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Actions of N-acetylcysteine,daptomycin,vancomycin,and linezolid on methicillin-resistant Staphylococcus aureus biofilms in the ventriculoperitoneal shunt infections:an experimental study

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Chinese Neurosurgical Journal 2022年第4期8卷 239-247页

作者： Tuba kuruoglu Gamze Altun enis kuruoglu Derya BayırlıTuran Mehmet EminÖnger Department of Infectious Diseases and Clinical Microbiology Medical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Histology and Embryology Medical FacultyOndokuz Mayıs University55139 SamsunTurkey Department of Neurosurgery Medical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Infectious Diseases and Clinical Microbiology School of MedicineYeni Yuzyil UniversityIstanbulTurkey Department of Neuroscience Health Science InstituteOndokuz Mayıs UniversitySamsunTurkey

Background:Shunt systems are used to provide cerebrospinal fluid drainage in the treatment of ***,antibiotic-impregnated shunt systems are used to prevent colonization in the ventriculoperitoneal ***-resistant Staphylococcus aureus(MRSA)is the most common causative microorganism of shunt *** aim of the study is to investigate effects of several substances on MRSA biofilms in the ventriculoperitoneal ***:The present study consists of mainly eight groups(each has two subgroups as antibiotic-impregnated and nonantibiotic-impregnated catheters).In addition,each group contains six molds using MRSA *** this study,daptomycin(DAPT)(2 mg/ml),vancomycin(VAN)(10 mg/ml),linezolid(LIN)(2 mg/ml),N-acetylcysteine(NAC)(6 mg/ml),and various combinations of these substances were used to evaluate the treatment against MRSA using scanning electron microscope(SEM)images and microbiological ***:The colony count in the antibiotic-impregnated samples significantly decreased compared to nonantibiotic-impregnated samples in the MRSA,MRSA+DAPT,and MRSA+LIN groups(p<0.01),***,the colony count in antibiotic-impregnated samples significantly increased compared to nonantibiotic-impregnated samples in NAC+DAPT and NAC+VAN groups(p<0.01),***:The results showed that the use of antibiotic-impregnated catheters has a significant impact on the prevention of infection whereas the combination of NAC and DAPT showed better antibiofilm and antibacterial effects than other combinations on the prevention and treatment of nonantibiotic-impregnated catheter infections.

关键词： Methicillin-resistant Biofilm Antibiotic-impregnated catheters Scanning electron microscope

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Change in dielectric relaxation with the presence of water in highly filled composites

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Journal of Advanced Dielectrics 2017年第5期7卷 36-46页

作者： enis Tuncer Texas Instruments Incorporated Dallas Texas 75243USA

It is important to determine the dielectric characteristics of semiconductor encapsulation materials based on epoxy *** employed the dielectric spectroscopy technique to investigate the dielectric relaxation in the presence of water and how it changes the *** was observed that the dielectric relaxation of the material was significantly influenced by absorbed water,the local segmental motion(also known as Johari-Goldstein(β)relaxation)was influenced most by the presence of the water,it was modified by the wet sample compared to dry one,and required high activation *** relaxation related to the glass transition was contributed by the cooperative motion(the a-relaxation)of the epoxy resin *** a-relaxation was shifted to a low temperature in the wet sample compared to dry *** relaxation was modeled with a clear Vogel-Fulcher-Tammann-Hesse(VFTH)behavior;the Vogel temperature of the wet sample was 8 K lower than the dry *** presence of water acts as a plasticizer for the molecular relaxation,and speed-up the cooperative *** measured data were also used to estimate the electrical properties of the resin system by employing an effective-medium model together with a porous media continuum model by taking into account the physical properties of the *** is already known that the influence of water in semiconductor packaging is important in sensitive *** presented measurements and the analysis method would be appreciated within the semiconductor packaging community to improve material selection and performance evaluation efforts.

