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Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 269-278页

作者： Meshack Antwi-Adjei Ernest Obese emmanuel Awintiig Adakudugu Benjamin Aboagye Daniel Anokwah Akua Afriyie Karikari Roberta Antwi-Adjei Elvis Ofori Ameyaw Department of Pharmacology School of Medical SciencesUniversity of Cape CoastCape CoastGhana Department of Pharmacotherapeutics and Pharmacy Practice School of Pharmacy and Pharmaceutical SciencesUniversity of Cape CoastCape CoastGhana Department of Forensic Sciences School of Biological SciencesUniversity of Cape CoastCape CoastGhana Department of Pharmacognosy and Herbal Medicine School of Pharmacy and Pharmaceutical SciencesUniversity of Cape CoastCape CoastGhana Department of Biomedical Sciences School of Allied Health SciencesCollege of Agriculture and Natural SciencesUniversity of Cape CoastCape CoastGhana

Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative ***:Rats were randomly divided into six groups:normal control,negative control,positive control(dexamethasone or sulfasalazine)as well as Persicaria lanigera(100-600 mg/kg)-treated *** effects of the extracts on body weight,antioxidant,and hematological parameters,as well as mast cell proliferation,were *** addition,a histological evaluation was ***:Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats(P<0.05).Additionally,the extract significantly increased body weight,improved hematological profile,reduced the disease activity index score and malondialdehyde level,as well as enhanced catalase and superoxide dismutase activities(P<0.05).Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages,as evidenced by decreased cell necrosis,edema,and inflammatory cell ***:Persicaria lanigera extract possesses antiproliferative,antioxidative,and anti-colitis ***,its underlying mechanisms of action need further investigation.

关键词： Colitis Persicaria lanigera Antioxidant Cotton pellets Mast cells Granuloma tissue formation

Multi-site Passivation of ZnO Metal Oxides via Biomolecules for Efficient and Highly Stable Organic Solar Cells

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Chinese Journal of Chemistry 2024年第14期42卷 1582-1592页

作者： Irfan Ismail Maria Khalil Xiaomei Gao Xingze Chen Muhammad Jawad Rong Huang Zhiyun Li emmanuel Acheampong Tsiwah Wei-shi Li Qun Luo Chang-Qi Ma i-Lab&Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)SuzhouJiangsu215123 China University of Chinese Academy of Sciences(UCAS) Beijing100040 China School of Nano-Tech and Nano-Bionics University of Science and Technology of China(USTC)HefeiAnhui230027 China Shanghai Institute of Organic Chemistry(SIOC) Chinese Academy of Sciences(CAS)Shanghai200032 China Vacuum Interconnected Nanotech Workstation(Nano-X) SuzhouJiangsu215123 China

ZnO nanoparticles(nps)among metal oxide(MOs)are proven to be essential electron transporting layers(ETLs)applied in organic solar cells(OSCs).However,intrinsic defects,interfacial charge recombination,and catalytic behavior towards the active layer restrict the applications of ZnO nps for efficient and long-term stable *** commonly available biomolecule cytidine 5'-monophosphate(CMP-OH)with phosphonic acid,its salt cytidine 5'-monophosphate disodium salt(CMP-ONa)with a phosphate group as an anchoring group and conjugated terminal functional in both analogous molecules provide carrier transfer bridge at bottom interface of the active *** theoretical investigations and characterizations have discovered the multi-site coordination of CMP-OH towards acceptor molecules and ZnO *** dual-side alignment of CMP analogous molecules hinders interfacial charge recombination and enhances charge transfer potential at ***,PM6:L8-BO-based OSCs with modified ETL obtain 18.13%efficiency,12%higher than that of unmodified *** higher efficiency,CMP-OH-based OSC devices illustrate remarkably improved thermal stability for 500 h at 85℃with 72%of initial PCE and operation stability for 2000 h with 90.1%of initial *** work reveals the passivation mechanism of multi-anchoring groups towards MOs and single-functional groups towards the active layer to optimize the interface for efficient and highly stable OSCs.

关键词： Organic solar cells Nanoparticles Nucleotides Interfacial interactions Surface chemistry Multi-site passivation

检查清单和错误报告系统在提高患者安全和减少医疗差错方面的有效性:叙述性回顾

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International Journal of Nursing Sciences 2024年第3期11卷 387-398页

作者： emmanuel Aoudi Chance Dia Florence Innocent Sardi Abdoul VID Specialized University BergenNorway Universite de Bertoua Cameroon Univerity of Ngaoundere Cameroon

目的探讨检查清单和错误报告系统对医院患者安全和医疗错误的影响。方法系统检索2013-2023年的学术数据库,对符合纳入标准的同行评议研究进行严谨的方法学评估。该综述强调了支持核对表在减少用药错误、手术并发症和其他不良事件方面的... 详细信息

