检索结果-南通市图书馆

Endoscopic management of biliary strictures after liver transplantation

World Journal of Gastroenterology 2009年第30期15卷 3725-3733页

作者： emmanuelle d williams Peter V draganov division of Gastroenterology University of FloridaGainesvilleFL 32610-0214United States

Bile duct strictures remain a major source of morbidity after orthotopic liver transplantation (OLT). Biliary strictures are classifi ed as anastomotic or non-anastomotic strictures according to location and are defi ned by distinct clinical behaviors. Anastomotic strictures are localized and short. The outcome of endoscopic treatment for anastomotic strictures is excellent. Nonanastomotic strictures often result from ischemic and immunological events, occur earlier and are usually multiple and longer. They are characterized by a far less favorable response to endoscopic management, higher recurrence rates, graft loss and need for retransplantation. Living donor OLT patients present a unique set of challenges arising from technical factors, and stricture risk for both recipients and donors. Endoscopic treatment of living donor OLT patients is less promising. Current endoscopic strategies for biliary strictures after OLT include repeated balloon dilations and placement of multiple side-by-side plastic stents. Lifelong surveillance is required in all types of strictures. despite improvements in incidence and long term outcomes with endoscopic management, and a reduced need for surgical treatment, the impact of strictures on patients after OLT is signifi cant. Future considerations include new endoscopic technologies and improved stents, which could potentially allow for a decreased number of interventions, increased intervals before retreatment, and decreased reliance on percutaneous and surgical modalities. This review focuses on the role of endoscopy in biliary strictures, one of the most common biliary complications after OLT.

关键词： Anastomotic strictures Bile duct diseases Endoscopic retrograde cholangiopancreatography Orthotopic liver transplantation Surgical anastomosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

引用

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： Alessio Canovai Pete A.williams department of Biology University of PisaPisaItaly department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sclerosis is at a checkpoint: advancing the program

引用

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica L.williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased Light, Moderate, and Severe Clear-Air Turbulence in Response to Climate Change

引用

Advances in Atmospheric Sciences 2017年第5期34卷 576-586页

作者： Paul d. williams department of Meteorology University of Reading Reading RG6 6BB United Kingdom

Anthropogenic climate change is expected to strengthen the vertical wind shears at aircraft cruising altitudes within the atmospheric jet streams. Such a strengthening would increase the prevalence of the shear instabilities that generate clear-air turbulence. Climate modelling studies have indicated that the amount of moderate-or-greater clear-air turbulence on transatlantic flight routes in winter will increase significantly in future as the climate changes. However,the individual responses of light,moderate,and severe clear-air turbulence have not previously been studied,despite their importance for aircraft operations. Here,we use climate model simulations to analyse the transatlantic wintertime clear-air turbulence response to climate change in five aviation-relevant turbulence strength categories. We find that the probability distributions for an ensemble of 21 clear-air turbulence diagnostics generally gain probability in their right-hand tails when the atmospheric carbon dioxide concentration is doubled. By converting the diagnostics into eddy dissipation rates,we find that the ensembleaverage airspace volume containing light clear-air turbulence increases by 59%(with an intra-ensemble range of 43%–68%),light-to-moderate by 75%(39%–96%),moderate by 94%(37%–118%),moderate-to-severe by 127%(30%–170%),and severe by 149%(36%–188%). These results suggest that the prevalence of transatlantic wintertime clear-air turbulence will increase significantly in all aviation-relevant strength categories as the climate changes.

关键词： turbulence climate change aviation jet stream

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review of screening for pancreatic cancer in high risk individuals

引用

World Journal of Gastroenterology 2011年第19期17卷 2365-2371页

作者： Alina Stoita Ian d Penman david B williams department of Gastroenterology St Vincent's Hospital 390 Victoria StreetDarlinghurst2010NSWAustralia Centre for Liver and digestive disorders Royal Infirmary of Edinburgh51 Little France CrescentEdinburghEH16 4SAUnited Kingdom

Pancreatic cancer is difficult to diagnose at an early stage and is associated with a very poor *** percent of pancreatic cancers result from genetic susceptibility and/or familial *** from families with multiple affected first-degree relatives and those with a known cancer-causing genetic mutation have been shown to be at much higher risk of developing pancreatic *** efforts have focused on detecting disease at an earlier stage to improve survival in these high-risk *** article reviews high-risk groups,screening methods,and current screening programs and their results.

关键词： Pancreatic cancer Familial cancer Cancer screening Risk factors Endoscopic ultrasound Hereditary cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crustacean parasites associated with hermit crabs from the western Mediterranean Sea,with first documentation of egg predation by the burrowing barnacle Trypetesa lampas(Cirripedia:Acrothoracica:Trypetesidae)

引用

Integrative Zoology 2011年第1期6卷 13-27页

作者： Jason d.williams Alejandra GALLARdO Angela E.MURPHY department of Biology Hofstra UniversityHempsteadNYUSA

