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World Journal of Vaccines 2015年第3期5卷 147-147页

作者： Beckie Nnenna Tagbo Jason Mwenda Christopher Eke Tagbo Oguonu Sebastian Ekenze Uchechukwu Obiora Ezomike Benedict Edelu Ogechukwu Amadi Ifeyinwa Okeke Okechukwu Ani Roservelt Okechukwu Nnani Vina Okafor Henrietta Uche Okafor Egbuna Obidike emmanuel Abanida Chris Elemuwa Toyin Odetunde Institute of Child Health and Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria World Health Organization Regional Office for Africa (WHO/AFRO) Brazzaville Republic of Congo Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria Department of Paediatric Surgery University of Nigeria Teaching Hospital Enugu Nigeria Department of Paediatrics Enugu State University Teaching Hospital Enugu Nigeria Institute of Child Health University of Nigeria Teaching Hospital Enugu Nigeria National Primary Health Care Development Agency Federal Ministry of Health Abuja Nigeria Department of Paediatric Surgery Enugu State University Teaching Hospital Enugu Nigeria

The original online version of this article (Tagbo, B. N., et al. 2014 “Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria”, 2014, 4, 123-132, http://***/10.4236/wjv.2014.43015) was publis... 详细信息

关键词： Intussusception Children Rotavirus Surgery Bloody Stool Nigeria

寻求鼻成形术者有较高的身体畸形恐惧症发病率

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中国美容整形外科杂志 2012年第1期23卷 I0003-I0003页

作者： Valerie A．Picavet emmanuel P．Prokopakis Lutgardis Gabriels Mark Jorissen Peter W．Hellings 魏峰(译) 高景恒(译) 袁继龙(译) 石杰(译) 张晨(译) 乐芬大学医院耳鼻喉科比利时乐芬市乐芬大学医院精神病科伊拉克利翁大学医院耳鼻喉科《中国美容整形外科杂志》编辑部辽宁省人民医院整形外科大连大学附属新华医院整形外科

背景与目的鼻美学畸形可明显导致对体像的不满意。目前，仅有的对此类患者心理疾病的诊断种类是身体畸形恐惧症。本文将对身体畸形恐惧症在鼻成形术患者中存在的普遍性进行大规模的研究，并对此类患者的症状和临床属性进行阐释和评估。... 详细信息

背景与目的鼻美学畸形可明显导致对体像的不满意。目前，仅有的对此类患者心理疾病的诊断种类是身体畸形恐惧症。本文将对身体畸形恐惧症在鼻成形术患者中存在的普遍性进行大规模的研究，并对此类患者的症状和临床属性进行阐释和评估。方法本组共226例患者，采用人口学特征量表（DemographicCharacteristics）、评价鼻外形的视觉类比量表（VisualAnalogScale）、评价身体畸形恐惧症的改良Yale-Brown强迫症量表（Yale-BrownObsessiveCompulsiveScale）让患者进行问卷调查，以评估其症状的严重程度，并采用通用生活质量调查表和Derriford外貌59量表（DerrifordAppearanceScale59）对与外貌损毁相关的患者13常生活情况进行评估。由独立观察者分别对患者的鼻外形进行评分。结果本组共有39％的患者表现出至少中等程度的身体畸形恐惧症症状。有美学目标（P〈0．001）、希望行鼻成形术修复手术（P=0．003）和有心理疾病史（P：0．031）者被认为有严重的身体畸形恐惧症。对鼻外形的客观和主观评分结果间无关联。评价身体畸形恐惧症的改良***强迫症量表结果与鼻主观评分结果呈负相关（n=210，P〈0．001），与鼻客观存在的畸形无关。身体畸形恐惧症可显著降低患者的普通生活质量（n,=160，P〈0．001），并严重损害与面容相关的日常生活（n=161，P〈0．001）。结论中度至重度身体畸形恐惧症在美容鼻整复手术患者中具有普遍较高的发病率。患者行鼻成形修复手术和有心理疾病史尤其是诊断有身体畸形恐惧症的高危因素。身体畸形恐惧症可显著降低患者的普通生活质量，并严重损害患者与面容相关的日常生活。

