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母亲从未教我的事

少年儿童研究 2014年第12期 47-47页

作者： emily-jane cl

我小时候,妈妈从不在脸上涂涂抹抹。她不会在早上花几小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子、给我穿上必须保持干净的裙子、把我丢到一个迷你型化妆聚会里,或者给我买发亮的公主鞋。相反,她给我穿短裤和T恤,叫... 详细信息

我小时候,妈妈从不在脸上涂涂抹抹。她不会在早上花几小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子、给我穿上必须保持干净的裙子、把我丢到一个迷你型化妆聚会里,或者给我买发亮的公主鞋。相反,她给我穿短裤和T恤,叫我到户外跟朋友一起玩耍、奔跑。她给我穿上长筒雨靴,看我踩在水坑里,水花四溅。我玩泥巴弄脏了衣服,她一点儿都不在乎。

关键词：母亲化妆头发妈妈裙子朋友

Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

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World Journal of Gastroenterology 2024年第3期30卷 268-279页

作者： Lie-Qi Tang Johnathan Fraebel Shi Jin Steven P Winesett jane Harrell Wen-Han Chang Sam Xianjun Cheng Department of Pediatrics University of FloridaGainesvilleFL 32610United States College of Medicine University of FloridaGainesvilleFL 32610United States Applied Physiology and Kinesiology University of FloridaGainesvilleFL 32610United States Brain Rehabilitation Research Center Malcom Randall VA Medical CenterGainesvilleFL 32610United States Department of Medicine Endocrine Research UnitVeterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoSan FranciscoCA 94121United States Department of Pediatric Gastroenterology Hepatologyand NutritionUniversity of Florida Shands Children’s HospitalGainesvilleFL 32608United States

BACKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous ***-sensing receptor(CaSR)inhibits both *** latter has been well documented in vitro but not in *** hypothesis to be tested was that activating CaSR inhibits diarrhea in *** To determine whether CaSR agonists ameliorate secretory diarrhea evoked by cholera toxin(CTX)in *** CTX was given orally to C57BL/6 mice to induce *** and calci-mimetic R568 were used to activate *** maximize their local intestinal actions,calcium was administered luminally via oral rehydration solution(ORS),whereas R568 was applied serosally using an intraperitoneal *** verify that their actions resulted from the intestine,effects were also examined on Cre-lox intestine-specific CaSR *** outcome was measured biochemically by monitoring changes in fecal cl-or clinically by assessing stool consistency and weight *** CTX induced secretory diarrhea,as evidenced by increases in fecal cl-,stool consistency,and weight loss following CTX exposure,but did not alter CaSR,neither in content nor in ***,calcium and R568 were each able to ameliorate diarrhea when applied to diseased *** CaSR involvement is suggested by gene knockout experiments where the anti-diarrheal actions of R568 were lost in intestinal epithelial CaSR knockouts(villinCre/Casrflox/flox)and neuronal CaSR knockouts(nestinCre/Casrflox/flox).CONclUSION Treatment of acute secretory diarrheas remains a global *** advances in diarrhea research,few have been made in the realm of diarrhea *** therapy has remained the standard of care,although it does not halt the losses of intestinal fluid and ions caused by *** is no cost-effective therapeutic for *** and other studies suggest that adding calcium to ORS or using calcimimetics to activate intestinal CaSR might

关键词： Cholera Enteric nervous system Secretory diarrhea Oral rehydration solution Calcium-sensing receptor Gene knockout

Inhibition of tumor autophagy: a strategy to improve antitumorimmunity?

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Signal Transduction and Targeted Therapy 2021年第1期6卷 3-4页

作者： Andrew JFreeman emily JLelliott jane Oliaro Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVIC 3000Australia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVIC 3010Australia Department of Immunology and Pathology Monash UniversityMelbourneVIC 3004Australia

In a study recently published in Nature,Lawson et *** several pathways previously implicated in tumor cell sensitivity to cytotoxic T lymphocytes(CTLs),and identify autophagy as an additional pathway involved in mediating tumor immune evasion.1 Autophagy is a regulated and conserved multistep process that enables cells to degrade and recycle intracellular components and is critical for cellular *** has recently been associated with tumor immune evasion in pancreatic ductal adenocarcinoma,2 whereby this process selectively targeted the degradation of major histocompatibility complex I(MHC-I),limiting recognition,and anti-tumor responses by ***,Lawson et *** an additional role for autophagy in tumor immune evasion,by mediating resistance to cytokine-mediated cell death.

关键词： immunity homeostasis limiting

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Proposed age-stratified reference intervals of FSH derived from normozoospermic men

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作者： emily jane Fox.

