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Screening of Genes with Unique Mutations of Microcus

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Biomedical and environmental Sciences 2013年第9期26卷 778-781页

作者： SHen Xiao Na XIA Lian Xu HAI Rong LIANG Ying XU Dong Lei CAI Hong WANG Yu Meng ZHenG Xiao WANG Yan Hua zhang Zhi Kai WEI Jian Chun FU Xiu Ping zhang en Min zhang Hui Juan YU Dong Zheng State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention

Yersinia pestis is the causative agent of bubonic and pneumonic plagues. Strains of Y. pestis are classified into four biovars： antiqua, mediaevalis, orientalis, and microtus[11. There are two microtus-related plague loci in China： the Microtus brandti plague focus in the Xilin Gol Grassland （focus L） and the Microtus fuscus plague focus in the Ojnghai-Tibet Plateau （focus M）.

关键词： Screening of Genes with Unique Mutations of Microcus gene

Raman spectra of the GFP-like fluorescent proteins

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Biophysics Reports 2018年第5期4卷 265-272页

作者： Ye Yuan Dianbing Wang Jibin zhang Ji Liu Jian Chen Xian-en zhang National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences College of Life Science and Technology Huazhong Agricultural University College of Life Science Hubei University

The objective of the study was to elucidate optical characteristics of the chromophore structures of fluorescent proteins. Raman spectra of commonly used GFP-like fluorescent proteins（FPs） with diverse emission wavelengths（green, yellow, cyan and red）, including the enhanced homogenous FPs EGFP,EYFP, and ECFP（from jellyfish） as well as m Neptune（from sea anemone） were measured. High-quality Raman spectra were obtained and many marker bands for the chromophore of the FPs were identified via assignment of Raman spectra bands. We report the presence of a positive linear correlation between the Raman band shift of C;=C;and the excitation energy of FPs, demonstrated by plotting absorption maxima(cm;) against the position of the Raman band C;=C;in EGFP, ECFP, EYFP, the anionic chromophore and the neutral chromophore. This study revealed new Raman features in the chromophores of the observed FPs, and may contribute to a deeper understanding of the optical properties of FPs.

关键词： Chromophore Fluorescent protein Raman spectra

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区间集概念格属性约简的组成与结构

山东大学学报（理学版） 2018年第8期53卷 17-24页

作者：张恩胜鞍山师范学院数学与信息科学学院辽宁鞍山114007

区间集是解决部分已知概念、近似不可定义或复杂概念的研究工具。概念格是机器学习、数据挖掘、知识发现和信息检索等领域的一种很有效的数据分析工具。区间集概念格是这两种方法的结合,是对于部分已知概念或不可定义概念信息系统进行... 详细信息

区间集是解决部分已知概念、近似不可定义或复杂概念的研究工具。概念格是机器学习、数据挖掘、知识发现和信息检索等领域的一种很有效的数据分析工具。区间集概念格是这两种方法的结合,是对于部分已知概念或不可定义概念信息系统进行机器学习、数据挖掘、知识发现和信息检索的一种有效的数据分析工具。区间集属性约简是揭示区间集概念格本质特征的一种方法。本文揭示了区间集属性约简的组成与结构:两个区间集相对必要属性不能在同一个区间集属性约简中出现;区间集约简与任何一个区间集相对必要属性等价类的交都不空;核心属性和每个区间集相对必要属性等价类中取一个属性组成的集合一定是区间集属性约简。

关键词：区间集区间集概念格属性约简

生物可降解性消化道支架的应用及其生物相容性

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中国组织工程研究与临床康复 2011年第16期15卷 2961-2964页

作者：张恩沈阳医学院沈州医院消化科辽宁省沈阳市110002

背景:生物可降解支架可在消化道管腔内短期成形,具有良好的生物相容性,随后完全降解,并可以根据临床需要调节支架降解时间,避免了永久性支架的并发症。目的:评价不同材料制成的生物可降解性消化道支架的应用、相容性评价以及研究进展。... 详细信息

