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Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction

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World Journal of Methodology 2025年第2期15卷 125-136页

作者： emir Bećirović Minela Bećirović SabinaŠegalo Amir Bećirović Semir Hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović Malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo emir Begagić Department of Intensive Care University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Nephrology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Laboratory Technologies Faculty of Health SciencesUniversity of SarajevoSarajevo 71000Bosnia and Herzegovina Department of Endocrinology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina School of Medicine University of TuzlaTuzla 75000Bosnia and Herzegovina Department for Internal Diseases and Hemodialysis Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of Internal Medicine Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of Radiotherapy University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Cardiology University Clinical Center SarajevoSarajevo 72000Bosnia and Herzegovina Department of General Medicine University of ZenicaSchool of MedicineZenica 72000Bosnia and Herzegovina

BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction

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Neoliberalism,Anti-Neoliberalism and Socialism

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学术界 2019年第2期 193-196页

作者： emir Sader State Universty of Rio de Janiero

Neoliberalism,Anti-Neoliberalism and

关键词： neoliberalism anti-neoliberalism alternative socialism Latin America

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Inflammatory bowel disease in Tuzla Canton,Bosnia-Herzegovina:A prospective 10-year follow-up

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World Journal of Gastroenterology 2021年第20期27卷 2630-2642页

作者： emir Tulumović Nermin Salkić Denijal Tulumović Department of Gastroenterology and Hepatology University Clinical Center TuzlaTuzla 75000Tuzlanski KantonBosnia and Herzegovina Department of Nephrology Dialysis and TransplantationUniversity Clinical Center TuzlaTuzla 75000Tuzlanski KantonBosnia and Herzegovina

BACKGROUND The incidence and prevalence of inflammatory bowel disease(IBD)vary between regions but have risen globally in recent decades.A lack of data from developing nations limits the understanding of IBD *** To perform a follow-up review of IBD epidemiology in the Tuzla Canton of Bosnia-Herzegovina during a 10-year period(2009-2019).METHODS We prospectively evaluated the hospital records of both IBD inpatients and outpatients residing in Tuzla Canton for the specified period of time between January 1,2009 and December 31,*** all our patients had undergone proximal and distal endoscopic evaluations at the hospital endoscopy unit,we used the hospital’s database as a primary data source,alongside an additional cross-relational search of the *** adult and pediatric patients were included in the *** were grouped by IBD type,phenotype,age,and *** rates were calculated with age standardization using the European standard *** in incidence and prevalence were evaluated as a 3-year moving average and average annual percentage change *** During the 10-year follow-up period,651 patients diagnosed with IBD were monitored(of whom 334,or 51.3%,were males,and 317,or 48.7%,were females).Of all the patients,346(53.1%)had been diagnosed with ulcerative colitis(UC),292(44.9%)with Crohn’s disease(CD),and 13(2%)with indeterminate colitis(IC).We observed 440 newly diagnosed patients with IBD:240(54.5%)with UC,190(43.2%)with CD,and 10(2.3%)with *** mean annual crude incidence rates were found to be 9.01/100000 population for IBD[95%confidence interval(CI):8.17-9.85],with 4.91/100000(95%CI:4.29-5.54)for UC and 3.89/100000(95%CI:3.34-4.44)for *** IBD prevalence in 2019 was 146.64/100000(95%CI:128.09-165.19),with 77.94/100000(95%CI:68.08-87.70)for UC and 65.77/100000(95%CI:54.45-74.1)for *** average annual IBD percentage change was 0.79%(95%CI:0.60-0.88),with-2.82%(95%CI:-2.67 to-2.97)for UC and

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Indeterminate colitis Epidemiology Endoscopy

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Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats

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Acta Pharmacologica Sinica 2005年第4期26卷 417-422页

作者： Giyasettin BAYDAS Ertugrul SONKAYA Mehmet TUZCU Abdullah YASAR emir DONDER Department of Physiology Department of Internal Medicine College of Medicine Firat University Department of Biology Faculty of Science Firat University Elazig 23119 Turkey Department of Physiology Department of Internal Medicine College of Medicine Firat University