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Asian pacific Journal of Reproduction 2021年第4期10卷 162-167页

作者： emily-jane Waller Jason Conceicao Phillip Matson John L Yovich School of Medical and Health Sciences Edith Cowan UniversityJoondalupPerthAustralia PIVET Medical Centre LeedervillePerthAustralia School of Pharmacy and Biomedical Sciences Faculty of Health SciencesCurtin UniversityBentleyPerthAustralia

Objective:To demonstrate that serum follicle-stimulating hormone(FSH)in men rises with age,and to explore FSH reference intervals of age-related ***:Men aged 20-50 years(n=1190)underwent semen analysis according to World Health Organization(2010)*** was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur®XP immunoassay *** central 95%intervals after logarithmic transformation based on age were derived from 1037 normozoospermic *** were then applied to oligozoospermic and azoospermic *** producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria,including genetic analysis and surgical ***:Serum FSH in normozoospermic men increased with age(Pclusions:FSH concentrations increase in men between 20-50 years,and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals.

关键词： Male infertility FSH Reference intervals Age Obstructive azoospermia Non-obstructive azoospermia

Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations:a systematic review and meta-analysis

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World Journal of Pediatric Surgery 2022年第4期5卷 204-210页

作者： Irina Oltean Lamia Hayawi Victoria Larocca Vid Bijelić emily Beveridge Manvinder Kaur Viviane Grandpierre jane Kanyinda Ahmed Nasr Department of Surgery Children's Hospital of Eastern OntarioOttawaOntarioCanada clinical Research Unit Children's Hospital of Eastern Ontario Research InstituteOttawaOntarioCanada

Background No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life(QoL)in pediatric populations affected by Hirschsprung’s disease(HD)and anorectal malformations(ARM).The objective of this systematic review is to quantitatively summarize the parent-reported and child-reported psychosocial and physical functioning scores of such *** Records were sourced from the CENTRAL,EMBASE,and MEDLINE *** that reported child and parent reported QoL in children with HD and ARM,regardless of surgery intervention,versus children without HD and ARM,were *** primary outcome was the psychosocial functioning scores,and the secondary outcomes were the presence of postoperative constipation,postoperative obstruction symptoms,fecal incontinence,and enterocolitis.A random effects meta-analysis was *** Twenty-three studies were included in the systematic review,with 11 studies included in the ***,1678 total pediatric patients with HD and ARM underwent surgery vs 392 healthy *** parent-reported standardized mean(SM)scores showed better social functioning after surgery(SM 91.79,95%CI(80.3 to 103.3),I2=0).The pooled standardized mean difference(SMD)showed evidence for parent-reported incontinence but not for constipation in children with HD and ARM after surgery that had a lower mean QoL score compared with the normal population(SMD−1.24(-1.79 to–0.69),I2=76%and SMD−0.45,95%CI(−1.12 to 0.21),I2=75%).The pooled prevalence of child-reported constipation was 22%(95%CI(16%to 28%),I2=0%).The pooled prevalence of parent-reported postoperative obstruction symptoms was 61%(95%CI(41%to 81%),I2=41%).Conclusion The results demonstrate better social functioning after surgery,lower QoL scores for incontinence versus controls,and remaining constipation and postoperative obstruction symptoms after surgery in children with HD and ARM.

关键词： surgery Hirschsprung analysis

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn School of Medicine at Mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend clusion: A higher intake of (poly)phenols， espe

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Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

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Acta Pharmaceutica Sinica B 2014年第5期4卷 358-367页

作者： Aline Augusti Boligon Robson Borba de Freitas Thiele Faccim de Brum emily Pansera Waczuk cláudia Vargas Klimaczewski Daiana Silva deÁvila Margareth Linde Athayde Liliane de Freitas Bauermann Department of Industrial Pharmacy Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Physiology and Pharmacology Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Biochemistry Federal University of PampaUruguaiana 97500-970RSBrazil

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric *** buxifolia,commonly known as coronilha,has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic *** this study,the preventive effects of the crude extract of Scutia buxifolia(ceSb)against gastric ulcer induced by 70%ethanol were evaluated in male Wistar *** addition,the composition of ceSb was clarified by high-performance liquid chromato-graphy(HPLC).*** extract(100,200 and 400 mg/kg body weight)attenuated oxidative and histopathological features induced by ***,all evaluated doses of ceSb caused significant(P<0.001 and P<0.0001)and dose-dependent increase in sulfhydryl groups(NPSH)levels,catalase(CAT)and superoxide dismutase(SOD)***,the administration of ceSb reversed the increase in lipid peroxidation produced by *** protective effect of the extract could be attributed to antioxidant compounds present in the ceSb,such as flavonoids and phenolic acids,which were quantified by ***,an antioxidant effect of the extract leads to a protection on gastric *** results indicate that *** could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

关键词： Scutia buxifolia Antioxidant Gastric ulcer HPLC

Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 1604-1617页

作者： Katie J.Hogan Hayriye Oztatlı Marissa R.Perez Sophia Si Reyhan Umurhan Elysa Jui Ziwen Wang emily Y.Jiang Sa R.Han Mani Diba K.jane Grande-Allen Bora Garipcan Antonios G.Mikos Department of Bioengineering Rice UniversityMS-1426500 Main StreetHoustonTX 77030USA Baylor College of Medicine Medical Scientist Training Program HoustonTX 77030USA Institute of Biomedical Engineering Bo�gazic¸i University_Istanbul34684Turkey

Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and *** methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and ***,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP *** objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal *** addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or *** crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked *** incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase *** in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examine

关键词： demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering