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Evaluation of the Antidiabetic Activity and Toxicological Properties of Hippocratea Velutina (Afzel.)

Clinical Complementary Medicine and Pharmacology 2023年第2期3卷 50-56页

作者： Farouk A.Oladoja emmanuel SIrokosu Marcus D.Ayoola Oyinloye O.Elijah Murtala A.Akanji Ogunleye T.Beatrice Odewo A.Samuel Department of Pharmacology and Toxicology Faculty of PharmacyOlabisi Onabanjo UniversityAgo-Iwoye 121102Ogun-State.Nigeria Department of Pharmacology and Therapeutics Faculty of Basic Medical ScienceOlabisi Onabanjo University.Ago-Iwoye 121102Ogun-State.Nigeria Department of Pharmacognosy Faculty of PharmacyObafemi Awolowo University Ile-Ife 220282Osun-State.Nigeria Forest Research Institute of Nigeria Ibadan 200221Oyo-State.Nigeria

Background:Hippocratea velutina(HV)is a novel plant folklorically used for lowering blood glucose,hence a potential source of new antidiabetic ***:The study evaluated the anti-diabetic potentials of the methanol extract of Hippocratea velutina leaf and its toxicity profile in mice and ***:Acute and subacute toxicity tests of the plant extract were carried out by using a modified OECD *** antidiabetic activity in streptozotocin-induced diabetic rats at 50,150,and 300 mg/kg for 28 days was assayed,while glibenclamide(5 mg/kg)and distilled water were the positive and negative controls,*** examination of vital organs was also carried ***:Preliminary phytochemical screening of the leaf extract showed the presence of tannins,flavonoids,saponins,alkaloids,terpenoids,deoxy-sugars,and anthraquinones in *** extract had LD 50 greater than 2000 mg/kg in *** had no toxic effects on the haematological and biochemical components from blood samples collected but caused significant blood glucose level reduction in normal rats at 150 and 300 mg/*** streptozotocin-induced diabetic rats,the extract elicited a non-dose-dependent antidiabetic effect on day seven at all the tested doses,significantly higher than glibenclamide(10 mg/kg).However,on days 14,21,and 28,the extract activity at all the tested doses and glibenclamide were *** extract did not affect the liver,brain,kidney,and pancreas histology at 200 mg/kg but caused slight and severe effects on these organs at 400 and 800 mg/kg,***:The study concluded that Hippocratea velutina possessed antihyperglycaemic activity and was non-toxic at low doses but could have deleterious effects to the liver and kidney at high concentrations.

关键词： Hippocratea Velutina Diabetes mellitus Haematological and biochemical parameters

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简即是多——关于法国建筑趋势的思考

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建筑师 2023年第3期 4-12页

作者： [法]伊曼纽尔·卡耶黄新洋(译) 孙夕茜(译) 胡昊然(译) 法国d’a建筑杂志举折建筑巴黎马拉盖国立高等建筑学院埃因霍温理工大学

本文探讨了当前法国建筑实践的趋势,重点关注其主要特征,如以使用者与内容计划为中心,功能的灵活性,结构和材料特性的表达。除了部分建筑师和事务所的实践外,理论框架和建筑历史也为这些实践奠定了基础。此外,法国建筑师与其他欧洲同行... 详细信息

本文探讨了当前法国建筑实践的趋势,重点关注其主要特征,如以使用者与内容计划为中心,功能的灵活性,结构和材料特性的表达。除了部分建筑师和事务所的实践外,理论框架和建筑历史也为这些实践奠定了基础。此外,法国建筑师与其他欧洲同行的经常性交流与合作也发挥了重要作用。原作法文卷首评论刊登于法国d’a建筑杂志2020年12月第286期“简即是多”,它也是对德国建筑杂志Baumeister和ARCH+于2019、2020年发布的两期法国主题专辑的回应。

关键词：建筑杂志建筑师材料特性交流与合作灵活性建筑趋势事务所

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国际视野下的学前教育课程发展

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幼儿教育（教育科学） 2017年第11期 3-10,24页

作者：瓦西里奥斯·伊曼努埃尔·菲纳克思胡亿军张虹德国巴伐利亚学前教育研究所慕尼黑浙江外国语学院德国研究中心杭州310012 浙江师范大学杭州幼儿师范学院《幼儿教育》编辑部杭州310012