关键词： Composite materials semiconductor packaging dielectric spectroscopy

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Microbe-derived carbon materials for electrical energy storage and conversion

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Journal of Energy Chemistry 2016年第2期25卷 189-196页

作者： Li Wei H.enis Karahan Shengli Zhai Yang Yuan Qihui Qian Kunli Goh Andrew Keong Ng Yuan Chen School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive 637459 Singapore Singapore Institute of Technology 10 Dover Drive 138683 Singapore School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Microbes are microscopic living organisms that surround us which include bacteria, archaea, most protozoa, and some fungi and algae. In recent years, microbes have been explored as novel precursors to synthesize carbon-based（nano）materials and as substrates or templates to produce carbon-containing（nano）composites. Being greener and more affordable, microbe-derived carbons（MDCs） offer good potential for energy applications. In this review, we describe the unique advantages of MDCs and outline the common procedures to prepare them. We also extensively discuss the energy applications of MDCs including their use as electrodes in supercapacitors and lithium-ion batteries, and as electrocatalysts for processes such as oxygen reduction, oxygen evolution, and hydrogen evolution reactions which are essential for fuel cell and water electrochemical splitting cells. Based on the literature trend and our group＇s expertise, we propose potential research directions for developing new types of MDCs. This review, therefore, provides the state-of-the-art of a new energy chemistry concept. We expect to stimulate future research on the applications of MDCs that may address energy and environmental challenges that our societies are facing.

关键词： Microbe Carbon materials Supercapacitor Lithium-ion battery Oxygen reduction reaction Hydrogen evolution reaction

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Early detection and classification of live bacteria using time-lapse coherent imaging and deep learning

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Light(Science & Applications) 2020年第1期9卷 890-906页

作者： Hongda Wang Hatice Ceylan Koydemir Yunzhe Qiu Bijie Bai Yibo Zhang Yiyin Jin Sabiha Tok enis Cagatay Yilmaz Esin Gumustekin Yair Rivenson Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Biophysics Istanbul Medical FacultyIstanbul UniversityIstanbul 22000Turkey Department of Microbiology Immunologyand Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Early identification of pathogenic bacteria in food,water,and bodily fluids is very important and yet challenging,owing to sample complexities and large sample volumes that need to be rapidly *** screening methods based on plate counting or molecular analysis present various tradeoffs with regard to the detection time,accuracy/sensitivity,cost,and sample preparation ***,we present a computational live bacteria detection system that periodically captures coherent microscopy images of bacterial growth inside a 60-mm-diameter agar plate and analyses these time-lapsed holograms using deep neural networks for the rapid detection of bacterial growth and the classification of the corresponding *** performance of our system was demonstrated by the rapid detection of Escherichia coli and total coliform bacteria(i.e.,Klebsiella aerogenes and Klebsiella pneumoniae ***)in water samples,shortening the detection time by >12 h compared to the Environmental Protection Agency(EPA)-approved *** the preincubation of samples in growth media,our system achieved a limit of detection(LOD)of ~1 colony forming unit(CFU)/L in≤9 h of total test *** platform is highly cost-effective(~$0.6/test)and has high-throughput with a scanning speed of 24 cm2/min over the entire plate surface,making it highly suitable for integration with the existing methods currently used for bacteria detection on agar *** by deep learning,this automated and cost-effective live bacteria detection platform can be transformative for a wide range of applications in microbiology by significantly reducing the detection time and automating the identification of colonies without labelling or the need for an expert.

