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“Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis

Cellular & Molecular Immunology 2021年第2期18卷 307-317页

作者： Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi emanual maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson Graduate Program in Immunology University of MichiganAnn ArborMIUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Dermatology University of CaliforniaDavisSacramentoCAUSA Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMIUSA A.Alfred Taubman Medical Research Institute Ann ArborMIUSA Departments of Nutrition and Dermatology Case Western Reserve UniversityClevelandOHUSA

Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical *** psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune *** recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis *** this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular *** further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis.

关键词： Pustular psoriasis Genetics IL-36 Autoinflammation Clinical features Histology

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Complete regression of subcutaneous and cutaneous metastatic melanoma with high-dose intralesional interleukin 2 in combination with topical imiquimod and retinoid cream

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中国神经肿瘤杂志 2011年第1期9卷 65-65页

作者： Garcia MS Ono Y Martinez SR Chen SL Goodarzi H Phan T Wehrli LN Miyamura Y Fung MA maverakis E Departments of Dermatology Surgery Division of Surgical Oncology University of California Davis School of Medicine Department of Veteran Affairs Northern California Health Care System Sacramento California USA

There are limited treatment options for metastatic melanoma, which is almost universally fatal. We report the successful treatment of 64 of 64 cutaneous and subcutaneous melanoma metastases in three patients using high-dose (22 million units per 1.2 ml) intralesional interleukin 2 (IL-2) in combination with topical imiquimod and a retinoid cream. Before intralesional therapy, all patients had been treated surgically and were no longer considered surgical candidates.

关键词：黑色素瘤咪喹莫特白细胞介素2 高剂量转移性维甲酸皮肤外用

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