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Cancer Communications 2022年第6期42卷 567-571页

作者： emma polonio-alcala Sònia Solé-Sánchez Pau Munoz-Guardiola Elisabet Megías-Roda Héctor Perez-Montoyo Marc Yeste-Velasco Jose Alfón Jose Miguel Lizcano Carles Domènech Santiago Ruiz-Martínez Teresa Puig New Therapeutic Targets Laboratory(TargetsLab)-Oncology Unit Department of Medical SciencesUniversity of GironaGirona 17003Spain Product Process and Production Engineering Research Group(GREP)Department of Mechanical Engineering and Industrial ConstructionUniversity of GironaGirona 17003Spain Ability Pharmaceuticals SLCerdanyola del VallesBarcelona 08290Spain Protein Kinases and Signal Transduction Laboratory Department de Bioquimica i Biologia Molecular and Institut de NeurocienciesUniversitat Autonoma de BarcelonaBellaterraBarcelona 08193Spain

Dear Editor,Triple-negative breast cancer(TNBC)accounts for 20%of all breast carcinomas and lacks a validated targeted therapy;thus,currently,cytotoxic chemotherapy is the treatment of choice[1].Compared with other breast cancer types,patientswith TNBCare younger,have larger tumors,a higher risk of metastasis,and a higher rate of recurrence[2].Among all the subtypes described by Lehmann et al.[3],mesenchymal-like and mesenchymal stem-like(MSL)subtypes had the lowest 5-year distant metastasis-free survival rates.

关键词： ABTL0812 TRIB3 Autophagy Breast Cancer Targeted Therapy Chemoresistance

Interconnection Gridlock Threatens Transition to Renewable Energy

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Engineering 2024年第5期36卷 3-5页

作者： emma Hiolski Senior Technology Writer

In October 2023,the International Energy Agency(IEA)released a report identifying inadequate grid infrastructure as a key threat to meeting the climate goals laid out by the Paris Agreement[1],the landmark 2015 international treaty in which 196 parties agreed to limit global warming to well below 2℃ above preindustrial levels[2].Importantly,funding for the treaty’s calledfor transition from fossil fuels to clean energy has accelerated[3],with recently legislated massive governmental subsidies and other incentives(e.g.,the Inflation Reduction Act[4])aimed specifically at promoting renewable ***,a commensurate surge in investment in electrical grids has not materialized;instead,it has stagnated for the past decade at around 300 billion USD per year worldwide[1].

关键词： Transition instead massive

Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in Ohio: An Eight-County Assessment

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International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao Fiona C.Doherty Anthony Traver Marisa Sheldon emma Sakulich Holly Dabelko‑Schoeny College of Social Work The Ohio State UniversityColumbusOH 43210USA Age Friendly Innovation Center College of Social WorkThe Ohio State UniversityColumbusOH 43210USA College of Public Health The Ohio State UniversityColumbusOH 43210USA

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central Ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central Ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

Does Herd Immunity Reduce the Risk of Contracting COVID-19?

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Journal of Biosciences and Medicines 2024年第9期12卷 21-27页

作者： emma Li Unionville High School Kennett Square PA USA

Herd immunity is often considered a measure to protect a whole community or population from disease if the vaccination threshold is met. Using the demographic and COVID-19 infection data from the state of Pennsylvania, United States, the study aimed to determine if herd immunity by vaccination is an effective way to reduce the spread of the COVID-19 virus. The Pennsylvania counties were split into two groups based on qualification of herd immunity: counties that met the COVID-19 herd immunization rate of 70% and counties that did not. The ANOVA test was used to analyze the difference between the groups with and without herd immunity by the COVID-19 vaccine. The results demonstrated that there was no significant statistical difference between counties that did achieve and those that did not achieve the herd immunity threshold for the COVID-19 vaccine. On the other hand, it was observed that there had been a significant decrease in positive cases between 2020 and 2023. This decline can be attributed to the overall protection by the vaccination and adaptability to the disease, not specifically due to herd immunity alone. Ultimately, these outcomes suggest that herd immunity cannot reduce the risk of contracting COVID-19. Increased efforts to get vaccinated should be implemented to protect the general community and a wider scope of age.

