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Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats

Acta Pharmacologica Sinica 2005年第4期26卷 417-422页

作者： Giyasettin BAYDAS Ertugrul SONKAYA Mehmet TUZCU Abdullah YASAR emir donder Department of Physiology Department of Internal Medicine College of Medicine Firat University Department of Biology Faculty of Science Firat University Elazig 23119 Turkey Department of Physiology Department of Internal Medicine College of Medicine Firat University

Aim:To investigate the effect of gabapentin on neural [neuron-specific enolase（NSE）] and glial markers [glial fibrillary acidic protein （GFAP） and S 100B] in differ-ent brain regions of diabetic ***:Diabetes was induced by a singleintraperitoneal injection of streptozotocine （50 mg/kg body weight）.Rats in onediabetic group received gabapentin (50 ***-1.d-1) and rats in the other diabeticgroup received vehicle only for 6 *** levels of GFAP,S100B,and NSE weredetermined by immunoblotting in the hippocampus,cortex,and *** （LPO as malondialdehyde+ 4-hydroxyalkenals） and glutathione （GSH）levels were also determined in the same brain ***:Total and degradedGFAP content and S100B protein expression in different areas of brain tissuessignificantly increased in diabetic rats compared to control ***,NSElevels were also significantly elevated in hyperglycemic *** addition,therewas a significant increase in LPO levels in the diabetic rat brain compared tocontrol rat *** with gabapentin prevented the upregulation ofGFAP,S 100B,and NSE in all brain regions of diabetic *** level of LPO wasreduced,but not completely halted,by treatment with ***:These results suggest that diabetes causes glial and neuronal injury,possibly asa result of elevated oxidative stress,and that gabapentin protects neurons andglial ***,we predict that gabapentin treatment will attenuate the hippo-campal and cortical neurodegeneration observed during diabetes mellitus in rats.

关键词： gabapentin glial fibrillary acidic protein neurotrophic protein S100beta phosphopyruvate hydratase lipid peroxidation

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