背景:生物可降解支架可在消化道管腔内短期成形,具有良好的生物相容性,随后完全降解,并可以根据临床需要调节支架降解时间,避免了永久性支架的并发症。目的:评价不同材料制成的生物可降解性消化道支架的应用、相容性评价以及研究进展。方法:以"生物可降解,消化道,支架,相容性"为关键词,采用电子检索方式在万方数据库中检索1999-01/2009-12有关生物可降解性消化道支架的研究。排除重复研究、普通综述或Meta分析类文章,筛选纳入22篇文献进行评价。结果与结论:可降解支架在消化道疾病中的应用已经显示其有效的扩张性及临床安全性等。可降解材料大多是高分子材料,包括天然可降解高分子、微生物合成高分子材料和合成可降解高分子3类。天然可降解高分子大多是多糖类。天然可降解高分子一般生物相容性良好,但是力学性能较差。微生物合成高分子材料目前研究及应用尚较少。合成高分子种类比较多,常见的有聚丙交酯、聚己内酯、聚乙二醇等。合成高分子优点在于可以比较灵活的设计分子结构,通过发展共聚物、共混物来得到不同性质的材料。可降解支架可以解决良恶性狭窄的再通及瘘口的封堵等,但可降解支架在消化道系统中应用的效力还需要未来进行大量的研究工作来评估。

关键词：生物可降解性支架超声引导材质生物相容性消化道

Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas

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World Journal of Gastroenterology 2020年第37期26卷 5682-5692页

作者： Qin-Fen Chen Xiao-Dong Zhou Dan-Hong Fang en-Guang zhang Chun-Jing Lin Xiao-Zhen Feng Na Wang Jian-Sheng Wu Dan Wang Wei-Hong Lin Department of Physical Examination Medical Care Center The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The significance of Helicobacter pylori(***)infection and atrophic gastritis(AG)in the prevalence of colorectal adenomas has been examined in a limited number of ***,these studies reported disputed *** To investigate whether *** infection,AG,and ***-related AG increase the risk of colorectal *** This retrospective cross-sectional study included 6018 health-check *** relevant data for physical examination,laboratory testing,13C-urea breath testing,gastroscopy,colonoscopy and histopathological examination of gastric and colorectal biopsies were *** and multivariate logistic regression analyses were performed to determine the association between ***-related AG and colorectal *** Overall,1012 subjects(16.8%)were diagnosed with colorectal adenomas,of whom 143(2.4%)had advanced *** the enrolled patients,the prevalence of *** infection and AG was observed as 49.5%(2981/6018)and 10.0%(602/6018),*** with *** infection had an elevated risk of colorectal adenomas(adjusted odds ratio[OR]of 1.220,95%confidence interval(CI):1.053-1.413,P=0.008)but no increased risk of advance adenomas(adjusted OR=1.303,95%CI:0.922-1.842,P=0.134).AG was significantly correlated to an increased risk of colorectal adenomas(unadjusted OR=1.668,95%CI:1.352-2.059,Penomas(adjusted OR=1.491,95%CI:1.103-2.015,P=0.009)and advanced adenomas(adjusted OR=1.910,95%CI:1.022-3.572,P=0.043).CONCLUSION ***-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.

关键词： Helicobacter pylori Gastritis Atrophy Adenomas Colorectal Health-check

Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months

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Virologica Sinica 2021年第5期36卷 869-878页

作者： Yang Zheng Qing zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-en zhang National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Guang’an Men Hospital China Academy of Chinese Medical SciencesBeijing 100053China Health Bureau of Wuchang District Wuhan 430070China Hubei University Wuhan 430074China Shenzhen Mindray Bio-Medical Electronics Co. LtdShenzhen 518057China Hubei Provincial Center for Disease Control&Prevention Wuhan 430079China University of Chinese Academy of Sciences Beijing 100049China

Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd *** retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to *** in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the ***,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th *** titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values *** contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of *** behavior of antibodies and their correlation in age,gender and severity groups were *** general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent *** a few patients with antibody reducing to an undetectable level which needs further *** humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity.

关键词： Coronavirus disease 2019(COVID-19) Humoral Responses Sustainability Convalescent

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电化学循环水阻垢技术在电力行业的应用展望

环境科技 2024年第5期37卷 73-77页

作者：黄治军封明敏刘露璠祁建民张恩先韩卫清江苏方天电力技术有限公司江苏南京211100 南京理工大学环境与生物工程学院江苏南京210094

在工业发展中,循环冷却水的结垢问题一直备受关注,有效的阻垢技术对降低生产能耗和减少水资源的浪费具有重要意义。电化学阻垢技术因具有高效、无需投加药剂、同步杀菌等优点受到了广泛的关注。从电化学阻垢技术的发展、原理以及实际应... 详细信息