关键词： COVID-19 Herd Immunity Vaccine

Methane cracking in molten tin for hydrogen and carbon production—a comparison with homogeneous gas phase process

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 155-166页

作者： emmanuel Busillo Benedetta de Caprariis Maria Paola Bracciale Vittoria Cosentino Martina Damizia Gaetano Iaquaniello emma Palo Paolo De Filippis Chemical Engineering Department Sapienza University of RomeRome 00184Italy NextChem S.p.A. Rome 00156Italy

Methane cracking is considered a bridge technology between gray and green hydrogen production *** this work an experimental study of methane cracking in molten tin is *** tests were conducted in a quartz reactor(i.d.=1.5 cm,L=20 cm)with capillary injection,varying temperature(950–1070℃),inlet methane flow rate(30–60 mL·min^(-1))and tin height(0–20 cm).The influence of the residence time in the tin and in the headspace on methane conversion and on carbon morphology was *** conversions obtained in tin and in the empty reactor were measured and compared with results of detailed kinetic simulations(CRECK).Furthermore,an expression of a global kinetic constant for methane conversion in tin was also *** highest conversion(65%at Q_(0)=30 mL·min^(-1) and t=1070℃)is obtained for homogeneous gas phase reaction due to the long residence time(70 s),the presence of tin leads to a sharp decrease of residence time(1 s),obtaining a conversion of 35%at 1070℃,thus meaning that tin owns a role in the *** characterization(scanning electron microscopy,Raman)reported a change in carbon toward sheet-like structures and an increase of the carbon structural order in the presence of molten tin media.

关键词： methane cracking molten media H2 production carbon morphology

Conducting Polymer-Based e-Refinery for Sustainable Hydrogen Peroxide Production

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Energy & Environmental Materials 2024年第2期7卷 334-342页

作者： Zhixing Wu Penghui Ding Viktor Gueskine Robert Boyd Eric Daniel G■owacki Magnus Odén Xaνier Crispin Magnus Berggren emma M.Björk Mikhail Vagin Nanostructured Materials Department of PhysicsChemistry and Biology(IFM)Linköping UniversitySE 58183LinköpingSweden Laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversitySE 60174NorrköpingSweden

Electrocatalysis enables the industrial transition to sustainable production of chemicals using abundant precursors and electricity from renewable ***-centralized production of hydrogen peroxide(H_(2)O_(2))from water and oxygen of air is highly desirable for daily life and *** report an effective electrochemical refinery(e-refinery)for H_(2)O_(2)by means of electrocatalysis-controlled comproportionation reaction(2_(H)O+o→2HO),feeding pure water and oxygen *** nickel(Ⅱ)oxide(NiO)was used as electrocatalyst for oxygen evolution reaction(OER),producing oxygen at the *** polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)drove the oxygen reduction reaction(ORR),forming H_(2)O_(2)on the *** reactions were evaluated in both half-cell and device *** performance of the H_(2)O_(2)e-refinery,assembled on anion-exchange solid electrolyte and fed with pure water,was limited by the unbalanced ionic *** of the operation conditions allowed a conversion efficiency of 80%.

关键词： conducting polymer hydrogen peroxide nickel(Ⅱ)oxide oxygen evolution reaction oxygen reduction reaction

Modern internet search analytics and thyroidectomy:What are patients asking?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 49-58页

