Toxicity and phyto-bioactive constituent of Ficus aurea L. leaf extract: A trado-medicinal herb used in southeastern Nigeria
作者机构：Department of BiochemistryAbia State UniversityUturuPMB 2000Uturu Abia StateNigeria Department of Animal SciencesCollege of FoodAgricultural and Environmental Sciencesthe Ohio State UniversityWoosterOH 44691US
出 版 物：《Clinical Traditional Medicine and Pharmacology》 (临床传统医学和药理学（英文）)
年 卷 期：2024年第5卷第4期
页 面：54-64页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Antioxidant Ficus aurea Phytochemical Toxicity Trado-medicine
摘 要：Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal *** of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health ***:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of *** L.(herein afterwards referred to as ELEFA)in albino rats of both ***:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of *** the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was *** the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew *** groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled *** analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney ***:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological *** bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic *** the acute toxicity,no death was recorded within 24 h following oral administration of ***,haematological and renal biomarkers remained unaltered post-ELEFA ***,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative ***:The study emphasized caution reg
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