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Open Journal of Endocrine and metabolic Diseases 2019年第1期9卷 1-7页

作者： megan A. Traxinger emily A. Beckett Dana Danley Udaya m. Kabadi Broadlawns medical Center Des Moines USA University of Iowa Iowa City USA

Background: Central or hypothalamic hypogonadism as an initial manifestation of Shapiro Syndrome has not been described in the literature. Herein, we report first case in which initial presentation of central hypogonadism led to a confirmed diagnosis of Shapiro Syndrome during a casual evaluation of hypothalamic pituitary anatomy with mRI of brain. Case presentation: 53 year old Caucasian man was documented to manifest Central or hypogonadotropic hypogonadism following evaluation of excessive sweating episodes, lack of libido and erectile dysfunction for a duration of several years. Brain mRI performed for assessment of the etiology documented no pituitary abnormality. Instead agenesis of Corpus Callosum was noted. The subject had been hospitalized on many occasions at this and several other medical centers with hypothermia or hyperthermia without a documentation of a definite cause. Therefore, the diagnosis of Shapiro Syndrome was made. Conclusion: This report is the first documentation of subject manifesting central, more likely to be hypothalamic rather than hypogonadotropic hypogonadism in conjunction with Shapiro Syndrome.

关键词： Hyperhidrosis Central Hypogonadism Temperature Dysregulation Callosal Agenesis Shapiro Syndrome

Perceptions of the osteopathic profession in New York City’s Chinese Communities

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Family medicine and Community Health 2020年第1期8卷 24-30页

作者： Justin Chin Sarah Li Gregory Yim YaQun Arlene Zhou Peter Justin Wan emily R Dube mikhail Volokitin Sonu Sahni mark A Terrell Christine m Lomiguen Primary Care Touro College of Osteopathic MedicineNew York CityNew YorkUSA Pathology New York University School of MedicineNew York CityNew YorkUSA Osteopathic manipulative medicine Touro College of Osteopathic MedicineNew York CityNew YorkUSA Research medicine New York Institute of Technology College of Osteopathic MedicineOld WestburyNew YorkUSA medical Education Lake Erie College of Osteopathic MedicineEriePennsylvaniaUSA Pathology Lake Erie College of Osteopathic MedicineEriePennsylvaniaUSA

Objective The purpose of this study was to assess knowledge of and barriers to osteopathic medicine in Chinese immigrant communities in New York City(NYC).Design A cross-sectional study was designed in which a culturally appropriate survey in Chinese and English versions was administered anonymously to measure immigrant perceptions and knowledge of osteopathic *** Data collection occurred in the municipal delineations for the Chinatown neighbourhood within the New York,New York borough of *** Community members were selected using convenience sampling from high-density areas to *** gathered from the survey included demographics,education level,healthcare habits and knowledge of the osteopathic *** 120 surveys were conducted with 68 males and 52 females,with an average age=*** in the age range of 18-29 years,those with fluent English-language proficiency,and participants with graduate-level education status demonstrated a higher proportion of knowledge of osteopathic manipulative medicine and osteopathic physicians(doctors of osteopathic medicine)among the study *** Compared with research on the general US population,a general lack of knowledge of osteopathic medicine exists within NYC’s Chinese immigrant *** this difference may be ascribed to linguistics and ethnosociological factors,greater outreach and education is needed in urban minority communities to make immigrants aware of all healthcare resources available during the current shortage of US primary care physicians.

