Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats
Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats作者机构：Department of Physiology Department of Internal Medicine College of Medicine Firat University Department of Biology Faculty of Science Firat University Elazig 23119 Turkey Department of Physiology Department of Internal Medicine College of Medicine Firat University
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2005年第26卷第4期
页 面：417-422页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Study supported by the Firat University Research Foundation(FUBAP Project number 831)
主 题：gabapentin glial fibrillary acidic protein neurotrophic protein S100beta phosphopyruvate hydratase lipid peroxidation
摘 要：Aim:To investigate the effect of gabapentin on neural [neuron-specific enolase（NSE）] and glial markers [glial fibrillary acidic protein （GFAP） and S 100B] in differ-ent brain regions of diabetic ***:Diabetes was induced by a singleintraperitoneal injection of streptozotocine （50 mg/kg body weight）.Rats in onediabetic group received gabapentin (50 ***-1.d-1) and rats in the other diabeticgroup received vehicle only for 6 *** levels of GFAP,S100B,and NSE weredetermined by immunoblotting in the hippocampus,cortex,and *** （LPO as malondialdehyde+ 4-hydroxyalkenals） and glutathione （GSH）levels were also determined in the same brain ***:Total and degradedGFAP content and S100B protein expression in different areas of brain tissuessignificantly increased in diabetic rats compared to control ***,NSElevels were also significantly elevated in hyperglycemic *** addition,therewas a significant increase in LPO levels in the diabetic rat brain compared tocontrol rat *** with gabapentin prevented the upregulation ofGFAP,S 100B,and NSE in all brain regions of diabetic *** level of LPO wasreduced,but not completely halted,by treatment with ***:These results suggest that diabetes causes glial and neuronal injury,possibly asa result of elevated oxidative stress,and that gabapentin protects neurons andglial ***,we predict that gabapentin treatment will attenuate the hippo-campal and cortical neurodegeneration observed during diabetes mellitus in rats.
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