目的探讨检查清单和错误报告系统对医院患者安全和医疗错误的影响。方法系统检索2013-2023年的学术数据库,对符合纳入标准的同行评议研究进行严谨的方法学评估。该综述强调了支持核对表在减少用药错误、手术并发症和其他不良事件方面的有效性证据。错误报告系统提高了透明度,鼓励专业人员报告事件并识别系统漏洞。结果检查表和错误报告系统相互关联,在检查表的实施中强调跨专业合作。文章中使用的不同方法和潜在的发表偏倚可能产生局限性;此外,语言限制可能会排除有价值的非英语研究。虽然积极的影响是显而易见的,但成功取决于组织文化和资源。结论通过查阅相关文献,强调干预措施的重要性,并呼吁进一步研究检查清单和错误报告系统在不同医疗保健和文化背景下的有效性,有助于提高患者安全知识。了解这些动态变化对于医疗保健提供者优化患者安全至关重要。

关键词：患者安全医疗错误检查表错误报告系统健康状况

Unintended Pregnancy Determinants among Antenatal Clinic Attendees: A University of Port Harcourt Teaching Hospital Experience

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Journal of Biosciences and Medicines 2024年第4期12卷 229-245页

作者： Ijeoma Chioma Oppah Terhemen Kasso emmanuel Okwudili Oranu Department of Obstetrics and Gynaecology University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Department of Obstetrics and Gynaecology University of Port Harcourt Port Harcourt Nigeria

An unintended pregnancy is a pregnancy that is either mistimed or unplanned. The objectives of this study were to determine the prevalence of unintended pregnancy as well as to document the determinant factors among pregnant women attending antenatal clinics at the University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, Rivers State, Nigeria. It was a descriptive, cross-sectional study of 215 women attending the antenatal clinic of UPTH from July to August 2022. Information on socio-demographic characteristics, reproductive history, desirability of the current pregnancy at the time of conception, knowledge and use of contraceptive methods were collected using a pretested questionnaire and analyzed using SPSS version 26.0. Chi-square test was used for test of associations with the level of significance set at P < 0.05. The prevalence rate of unintended pregnancy from the study was 16.28% (≈16%). The contraceptive awareness was very high (209, 97.21%), however, 101 (46.98%) participants had never used any form of contraceptives. Univariate analysis using Chi-square test showed a statistically significant association between age and unintended pregnancy (P = 0.042), level of education and unwanted pregnancy (P = 0.033) as well as parity and unintended pregnancy (P = 0.019). The prevalence of unintended pregnancy among women attending antenatal clinics was high, possibly due to low contraceptive usage. More efforts should be geared towards ensuring access to comprehensive contraceptive care and contraceptive methods, this will enhance uptake and reduce the rate of unintended pregnancy.

关键词： Unintended Pregnancy Determinants Prevalence Antenatal Attendees

Influence of Production Factors on the Physico-Chemical Characteristics of Fermented Cassava Dough and Sensory Evaluation of Attieke

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Food and Nutrition Sciences 2024年第5期15卷 361-376页

作者： Weiléko Hélène Dougba Djedjro Clément Akmel emmanuel Aya Diane Boudouin Dibi Nogbou emmanuel Assidjo Laboratory of Industrial Processes for Environmental Synthesis and New Energies Institut National Polytechnique F&#233lix Yamoussoukro C&#244te d&#8217Ivoire Department of Agro-Food and Food Industries UFR Agriculture Fisheries Resources and Agro-Industry University of San-Pedro San-Pedro C&#244te d&#8217Ivoire

Attieke is an Ivorian semolina which obtained by fermenting, pressing and steaming cassava dough. Attieke production remains a traditional activity carried out by less literate women. However, perceived differences in measurable factors and attieke qualities require an investigation of their influence on the characteristics of the pressed dough and attieke. The aim of this study is to improve the quality of the dough in relation to that of the attieke produced. The experiment was carried out on 4 production factors, namely the type of boiled or braised ferment, the incorporation rate of the ferment between 8 and 10%, the addition of oil from 0.1 to 1% and the fermentation time from 12 to 15 hours applied to the Improved African Cassava (IAC) variety. A complete experiment design of 16 samples of fermented dough and attieke was employed. These samples underwent physic-chemical analyses for the fermented dough and sensory evaluation for the attieke. It was found that, except for titratable acidity, reducing sugar content and ash content, the physico-chemical characteristics of the dough of IAC variety were significantly influenced by all production factors and their interaction. Fermentation time significantly influences 60% of the physico-chemical characteristics of the fermented dough. The type of ferment, the oil addition and the ferment rate have a significant influence at 40% of these characteristics. At the sensory level, color, acidity and grain binding with an explained variance of 34.60% were essential for the appreciation of the attieke samples. Thus, these production factors could be considered for the improvement of the fermented dough and attieke production process.

