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Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis:A scoping review

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Chronic Diseases and Translational Medicine 2024年第1期10卷 22-30页

作者： Kanae Mukai Hiromasa Tanno Junko Sugama Toshihiko Yanagita emi kanno Department of Clinical Nursing Faculty ofHealth SciencesInstitute of MedicalPharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan Department of Translational Science forNursing Tohoku University Graduate School ofMedicineSendaiJapan Research Center for Implementation NursingScience Initiative School of Health SciencesFujita Health UniversityToyoakeJapan Department of Clinical Pharmacology Schoolof NursingUniversity of MiyazakiMiyazakiJapan

Insulin is used as a therapeutic agent in patients with diabetes,and cutaneous lipohypertrophy(LH)and localized insulin-derived amyloidosis(LIDA)are well-known adverse effects associated with insulin *** clinical implications,management,assessment methods,and pathological differentiation of LH and LIDA have been recently *** review was to update our knowledge of the pathological differentiation,effects of insulin absorption,hypoglycemic events,and recent assessment methods for LH and LIDA.A scoping review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for Scoping Reviews *** studies and case reports in English were also *** and Scopus databases were searched for keywords to identify papers published up to January 2022.A total of 113 studies were identified through a database search,and 31 were eligible for inclusion in this scoping *** the 31 studies included in this review,patients with type 2 diabetes had high frequencies of LH and *** outcome parameters were assessed using pathological findings and *** is mainly determined by pathological methods,such as hematoxylin and eosin and Congo red *** in vitro and in vivo LIDA models of LIDA have been *** results suggest that pathological analysis is required to identify LH and *** is important to consider LIDA,as it likely influences insulin adsorption and glycemic *** several studies have evaluated the LIDA process,little is known about the mechanisms underlying the development of adverse effects associated with insulin injections.

关键词： diabetes mellitus insulin injection lipohypertrophy localized insulin-derived amyloidosis

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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

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Comparative Analysis of Machine Learning Models for Customer Churn Prediction in the U.S. Banking and Financial Services: Economic Impact and Industry-Specific Insights

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Journal of Data Analysis and Information Processing 2024年第3期12卷 388-418页

作者： Omoshola S. Owolabi Prince C. Uche Nathaniel T. Adeniken Oghenekome Efijemue Samuel Attakorah Oluwabukola G. emi-Johnson Emmanuel Hinneh Department of Data Science Carolina University Winston-Salem NC USA Department of Computer Science Austin Peay State University Clarkesville TN USA Department of Statistical Sciences Wake Forest University Winston-Salem NC USA

Customer churn poses a significant challenge for the banking and finance industry in the United States, directly affecting profitability and market share. This study conducts a comprehensive comparative analysis of machine learning models for customer churn prediction, focusing on the U.S. context. The research evaluates the performance of logistic regression, random forest, and neural networks using industry-specific datasets, considering the economic impact and practical implications of the findings. The exploratory data analysis reveals unique patterns and trends in the U.S. banking and finance industry, such as the age distribution of customers and the prevalence of dormant accounts. The study incorporates macroeconomic factors to capture the potential influence of external conditions on customer churn behavior. The findings highlight the importance of leveraging advanced machine learning techniques and comprehensive customer data to develop effective churn prevention strategies in the U.S. context. By accurately predicting customer churn, financial institutions can proactively identify at-risk customers, implement targeted retention strategies, and optimize resource allocation. The study discusses the limitations and potential future improvements, serving as a roadmap for researchers and practitioners to further advance the field of customer churn prediction in the evolving landscape of the U.S. banking and finance industry.