关键词： coherent Early lapse

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Nanofiller Dispersion in Polymer Dielectrics

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Materials Sciences and Applications 2013年第4期4卷 6-15页

作者： Daniel Tan Yang Cao enis Tuncer Patricia Irwin Dielectrics & Electrophysics Lab GE Global Research Center Niskayuna Schenectady USA

Nanodielectric composites have been developed in recent years attempting to improve the dielectric properties such as dielectric constant, dielectric strength and voltage endurance. Among various investigations, nanoparticle dispersion was particularly emphasized in this work. General Electric Global Research Center in Niskayuna NY USA has investigated various nanoparticles, nanocomposites and nanocomposite synthesis methods intending to understand particle dispersion and their impact on the nanocomposite dielectric properties. The breakdown strength and microstructures of the nanocomposites containing different particles were studied for projects related to capacitor and electrical insulation technologies. The nanocomposite synthesis methods either employed commerical nanoparticles or utilized nanoparticles that were self-assembled (in-situ precipitation) in a matrix. Our investigations have shown that nanocomposites prepared with solution chemistry were more favorable for producing uniform dispersion of nanoparticles. Structural information of nanocomposites was studied with transmission electron microscopy and the interection between particles and matrix polymers were tentatively probed using dielectric spectroscopy. In these new class of materials high energy densities on the order of 15J/cc were achievable in nanocomposites.

关键词： Nanoparticles Polymer Dielectrics Filler Dispersion Dielectric Properties

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Time spent outdoors and myopia:establishing an evidence base

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眼科学报：英文版 2015年第4期30卷 143-146页

作者： enis D.Kocak Justin C.Sherwin The Alfred Hospital Royal Victorian Eye and Ear Hospital Lions Eye Institute University of Western AustraliaCentre for Ophthalmology and Visual Science

Myopia is a highly prevalent refractive error in Asia(1).Although mild myopia does not have serious ocular ramifications,pathological myopia is associated with the development of various ocular pathologies that can lead to irreversible visual loss or blindness(2).The prevalence of visual impairment attributable to pathologic myopia is 0.2-1.4% in Asian populations(3).Over the past few generations,the prevalence of myopia has increased significantly(4).In urbanized areas of East

关键词：近视眼基础证据户外时间视力障碍折射误差眼部疾病

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SUPERIORITY OF LIQUID-LIQUID EXTRACTION FOR TOXICOLOGICAL SCREENING IN GAS CHROMATOGRAPHY/MASS SPECTROME- TRY ANALYSIS

SUPERIORITY OF LIQUID-LIQUID EXTRACTION FOR TOXICOLOGICAL SC...

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第十五届国际药理学大会

作者： enis Macit Sahan Saygi Husamettin Gul Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY

＜正＞ Gas chromatography/mass spectrometry （GC/MS） is the main device for lexicological screening. Although solid phase extraction （SPE） methods have been developing each day. the comparison of the liquid- liquid （LL） and SPE has not been explored for rutin lexicological screening of biological samples. We compared LL and SPE method for the most encountered lexicological drugs in the emergency department using recovery values in GC/MS analysis. We found that the recovery of an antidepressanl amytriptilline. a non - steroidal anti - inflammatory drug diclophenac and an antihislamine chlorpheniramine maleal was 96.71 ±2.62. 90.99±3.84. 93.43±3.15 for LL and 87.05± 9. 33. 81.43 ± 1.76. 80.97 ± 3.85 for SPE respectively. The difference belween the LL and SPE extraction was statistically significanl （p＜ 0.01）. In conclusion, our resulls show that the recovery values of LL extraction used in this study is higher than SPE. thus offers an inexpensive and acceplable extraction method for the screening of toxicological emergency.

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The Efficacy of 1% Chlorhexidine Gel on the Reduction of Dry Socket Occurence Following Surgical Third Molar Extraction—Pilot Study

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Open Journal of Stomatology 2014年第3期4卷 152-160页

作者： Jehona Ahmedi enis Ahmedi Zana Agani Vjosa Hamiti Bylbyl Recica Arlinda Tmava-Dragusha Department of Oral Surgery University Dental Clinical Center of KosovaPrishtinaKosovo Department of Prosthodontists University Dental Clinical Center of KosovaPrishtinaKosovo