关键词：身体畸形恐惧症鼻成形术发病率生活质量调查表心理疾病生活情况修复手术人口学特征

Enriched Artemia Nauplii with Commercial Probiotic in the Larviculture of Angelfish Pterophyllum scalare Lichtenstein (1823)

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Journal of Fisheries Science 2020年第1期2卷 17-21页

作者： Natalino da Costa Sousa José Araújo da Silva Emilly Monteiro Lopes Arthur Felipe Lima dos Santos Francisco Alex Lima Barros Carlos Alberto Martins Cordeiro Peterson emmanuel Guimarães Paixão Estela dos Santos Medeiros João Carlos Nunes de Souza Márcia Valéria Silva do Couto Federal University of Pará(UFPA) Campus BragançaAlameda Leandro RibeiroBragança68600-000PABrazil Tiradentes University(UNIT)-Av.Murilo Dantas 300-FarolândiaCEP 49032-490AracajuSergipeBrazil Faculdade Pio Décimo Av.Pres.Tancredo Neves 5655-Jabotiana49095-000Aracaju-SE.Brazil

This study evaluated the effect of enriched artemia nauplii with commercial probiotic for angelfish larvae determining growth perfomance,survival and modulation of the intestinal ***,it experiment occurred in completely randomized design with five treatments(T1-0.0,T2-1.5,T3-3.0,T4-4.5 and T5-6.0g of commercial probiotic)and four replaces during 20 *** larvaculture,post larvae passed by biometric procedures to determine productive performance and then microbiological *** reduction of total heterotrophic bacteria while increased lactic acid bacteria in the intestinal tract from the post larvae for treatments T3,T4 and *** commercial probiotic also increased the survival and performance as final weight,weight gain and specific growth *** these reasons,the use of 3g of commercial probiotic promotes greater performance and intestinal modulation for angelfish larvae.

关键词： Ornamental fish Probiotic Larvaculture

非正式地方治理机构与族群内部的冲突管理:对坦桑尼亚东北部塔里梅区库里阿地方治理的反思

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非洲研究 2019年第1期14卷 -页

作者： [坦桑尼亚]伊曼纽·雅各布·基翁多里亚布委内·姆塔哈布阿彼得·安东尼·寇泊卡陈倩瑜祝亚雄(校) 雷雯(校) 坦桑尼亚多多马大学坦桑尼亚国立尼雷尔博物馆坦桑尼亚多多马大学、教育学院坦桑尼亚多多马大学社会科学学院政治学与公共管理系不详

本文探究了坦桑尼亚东北部塔里梅(Tarime)专区库里阿(Kuria)传统的地方治理机构如何影响该地区族群内部冲突管理,旨在理解非正式地方治理机构的惯例和决策对族群内部冲突管理的影响。本文采用质性研究的民族志方法收集信息,采取系统思... 详细信息

本文探究了坦桑尼亚东北部塔里梅(Tarime)专区库里阿(Kuria)传统的地方治理机构如何影响该地区族群内部冲突管理,旨在理解非正式地方治理机构的惯例和决策对族群内部冲突管理的影响。本文采用质性研究的民族志方法收集信息,采取系统思维理论(STT)分析库里阿现有族群内部冲突的治理问题。研究发现,塔里梅的各库里阿社区(氏族)普遍拥有非正式治理机构,这些机构已是该地区文化和历史的一部分。库里阿非正式地方治理机构对族群内部冲突的影响为消极影响与积极影响并存:可能会引发冲突,也可能在管理族群内部冲突方面发挥重要作用,即使这些机构存在局限性,它们在非正式方法解决地区冲突方面仍有其合理之处。然而,尽管非正式地方治理机构在管理族群内部冲突方面具有优势,但在该地区调解冲突的进程中,这些机构的潜力尚未得到充分利用。因此,本文建议认可非正式地方治理机构在处理塔里梅区库里阿族内冲突中的作用,并将其视为正规机制的一部分。

关键词：冲突管理族群内部冲突非正式治理机构

Effectiveness of Gardnerella vaginalis culture and Nugent scoring in identifying bacterial vaginosis in pregnant women

