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Role of lipids in the control of autophagy and primary cilium signaling in neurons

Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-cáceres Daniela pinto-Nuñez Patricia Rivera Paulina Burgos Francisco Díaz-castro Alfredo criollo Maria Jose Yañez Eugenia Morselli Instituto de Investigación en ciencias Odontológicas(IcOD) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced center for chronic Diseases(AccDiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPcR lysosomal storage diseases neurons NPc1 phosphoinositides primary cilium

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Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana pinto Sabrina F.Lütke Eder c.Lima Luis F.O.Silva Irineu A.S.De Brum Guilherme L.Dotto Department of Forest Biomaterials and Technology Biomass Technology centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and catalytic Process Engineering(ENGEPAc) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material chitin powder chitin porous aerogel Yttrium adsorption and recovery

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制造工艺对铝气缸盖高周疲劳耐久性的影响

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汽车与新动力 2013年第4期45卷 40-43页

作者： chen X F engler-pinto c King M Li M Prabhu E Su X 张然治

由于铸造工艺的缘故,导致气缸盖的材料高周疲劳特性分布不均匀。为了模拟制造工艺对铸件机械性能的影响,Ford汽车公司开发了虚拟铝铸造工具。虚拟铝铸造的特点之一是能预测高周疲劳强度分布。由于残余应力对气缸盖的高周疲劳也起着重要... 详细信息

由于铸造工艺的缘故,导致气缸盖的材料高周疲劳特性分布不均匀。为了模拟制造工艺对铸件机械性能的影响,Ford汽车公司开发了虚拟铝铸造工具。虚拟铝铸造的特点之一是能预测高周疲劳强度分布。由于残余应力对气缸盖的高周疲劳也起着重要作用,因此对残余应力也进行了模拟,并将其用于气缸盖的高周疲劳分析。采用ABAQUSTM软件对气缸盖总成、热应力和工作应力进行模拟。将工作应力与残余应力结合在一起,进行高周疲劳计算。采用FEMFATTM疲劳测试有限元分析软件进行高周疲劳分析。基于虚拟铝铸造模拟获得的局部材料特性,建立了用户定义的赫氏图。结果证明,利用在FEMFATTM软件中得到的局部特性分布,可显著提高气缸盖高周疲劳模拟结果的精确度。

关键词：高周疲劳耐久性铝气缸盖制造工艺虚拟铸造

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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta c Marchiori cleber Rosito pinto Kruel Marcio Fernandes chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BAcKGROUND Hepatocellular carcinoma(Hcc)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with Hcc being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with Hcc awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TAcE).However,the superiority of TAcE over TAE has not been consistently shown in the *** To compare the outcomes of TAcE and TAE in patients with Hcc awaiting *** All consecutive patients with Hcc awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TAcE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each Hcc nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TAcE group(only TAcE and TAcE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TAcE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TAcE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TAcE and TAE groups,respectively(P=0.145).Post-LT,Hcc recurred in 9(18.8%)and 4(13.8%)patients in the TAcE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Treatment of Vulvovaginal candidiasis with A Strategy Based on Phototherapy (M.A.c.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： Marcus Vinicius de Mello pinto Karin Yuri Fernández Iturra Aline Ronis Sampaio María Elena Silva Álvarez Esteban Fortuny celulare Institute Petrópolis Brazil Bienus clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of candida fungi, the most frequent being candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAc® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAc®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal candidiasis candidiasis candida M.A.c. MAc®

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Experimental study on the wear evolution of different PVD coated tools under milling operations of LDX2101 duplex stainless steel

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Advances in Manufacturing 2023年第1期11卷 158-179页

作者： Vitor F.c.Sousa Francisco J.G.Silva Ricardo Alexandre Jose S.Fecheira Gustavo pinto Andresa Baptista ISEP-School of Engineering Polytechnic of PortoRua Dr.António Bernardino de Almeida4314200–072PortoPortugal INEGI-Driving Science and Innovation Rua Dr.Roberto Frias4004200–465PortoPortugal TEandM-Technology Engineering and MaterialsS.A.Parque Industrial do TaveiroLotes 41-423045–504TaveiroPortugal

Duplex stainless steels are being used on applications that require,especially,high corrosion resistance and overall good mechanical properties,such as the naval and oil-gas exploration *** components employed in these industries are usually obtained by machining,however,these alloys have low machinability when compared to conventional stainless *** this work,a study of the wear developed when milling duplex stainless-steel,LDX 2101,is going to be presented and evaluated,employing four types of milling tools with different geometries and coatings,while studying the influence of feed rate and cutting length in the wear of these *** used have been provided with two and four flutes,as well as three different coatings,namely:TiAlN,TiAlSiN and *** cutting behavior of these tools was analyzed;data relative to the cutting forces developed during the process were obtained;and roughness measurements of the machined surfaces were *** tools were then submitted to scanning electron microscope(SEM)analysis,enabling the identification of the wear mechanisms that tools were subjected to when machining this material,furthermore,the early stages of these mechanisms were also *** this work was done with the goal of relating the machining parameters and cutting force values obtained,identifying,and discussing the wear patterns that were observed in the coating and tools after the milling tests,providing further information on the machining of these alloys.