关键词： education profession sectional

Steatotic livers are susceptible to normothermic ischemiareperfusion injury from mitochondrial Complex-Ⅰ?dysfunction

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World Journal of Gastroenterology 2016年第19期22卷 4673-4684页

作者： michael JJ Chu Rakesh Premkumar Anthony JR Hickey Yannan Jiang Brett Delahunt Anthony RJ phillips Adam SJR Bartlett Department of Surgery University of Auckland School of Biological Sciences University of Auckland maurice Wilkins Centre for Biodiscovery University of Auckland Department of Statistics University of Auckland Department of Pathology and molecular medicine Wellington School of Medicine University of Otago New Zealand Liver Transplant Unit Auckland City Hospital

AIm: To assess the effects of ischemic preconditioning(IPC, 10-min ischemia/10-min reperfusion) on steatotic liver mitochondrial function after normothermic ischemia-reperfusion injury(IRI).mETHODS: Sixty male Sprague-Dawley rats were fed8-wk with either control chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IRI group underwent 60 min partial hepatic ischemia and 4 h reperfusion;(2) the IPC group underwent IPC prior to same standard IRI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I R I o r I P C. H e p a t i c mitochondrial function was analyzed by oxygraphs. mitochondrial Complex-Ⅰ, Complex-Ⅱ enzyme activity, serum alanine aminotransferase(ALT), and histological injury were ***: Steatotic-IRI livers had a greater increase in ALT(2476 ± 166 vs 1457 ± 103 IU/L, P mpared to the lean liver group. Steatotic-IRI demonstrated lower Complex-Ⅰ?activity at baseline [78.4 ± 2.5 vs 116.4 ± 6.0 nmol/(*** protein), P mol/(*** protein), P monstrated impaired Complex-Ⅰ?function post-IRI compared to the lean liver IRI group. Complex-Ⅱ activity was unaffected by hepatic steatosis or IRI. Lean liver mitochondrial function was unchanged following IRI. IPC normalized ALT and histological injury in steatotic livers but had no effect on overall steatotic liver mitochondrial function or individual mitochondrial complex enzyme activities. CONCLUSION: Warm IRI impairs steatotic liver Complex-Ⅰ?activity and function. The protective effects of IPC in steatotic livers may not be mediated through mitochondria.

关键词： mitochondrial respiration Fatty liver Liver ischemia Oxidative phosphorylation Liver injury Hepatic steatosis Ischemic preconditioning

Divergent Nanotube Synthesis through Reversible macrocycle Assembly

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Accounts of materials Research 2022年第9期3卷 935-947页

作者： michael J.Strauss Austin m.Evans emily K.Roesner Richard J.monsky madison I.Bardot William R.Dichtel Department of Chemistry Northwestern UniversityEvanstonIllinois 60208United States

CONSPECTUS:Nanotubes offer a unique combination of structural precision,tunable interior environments,and high aspect ratios that will be useful for many *** these desirable attributes,widespread explorations into the properties and applications of chemically designed nanotubes have been limited by challenges related to their *** realization has motivated developing a unified synthetic nanotube design,which would enable wide-reaching explorations into one-dimensional molecular architectures.

关键词： realization cycle interior

改进基本医疗(初级保健)研究报告内容的CRISP共识声明

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中国全科医学 2025年第4期28卷 385-392页

作者： William R.phillips Elizabeth Sturgiss Paul Glasziou Tim Colde Hartman Aaron m.Orkin Pallavi Prathivadi Joanne Reeve Grant m.Russell Chris van Weel University of Washington SeattleWashington98195 School of Primary and Allied Health Care Monash UniversityMelbourneVictoriaAustralia3168 Bond University RobinaQueenslandAustralia4226 Radboud Institute of Health Sciences Radboud University Medical CenterNijmegenthe Netherlands6525 University of Toronto TorontoOntarioCanadaM5S monash University MelbourneVictoriaAustralia3168 University of Hull HullUnited KingdomHU6

基本医疗(初级保健)是一门独特的临床专业和研究学科,具有其自身的视角和方法。该领域的研究使用多种研究方法和研究设计来调查各种主题。基本医疗(初级保健)的多样性对其研究内容的报告提出了挑战,尽管已有大量报告指南问世,但没有一... 详细信息