关键词： Influence Production Fermented Dough Attieke

Leadership and Top Management Influence on Total Quality Management Implementation in the Ghanaian Construction Industry

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Journal of Building Construction and Planning Research 2024年第2期12卷 37-51页

作者： Ansah Samuel Kwame Tekpe emmanuel Ametepey Simon Ofori Department of Construction Technology and Management Cape Coast Technical University Cape Coast Ghana Department of Building Technology Koforidua Technical University Koforidua Ghana

This study aims to determine the key and underlying Leadership and Top Management (LTM) factors that have a significant impact on sustaining the implementation of Total Quality Management (TQM) within the construction industry in Ghana. The research methodology employed in this study was a quantitative technique. Questionnaires were distributed to 641 participants within construction industry in Ghana. Questionnaires retrieved for the analysis were 536. Three steps approached were used for the data analysis. These include Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Modeling (SEM) analysis. After conducting the EFA and CFA, SEM was also used to analyze the construct validity. The SEM analysis helps to determine four key indicator variables for the leadership and top management construct. These include Leadership/Top Management approach to employees’ management, Leadership/Top Management understanding of TQM, Leadership/Top Management empowerment of employees to resolve quality issues, and Leadership/Top Management endorsement of TQM. All the four indicator variables were found to be good of fit and closely associated with the dependent variable. The study adds to the body of knowledge by using EFA, CFA and SEM techniques to establish key leadership and top management factors affecting TQM implementation in Ghana’s construction industry. The findings in general suggested that leadership and top Management factors identified have a direct positive impact on sustaining TQM implementation in the Ghanaian construction industry. Consequently, the leadership and top management factors identified in this study can help improve TQM in the Ghanaian construction industry.

关键词： Construction Industry Leadership Top management Total Quality Management

A Pragmatic Template for Quadcopter Development

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Advances in Aerospace Science and Technology 2024年第2期9卷 61-74页

作者： Iyenagbe Benjamin Ugheoke Abdulhakeem Hassan Nurudeen Olusola Ayodeji Abiire Aniedi Okon Edem emmanuel Adedayo Towoju emmanuel Ogo Onche Department of Mechanical Engineering Faculty of Engineering University of Abuja Abuja Nigeria

This article presents a pragmatic quadcopter development template for parcel delivery in Nigeria. The quadcopter is equipped with a camera, parcel pouch and wireless telecommunication to capture live events and send them back to the control station for real-time delivery feedback. The study also discusses the design methodology adopted as a conceptual design approach vital to product development, it encompasses information gathering and identifying the problem, creating the solutions systematically and eventually evaluating and developing a concept for the drone and its attributes and presenting clear results for design calculations.

关键词： Drone Unmanned Aeriel Vehicles Quadcopter Drone Development Flight

The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development

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Plant Communications 2024年第7期5卷 178-199页

作者： Simon Amiard Léa Feit emmanuel Vanrobays Lauriane Simon Samuel Le Goff Loriane Loizeau Léa Wolff Falk Butter Clara Bourbousse Fredy Barneche Christophe Tatout Aline V.Probst iGReD CNRSInsermUniversite´Clermont Auvergne63000 Clermont-FerrandFrance Institut de biologie de I’Ecole normale supe´rieure(IBENS) Ecole normale supe´rieureCNRSINSERMUniversite´PSLParisFrance Institute of Molecular Biology 55128 MainzGermany

Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins(TRBs)combine two DNA-binding domains,the GH1 domain,which binds to linker DNA and is shared with H1 histones,and the Myb/SANT domain,which specifically recognizes the telobox DNA-binding site ***1,TRB2,and TRB3 proteins recruit Polycomb group complex 2(PRC2)to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress ***,we demonstrate that TRB4 and TRB5,two related paralogs belonging to a separate TRB clade conserved in spermatophytes,regulate the transcription of several hundred genes involved in developmental responses to environmental ***4 binds to several thousand sites in the genome,mainly at transcription start sites and promoter regions of transcriptionally active and H3K4me3-marked genes,but,unlike TRB1,it is not enriched at H3K27me3-marked gene ***,TRB4 can physically interact with the catalytic components of PRC2,SWINGER,and CURLY LEAF(CLF).Unexpectedly,we show that TRB4 and TRB5 are required for distinctive phenotypic traits observed in clf mutant plants and thus function as transcriptional activators of several hundred CLF-controlled genes,including key flowering *** further demonstrate that TRB4 shares multiple target genes with TRB1 and physically and genetically interacts with members of both TRB ***,these results reveal that TRB proteins engage in both positive and negative interactions with other members of the family to regulate plant development through both PRC2-dependent and-independent mechanisms.

关键词： chromatin TRB proteins transcriptional regulation PRC2 plant development

Toxicity and phyto-bioactive constituent of Ficus aurea L. leaf extract: A trado-medicinal herb used in southeastern Nigeria

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 54-64页

作者： Sonachi Nnedimma Okeke Chinyere Godwin Chinyere Okezie emmanuel Department of Biochemistry Abia State UniversityUturuPMB 2000Uturu Abia StateNigeria Department of Animal Sciences College of FoodAgricultural and Environmental Sciencesthe Ohio State UniversityWoosterOH 44691US

Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal *** of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health ***:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of *** L.(herein afterwards referred to as ELEFA)in albino rats of both ***:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of *** the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was *** the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew *** groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled *** analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney ***:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological *** bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic *** the acute toxicity,no death was recorded within 24 h following oral administration of ***,haematological and renal biomarkers remained unaltered post-ELEFA ***,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative ***:The study emphasized caution reg

关键词： Antioxidant Ficus aurea Phytochemical Toxicity Trado-medicine