关键词： Duplex stainless-steel Milling Tool coatings Surface roughness Wear mechanisms

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Deposition of nanoparticles on school eyeglasses in urban and rural areas:A methodology for a more real assessment of the possible impacts

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Geoscience Frontiers 2022年第1期13卷 498-505页

作者： Kátia Martinello James c.Hower Guilherme L.Dotto claudete G.Ramos carlos E.Schnorr Diana pinto Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA chemical Engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil Department of civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia

Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye *** that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural *** important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.

关键词： Indoor air pollution Nanoparticles Eyes health Allergic reaction Schools

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Geochemical study of submicron particulate matter(PM1)in a metropolitan area

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Geoscience Frontiers 2022年第1期13卷 417-429页

作者： Ismael L.Schneider Elba c.Teixeira Guilherme L.Dotto Diana pinto cheng-Xue Yang Luis F.O.Silva Postgraduate Program in Remote Sensing and Meteorology Universidade Federal do Rio Grande do SulAv.Bento Gonçalves9500 Porto AlegreRSBrazil Department of civil and Environmental Universidad de la CostaCUCCalle 58#55-66BarranquillaAtlanticoColombia Research Department Fundação Estadual de Proteção Ambiental Henrique Luís RoesslerAv.Borges de Medeiros261Porto AlegreRSBrazil chemical Engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil School of Earth Sciences and Resources China University of Geosciences BeijingBeijing 100083PR China Departamento de Ingeniería civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Perú

Air pollution has become a major problem in urban areas due to increasing industrialization and *** this study ambient concentrations of PM1 and metal concentrations as well as source contributions were identified and quantified by using Positive Matrix Factorization(PMF)in receptor modeling in the Metropolitan Area of Porto Alegre,*** PM1 samples were collected on PTFE filters from December 2012 to December 2014 in two sampling *** ion and trace element concentrations were *** average concentrations were 12.8 and 15.2μg/m^(3) for canoas and Sapucaia do Sul sites,*** ion contributions of PM1 were secondary pollutants such as sulfate and *** elements,especially cu,Pb,Zn,cd,and Ni also made important contributions which are directly associated with anthropogenic *** results show significantly higher levels in winter than in *** of the PM1 and the analyzed PM species and elements originated from anthropogenic sources,especially road traffic,combustion processes and industrial activities,which are grouped in 7 major contributing sources.A back-trajectory analysis showed that the long-range transport of pollutants was not relevant in relation to the contribution to PM1 and metal *** work highlights the importance of urban planning to reduce human health exposure to traffic and industrial emissions,combined with awareness-raising actions for citizens concerning the impact of indoor sources.

关键词： PM1 Trace elements Source apportionment PMF Back trajectory

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Artisanal ceramic factories using wood combustion:A nanoparticles and human health study

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Geoscience Frontiers 2022年第1期13卷 488-497页

作者： Kátia Martinello James c.Hower Diana pinto carlos E.Schnorr Guilherme L.Dotto Marcos Leandro Silva Oliveira claudete G.Ramos Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil Department of civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA centro de Estudos em Estresse Oxidativo-Departamento de Bioquímica-Instituto de ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul(UFRGS) Porto AlegreRSBrazil chemical Engineering Department Federal University of Santa MariaUFSMRoraima Avenue1000Santa MariaRS97105-900Brazil Departamento de Ingeniería civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Peru

The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide *** ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and *** improvements are indispensable to diminish contact with *** present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic *** matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman *** NPs configuration(10 nm)were produced around the studied artisanal ceramic *** study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.

关键词： ceramic manufacturing Nanoparticles Advanced characterization Multiple impacts

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环境湿度对铸铝合金超声疲劳裂纹扩展速率的影响研究

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中国机械工程 2016年第17期27卷 2396-2401页

作者：李文凯崔海涛温卫东苏旭明 c c engler-pinto Jr 南京航空航天大学江苏省航空动力系统重点实验室南京210016 北美福特汽车研究与创新中心迪尔伯恩密歇根州美国48121

针对铸铝合金A356-T6开展了不同环境湿度下的超声疲劳裂纹扩展试验和实验室环境湿度下的常规疲劳裂纹扩展试验。由试验结果可知,超声疲劳在干空气环境中的疲劳裂纹扩展速率最低,而在蒸馏水环境中的疲劳裂纹扩展速率最高。常规疲劳在实... 详细信息

针对铸铝合金A356-T6开展了不同环境湿度下的超声疲劳裂纹扩展试验和实验室环境湿度下的常规疲劳裂纹扩展试验。由试验结果可知,超声疲劳在干空气环境中的疲劳裂纹扩展速率最低,而在蒸馏水环境中的疲劳裂纹扩展速率最高。常规疲劳在实验室环境中的疲劳裂纹扩展速率和超声疲劳在蒸馏水环境中的疲劳裂纹扩展速率几乎一致。针对Wei建立的环境湿度对铝合金材料疲劳裂纹扩展速率预测模型进行了修正,得到了铸铝合金A356-T6在任意环境湿度和试验频率下的疲劳裂纹扩展速率预测模型。

关键词：铸铝合金超声疲劳裂纹扩展环境湿度

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