基本医疗(初级保健)是一门独特的临床专业和研究学科,具有其自身的视角和方法。该领域的研究使用多种研究方法和研究设计来调查各种主题。基本医疗(初级保健)的多样性对其研究内容的报告提出了挑战,尽管已有大量报告指南问世,但没有一项指南专门针对基本医疗(初级保健)学科的需求而设。基本医疗(初级保健)研究报告内容的条目共识(CRISP)清单,旨在指导基本医疗(初级保健)研究的报告,包括提供基本医疗(初级保健)相关人群(从业者、患者和社区)所需的信息。CRISP清单完善了现有指南,有利于基本医疗(初级保健)研究结果的报告、传播和应用。先前的CRISP研究,探索了在该领域改善研究内容报告的可能性。工作组通过对国际化、跨学科和跨专业的基本医疗(初级保健)社区的调查,确定了基本医疗(初级保健)研究报告中需要包含的基本条目。工作组开展了一项包含两轮德尔菲的研究,对必要的条目达成了共识,并汇总成清单。CRISP清单包含24个条目,涵盖了基本医疗(初级保健)研究报告中的研究团队、患者、研究参与者、健康状况、临床接触、护理团队、干预、研究测量、照护环境,以及研究结果的实施等方面。并非全部条目都适用于每种研究设计或主题。CRISP指南为设计和报告以下三类研究提供了参考信息:(1)基本医疗(初级保健)研究人员开展的研究,(2)其他研究人员在基本医疗(初级保健)人群和环境中开展的研究,(3)旨在应用于基本医疗(初级保健)实践中的研究,从而改进对临床服务和研究过程背景的报告。这对于解释研究结果并将其应用于基本医疗(初级保健)的不同人群和环境至关重要。

关键词：指南研究报告清单基本医疗研究共识利益相关者参与德尔菲研究研究影响研究设计调查和问卷作者编辑审稿人文章出版期刊

Beyond monogenetic rare variants:tackling the low rate of genetic diagnoses in predominantly antibody deficiency

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Cellular & molecular Immunology 2021年第3期18卷 588-603页

作者： emily S.J.Edwards Julian J.Bosco Samar Ojaimi Robyn E.O’Hehir menno C.van Zelm Department of Immunology and Pathology Central Clinical SchoolMonash UniversityMelbourneVICAustralia The Jeffrey modell Diagnostic and Research Centre for Primary Immunodeficiencies MelbourneVICAustralia Department of Allergy Immunology and Respiratory MedicineCentral Clinical SchoolMonash University and AllergyAsthma and Clinical Immunology ServiceAlfred HospitalMelbourneVICAustralia Department of Infectious Diseases Monash HealthClaytonVICAustralia Centre for Inflammatory Diseases Monash HealthClaytonVICAustralia Department of Allergy and Immunology Monash HealthClaytonVICAustralia

Predominantly antibody deficiency(PAD)is the most prevalent form of primary immunodeficiency,and is characterized by broad clinical,immunological and genetic *** the current gold standard of whole exome sequencing for diagnosis,pathogenic gene variants are only identified in less than 20% of *** elucidation of the causal genes underlying PAD has provided many insights into the cellular and molecular mechanisms underpinning disease pathogenesis,many other genes may remain as yet undefined to enable definitive diagnosis,prognostic monitoring and targeted therapy of *** that many patients display a relatively late onset of disease presentation in their 2^(nd) or 3^(rd) decade of life,it is questionable whether a single genetic lesion underlies disease in all ***,combined effects of other gene variants and/or non-genetic factors,including specific infections can drive disease *** this review,we define(1)the clinical and immunological variability of PAD,(2)consider how genetic defects identified in PAD have given insight into B-cell immunobiology,(3)address recent technological advances in genomics and the challenges associated with identifying causal variants,and(4)discuss how functional validation of variants of unknown significance could potentially be translated into increased diagnostic rates,improved prognostic monitoring and personalized medicine for PAD patients.A multidisciplinary approach will be the key to curtailing the early mortality and high morbidity rates in this immune disorder.

