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The prevention role of Spirulina platensis(Arthrospira platensis)on intestinal health

Food Science and Human Wellness 2022年第5期11卷 1342-1346页

作者： ender deniz asmaz Nilay Seyidoglu Department of Histology and Embryology Veterinary FacultyBursa Uludag UniversityNilufer 16059Turkey Department of Physiology Veterinary FacultyTekirdag Namik Kemal UniversitySuleymanpasa 59030Turkey

Spirulina is a popular herbal food that has a preventive effect on *** the study,it aimed to evaluate the effects of different doses of Spirulina platensis(Arthrospira platensis)on the morphological properties of the duodenum of rats,and to assign the effect of Spirulina on the expression of proliferating cell nuclear antigen(PCNA)in the rat duodenum,and thereby to observe the effects on intestinal health.30 male Wistar albino rats were divided into 3 groups for 45 *** first group was received the basal diet;the second group was given 500 mg/kg Spirulina daily by oral gavage;the third group was given 1000 mg/kg Spirulina *** duodenum segments were taken at the end of the trial and processed for histological *** the total mucosa,villus height and villus/cript ratio were found higher in high dose Spirulina,the lower cript depth was detected in same group compared to control and low dose group.A significant increase was observed at high dose compared to the control and low dose group in terms of PCNA expression intensity and proliferation *** suggest that high dose of Spirulina may support the duodenal growth,and thereby intestinal health.

关键词： Histochemistry Duodenum Spirulina platensis Intestinal health

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The prevention role of Spirulina platensis(Arthrospira platensis) on intestinal health

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Food Science and Human Wellness 2022年

作者： Nilay SEY?DOGLU ender deniz asmaz Tekirdag Namik Kemal University Veterinary Faculty Department of Physiology Bursa Uludag University Veterinary Faculty Department of Histology and Embryology

Spirulina is a popular herbal food that has a preventive effect on health. In the study, it aimed to evaluate the effects of different doses of Spirulina platensis(Arthrospira platensis) on the morphological properties of the duodenum of rats, and to assign the effect of Spirulina on the expression of proliferating cell nuclear antigen(PCNA) in the rat duodenum, and thereby to observe the effects on intestinal health. 30 male Wistar albino rats were divided into 3 groups for 45 days. The first group was received the basal diet; the second group was given 500 mg/kg Spirulina daily by oral gavage; the third group was given 1 000 mg/kg Spirulina daily. The duodenum segments were taken at the end of the trial and processed for histological assay. Although the total mucosa, villus height and villus/cript ratio were found higher in high dose Spirulina, the lower cript depth was detected in same group compared to control and low dose group. A significant increase was observed at high dose compared to the control and low dose group in terms of PCNA expression intensity and proliferation index. Findings suggest that high dose of Spirulina may support the duodenal growth, and thereby intestinal health.

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Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

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World Journal of Gastroenterology 2008年第20期14卷 3218-3223页

作者： Engin Tutar deniz Ertem Goksenin Unluguzel Sevda Tanrikulu Goncagul Haklar Cigdem Celikel Evin Ademoglu ender Pehlivanoglu Division of Pediatric Gastroenterology Hepatology and Nutrition Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Istanbul University Istanbul Faculty of Medicine apa stanbul 34390 Turkey Department of Pathology Marmara University School of Medicine Altunizade stanbul 81190 Turkey

AIM: To determine the role of inflammatory cytokines and reactive oxygen species (ROS) in childhood reflux esophagitis. METHODS: A total of 59 subjects who had complaints suggesting GERD underwent esophagogastroduoden oscopy. Endoscopic and histopathologic diagnosis of reflux esophagitis was established by Savary-Miller and Vandenplas grading systems, respectively. Esophageal biopsy specimens were taken from the esophagus 20% proximal above the esophagogastric junction for conventional histopathological examination and the measurements of ROS and cytokine levels. ROS were measured by chemiluminescence, whereas IL-8 and MCP-1 levels were determined with quantitative immunometric ELISA on esophageal tissue. Esophagealtissue ROS, IL-8 and MCP-1 levels were compared among groups with and without endoscopic/histo- pathologic esophagitis. RESULTS: Of 59 patients 28 (47.5%) had normal esophagus whereas 31 (52.5%) had endoscopic esophagitis. In histopathological evaluation, almost 73% of the cases had mild and 6.8% had moderate degree of esophagitis. When ROS and chemokine levels were compared among groups with and without endoscopic esophagitis, statistical difference could not be found between patients with and without esophagitis. Although the levels of ROS, IL-8 and MCP-1 were found to be higher in the group with histopathological reflux esophagitis, this difference was not statistically significant. CONCLUSION: These results suggest that the grade of esophagitis is usually mild or moderate during childhood and factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children.

关键词： Gastroesophageal reflux disease Refluxesophagitis Reactive oxygen species Interleukine-8 Monocyte chemoattractant protein-1

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Predictors of poor outcome in gastrointestinal bleeding in emergency department

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World Journal of Gastroenterology 2016年第16期22卷 4219-4225页

作者： ender Kaya Mehmet Ali Karaca deniz Aldemir M Mahir Ozmen Dr. Nafiz Korez State Hospital Sincan 06932 Ankara Turkey Emergency Medicine Department Faculty of Medicine Hacettepe University Sihhiye 06100 Ankara Turkey General Surgery Department Faculty of Medicine Hacettepe University Sihhiye 06100 Ankara Turkey

AIM: To determine the prognostic risk factors of gastrointestinal bleeding in emergency department ***: The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit(ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary ***: The mean age of patients was 61.92-yearsold. Among the 600 total patients, 363(60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer(19.2%) and gastric ulcer(12.8%). One-hundred-and-fifteen(19.2%) patients required endoscopic treatment, 20(3.3%) required surgical treatment, and 5(0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates(P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay(P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels(P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation(P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale(GCS) were independent predictive factors of ***: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hyp

关键词： Gastrointestinal bleeding Poor prognosis Mortality Emergency department Kidney function Malignancy

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