Intrahepatic Cholangiocarcinoma and Thermal Ablation:Long-term Results of An Italian Retrospective Multicenter Study

作     者：Antonio Giorgio Pietro Gatti Luca Montesarchio Bruno Santoro Andrea Dell’Olio Nicola Crucinio Carmine Coppola Ferdinando Scarano Fabio De Biase Emanuela Cirac Stefano Semeraro Valentina Giorgio 

作者机构：Liver Unit and Interventional Ultrasound UnitAthena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine UnitBrindisi General HospitalBrindisiItaly General Surgery UnitPolla General HospitalPolla(SA)Italy Department of RadiologyBisceglie Hospital-ASL BATBisceglieItaly Gastroenterology UnitFoggia General HospitalFoggiaItaly Department of Internal MedicineHepatology Interventional UnitGragnano HospitalGragnano(NA)Italy Internal Medicine UnitOstuni HospitalOstuni(BR)Italy Fondazione Policlinico A.Gemelli IRCCSDepartment of Woman and Child Health and Public HealthLargo A GemelliRomaItaly 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2019年第7卷第4期

页      面：287-292页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Intrahepatic cholangiocarcinoma Thermal ablation Microwaves Radiofrequency Percutaneous treatment 

摘      要：Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma(ICC),percutaneous thermal ablation can be an alter-native treatment for patients unfit for *** aim was to compare long-term results of percutaneous sonographi-cally-guided radiofrequency ablation(RFA)with high-powered microwave ablation(MWSA)in treatment of ***: Results of 71 ICC patients with 98 nodules treated with RFA(36 patients)or MWSA(35 patients)between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively ***-mulative overall survival curves were calculated with the Ka-plan-Meyer method and differences with the log-rank *** possible factors affecting survival were ***: Overall survival of the entire series was 88%,65%,45%and 34%at 12,36,60 and 80 months,*** treated with MWSA survived longer than pa-tients treated with RFA(p 4 cm,no significant difference was ***-free sur-vival and progression-free survival were better in the MWSA group compared to the RFA group(p 0.005).Diameter of nodules and MWSA were independent factors predicting a better *** major complications were ***: MWSA is superior to RFA in treating ICC unfit for surgery,achieving better long-term survival in small(≤3 cm)ICC nodules as well as nodules up to 4 cm of neo-plastic tumors and should replace RFA.