在工业发展中,循环冷却水的结垢问题一直备受关注,有效的阻垢技术对降低生产能耗和减少水资源的浪费具有重要意义。电化学阻垢技术因具有高效、无需投加药剂、同步杀菌等优点受到了广泛的关注。从电化学阻垢技术的发展、原理以及实际应用等方面,综述了电化学阻垢技术在循环冷却水处理中的应用情况并展望了在电力行业冷却水处理中的应用前景。包括以时间为向导结合文献计量学可视化分析,比较了近十年阻垢技术相关研究热点;进一步从电化学阻垢技术的简介、与传统阻垢技术的比较、研究现状以及影响因素出发,并结合实际应用情况,提出了电化学阻垢技术尚且存在的困难和挑战,最后对电化学阻垢技术在电力行业中的应用前景进行了展望。

关键词：循环冷却水电力行业结垢电化学沉淀杀菌

Mechanical Behavior and Failure Mechanism of an As-Extruded Mg-11wt%Y Alloy at Elevated Temperature

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Acta Metallurgica Sinica(english Letters) 2024年第6期37卷 969-981页

作者： Lan zhang Dao-Kui Xu Bao-Jie Wang Cui-Lan Lu Shuo Wang Xiang-Bo Xu Dong-Liang Wang Xin Lv en-Hou Han School of Materials Science and engineering University of Science and Technology of ChinaShenyang110016China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of environmental and Chemical engineering Shenyang Ligong UniversityShenyang110159China Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangdong510070China

Through carrying out the high-temperature tensile experiments on an as-extruded Mg-11wt%Y alloy at 350℃,400℃,450℃,500℃and 550℃,the mechanical behavior and fracture mechanisms at elevated temperatures are investigated and *** results show that with the increase of temperature,the yield strength and ultimate tensile strength of the alloy increase at first and then decrease,while that the elongation ratio decreases firstly and then *** the sample being tested at 350℃,the values of yield strength,ultimate tensile strength and the elongation ratio are 188 MPa,266 MPa and 11%,*** 400℃,the yield strength and ultimate tensile strength reach the maximum values of,respectively,198 MPa and 277 MPa,but the elongation ratio is the lowest and its value is only 8%.When the applied temperature is increased to 550℃,the values of yield strength and ultimate tensile strength,respectively,decrease to 140 MPa and 192 MPa and the elongation ratio increases to 38%.Failure analysis demonstrates that the fracture surfaces of different samples are mainly composed of plastic dimples and exhibit the typical characteristic of ductile *** observation to the fracture side surfaces indicates that at the temperatures of 350℃and 400℃,microcracks mainly initiate in the interior of Mg_(24)Y_(5)*** the temperatures are 450℃,500℃and 550℃,the cracks preferentially initiate at the Mg_(24)Y_(5)/α-Mg interfaces.

关键词： Mg-Y alloy High-temperature tensile properties Fracture mechanism Failure analysis

夏威夷群岛东南海域多金属结核的物源特征及其对古海水、亚洲季风信息的记录

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矿物岩石地球化学通报 2019年第1期38卷 61-68页

作者：袁良榕张恩中山大学地球科学与地质工程广州510275 广东省地质过程与矿产资源探查重点实验室广州510275

为深入探讨夏威夷群岛东南海域结核的物源特征及其所记录的古海水、亚洲季风信息,采用电感耦合等离子体质谱(ICP-MS)、X射线荧光光谱仪(XRF)、电子探针(EPMA)方法,对来源于原地质矿产部和国家海洋局"海洋四号"科考船DY85-1航次采集的研... 详细信息

为深入探讨夏威夷群岛东南海域结核的物源特征及其所记录的古海水、亚洲季风信息,采用电感耦合等离子体质谱(ICP-MS)、X射线荧光光谱仪(XRF)、电子探针(EPMA)方法,对来源于原地质矿产部和国家海洋局"海洋四号"科考船DY85-1航次采集的研究区的4块多金属结核样品进行了详细的元素地球化学分析测试,并对分析结果进行了Fe-Mn-[(Cu+Ni)×10]、Fe-Mn-[(Cu+Co+Ni)×10]图解与元素间相关性分析。结果表明,结核中的成矿元素直接来源于海水;应用Co含量经验公式、结合Mn/Fe值计算方法对其生长速率进行验证,得到结核的Fe/Mn、Al/(Fe+Mn)值变化曲线与太平洋底栖有孔虫的δ18O曲线、亚洲内陆粉尘通量曲线呈现出相似的变化趋势,表明多金属结核可作为古海水氧化程度及亚洲季风演化研究的新载体。

关键词：夏威夷群岛多金属结核元素地球化学古海水亚洲季风演变