自上世纪90年代开始，世界各国政府对本国学前教育课程发展的影响越来越大。以现代建构主义“自我发展”儿童观为指导的第一代学前教育课程慢慢被以后现代社会建构主义“合作建构”儿童观为指导的第二代学前教育课程所取代。第二代学前... 详细信息

自上世纪90年代开始，世界各国政府对本国学前教育课程发展的影响越来越大。以现代建构主义“自我发展”儿童观为指导的第一代学前教育课程慢慢被以后现代社会建构主义“合作建构”儿童观为指导的第二代学前教育课程所取代。第二代学前教育课程强调异质性所具有的意义、强调学习和教育是一个社会过程、强调从开端开始强化儿童的素养。这些体现的是后现代的特征。对异质性的理解和应对、主张强化儿童的强项、强调以评估保证教育的高质量等则体现了第二代课程的基本特点。

关键词：学前教育课程后现代异质性合作建构

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Innovative Education and Training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser-matter interactions and high energy density physics-theory and experiments

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High Power Laser Science and Engineering 2019年第2期7卷 22-26页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna Cook emmanuel D'Humieres Vasilios Dimitriou Brendan Dromey Michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen Lavery Jiri Limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave Riley Maria Serena Rivetta Laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou Luca Volpe Steven White Mark Yeung Michael Tatarakis York Plasma Institute University of York Technological Educational Institute of Crete School of Applied SciencesCentre for Plasma Physics and Lasers-CPPL Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications) Department of Physics University of Ioannina Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University Belfast Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague LULI-CNRS Ecole Polytechnique CEA:UniversitéParis-Saclay UPMC Univ Paris 06:Sorbonne Universités CLPU Laser-Plasma Chair University of Salamanca Centro de Láseres Pulsados(CLPU) Edificio M5.Parque Cientfico.C/Adaja

The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of *** ’in class’ time is limited to four weeks a year,and the programme spans two *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).Lectures are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first *** far three Learning Teaching Training(LTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and Lasers(CPPL)of TEI *** last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in *** far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density *** nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented.

关键词： higher education inertial confinement fusion laser-plasma interactions post-graduate education

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一项BIS指导下闭环联合输注丙泊酚和雷米芬太尼的随机多中心研究

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麻醉与镇痛 2012年第3期8卷 81-93页

作者： Ngai Liu, MD, PhD Thierry Chazot, MD Sophie Hamada, MD Alain Landais, MD Nathalie Boichut, MD Corinne Dussaussoy, MD Bernard Trillat, MSc Laurent Beydon, MD emmanuel Samain, MD Daniel I. Sessler, MD and Marc Fischler, MD 蒋嘉(译) 岳云(校) Service d'Anesthésie Service d'Informatique Hopital Foch Suresnes Service d'Anesthésie CH Victor Dupouy Argenteui Département d'Anesthésie et de Réanimation Chirurgicale CHU de Besangon Besangon Département d'Anesthésie et de Réanimation Chirurgicale CHU d'Angers Angers France Department of Outcomes Research Cleveland Clinic Cleveland Ohio 不详

背景我们开发出来一种比例-积分-微分控制器，可以在全麻诱导和维持期间实现在双频指数（bispeclral index，BIS）监测指导下对丙泊酚和雷米芬太尼的闭环联合输注。本研究比较了其与人工靶控输注的差异。方法这项多中心研究纳入了196例... 详细信息

背景我们开发出来一种比例-积分-微分控制器，可以在全麻诱导和维持期间实现在双频指数（bispeclral index，BIS）监测指导下对丙泊酚和雷米芬太尼的闭环联合输注。本研究比较了其与人工靶控输注的差异。方法这项多中心研究纳入了196例手术患者，随机分入双闭环或人工输注丙泊酚和雷米芬太尼组。通过计算总体分数对两组进行比较，该分数包括充分麻醉即BIS在40～60的时间比例、执行误差绝对中位数及摆动等整体性能。其他次要的观察指标包括爆发抑制比的发生率、气管插管所需时间以及用药量。结果双环控制组中83例患者和人工控制组中84例患者完成了试验。双环组的总体分数较好、充分麻醉的时1＇4较长（26±11vs43±40，P〈0．0001；82％±12％vs71％±19％，P〈0．0001）。超过目标值（BIS〈40）、未达目标值（BIS〉60）以及爆发抑制比的发生在双环组出现明显较少。双环组需要更频繁地对丙泊酚和雷米芬太尼的输注做出调整，但调节幅度较小；该组患者雷米芬太尼的使用量较大[（0.22±0．07）μg·kg^-1·min^-1 vs（0．16±0．07）μg·kg^-1·min^-1；P〈0．0001]，而气管插管的速度较快[（10±4）分钟vs（11±5）分钟；P=0．02]。结论全身麻醉期间，控制器可以帮助自动输注丙泊酚和雷米芬太尼，并将BIS值维持在预定范围内，这一点优于人工输注。