关键词： Churn Prediction Machine Learning Economic Impact Industry-Specific Insights Logistic Regression Random Forest Neural Networks

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Blockchain-Based System for Secure and Efficient Cross-Border Remittances: A Potential Alternative to SWIFT

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Journal of Software Engineering and Applications 2024年第8期17卷 664-712页

作者： Omoshola S. Owolabi Emmanuel Hinneh Prince C. Uche Nathaniel T. Adeniken Jennifer A. Ohaegbulem Samuel Attakorah Oluwabukola G. emi-Johnson Chinaza S. Belolisa Harold Nwariaku Department of Data Science Carolina University Winston Salem NC USA Patterson School of Business Carolina University Winston Salem NC USA Department of Statistical Sciences Wake Forest University Winston Salem NC USA Department of Computer Science Fisk University Nashville TN USA Harold & Co Procurement and Supply Chain Consulting Lagos Nigeria

This paper proposes a blockchain-based system as a secure, efficient, and cost-effective alternative to SWIFT for cross-border remittances. The current SWIFT system faces challenges, including slow settlement times, high transaction costs, and vulnerability to fraud. Leveraging blockchain technology’s decentralized, transparent, and immutable nature, the proposed system aims to address these limitations. Key features include modular architecture, implementation of microservices, and advanced cryptographic protocols. The system incorporates Proof of Stake consensus with BLS signatures, smart contract execution with dynamic pricing, and a decentralized oracle network for currency conversion. A sophisticated risk-based authentication system utilizes Bayesian networks and machine learning for enhanced security. Mathematical models are presented for critical components, including transaction validation, currency conversion, and regulatory compliance. Simulations demonstrate potential improvements in transaction speed and costs. However, challenges such as regulatory hurdles, user adoption, scalability, and integration with legacy systems must be addressed. The paper provides a comparative analysis between the proposed blockchain system and SWIFT, highlighting advantages in transaction speed, costs, and security. Mitigation strategies are proposed for key challenges. Recommendations are made for further research into scaling solutions, regulatory frameworks, and user-centric designs. The adoption of blockchain-based remittances could significantly impact the financial sector, potentially disrupting traditional models and promoting financial inclusion in underserved markets. However, successful implementation will require collaboration between blockchain innovators, financial institutions, and regulators to create an enabling environment for this transformative system.

关键词： Interoperability Tokens AML/KYC Compliance Peer-to-Peer Transfers Financial Inclusion

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Self-/conspecific discrimination and superparasitism strategy in the ovicidal parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2014年第6期21卷 741-749页

作者： emi Ito Yoshihiro Y. Yamada Insect Ecology Laboratory Graduate School of Bioresources Mie University Tsu Mie Japan

Superparasitism in solitary parasitoids results in fatal competition between the immature parasitoids, and consequently only one individual can emerge. In the semisoli- tary ovicidal parasitoid Echthrodelphaxfairchildii （Hymenoptera： Dryinidae）, 2 adults can emerge under superparasitism with a short interval （〈24 h） between the first and second ovipositions. We determined the female parasitoid＇s behavioral responses under self- and conspecific superparasitism bouts with first-to-second oviposition intervals of 〈2 h. The self- and conspecific superparasitizing frequencies increased up to an oviposition interval of 0.75 h, with the former remaining lower than the latter, particularly for oviposition intervals of _〈0.25 h, suggesting the existence of self-/conspecific discrimination. The superparasitizing frequency plateaued for oviposition intervals of _〉0.75 h, with no dif- ference between self- and conspecific superparasitism. The ovicidal-probing frequency did not differ under self- and conspecific superparasitism, and was usually 〈20%. The females exhibited no preference for the oviposition side （i.e., ovipositing on the side with or without the first progeny） and almost always laid female eggs for any oviposition in- terval under self- and conspecific superparasitism. The sex ratio was not affected by the type of superparasitism, oviposition sides, or the occurrence of ovicidal probing. These observed results about the oviposition side, ovicidal probing, and sex ratios differed from the predictions obtained assuming that the females behave optimally. Possible reasons for the discrepancies are discussed： likely candidates include the high cost of selecting oviposition sides and ovicidal probing, and, for the sex ratio, the low frequency of encountering suitable hosts before superparasitism bouts.

