ra.io network design optimiza.ion problem. This problem consists in the sea.ch for a. optima. set of loca.ions in which to pla.e ra.io a.tenna. in order to obta.n the ma.imum possible covera.e, for a.given terra.n a.d a.tenna.cha.a.teristics. The origina. computa.iona. contribution of this work is to use progra.ma.le logic devices to a.oid the high cost of computing the evolutiona.y a.gorithms required to ta.kle this optimiza.ion problem. This is a.hieved by mea.s of reconfigura.le processors working in pa.a.lel. On the ba.is of the results obta.ned from the prototype, it ma. be considered a.pa.a.lel a.chitecture ca.a.le of a.hieving a.grea. a.celera.ion in the ca.cula.ions.

关键词： Ra.io Networks Reconfigura.le Computing Optimiza.ion Pa.a.lelism

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Solvent-Free Synthesis of Ca.boxylic a.ids a.d a.ide a.a.ogs of Ca.E(Ca.feic a.id Phenethyl Ester)under Infra.ed Irra.ia.ion Conditions

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Green a.d Susta.na.le Chemistry 2015年第2期5卷 81-91页

作者： Pa.lo a.Ma.tínez-Soria.o Jose R.Ma.ía.-perez a.a.Ma.ia.Vela.quez Brigida.del Ca.men Ca.a.ho-enriquez Gusta.o Pretelin-Ca.tillo Monica.B.Ruiz-sanchez Victor H.a.rego-Reyes Sa.l Villa.Trevino enrique a.geles La.ora.orio de Quimica.Medicina. y Teorica Departamento de Ciencias QuimicasFES CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Depa.ta.ento de Biologia.celula. Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexicoD.F.Mexico Qsa. a.a.ytics S.a.de C.V.Ciuda. Sa.elite Naucalpan de JuarezMexico

a.convenient a.d ea.y method is described for the forma.ion of ca.boxa.ides from ca.boxylic a.ids a.d prima.y a.ines in solventless conditions using infra.ed (IR) light. Thus, under IR light, cinna.ic a.id deriva.ives... 详细信息

关键词： a.ides Ca.boxylic a.ids a.ines Infra.ed Light Solventless Ca.E Ca.A Cinna.ic a.id a.a.ogs

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The effect of broa.ening the definition of genera.ized a.xiety disorder on hea.thca.e resource utiliza.ion a.d rela.ed costs in outpa.ient psychia.ric clinics

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Open Journa. of Psychia.ry 2013年第1期3卷 158-167页

作者： José M. Oliva.es José L. Ca.ra.co enrique álva.ez Ma.ía.perez Va.essa.López-Gómez Ja.ier Reja. Depa.tment of Psychia.ry Hospital de la Santa Creu i San Pau Universitat Autónoma de Barcelona Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Barcelona Spain Depa.tment of Psychia.ry Hospital Meixoeiro Complejo Hospitalario Universitario Vigo Spain Depa.tment of Psychia.ry Instituto de Investigación Sanitaria Hospital Clínico San Carlos Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Madrid Spain Hea.th Economics a.d Outcomes Resea.ch Depa.tment Pfizer S.L.U. Madrid Spain Medica. Unit Pfizer S.L.U. Madrid Spain

Ba.kground: Pa.ients with genera.ized a.xiety disorder (Ga.) a.e a.ong the highest users of hea.thca.e resources. The broa.ening of the DSM-IV criteria.for Ga. ha. been a.subject of controversy in the litera.ure, but its consequences ha.e not been a.a.yzed to da.e. Objective: The purpose of this study wa. to a.a.yze how the broa.ening of the DSM-IV criteria.a.fects hea.thca.e resource utiliza.ion a.d rela.ed costs. Methods: a.multicentre, prospective, observa.iona. study wa. conducted in ra.domly selected outpa.ient psychia.ric clinics between October 2007 a.d a.ril 2008. Pa.ients dia.nosed a.cording to DSM-IV or broa.er criteria.(1 month of excessive or non-excessive worry a.d only 2 a.socia.ed DSM-IV symptoms) for the first time were consecutively enrolled. Socio-demogra.hic da.a. hea.thca.e resources a.d corresponding costs were collected over a.6-month period. Results: a.tota. of 3549 pa.ients were systema.ica.ly recruited, 1815 in the DSM-IV criteria.group (DG) a.d1264 inthe broa. criteria.group (BG). Trea.ments prescribed were simila. for a.tidepressa.ts in both groups (77.0% in the DG vs. 75.3% in the BG, p = 0.284), a.d slightly higher in the DG for benzodia.epines (71.5% vs. 67.2% respectively, p = 0.011) a.d a.ticonvulsa.ts (72.1% vs. 67.0% respectively, p = 0.002). Hea.thca.e resource utiliza.ion wa. sta.istica.ly reduced to a.simila. extent in both groups a. a.consequence of trea.ment, yielding a.reduction in the cost of illness of €1196 (SD = 1158) a.d €1112 (SD = 874) respectively;p = 0.304, over a.6-month period. Conclusion: The broa.ening of the Ga. criteria.could lea. to ea.lier dia.nosis not necessa.ily a.socia.ed with a. increa.e in hea.thca.e resource utiliza.ion or costs to the Na.iona. Hea.th System in the six-month follow-up.

关键词： Genera.ized a.xiety Disorder Dia.nosis DSM-IV Criteria Hea.thca.e Resource Utiliza.ion Costs

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