关键词：雷米芬太尼联合输注多中心研究 BIS值丙泊酚闭环随机双频指数

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Materno-Fetal Outcomes of COVID-19 Infected Pregnant Women Managed at the Douala Gyneco-Obstetric and Pediatric Hospital—Cameroon

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Open Journal of Obstetrics and Gynecology 2020年第9期10卷 1279-1294页

作者： Alphonse Nyong Ngalame Humphry Tatah Neng Rakya Inna Dominique Tamchom Djomo Diane Estelle Modjo Kamdem Bilkissou Moustapha Julie Ngo Batta Diomede Njinkui Noukeu Dominique Enyama Rodrigue Tiokeng Yannick Onana Yves Moumbe Martial Zanga Jules Fils Ndongo Armand Kamga Robert Tchounzou Ultrich Keumayou Lemone Chingnabo Toudjirob Djiallati emmanuel Passoret Estella Toyoum Ramadji Jean Blaise Ebimbe Servais Albert F. Bagnaka Eloumou Darolles Wekam Mwadjie Guy Pascal Ngaba Emile Telesphore Mboudou Gynecology and Obstetrics Unit Douala Gyneco-Obstetric and Pediatric Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Ngaoundere Ngaoundere Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Introduction: The first case of the novel coronavirus (COVID-19) pandemic in Cameroon was confirmed on March 6, 2020. Though widely considered that pregnant women are more susceptible to respiratory tract infections, the available body of literature on the effect of COVID-19 on pregnancy outcomes is shy from being conclusive. In Cameroon, the Douala Gyneco-Obstetric and Pediatric Hospital (DGOPH) was one of the main frontline tertiary health facilities for the management of severe forms of the disease. After four months of managing COVID-19 cases in the general population and especially in pregnant women at the DGOPH, we decided to take a stop, analyze our findings from the patients managed in order to drive future policies and clinical practices via informed decisions. Overall objective: To describe and understand the clinical burden of patients managed for COVID-19 in pregnancy or post-partum at the DGOPH. Methodology: Cross-sectional and descriptive study covering four months—March 24th to July 24th 2020 at DGOPH. Using a pretested questionnaire, we systematically enrolled all patients who fulfilled the inclusion criteria, with analysis done using proportions from an excel spreadsheet. Results: A

关键词： COVID-19 DGOPH Pregnancy Outcome Mortality

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Comprehensive Left Ventricular Mechanics Analysis by Speckle Tracking Echocardiography in COVID-19

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World Journal of Cardiovascular Diseases 2021年第2期11卷 113-125页

作者： Francisco J. González-Ruiz emmanuel A. Lazcano-Díaz Zuilma Y. Vásquez-Ortiz Fernanda Bernal-Ceballos Rodrigo Gopar-Nieto Consuelo Orihuela-Sandoval José P. Hernández-Reyes Edgar García-Cruz Eduardo Bucio-Reta Ángel Ramos-Enríquez Luis A. Cota-Apodaca Luis Efren-Santos Blanca Estela Broca-García Daniel Manzur-Sandoval Efrén Melano-Carranza Fernandez de la Reguera Guillermo Gustavo Rojas-Velasco Francisco Baranda-Tovar Department of Cardiovascular Critical Care National Institute of Cardiology “Dr. Ignacio Chávez” México City México Department of Echocardiography National Institute of Medical Science and Nutrition “Dr. Salvador Zubirán” México City México PhD Program National University of Mexico (UNAM) México City México Cardiovascular Diseases Department National Institute of Cardiology “Dr. Ignacio Chávez” México City México

Background: Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. Objective: To describe left ventricular mechanics in hospitalized patients with COVID-19. Methods: In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. Results: Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] -17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. Conclusion: In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated.

