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基因工程T细胞临床研究专家指导意见(2021)

中国肿瘤生物治疗杂志 2021年第5期28卷 431-434页

作者：中国医药质量管理协会细胞治疗质量控制与研究专业委员会赵璇黄建敏夏建川张毅韩为东不详郑州大学第一附属医院中山大学肿瘤防治中心解放军总医院第一医学中心

目前,越来越多的基因工程T细胞临床研究在中国开展,但尚无适用于临床研究中供临床研究医生参考的指导意见。因此,中国医药质量管理协会细胞治疗质量控制与研究专业委员会针对基因工程T细胞临床研究的特点,从开展临床研究医生的角度,对... 详细信息

目前,越来越多的基因工程T细胞临床研究在中国开展,但尚无适用于临床研究中供临床研究医生参考的指导意见。因此,中国医药质量管理协会细胞治疗质量控制与研究专业委员会针对基因工程T细胞临床研究的特点,从开展临床研究医生的角度,对患者的选择、细胞的采集与制备、细胞的储存与运输、围细胞输注期治疗及疗效评价等多方面,组织细胞治疗领域的多名专家,综合国内外研究最新进展并结合临床实践经验,经多次讨论和修改,最终形成基因工程T细胞临床研究专家指导意见(2021)。本指导意见旨在为基因工程T细胞的临床研究医生提供专业指导,保护临床研究中患者的安全并争取最大的获益。

关键词：基因工程T细胞临床研究专家共识指导意见

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我国体检人群常见疾病检出率分布特点

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中华健康管理学杂志 2012年第1期6卷 9-12页

作者：中华医学会健康管理学分会体检评估学组中华医学会健康管理学分会体检评估学组

目的了解我国健康体检人群的疾病及异常检出率情况。方法收集全国65家体检中心2009年2332046人次的体检数据，按不同性别、地区、城市健康体检人群常见疾病和异常情况进行统计学分析。结果2332046人次体检中，常见疾病及异常中检出率最... 详细信息

目的了解我国健康体检人群的疾病及异常检出率情况。方法收集全国65家体检中心2009年2332046人次的体检数据，按不同性别、地区、城市健康体检人群常见疾病和异常情况进行统计学分析。结果2332046人次体检中，常见疾病及异常中检出率最高的是乳腺增生，为43．63％；检出率最低的是前列腺癌，为7．3／10万。同时常见疾病及异常检出率具有性别、地域差异。男性异常检出率最高的是脂肪肝，达31．05％，女性是乳腺增生，达43．63％。肥胖检出率南方为8．91％，北方为14．66％。骨质疏松检出率南方为17．06％，北方为5．37％。结论健康体检是一种有效的疾病早期筛查与慢性病风险因素监测手段，但在设置体检项目目录时，应考虑性别和地域因素。

关键词：体格检查人口统计学疾病检出率

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Variable Structure Guaranteed Cost Control for Uncertain Networked Systems with Time Delay

Variable Structure Guaranteed Cost Control for Uncertain Net...

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第二十九届中国控制会议

作者： YAO Hejun,YUAN Fushun,GAO Fangzheng School of Mathematics and Statistics,Anyang Normal University,Henan Anyang 455002,P.R.china

A novel method for the stability of a class of uncertain networked control systems with state delay and communication delay has been *** on the lyapunov stability theorem,a sliding manifold that can compensate delay has been designed by using LMI *** a guaranteed cost control law is given to make the sliding manifold ***,a numerical example is given to demonstrates the application and effectiveness of the proposed variable structure controller design method.

关键词： Uncertain Networked Control Systems Variable Structure Control Guaranteed Cost Control

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Path Tracking and Trajectory Planning for Nonholonomic Wheeled Mobile Robots

Path Tracking and Trajectory Planning for Nonholonomic Wheel...

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第二十七届中国控制会议

作者： Xie Kewei,Zhuang Yan,Wang Wei Research Center of Information and Control,Dalian University of Technology,Dalian 116024,P.R.china

In order to track multiform curves planned for nonholonomic wheeled mobile robots stably,this paper presents an effective trajectory planning scheme and an improved tracking controller using a biological incentive *** trajectory planning scheme,which includes a curvature estimator based on two adjacent points,combines the results of path planning with the policies of tracking..The kinetic restrictions method based on biological incentive model is introduced in backstepping technique to improve the control *** resolves the velocity jump problem existing in some previous tracking controllers and deals with the situations with large tracking *** results demonstrate the effectiveness of tracking capability of the proposed scheme

关键词： Kinetic restriction Trajectory planning Path tracking Nonholonomic wheeled mobile robot

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Adaptive Fuzzy Logic Control for a Class of Input Delay Nonlinear Systems

Adaptive Fuzzy Logic Control for a Class of Input Delay Nonl...

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第二十九届中国控制会议

作者： ZHU Qing1,ZHANG Tianping1,FEI Shumin2,YAO Xiang1 1.College of Information Engineering,Yangzhou University,Yangzhou 225009,P.R.china2.School of Automation,Southeast University,Nanjing 210096,P.R.china

An output feedback control scheme combined with backstepping,fuzzy logic system and adaptive control is proposed for the output tracking control problem of a class of nonlinear systems with input delay and disturbances.A filter and a virtual observer are constructed to substitute the immeasurable system *** logic systems are employed to estimate the unknown continuous *** control scheme ensures that the closed-loop system is semi-globally uniformly ultimately bounded（SGUUB）.The tracking error is proved to be bounded and ultimately converges to an adequately small compact *** feasibility is investigated by a simulation example.

关键词： Output Feedback Input Felay Backstepping Fuzzy Logic System Adaptive Control

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Decentralized Control of Linear Systems Based on the New Viewpoint of Cooperative Control

Decentralized Control of Linear Systems Based on the New Vie...