Parasitic isopods(family Bopyridae)and burrowing barnacles(family Trypetesidae)infesting hermit crabs were investigated from shallow subtidal collections made along the southeastern coast of Spain in 2009.A total of 713 specimens of Clibanarius erythropus(Latreille,1818)and 82 Calcinus tubularis(L.,1767)were *** shells and worm tubes inhabited by hermit crabs were collected by hand while snorkeling and were cracked to determine host species,size,sex and presence of *** species of bopyrid isopods were found on ***:the branchial parasite Bopyrissa fraiseii(Carayon,1943)and the abdominal parasite Parathelges cardonae Codreanu and Codreanu in Codreanu,*** all *** examined,Bopyrissa fraiseii was found on 0.6%of hermit crabs and *** was found on 0.3%.A redescription of *** is provided and the species is documented with light and scanning electron microscopy for the first *** Calcinus tubularis harbored parasitic isopods,but one specimen was parasitized by an unidentified rhizocephalan barnacle of the genus Septosaccus(1.2%).The burrowing barnacle Trypetesa lampas(Hancock,1849)was found associated with both hermit crab species and evidence of predation on host eggs by this barnacle is shown for the first *** lampas was found in 4.2%of the shells *** present study expands our knowledge of the parasite fauna of hermit crabs from the Mediterranean Sea and indicates that additional research is needed to determine the impact of trypetesid egg predators on hermit crab populations.

关键词： Bopyridae egg predator Isopoda parasitism Rhizocephala

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Landmarks in the application of electrical tomography in particle science and technology

引用

Particuology 2010年第6期8卷 493-497页

作者： Richard A.williams Institute of Particle Science and Engineering School of ProcessEnvironmental and Materials EngineeringUniversity of LeedsLeedsWest YorkshireLS2 9JTUK

Selected milestones in the development and use of electrical tomography in powder conveying, slurry processing and multi-phase flow are highlighted. The ability to map concentration in opaque mixtures under process-realistic conditions was a major innovation for the method and has had far reaching implications. Subsequent developments have enabled velocity information to be abstracted resulting in the ability to measure component flux and motion.

关键词： Computational fluid dynamics Fault condition and maloperation Flow measurement Flow regime identification Particle concentration Process control Process safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6

引用

Bone Research 2015年第4期3卷 235-245页

作者： Cassie A Schumacher danese M Joiner Kennen d Less Melissa Oosterhouse drewry Bart O williams Center for Cancer and Cell Biology Program in Skeletal Disease and Tumor MicroenvironmentVan Andel Research Institute

Mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and *** lacking either gene alone were viable and fertile with normal knee *** in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during *** addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre transgene was active in cells that subsequently differentiated into *** both embryonic skeletal development and establishment of adult bone mass,Lrp5 and Lrp6 carry out redundant functions.

关键词： carrying Collagen displayed deletion engineered transgene viable embryogenesis redundant embryonic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Syntheses,structures,and reactivity of ruthenium(Ⅱ) hydride complexes containing Klui's oxygen tripodal ligand

引用

Science China Chemistry 2010年第10期53卷 2139-2143页

作者： NG Ho-Yuen LAI Chun-Sing williams Ian d. LEUNG Wa-Hung department of Chemistry The Hong Kong University of Science and Technology

Treatment of Ru(CO)(Cl)(H)(PPh3)3 with NaLOEt (LOEt-= [CpCo{P(O)(OEt)2}3]-) afforded the hydride complex (PPh3)(CO)-LOEtRu(H) (1), which has been characterized by X-ray crystallography. Similarly, the tricyclohexylphosphine analogue, (PCy3)(CO)LOEtRu(H) (2), was synthesized from Ru(CO)Cl(H)(PCy3)2 and NaLOEt. Treatment of complex 1 with R'SO2N3 afforded the (arylsulfonyl)amido complexes LOEtRu(CO)(PPh3)(NHSO2R) (R = 2,4,6-i-Pr3C6H2 (3), 4-t-BuC6H4 (4)). The crystal structure of complex 3 has been determined. The Ru-N distance and Ru-N-S angle in 3 are 2.076(3) and 126.14(16)°, respectively. Reactions of complex 1 with acids have been studied.

关键词： ruthenium oxygen tripodal ligand hydride complex (arylsulfonyl)amido complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advancements in non-starch polysaccharides research for frozen foods and microencapsulation of probiotics

引用

Frontiers of Chemical Science and Engineering 2009年第4期3卷 413-426页

作者： Pavan Kumar SOMA Patrick d.williams Y.Martin LO department of Nutrition and Food Science University of MarylandCollege ParkMD 20742USA

Conventionally used in the food industry as stabilizing,thickening,gelling,and suspending or dispersing agents,non-starch polysaccharides such as xanthan gum are known to improve the texture of certain frozen *** polysaccharide that has received significant attention in recent years is chitosan,a natural biopolymer derived from *** the wake of growing interest in finding ideal encapsulating agents for probiotics,non-starch polysaccharides have been *** research can be found on the effect of each individual polysaccharide,but there remains a void in the literature in terms of closely comparing the characteristics of nonstarch polysaccharides for these applications,especially when more than one biopolymer is employed.A good understanding of the tools capable of elucidating the underlying mechanisms involved is essential in ushering further development of their ***,it is this review’s intention to focus on the selection criteria of non-starch polysaccharides based on their rheological properties,resistance to harsh conditions,and ability to improve sensory quality.A variety of critical tools is also carefully examined with respect to the attainable information crucial to frozen food and microencapsulation applications.

关键词： microencapsulation xanthan galactomannan chitosan curdlan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：