关键词： COVID-19 Speckle Tracking Echocardiography Myocarditis Cardiomyopa-thy Cardiac Mechanics Strain Myocardial Damage Deformation Imaging Myocardial Strain

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稀疏性（及其它几个）的数学

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数学译林 2014年第4期33卷 290-290页

作者： emmanuel J. Candes 黄际政孙宇阳美国斯坦福大学不详

过去的10年，人们对于何时有可能找到欠定线性方程组的结构稳定解怀有浓厚的兴趣．这篇文章综述其数学理论，即人们熟知的压缩感知和矩阵完备性，

关键词：数学理论稀疏性线性方程组稳定解完备性矩阵

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New Data on the Genesis and Evolution of the Primitive Magmas of Mount Cameroon: Contribution of Melt Inclusions

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Journal of Geological Research 2020年第4期2卷 46-61页

作者： Legrand Joseph Tchop Pauline Wokwenmendam Nguet Benjamin Ntieche Victor Metang Jacques Dili Rake Merlin Isidore Teitchou Jacqueline Vander Auwera Georges emmanuel Ekodeck Charles Nkoumbou Department of Earth Sciences Faculty of SciencesUniversity of YaoundéIPO Box 812 YaoundéCameroon Geophysical and Volcanological Research Unit Institute of Geological and Mining ResearchPO Box 370 BueaCameroon Higher Teacher Training College University of Yaounde1 PO Box 812 YaoundéCameroon Deparement de Geology University of Liège B-4000 Sart-TilmanBelgium

Mount Cameroon is a Plio-Quaternary volcanic massif, without a centralcrater, made up of more than 140 pyroclastic cones. It is one of theactive volcanoes of the Cameroon Volcanic Line. Mount Cameroon meltinclusions are found in microdroplets trapped in the early minerals (olivines)from the pyroclastic products. The analysis of these melt inclusions allowedus to find primitive liquids compared to lavas. Major elements study ofthe magmatic inclusions, trapped in the most magnesian olivines (Mg#84-86) of Mount Cameroon revealed “primitive” liquids of basanite and alkalibasalt type with variable composition compared to the much more uniformbasalts of the magmatic series of Mount Cameroon. The study of thesetrapped liquids shows that: (1) the original primitive lavas did not undergothe process of evolution by FC, but rather underwent fundamentally (orexclusively) the process of partial melting;(2) the emitted lavas, evolvedessentially by FC;(3) the variations in the trace element contents of theprimitive liquids directly reflect a variation in the rate of partial melting ofa homogeneous mantelic source. The very high La/Yb ratios of the MountCameroon melt inclusions (> 20) characterize a garnet lherzolite *** of the melt inclusions show a negative anomaly or depletion in K,Rb and Ba as those of HIMU. The “primitive” liquids and lavas of MountCameroon represent a co-genetic sequence formed by varying degrees ofpartial melting of a source considered as homogeneous.

关键词： Primitive magma Partial melting Fractional crystallization Alkali basalt Mount Cameroon Active volcano

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MINT:德国学前教育中的自然科学教育

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幼儿教育（教育科学） 2018年第5期 3-8页

作者：瓦西里奥斯·伊曼努埃尔·菲纳克思张虹(译) 胡亿军(译) 德国巴伐利亚学前教育研究所慕尼黑浙江师范大学杭州幼儿师范学院杭州310012 浙江外国语学院德国研究中心杭州310012

在学前教育领域，德国的MINT课程提倡对儿童进行跨领域的综合素养培养。MINT课程强调引导儿童感知、探索身边的世界，即儿童在日常生活中可以接触到的有机和无机世界现象，从而帮助他们获得有关自然科学的基本经验和基础知识，进而促使... 详细信息

在学前教育领域，德国的MINT课程提倡对儿童进行跨领域的综合素养培养。MINT课程强调引导儿童感知、探索身边的世界，即儿童在日常生活中可以接触到的有机和无机世界现象，从而帮助他们获得有关自然科学的基本经验和基础知识，进而促使他们形成科学的思维和行动能力。本文以“空气”这一主题为例，简要说明MINT自然科学教育的内容与过程。

关键词：学前教育自然科学 MINT 科学思维

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