Aim:To investigate the effect of gabapentin on neural [neuron-specific enolase（NSE）] and glial markers [glial fibrillary acidic protein （GFAP） and S 100B] in differ-ent brain regions of diabetic ***:Diabetes was induced by a singleintraperitoneal injection of streptozotocine （50 mg/kg body weight）.Rats in onediabetic group received gabapentin (50 ***-1.d-1) and rats in the other diabeticgroup received vehicle only for 6 *** levels of GFAP,S100B,and NSE weredetermined by immunoblotting in the hippocampus,cortex,and *** （LPO as malondialdehyde+ 4-hydroxyalkenals） and glutathione （GSH）levels were also determined in the same brain ***:Total and degradedGFAP content and S100B protein expression in different areas of brain tissuessignificantly increased in diabetic rats compared to control ***,NSElevels were also significantly elevated in hyperglycemic *** addition,therewas a significant increase in LPO levels in the diabetic rat brain compared tocontrol rat *** with gabapentin prevented the upregulation ofGFAP,S 100B,and NSE in all brain regions of diabetic *** level of LPO wasreduced,but not completely halted,by treatment with ***:These results suggest that diabetes causes glial and neuronal injury,possibly asa result of elevated oxidative stress,and that gabapentin protects neurons andglial ***,we predict that gabapentin treatment will attenuate the hippo-campal and cortical neurodegeneration observed during diabetes mellitus in rats.

关键词： gabapentin glial fibrillary acidic protein neurotrophic protein S100beta phosphopyruvate hydratase lipid peroxidation

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Citric acid cross-linked curcumin/chitosan/chickpea flour film: An active packaging for chicken breast storage

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Food Bioscience 2022年第6期50卷 1074-1082页

作者： Eda Yildiz Ayca Aydogdu emir Gulum Sumnu Leyla Nesrin Kahyaoglu Department of Food Engineering Middle East Technical UniversityAnkaraTurkey Department of Food Technology Canakkale 18 Mart UniversityCanakkaleTurkey

Since there has been an increasing interest in natural, non-toxic, and biodegradable food packages instead of plastic ones, scientists put great effort into eliminating the potential drawbacks of these biodegradable films. In this study, citric acid (CA) was utilized as a crosslinker for the films produced by chitosan (CS), chickpea flour (CF), and active agent curcumin (CUR) by a solvent casting technique. CA was introduced into the film formulations at different concentrations (0, 0.5%, 1%, 1.5% w/v), and the influence on the functional film characteristics were extensively *** CA concentration in formulation caused a reduction in water vapor permeability (WVP) of the films such that the film with the highest CA concentration (1.5-CUR/CF/CS) was 62.6% more resistant to water vapor than film without CA (0-CUR/CF/CS). When CA concentration in the film formulation was increased, elongation at break (EAB) value increased from 1.64% ± 0.13%, to 11.1%± 1.21% whereas tensile strength (TS) value decreased from 7.83± 0.08 MPa to 3.58± 0.20 MPa. Contrary to expectations, antioxidant activity of the films decreased with increasing CA concentration. X-Ray Diffraction (XRD) patterns of the films proved the amorphous nature and inhibitory characteristic of CA against retrogradation. In addition to all these, CA concentration significantly influenced Thermogravimetric analysis (TGA) pattern of the films with the increasing number of degradation stages. Besides the cross-linker characteristic of CA, it also extensively enhanced the antibacterial characteristic of the films. Films formulated with 1.5% (w/v) CA (1.5-CUR/CF/CS) showed antibacterial effect against both Escherichia coli (***) (ATCC 11229) and Staphylococcus aureus (***) (ATCC 43300). Finally, chicken breast packed with 1.5-CUR/CF/CS films remained below unacceptable microbial threshold limits even at the end of the 9th -day of storage compared to samples packaged with the film with no antibacte

关键词： Chitosan Chickpea flour Curcumin Citric acid Antimicrobial activity Chicken

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Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2004年第3期10卷 381-384页

作者： Oguzhan Okutan Zafer Kartaloglu Ahmet Ilvan Ali Kutlu Erkan Bozkanat emir Silit GATA Haydarpasa Training Hospital Department of Pulmonary DiseasesIstanbulTurkey Gumussuyu Military Hospital Department of Pulmonary DiseasesIstanbulTurkey GATA Haydarpasa Training Hospital Department of RadiologyIstanbulTurkey