作者： Neeraj Suresh Christian Fritz emma De Ravin Karthik Rajasekaran Department of Otorhinolaryngology–Head&Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives:Thyroidectomy is among the most commonly performed head and neck surgeries,however,limited existing information is available on topics of interest and concern to *** Design:***:***:A search engine optimization tool was utilized to extract metadata on Google‐suggested questions that“People Also Ask”(PAA)pertaining to“thyroidectomy”and“thyroid surgery.”These questions were categorized by Rothwell criteria and topics of *** Journal of the American Medical Association(JAMA)benchmark criteria enabled quality ***:A total of 250 PAA questions were ***‐oriented PAA questions describing what to expect during and after the surgery on topics such as postoperative management,risks or complications of surgery,and technical details were significantly less popular among the“thyroid surgery”group(P<0.001,P=0.005,and P<0.001,respectively).PAA questions about scarring and hypocalcemia were nearly threefold more popular than those related to pain(335 and 319 vs.113 combined search engine response page count,respectively).The overall JAMA quality score remained low(2.50±1.07),despite an increasing number of patients searching for“thyroidectomy”(r(77)=0.30,P=0.007).Conclusions:Patients searching for the nonspecific term“thyroid surgery”received a curated collection of PAA questions that were significantly less likely to educate them on what to expect during and after surgery,as compared to patients with higher health literacy who search with the term“thyroidectomy.”This suggests that the content of PAA questions differs based on the presumed health literacy of the internet user.

关键词： information quality online health education search analytics thyroid surgery thyroidectomy

Endoscopic push through tragal cartilage tympanoplasty: A 10-year retrospective review of our technique and outcomes

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World Journal of Otorhinolaryngology 2024年第2期11卷 18-24页

作者： K M Abidur Rahman Khalid Majeed emma Finnegan Ivan Keogh Ear Noseand Throat/Head and Neck SurgeryGalway University HospitalGalway H91 YR71Ireland Academic Department of Otorhinolaryngology and Head and Neck Surgery University of GalwayGalway H91 TK33Ireland

BACKGROUND Endoscopic ear surgery(EES)provides a magnified,high-definition view of the otological surgical *** allows otologists to avoid surgical incisions and associated postoperative *** is an ideal technique for the perfor-mance and teaching of *** To examine the efficacy of total Endoscopic Push Through Tragal Cartilage Tympanoplasty(EPTTCT),at our institution over a 10-year *** A retrospective analysis of 168 cases of EPTTCT for closure of small to medium tympanic membrane perforations from 2013-2023 was *** sex,age range(pediatric vs adult),etiology of injury,success rate,complications,and postoperative hearing status were *** Graft uptake results indicated success in 94%of patients,with less than a 2%complication *** pure tone audiometry demonstrated hearing status improvement in 69%of *** EPTTCT has been shown to be effective in tympanic membrane perforation closures with minimal *** study further demonstrates the efficacy and safety of these procedures in a single-center review.

关键词： Total endoscopic ear surgery Otology Tympanoplasty Hearing Perforation Tragal cartilage graft

Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry emma D.McLennan Carolina Chavez emma L.Burrows John W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

Isolated traumatic orbital floor fracture:An analysis of the National Trauma Data Bank

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 187-192页

作者： emma De Ravin D Katherine Xu Christian Fritz Harman S.Parhar Karthik Rajasekaran Department of Otorhinolaryngology Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives:To date,no study provides a comprehensive analysis of traumatic orbital floor fractures across the United *** aimed to characterize patient demographics,injury-related variables,and operative management in this ***:The National Trauma Data Bank was queried for open or closed orbital floor fractures from 2008 to *** data were ***:Overall,148,592 orbital floor fractures were identified,with 142,577(95.9%)closed-and 6158(4.1%)open-type fractures.A total of 106,243(71.5%)patients were male and the median patient age was 41 *** majority of patients(79.2%)had abbreviated injury scale scores of≤2,indicating minor/moderate *** mechanism of injury(MOI)differed by gender,with the most frequent being unarmed fights in men(34.3%)and falls in women(14.0%).There were 29,600 patients(19.9%)with isolated orbital floor(I-OF)*** MOI most strongly associated with operative intervention of with I-OF fractures were penetrating injuries caused by a firearm(odds ratio[OR]:2.91;95%confidence interval[CI]:1.62–5.20)and cuttings/piercings(OR:2.17;95%CI:1.29–3.65).Conclusion:This large epidemiological study reveals that orbital floor fractures tend to present with minor or moderate injuries and are more likely to require operative intervention in setting of firearm or cut/pierce injuries.

关键词： epidemiology National Trauma Data Bank orbital fracture risk factors trauma