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Gsα^(R201C)and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

Bone Research 2022年第4期10卷 784-798页

作者： Biagio Palmisano Rossella Labella Samantha Donsante Cristina Remoli emanuela Spica Ilenia Coletta Giorgia Farinacci Michele Dello Spedale Venti Isabella Saggio Marta Serafini Pamela Gehron Robey Alessandro Corsi Mara Riminucci Department of Molecular Medicine Sapienza University of RomeRome 00161Italy Tettamanti Research Center Department of PediatricsUniversity of Milano Bicocca/Fondazione MBBMMonza 20900Italy Department of Biology and Biotechnology Sapienza University of RomeRome 00185Italy Institute of Structural Biology and School of Biological Sciences Nanyang Technological University 639798 SingaporeSingapore CNR Institute of Molecular Biology and Pathology Piazzale Aldo Moro 5Rome 00185Italy Skeletal Biology Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthDepartment of Health and Human ServicesBethesdaMD 20892USA

The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal ***,the dysregulated activity of Gsαdue to gain-of-function mutations (R201C/R201H)results in severe architectural and functional derangements of the entire bone/bone marrow *** the consequences of gain-of-function mutations of Gsαhave been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages,their effect in adipogenically-committed bone marrow stromal cells has remained *** generated a mouse model with expression of Gsα^(R201C) driven by the Adiponectin(Adq)***-Gsα^(R201C) mice developed a complex combination of metaphyseal,diaphyseal and cortical bone *** the metaphysis,Gsα^(R201C) caused an early phase of bone resorption followed by bone *** bone formation was sustained by cells that were traced by Adq-Cre and eventually resulted in a high trabecular bone mass *** the diaphysis,Gsα^(R201C),in combination with estrogen,triggered the osteogenic activity of Adq-Cre-targeted perivascular bone marrow stromal cells leading to intramedullary bone ***,consistent with the previously unnoticed presence of Adq-Cre-marked pericytes in intraosseous blood vessels,Gsα^(R201C) caused the development of a lytic phenotype that affected both cortical(increased porosity)and trabecular(tunneling resorption)*** results provide the first evidence that the Adq-cell network in the skeleton not only regulates bone resorption but also contributes to bone formation,and that the Gsα/cAMP pathway is a major modulator of both functions.

关键词： estrogen sustained skeleton

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Intrahepatic Cholangiocarcinoma and Thermal Ablation:Long-term Results of An Italian Retrospective Multicenter Study

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 287-292页

作者： Antonio Giorgio Pietro Gatti Luca Montesarchio Bruno Santoro Andrea Dell’Olio Nicola Crucinio Carmine Coppola Ferdinando Scarano Fabio De Biase emanuela Cirac Stefano Semeraro Valentina Giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly General Surgery Unit Polla General HospitalPolla(SA)Italy Department of Radiology Bisceglie Hospital-ASL BATBisceglieItaly Gastroenterology Unit Foggia General HospitalFoggiaItaly Department of Internal Medicine Hepatology Interventional UnitGragnano HospitalGragnano(NA)Italy Internal Medicine Unit Ostuni HospitalOstuni(BR)Italy Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthLargo A GemelliRomaItaly

Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma(ICC),percutaneous thermal ablation can be an alter-native treatment for patients unfit for *** aim was to compare long-term results of percutaneous sonographi-cally-guided radiofrequency ablation(RFA)with high-powered microwave ablation(MWSA)in treatment of ***: Results of 71 ICC patients with 98 nodules treated with RFA(36 patients)or MWSA(35 patients)between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively ***-mulative overall survival curves were calculated with the Ka-plan-Meyer method and differences with the log-rank *** possible factors affecting survival were ***: Overall survival of the entire series was 88%,65%,45%and 34%at 12,36,60 and 80 months,*** treated with MWSA survived longer than pa-tients treated with RFA(p 4 cm,no significant difference was ***-free sur-vival and progression-free survival were better in the MWSA group compared to the RFA group(p < 0.005).Diameter of nodules and MWSA were independent factors predicting a better *** major complications were ***: MWSA is superior to RFA in treating ICC unfit for surgery,achieving better long-term survival in small(≤3 cm)ICC nodules as well as nodules up to 4 cm of neo-plastic tumors and should replace RFA.

关键词： Intrahepatic cholangiocarcinoma Thermal ablation Microwaves Radiofrequency Percutaneous treatment

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Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life

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Journal of Geriatric Cardiology 2018年第10期15卷 644-646页

作者： Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari Geriatric Unit Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Department of Clinical Sciences and Community Health University of MilanMilanItaly Unit of Epidemiology Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Fellowship in Geriatrics and Gerontology University of MilanMilanItaly

Orthostatic hypotension (OH)is a common condition in older *** to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH.