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Infectious Diseases Research 2023年第2期4卷 14-24页

作者： Chijioke Ogomegbunam Ezeigwe George Uchenna Eleje Chidebe Christian Anikwe David Chibuike Ikwuka Boniface Chukwuneme Okpala Kindness Chidi Irikannu Emeka Philip Igbodike emmanuel Umegbolu Ngozichukwu Uzoewulu Olufunke Onaadepo Malarchy Ekwunife Nwankwo Onyecherelam Monday Ogelle Choice Chinemerem Nworgu Jide Uzowulu Uzoigwe Ifeoma Frances Okwuonu Chisom Godswill Chigbo LazarusUgochukwu Okafor Chinekwu Sochukwu Anyaoku Chukwuemeka Okwudili Ezeama Charlotte Blanche Oguejiofor Joseph Ifeanyichukwu Ikechebelu Department of Obstetrics and Gynaecology Nnamdi Azikiwe University Teaching Hospital NnewiAnambra State 435001Nigeria Department of Obstetrics and Gynaecology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Human Physiology Nnamdi Azikiwe UniversityNnewi Campus 435001Nigeria Department of Medical Physiology University of RwandaHuye CampusHuye 0000Rwanda Department of Parasitology and Entomology Nnamdi Azikiwe UniversityAwka 420007Nigeria Department of Outpatient Department General Hospital Oji River 401145Enugu StateNigeria Department of Medical Microbiology/Parasitology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Physiology University of Nigeria Enugu CampusEnugu 410001Nigeria Department of School of Public Health University of Port-HarcourtRivers State 500004Nigeria Department of Family Medicine Nnamdi Azikiwe University Teaching Hospital NnewiAnambra State 435001Nigeria.

Background:Bacterial vaginosis(BV),a lower genital tract syndrome,has been linked to adverse pregnancy outcomes and is regarded as the prevalent type of vaginal infection in females of childbearing ***:To determine the accuracy of Nugent scoring and Gardnerella vaginalis culture in the diagnosis of bacterial vaginosis(BV)among pregnant women attending antenatal clinic in Nnamdi Azikiwe University Teaching Hospital,Nnewi,***:This cross-sectional study evaluated biospecimen from 333 pregnant women enrolled through systematic random sampling *** of vaginal discharge were tested for BV infection using Amsel’s criteria,Nugent’s score and culture of *** Amsel’s criteria as a“gold standard”,the Nugent’s score and culture of *** were ***:Prevalence of 26.12%,25.82% and 28.20% of BV was found using Amsel criteria,Nugent’s method and culture of ***,*** statistical relationship exists between socio-demographic characteristics and BV(P>0.05).Sexual exposure,and vaginal hygienic practices influences BV(P<0.05)infection and also with fishy odor during or after sexual intercourse,Gardnerella morphotypes,Bacteroides morphotypes and BV(P<0.05).An inverse relationship existed between lactobacilli morphotypes and *** prevalence of HIV was 5.41% and 16 out of 18 had BV diagnosed using Amsel *** method correlated strongly with Amsel criteria(P<0.05).In comparison with Amsel criteria,it had 78.16% sensitivity,92.68% specificity,79.07% positive predictive value,92.31% negative predictive value and 88.89% accuracy *** was in contrast distinction to the culture of ***,which had 56.32%sensitivity,81.70% specificity,52.13% positive predictive value,84.10% negative predictive value and 75.08% accuracy ***:Nugent method correlated strongly with Amsel criteria(P<0.05)and had 78.16% sensitivity,92.68% specificity,79.07% positive predictive value,92.31% negative

关键词： Amsel criteria bacterial vaginosis Gardnerella vaginalis Nugent score pregnant women prevalence HIV

First-line cemiplimab monotherapy and continued cemiplimab beyond progression plus chemotherapy for advanced non-small-cell lung cancer with PD-L1 50% or more(EMPOWER-Lung 1):35-month follow-up from a multicentre,open-label,randomised,phase 3 trial