Aim & Objectives: The aim of this prospective pilot-study was to assess the efficacy of intra alveolar application of 1% chlorhexidine gel (CHX) on the reduction of dry socket (DS) occurrence following surgical extraction of mandibular third molars. Materials and Methods: A randomized split-mouth-design study included twenty-five patients with bilaterally impacted lower third molars (partial or full bone) requiring full thickness mucoperiastal flap reflection for extraction. Following surgical extraction of third lower molar, 2 ml of gel containing 1% chlorhexidine digluconate (Chlorhexamed? Gel 1%) were placed in the experimental side, and saline solution was used for irrigation in the control side of extraction sockets, both followed by suturing of extraction site. The surgeries and follow up examinations were performed by the same surgeon. The follow up visits were performed at 48 hours and on day seven, post surgery where presence or absence of dry socket using the Blum criteria for diagnosis was evaluated and pain intensity by Visual Analogue Scale (VAS) 0 - 100 was observed. Results: In this pilot study, dry socket was present in 4.0 and 28.0% of cases in the experimental and control groups, respectively (P = 0.048). Fisher’s test revealed a statistically significant reduction of dry socket occurrence following the use of 1% CHX gel versus saline solution. Conclusion: The application of CHX gel 1% may significantly reduce the incidence of DS following third molar extraction. Prophylactic use of CHX gel 1% may be suggested in all patients, especially in the patients at risk of development of DS.

关键词： Dry Socket Chlorhexidine 1% Third Molar Surgery

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飓风是怎样得名的（英文）

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大学英语 2015年第8期 53-54页

作者： enis Waitly 周采真

The first people who gave names to hurricanes were those who knew them best—the people of Puerto *** small island of Puerto Rico is in the West Indies2,off the coast of *** is where all the hurricanes begin that strike the east coast of the United *** they pass near Puerto Rico or cross it on their way *** people of Puerto Rico day expect some of these unwelcome visitors every year. Each one is named after the saint＇s on which it arrives. Two of the most destructive storms were the Santa Aria in 1825 and the San Ciriao in 1899.

关键词：英文得名飓风 the first where every after

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Effects of Electrical Stimulation in People with Post-Concussion Syndromes: A Pilot Study

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Health 2018年第4期10卷 381-395页

作者： Yi-Ning Wu Jessica Gravel Naseem Chatiwala Terrie enis Caroline Stark Robert C. Cantu Department of Physical Therapy University of Massachusetts Lowell Lowell MA USA Dr. Robert C. Cantu Concussion Center Emerson Hospital Concord MA USA Center for Rehabilitative and Sports Therapies Emerson Hospital Concord MA USA Department of Neurosurgery and Neurology Boston University School of Medicine Boston MA USA

Post-concussion syndrome (PCS) is a complex disorder with various symptoms. There is limited evidence to support that any intervention enhances recovery after a concussion. This pilot study aimed to examine the efficacy of neck paraspinal muscles electrical stimulation (ES) in conjunction with physical therapy (PT) on reducing the severity of post concussive symptoms. Twenty-four individuals with PCS were randomly assigned to the ES group (PT + ES) or the control group (PT only). Both groups received the intervention twice a week for eight weeks. Clinical measures including the Concussion Signs/Symptoms Checklist, balance error scoring system, King-Devick test, ImPACT, and the Standardized Assessment of Concussion were used to evaluate the symptoms. We investigated the recovery rate by calculating slopes of changes over time for each participant. A changing slope was derived by linearly fitting the symptoms severity over time with the initial severity score as the intercept. Significant overall improvement was observed in both groups after the interventions. There was no significant difference seen in total symptom recovery rate between two groups (-1.49 ± 1.59 versus -1.2 ± 1.56, p = 0.32). The cognitive symptoms recovery rate of the ES group was faster than the control group (-0.5 ± 0.49 and -0.13 ± 0.46 respectively, p = 0.04). Physical therapy targeting the cervical region is beneficial for persons with PCS. Moreover, peripheral electrical stimulation on the paraspinal muscles surrounding the neck region could potentially advance the cognitive function recovery of persons with PCS.

关键词： Post-Concussion Syndrome Cognitive Function Physical Therapy Electrical Stimulation

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