关键词： Elderly Orthostatic hypotension Prevalence Real-life

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Real and Perceived Physical Functioning in Italian Elderly Population: Associations with BADL and IADL

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Advances in Aging Research 2014年第5期3卷 349-359页

作者： Filippo Candela Giulia Zucchetti Daniele Magistro Enrique Ortega emanuela Rabaglietti Department of Psychology University of Torino Torino Italy Department of Functional Brain Imaging Tohoku University Sendai Japan Health Science Department California State University Dominguez Hills Carson USA

This study aimed to identify the key physical abilities (aerobic endurance, gait speed, balance, strength) and psychological variables associated with the level of basic (BADL) and instrumental (IADL) activities of daily living in an autonomous community-dwelling elderly population in Italy. 135 elderly people (63% women;mean age = 73.3, SD = 5.5) were included in the study. Stepwise regression was performed to verify the association between these variables and the level of BADL and IADL in the elderly participants. Results showed that balance (β = -0.21, p of physical functioning (β = 0.32, p L scores, and IADL score was associated with perception of physical functioning (β = 0.30, p 001) and upper limb strength (β = 0.21, p < 0.05). The results demonstrate a relationship between physical functioning and ADL, both real physical functioning and perceived physical functioning.

关键词： Physical Functioning ADL Psychological Status Elderly

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Synthesis, Textural and Structural Properties of Calcium Hydroxide Nanoparticles in Hydro-Alcoholic Suspension

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Advances in Materials Physics and Chemistry 2014年第3期4卷 50-59页

作者： Giuliana Taglieri Claudia Mondelli Valeria Daniele emanuela Pusceddu Giancarlo Scoccia CNR-IOM-OGG Institut Laue Langevin Grenoble France Department of Industrial and Information Engineering and Economics University of L’Aquila L’Aquila Italy Institute of Biometeorology National Research Council Firenze Italy

The use of calcium hydroxide nanoparticles (nanolime) in hydro-alcoholic suspensions represents a good enhancement in particular in the conservation of stones and surfaces of interest in Cultural Heritage. In this work we have produced nanolime by using our alternative method of synthesis (based on the use of a surfactant agent in the original solution) and we have studied, for the first time, structural and morphological properties of the synthesized nanoparticles directly in hydro-alcoholic suspension by synchrotron X-ray diffraction technique and transmission electron micro-scope observations. The particles characterization was performed on suspensions synthesized by varying surfactant content in the synthesis procedure and the water/alcohol ratio, too. We have found that only pure and crystalline Ca(OH)2 particles produced during the synthesis procedure and they maintained stably in suspension. These particles were hexagonally plated and regularly shaped with side dimension ranging from 300 to 40 nm or less;they had a platy habit and they presented, particularly with high alcohol content in suspension, a preferred orientation along z-axis.

关键词： Nanostructures Chemical Synthesis X-Ray Diffraction Crystal Structure

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Replacement Meal: Effectiveness of a Soluble Powder Rich in Fibers and at Low Glycemic Index in Overweight but Not in Obese Patients

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Food and Nutrition Sciences 2017年第6期8卷 591-597页

作者： Volpe Roberto Abdulkader Bisan Pacioni Fabrizio Reggiani Francesco Schiavetto emanuela Health and Safety Department Italian National Research Council (CNR) Rome Italy Central European University Budapest Hungary Central Laboratory Umberto I University Hospital “La Sapienza” University Rome Italy Faculty of Biology University of “La Sapienza” Rome Italy

Active lifestyle and qualitative and quantitative diets are the best way to lose weight. In our study we have assessed the effectiveness and tolerability of a soluble powder rich in fibers and at low glycemic index and used, with a portion of fresh fruit, as replacement meal (for a total calorie intake ranging from a minimum of about 130 kcal to a maximum of 260 kcal) in 52 overweight/obese subjects of the outpatient clinic of the Italian National Research Council (CNR) of Rome already in treatment with a low-fat low-carbohydrates qualitative diet. The study was a parallel, prospective trial of two randomized sample groups, “intervention” (26 subjects) and “control” (26 subjects). After 8 weeks, the treatment based on the replacement meal has improved the results obtained through the qualitative diet alone above all in the overweight subjects: 11/16, versus only 2/16 in the control group, became ranged within normal weight. On the contrary, the majority of obese subjects didn’t change their BMI classification suggesting that, in case of obesity, a controlled quantitative correction with weighing food portions could be a better strategy than low-calorie replacement meal.