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第二十六届中国控制会议

作者： Tang Wenyan,Nian Xiaohong,Cao Li The School of Information Science and Engineering,Central South University,Changsha 410075,P.R.china

The problem of designing cooperative control of linear system with a quadratic performance index is considered.A necessary and sufficient condition for optimal cooperative strategies is ***,the decentralized control of the large-scale linear system is studied based on the new viewpoint of cooperative control and the necessary and sufficient condition for optimal decentralized control is ***,the problem for designing the suboptimal decentralized control of linear quadratic large-scale system is formulated to a concave optimization problem with BMI constrains and solved by an alternative optimization algorithm via ***,an example is given to illustrate the main results of this paper.

关键词： Decentralized control Cooperative control Suboptimal strategies BMI LMI

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Phenol Degradation by a Hybrid Gas-liquid Discharge Reactor with Digital-analog Mixed Control

Phenol Degradation by a Hybrid Gas-liquid Discharge Reactor ...

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第二十九届中国控制会议

作者： XIE Rui,CHEN Chao,LI Wuhua,HE Xiangning College of Electrical Engineering,Zhejiang University,Hangzhou 310027,P.R.china

Wastewater treatment experiments to decompose the organic compounds,such as the phenol,the acetic acid,the chlorophenol,and so on,are conducted by using a hybrid gas-liquid discharge *** is shown that the characteristic of the high-voltage power is important for the degradation process.A digital-analog mixed control method is employed in the control solution to keep a high power *** important parameters,including the discharge gap,the initial concentration of the solution,and the discharge duration,are investigated for the phenol *** experimental results indicated that the amount of chemical oxygen demand（COD）is declined clearly by the mixed control high-voltage discharge.

关键词： Environmental Protection Wastewater Treatment LCC resonance Converter High-voltage Power Organic compounds degradation

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Role of endoplasmic reticulum stress in the biological functions of MCP-1-induced mesenchymal stem cells

Role of endoplasmic reticulum stress in the biological funct...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yi-Hua SUN,Meng XIANG,Si-Feng CHEN~* Department of Physiology and Pathophysiology,Shanghai Medical College,Fudan University,Shanghai 200032,china

＜正＞Background:Mesenchymal stem cells（MSCs） are pluripotent cells with promising therapeutic potential. Injection of MSCs decreases ischemia/reperfusion injury mainly through paracrine *** chemotactic protein-1（MCP-1） plays an important role in ischaemia/reperfusion injury and transplant *** reticulum（ER） stress is a protective cell response that repairs mild injured cells and sacrifices severely injured cells. We previously found MCP-1 is harmful to transplants in ***,it is beneficial when used to stimulate MSC in vitro before MSC is *** present study observed the role of RR on MCP-1-induced changes of MSC biological ***:Mesenchymal stem cells were isolated from rat bone marrow and treated with MCP- 1（10 ng/mL） with or without pretreatment of ER protein *** protein inhibitors used were Zinc protoporphyrin （ZnPP,an HO-1 inhibitor）,C/EBP homologous protein specific short interfering RNA（CHOP siRNA） or activating transcription factor-6 specific short interfering RNA（ATF-6 siRNA）.The cell function of proliferation, invasion and migration and mechanisms were analyzed by functional assays and western ***:HO-1 promoted cell growth and migration but inhibited cell apoptosis and adhesion independent of other ERS proteins. Without other treatment,siRNA of ERS protein CHOP or ATF-6 inhibited MSC migration but inducing apoptosis and have no effects on cell adhesion and *** siRNA induced ATF-6 ***-6 siRNA induced CHOP protein expression,indicating a bilateral compensation of CHOP and *** above treatments have no effect on HO-1 protein amount,indicating HO-1 is not the down stream molecule of other ER ***-1 induced MSC migration and adhesion while inhibited MSC *** effects of MCP-1 on MSCs were blocked by CHOP or ATF-6 ***:in vitro prestimulation of MSC with MCP-1 will promote beneficial effect while prevent harmful effect of MSC in vivo thr

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The Clinical Analysis of 45 Cases of Erythrodermic Psoriasis

The Clinical Analysis of 45 Cases of Erythrodermic Psoriasis

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The 10th china-Japan Joint Meeting of Dermatology 20th Anniversary

作者： Haiting Chen Ye Zhao Aoxue Wang Caixia Tu Department of Dermatology The Second Affiliated Hospital of Dalian Medical University Dalian 116027 china

＜正＞Objective:To study the precipitating factors,clinical manifestations,laboratory data and therapeutic effects of erythrodermic psoriasis. Methods:clinical data from 45 cases of erythrodermic psoriasis inpatients ...

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Turning of Fractional-Order Phase-Lead Compensators:A Graphical Approach

Turning of Fractional-Order Phase-Lead Compensators:A Graphi...

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第二十九届中国控制会议

作者： WANG De-Jin,CHEN Xue School of Electronic Information and Automation,Tianjin University of Science and Technology,Tianjin,300222,P.R.china.

This paper deals with the problem of graphical turning approach to fractional-order phase-lead compensators（FOPLC） for a class of all pole time-delay *** stabilization and phase-margin specification are considered,respectively,of this kind of delay systems using FOPLC,both based on a graphical stability criterion applicable to fractional-order time-delay *** algorithm for achieving the desired phase-margin is also *** examples are given to illustrate the shapes of the stabilizing region and to show the design *** graphical turning method of FOPLC discussed in this paper exhibits the flexible property in selecting the parameters of FOPLC.

关键词： Phase-Lead Compensators Fractional-Order Systems Graphical Stability Criterion Graphical Tuning

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