关键词： Predominantly antibody deficiency Genetic diagnosis Genomics Functional validation

Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

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Animal models and Experimental medicine 2021年第1期4卷 47-53页

作者： Carolyn T.Jordan emily m.Bradford Dennis C.Cheek mahesh Kudrimoti Craig S.miller molly H.Smith J.Zach Hilt Thomas D.Dziubla Department of Chemical and materials Engineering University of KentuckyLexingtonKYUSA Department of Internal medicine University of KentuckyLexingtonKYUSA Department of Radiation medicine University of KentuckyLexingtonKYUSA Department of Oral Health Practice University of KentuckyLexingtonKYUSA Department of Oral and maxillofacial Pathology University of KentuckyLexingtonKYUSA

Translational animal models for oral mucositis(Om)are necessary to simulate and assess the bioclinical effects and response in *** models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue *** models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective *** successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced Om hamster model was developed using a clinical linear accelerator utilized by cancer patients *** dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury *** findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 *** model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..

关键词： animal models radiotherapy stomatitis

A Numerical Study on Turbulent Oscillatory Plane Couette Flow

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A Numerical Study on Turbulent Oscillatory Plane Couette Flo...

Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis

第十七届全国水动力学研讨会暨第六届全国水动力学学术会议

作者： emily W．m．Ho C．O．Ng The University of Hong Kong Pokfulam RoadHong Kong The University of Hong Kong Pokfulam RoadHong Kong

＜正＞In this paper we investigate the turbulent structures and transport of heat in oscillatory plane Couette flow at Reynolds number = 5,000 by solving the unsteady incompressible Navier - Stokes equations directly. This flow consists of a working fluid sandwiched between a lower stationary wall and an upper wall moving with a prescribed velocity u =U+AUsin（2πft） , which is a combination of steady and oscillating components. With different velocity ratios A , the turbulence characteristics in steady and oscillatory Couette flows are studied.

关键词： plane Couette flow direct numerical simulation

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World Journal of Hepatology 2018年第1期10卷 155-165页

作者： Venkat Bhat Sujitha Srinathan Elisa Pasini marc Angeli emily Chen Cristina Baciu mamatha Bhat Department of Psychiatry University Health Network and University of Toronto multi Organ Transplant Program University Health NetworkToronto M5G2N2 Canada Division of Gastroenterology Department of Medicine University Health Network and University of Toronto

AIm To identify the key epigenetically modulated genes and pathways in HCC by performing an integrative meta-analysis of all major, well-annotated and publicly available methylation datasets using tools of network *** Pub med and Gene Expression Omnibus were searched for genome-wide DNA methylation datasets. Patient clinical and demographic characteristics were obtained. DNA methylation data were integrated using the Ingenuity Pathway Analysis, a software package for visualizing and analyzing biological networks. Pathway enrichment analysis was performed using IPA, which also provides literature-driven and computationallypredicted annotations for significant association of genes to curated molecular *** From an initial 928 potential abstracts, we identified and analyzed 11 eligible high-throughput methylation datasets representing 354 patients. A significant proportion of studies did not provide concomitant clinical data. In the promoter region, HIST1H2AJ and SPDYA were the most commonly methylated, whereas HRNBP3 gene was the most commonly hypomethylated. ESR1 and ERK were central genes in the principal networks. The pathways most associated with the frequently methylated genes were G-protein coupled receptor and c AmP-mediated signalling. CONCLUSION Using an integrative network-based analysis approach of genome-wide DNA methylation data of both the promoter and body of genes, we identified G-protein coupled receptor signalling as the most highly associated with HCC. This encompasses a diverse range of cancer pathways, such as the PI3 K/Akt/m TOR and Ras/Raf/mAPK pathways, and is therefore supportive of previous literature on gene expression in HCC. However, there are novel targetable genes such as HIST1H2 AJ that are epigenetically modified, suggesting their potential as biomarkers and for therapeutic targeting of the HCC epigenome.

关键词： Network analysis Hepatocellular carcinoma methylation