关键词： Overweight Obesity Cardiovascular Risk Functional Foods Replacement Meal

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Contribution to the Knowledge of Biodeteriogenic Flora on Three Historical Calabrian (Southern Italy) Churches

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Open Journal of Ecology 2021年第3期11卷 287-300页

作者： Maria emanuela Mascaro Giuseppe Pellegrino Ida De Rose Anna Maria Palermo Department of Biology Ecology and Earth Sciences University of Calabria Rende Italy

The effect of biodeteriogenic living organisms on historical and archeological sites is a well-known problem affecting the world’s cultural heritage. Indeed, the growth inside the bricks of shrubs and herbs roots can cause breakage, collapse and, detachment of materials. The knowledge of the spontaneous vascular flora present on monuments is essential for protection and safeguarding of cultural heritage. In this paper, we identify and describe biodeteriogenic vascular flora of three historical Calabrian (Southern Italy) churches, showing the relationship between plant biodiversity and exposure and building material of churches. The species present on the wall and in perimeter for each church were sampled noting substrate type, surface inclination (vertical or horizontal) and exposure. The total number of plant species recorded was 27. Hemicryptophytes (41%) prevail over the other biological forms and the most represented families are that of the Asteraceae. Parietaria judaica is the only species present in all three sites. Substrate type, climatic condition and surface inclination affect the floristic composition. Sixteen out of 27 species grow on vertical surfaces, all Geophythes and Chamaephytes grow on horizontal surfaces, while Therophytes were rather on vertical surfaces. A significant difference was found in the Hazard Index values in the three churches. Only one site, presents a high average value of Hazard Index, due to the simultaneous presence of Ailanthus altissima, Ficus carica, Rubus ulmifolius and Sambucus nigra. The data collected indicate that the flora growing on wall of three Calabrian churches partially reflects the floristic context in which they are located. The diversity of the vegetational spectrum is remarkable, most of the plants are ruderal herbaceous, many weeds and invasive, and for the most part typical of the Mediterranean environment. The data collected contribute to the knowledge of the spo

关键词： Biodeterioration Churches Flora Hazard Index Italy

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Physical functioning: The mediating effect on ADLs and vitality in elderly living in residential care facilities. “Act on ageing”: A pilot study

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Health 2012年第7期4卷 407-414页

作者： Monica Emma Liubicich Filippo Candela Daniele Magistro emanuela Rabaglietti Enrique Ortega Department of Psychology University of Turin Turin Italy University Interfaculty School of Motor Science (SUISM) Research Centre in Motor and Sport Science University of Turin Turin Italy

The present study aims at verifying whether participation in a physical activity programme has positive effects on the daily life autonomy and vitality of elderly people living in residential care facilities by the mediation of their physical well- being. Fifty-one institutionalised individuals took part in the study. The control group included 11 people (84.26, ± 7.4 years), whereas the experimental group was made up of 40 people (85 ± 6.6 years). The experimental group was involved in a physical activity programme twice a week. The 36-Item Short Form Health Survey Questionnaire, the Activities of Daily Living Scale, and the Tinetti Test were administered to the participants. The linear regression method as well as Sobel’s formula were used for the analysis. The results show that participation in a physical activity programme has positive effects on autonomy in bathing and on the participants’ sense of vitality due to the mediation of physical functioning. These results confirm the importance of physical activity for the elderly populations living in residential care facilities.

关键词： Physical Activity Basic Activities of Daily Living Older Elderly Exercise Mediation Health

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罗马尼亚汉语学习者定语习得偏误研究

罗马尼亚汉语学习者定语习得偏误研究

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作者：木兰（Boboc emanuela）哈尔滨师范大学

学位级别：硕士

作为一名罗马尼亚留学生,我在学习的过程中曾一度困扰于汉语定语规则的严格与复杂,如多项定语语序规律、汉语定语标记“的”的隐现规律以及汉罗定语不同的使用规则等,这些都是罗马尼亚学生学习汉语定语的难点,因此本文要就罗马尼亚汉语... 详细信息

作为一名罗马尼亚留学生,我在学习的过程中曾一度困扰于汉语定语规则的严格与复杂,如多项定语语序规律、汉语定语标记“的”的隐现规律以及汉罗定语不同的使用规则等,这些都是罗马尼亚学生学习汉语定语的难点,因此本文要就罗马尼亚汉语学习者习得定语的情况展开研究,以提高罗马尼亚汉语学者的学习效果。本文共分为四章,具体内容如下:第一章为绪论,介绍了本文的研究目的、研究意义及研究方法,并从汉语定语本体研究及汉语定语习得研究两个方面对相关研究做了述评。第二章从定语类型、定语与中心语的语义关系、多项定语语序及定语标记隐现规律四个方面对汉罗定语进行了比较与分析,发现了汉罗定语一一对应、不完全对应及不对应的部分。第三章首先以问卷调查的形式对罗马尼亚汉语学习者学习和使用定语的难点进行了调查,然后以调查数据为依据,归纳、总结、描写了偏误类型,发现偏误率最高的是多项定语语序的使用。第四章根据前文发现的偏误类型深入挖掘偏误原因,并对此进行了较为全面的分析,主要归纳出母语负迁移、目的语知识泛化及汉语语法的复杂性三种偏误原因。之后,根据实际情况提出了具有针对性及可行性的解决建议,分别为:加强汉罗定语对比、培养目的语语感以及课堂上精讲多练、增加有意义的练习。

关键词：定语罗马尼亚学习者对比分析偏误分析

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