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肿瘤药学 2023年第4期 384-384页

作者： Mustafa ?zgüroglu Saadettin Kilickap Ahmet Sezer Mahmut Gümüs Igor Bondarenko Miranda Gogishvili Marina Nechaeva Michael Schenker Irfan Cicin Gwo Fuang Ho Yaroslav Kulyaba Kasimova Zyuhal Roxana-loana Scheusan Marina Chiara Garassino Xuanyao He Manika Kaul emmanuel Okoye Yuntong Li Siyu Li Jean-Francois Pouliot Frank Seebach Israel Lowy Giuseppe Gullo Petra Rietschel 房超湖南省肿瘤医院GCP伦理办公室

肺癌是全球癌症相关死亡的主要原因,非小细胞肺癌(NSCLC)占所有肺癌病例的80%～85%。随着分子生物学的发展,针对驱动基因突变(如EGFR、ALK等)的靶向药物治疗已成为晚期NSCLC的标准一线治疗。但大多数NSCLC并没有可检测到的驱动基因突变...

肺癌是全球癌症相关死亡的主要原因,非小细胞肺癌(NSCLC)占所有肺癌病例的80%～85%。随着分子生物学的发展,针对驱动基因突变(如EGFR、ALK等)的靶向药物治疗已成为晚期NSCLC的标准一线治疗。但大多数NSCLC并没有可检测到的驱动基因突变,传统的铂类化疗效果不佳。免疫检查点抑制剂的出现极大地改变了这一领域的治疗格局。PD-1/PD-L1抑制剂已被证实可以显著提高NSCLC患者的疗效和生存期,特别是PD-L1表达阳性率≥50%的人群。在晚期NSCLC中,抗PD-1抗体Pembrolizumab和Atezolizumab已被证实可显著提高PD-L1高表达人群的客观缓解率、无进展生存期和总体生存期。

关键词：

The impact of COVID-19 on the birth rate in Nigeria:a report from population-based registries

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Infectious Diseases Research 2023年第1期4卷 14-18页

作者： Charlotte Blanche Oguejiofor Kenechi Miracle Ebubechukwu George Uchenna Eleje emmanuel Onyebuchi Ugwu Joseph Tochukwu Enebe Kingsley Emeka Ekwuazi Chukwuemeka Chukwubuikem Okoro Boniface Chukwuneme Okpala Charles Chukwunomunso Okafor Nnanyelugo Chima Ezeora Emeka Ifeanyi Iloghalu Chidebe Christian Anikwe Chigozie Geoffrey Okafor Polycarp Uchenna Agu Emeka Philip Igbodike Iffiyeosuo Dennis Ake Arinze Anthony Onwuegbuna Osita Samuel Umeononihu Onyedika Promise Anaedu Odigonma Zinobia Ikpeze David Chibuike Ikwuka Henry Ifeanyi Nwaolisa Ekene Agatha Emeka Jude Ogechukwu Okoye Ihechinyerem Kelechi Osuagwu Angela Ogechukwu Ugwu Toochukwu Benjamin Ejikeme Eziamaka Pauline Ezenkwele Chijioke Ogomegbunam Ezeigwe Malarchy Ekwunife Nwankwo Gerald Okanandu Udigwe Joseph Ifeanyichukwu Ikechebelu Grace Agbaeze Chukwuebuka Divine Nwanja Ahizechukwu Chigoziem Eke Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching HospitalNnewi PMB 5025Nigeria Preventive Medicine and Research Department Clina-Lancet LaboratoriesVictoria IslandLagos 101241Nigeria Effective Care Research Unit Department of Obstetrics and GynecologyNnamdi Azikiwe UniversityNnewi Campus 435001Nigeria Department of Obstetrics and Gynecology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Department of Obstetrics and Gynecology University of Nigeria Teaching HospitalItuku OzallaEnugu State 400102Nigeria Department of Obstetrics and Gynecology ESUT Teaching HospitalParklaneEnugu 400102Nigeria Medical Department Divine Medical CentreSouth West IkoyiLagos 1001233Nigeria Department of Obstetrics and Gynecology Havana Specialist HospitalSurulereLagos 100011Nigeria Clinical Trial Division Drug Evaluation and Research DirectorateNAFDAC office ComplexLagos 100011Nigeria Department of Ophthalmology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Human Physiology Nnamdi Azikiwe University NnewiAnambra State 435001Nigeria Department of Family Medicine Faculty of MedicineNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Medical Laboratory Science Faculty of Health Sciences and TechnologyNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Health Services Federal University of TechnologyOwerri 460103Nigeria Department of Haematology and Immunology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Musgrove Park Hospital Somerset NHS Foundation TrustUnited Kingdom TLTp Medical(UHS) Southampton WS15United Kingdom Division of Maternal Fetal Medicine Department of Gynecology and ObstetricsJohns Hopkins University School of MedicineBaltimore 21201U.S.A

