The prevention role of Spirulina platensis(Arthrospira platensis) on intestinal health

作     者：Nilay SEY?DOGLU Ender Deniz ASMAZ 

作者机构：Tekirdag Namik Kemal University Veterinary Faculty Department of Physiology Bursa Uludag University Veterinary Faculty Department of Histology and Embryology 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康(英文))

年 卷 期：2022年

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：supported by grant from the Research Foundations of University (Project number: NKUBAP.10.GA.16.074) 

摘      要：Spirulina is a popular herbal food that has a preventive effect on health. In the study, it aimed to evaluate the effects of different doses of Spirulina platensis(Arthrospira platensis) on the morphological properties of the duodenum of rats, and to assign the effect of Spirulina on the expression of proliferating cell nuclear antigen(PCNA) in the rat duodenum, and thereby to observe the effects on intestinal health. 30 male Wistar albino rats were divided into 3 groups for 45 days. The first group was received the basal diet; the second group was given 500 mg/kg Spirulina daily by oral gavage; the third group was given 1 000 mg/kg Spirulina daily. The duodenum segments were taken at the end of the trial and processed for histological assay. Although the total mucosa, villus height and villus/cript ratio were found higher in high dose Spirulina, the lower cript depth was detected in same group compared to control and low dose group. A significant increase was observed at high dose compared to the control and low dose group in terms of PCNA expression intensity and proliferation index. Findings suggest that high dose of Spirulina may support the duodenal growth, and thereby intestinal health.