SUPERIORITY OF LIQUID-LIQUID EXTRACTION FOR TOXICOLOGICAL SCREENING IN GAS CHROMATOGRAPHY/MASS SPECTROME- TRY ANALYSIS
作者单位：Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY Gulhane School Of Medicine Dept Of Analytical Toxicology Etlik Ankara06018 TURKEY
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
摘 要：正 Gas chromatography/mass spectrometry （GC/MS） is the main device for lexicological screening. Although solid phase extraction （SPE） methods have been developing each day. the comparison of the liquid- liquid （LL） and SPE has not been explored for rutin lexicological screening of biological samples. We compared LL and SPE method for the most encountered lexicological drugs in the emergency department using recovery values in GC/MS analysis. We found that the recovery of an antidepressanl amytriptilline. a non - steroidal anti - inflammatory drug diclophenac and an antihislamine chlorpheniramine maleal was 96.71 ±2.62. 90.99±3.84. 93.43±3.15 for LL and 87.05± 9. 33. 81.43 ± 1.76. 80.97 ± 3.85 for SPE respectively. The difference belween the LL and SPE extraction was statistically significanl （p 0.01）. In conclusion, our resulls show that the recovery values of LL extraction used in this study is higher than SPE. thus offers an inexpensive and acceplable extraction method for the screening of toxicological emergency.