关键词： infanticide ovicide plant hopper self-recognition sex ratio

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Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi Kobayashi Michaela Kearney emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

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Seemingly maladaptive refraining from infanticidal probing at the third parasitism attack by the semi-solitary parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2006年第3期13卷 229-233页

作者： emi ITO YOSHIHIRO Y. YAMADA Insect Ecology Laboratory Faculty of Bioresources Mie University Tsu Mie Japan

We assessed the adaptiveness of refraining from infanticidal probing at the third attack under triple parasitism in the parasitoid Echthrodelphaxfairchildii Perkins, by comparing fitness returns from the third attack with and without probing. Fitness returns were assessed in terms of the survival rate, mean developmental time, and mean adult head width of the progenies. Not probing was maladaptive under triple parasitism with oviposition intervals of 1/24 and 24/24 hours （where the numbers before and after the slash refer to the first-to-second and second-to-third oviposition intervals, respectively）, although no significant difference was detected in fitness returns for oviposition intervals of 24/1 hours. We suggest that the cost of probing （especially the decrease in the chance of future ovipositions） is a reason for the seemingly maladaptive absence of probing.

关键词： cost of reproduction Echthrodelphax fairchildii infanticide ovicide,superparasitism triple parasitism

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Formation of Edge Crack in 1.4%Si Non-oriented Electrical Steel during Hot Rolling

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Journal of Iron and Steel Research International 2014年第2期21卷 269-274页

作者： Ai-hua CHEN Hai-rong GUO Hua-long LI Toshihiko emi Institute of Research of Iron and Steel Shasteel

Microstructure evolution, dynamic recrystallization, high temperature oxidation and hot ductility of 1.4 % Si non-oriented electrical steel sheets were investigated to reduce edge cracking. The causes of cracking were found to be coarse as-cast microstructure, grain boundary oxidation in reheating furnace, lack of dynamic recrystallization during hot rolling and increase of temperature, resulting in reduced hot ductility in strip edge region. Countermeas- ures against the edge crack are proposed accordingly. Lowering reheating temperature and reducing holding time re- duced oxidation and decarburization. Hot charging temperature was increased to decrease reheating temperature. And using an edger can refine microstructure in strip edge region. Finally, edge heater can be added to increase edge re- gion formability by inducing dynamic reerystallization and ductility by increasing temperature.

关键词： edge crack non-oriented electrical steel hot rolling

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Identification of county-level health factors associated with COVID-19 mortality in the United States

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The Journal of Biomedical Research 2020年第6期34卷 437-445,I0014页

作者： Wei Pan Yasuo Miyazaki Hideyo Tsumura emi Miyazaki Wei Yang School of Nursing Duke UniversityDurhamNC 27710USA Department of Population Health Sciences School of MedicineDuke UniversityDurhamNC 27708USA School of Education Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Community Health Sciences University of NevadaRenoNV 89557USA.

Many studies have investigated causes of COVID-19 and explored safety measures for preventing COVID-19 ***,these studies fell short to address disparities in health status and resources among decentralized communities in the United *** this study,we utilized an advanced modeling technique to examine complex associations of county-level health factors with COVID-19 mortality for all 3141 counties in the United *** results indicated that counties with more uninsured people,more housing problems,more urbanized areas,and longer commute are more likely to have higher COVID-19 *** on the nationwide population-based data,this study also echoed prior research that used local data,and confirmed that county-level sociodemographic factors,such as more Black,Hispanic,and older subpopulations,are attributed to high risk of COVID-19 *** hope that these findings will help set up priorities on high risk communities and subpopulations in future for fighting the novel virus.

关键词： COVID-19 mortality health factors health disparity hierarchical generalized linear model

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Conjunctival cyst with apocrine hidrocystoma-like features:a case report

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 465-467页

作者： Takafumi Igarashi Satoru Kase Yuka Suimon emi Takakuwa Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 0608638Japan Department of Surgical Pathology Hokkaido University HospitalSapporo 0608638Japan

Dear Editor,I am Takafumi Igarashi from Hokkaido University Hospital,*** hidrocystoma is a benign cystic tumor arising in the apocrine sweat glands proposed by Mehregan^([1])in *** is likely that apocrine hidrocystoma arises in the uvula,ears,chest,and shoulders,as well as the (peri)ocular regions such as the eyelid,and sclera^([2-4]).

关键词： apo ocular likely

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