Background and objectives:Coronavirus disease 2019(COVID-19)is a pandemic that has become a major source of morbidity and mortality worldwide,affecting the physical and mental health of individuals influencing *** the threat,it poses to maternal health in sub-Saharan Africa and Nigeria,there is little or no data on the impact it has on fertility,conception,gestation and *** compare the birth rate between pre-COVID and COVID times using selected months of the *** and methods:This was a secondary analysis of cross-sectional analytical study data from the birth registries of three tertiary hospitals,comparing two years[2019(Pre-COVID)]versus[2020(COVID era)]using three months of the year(October to December).The data relied upon was obtained from birth registries in three busy maternity clinics all within tertiary hospitals in South-East Nigeria and we aimed at discussing the potential impacts of COVID-19 on fertility in *** secondary outcome measures were;mode of delivery,booking status of the participants,maternal age and ***:There was a significant decrease in tertiary-hospital based birth rate by 92 births(P=0.0009;95%CI:-16.0519 to-4.1481)among mothers in all the three hospitals in 2020 during the COVID period(post lockdown months)of October to *** was a significant difference in the mode of delivery for mothers(P=0.0096)with a 95%confidence interval of 1.0664 to 1.5916,as more gave birth through vaginal delivery during the 2020 COVID-19 period than ***:Tertiary-hospital based birth rates were reduced during the *** multi-centre study extrapolated on possible factors that may have played a role in this decline in their birth rate,which includes but is not limited to;decreased access to hospital care due to the total lockdowns/curfews and worsening inflation and economic recession in the country.

关键词： birth rates COVID-19 lockdown Nigeria pandemic pre-COVID

将卒中纳入心血管风险预测工具美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第11期20卷 801-828页

作者： Daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David C. Goff Jr Randall T. Higashida Leslie A. McClure Pamela H. Mitchell Ralph L. Sacco Cathy A. Sila Sidney C. Smith Jr David Tanne David L. Tirschwell emmanuel Touze Lawrence R. Wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) 代表美国心脏协会卒中委员会、流行病学和预防委员会、心血管放射学和介入委员会、心血管护理委员会、周围血管病委员会以及医疗质量和转归研究委员会苏州大学附属第二医院神经内科 215004

背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而，这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支... 详细信息

背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而，这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持：（1）将卒中（尤其是动脉粥样硬化性卒中）患者纳入心血管病绝对风险增高的患者群体；（2）将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名，并得到美国心脏协会（American Heart Association，AHA）卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾（覆盖1980年1月至2010年3月期间的文献）并参考以往公布的指南、个人资料以及专家观点，以归纳现有证据，提出当前知识的不足，并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后，最终获得AHA科学咨询和协调委员会的批准。将卒中患者（尤其是动脉粥样硬化性卒中患者）纳入冠状动脉和心血管病绝对高危人群的原因如下。首先，有证据显示，缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高，10年绝对风险≥20％，这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次，纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同，尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次，缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10％。然而，由于卒中的异质性，尚不确定其他卒中亚型，包括出血性卒中以及非动脉粥样硬化性卒中亚型，是否应被视为具有相同水平的风险，因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性，将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群，并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者（10年≥20％）。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防，缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入，可能对心血管病的预防具有重要意义，因为被评定为高危风险的患者数量将大幅增加。

关键词： AHA科学声明心血管疾病危险性评估风险预测卒中