AIM:To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study,PFT and HRCT were performed in all cases. RESULTS:A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients,in forced expiratory volume in one second in 8/34 patients,and in forced expiratory flow 25-75 in 15/34 patients,*** monoxide diffusing capacity (DLCO) was decreased in 26/34 *** of interstitial pulmonary involvement were detected in the HRCT of 16/34 *** difference was found between controls and patients with HCV infection in findings of HRCT (X^2=4.7,P=0.003).Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0±*** findings,PFT values and DLCO were not affected by KHAI in patients with HCV *** these patients,all the parameters were related with age. CONCLUSION:We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

关键词： Respiratory Function Tests Tomography, X-Ray Computed Adult Aged Female Hepatitis C, Chronic Humans Lung Diseases Male Middle Aged

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Experimental study on the effect of micro-carbon additives in vegetable oils for aquifer thermal energy storage

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Clean Energy 2024年第2期8卷 48-59页

作者： Takashi Suzuki Mitsuhisa Ichiyanagi emir Yilmaz Archie G.K.Maxwell Ekadewi Anggraini Handoyo Department of Engineering and Applied Sciences Sophia University7-1Kioi-choChiyoda-kuTokyo102-8554Japan Graduate School of Science and Technology Sophia University7-1Kioi-choChiyoda-kuTokyo102-8554Japan Department of Mechanical Engineering Petra Christian UniversitySiwalankerto 121-131Surabaya 60291Indonesia

Aquifer thermal energy storage is a versatile method for regulating building temperatures,utilizing groundwater as a medium for both summer cooling and winter *** has high thermal conductivity and specific heat but is corrosive,creating a mineral build-up that causes ***,its high freezing point presents operational *** oils emerge as a promising alternative,owing to their lower freezing *** light of environmental concerns,researchers are exploring vegetable oils as substitutes for petroleum-derived mineral *** paper is intended as an initial study using vegetable oils,*** and sunflower oil,as the heat-transfer medium in aquifer thermal energy *** experiments assess the heat-transfer coefficient of coconut,sunflower,mineral,and synthetic oils when exposed to the same heat *** study also evaluates the impact of introducing micro-carbon(graphite and charcoal)to the *** indicate that sunflower oil has the highest heat-transfer coefficient of 374.4 W/m^(2) K among the oils,making it suitable for aquifer thermal energy storage ***,augmenting sunflower oil with charcoal powder enhances its performance by increasing the heat-transfer coefficient to 474.9 W/m^(2) K,or a 27%*** contrast,coconut oil proves unsuitable for aquifer thermal energy storage deployment because of its low heat-transfer coefficient of 293.7 W/m^(2) *** heat-transfer coefficient of synthetic oil increases with graphite powder but decreases with charcoal powder introduction.

关键词： sunflower oil aquifer thermal energy storage charcoal graphite vegetable oil

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Total estimated effective doses from radiologic imaging modalities of children with cancer:a single center experience

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World Journal of Pediatrics 2017年第3期13卷 242-247页

作者： Derya Ozyorük Suna emir HacιAhmet Demir Gülsah Bayram Kabacam Bahattin Tunc Division of Pediatric Oncology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey Division of Radiology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey

Background:Recently,awareness of the cumulative radiation exposure for pediatric oncology patients has been increasing,together with increased survival rates and longer life *** aim of our study was to quantify the amount of ionising radiation from imaging modalities of pediatric oncology ***:Eighty-eight patients who were diagnosed with childhood cancer and followed up for 5 years between 2004-2014 in our center were included in the ***' medical files were reviewed retrospectively for imaging history in the first 5 years after *** estimated effective doses from radiologic imaging modalities were ***,the basic demographic data,histologic type,stage,and outcomes of disease were collected for all ***:The individual total estimated effective doses ranged from 8.73 to 167 mSv,with a median of 62.92 *** tomography was the greatest contributor of total effective *** doses ranged 21.45-113.20 mSv (median:62.92 mSv) in Hodgkin lymphoma,12.53-167.10 mSv (median:52 mSv) in non-Hodgkin lymphoma,4.13-172.98 mSv (median:52 mSv) in neuroblastoma,31-149.89 mSv (median:63.10 mSv) in Wilms' tumor,11.50-73.72 mSv (median:36.90 mSv) in germ cell tumor,26.46-125.86 mSv (median:80.90 mSv) in other solid tumor and 0.02-13.31 mSv (5.25 mSv) in brain tumor ***-two children (25%) died with progressive disease during the 5-year follow-up ***:Similar to previous studies,the total estimated effective doses in children with cancer have been found various according to diagnosis,stage and clinical *** clarify the harmfull effects of radiation burden,prospective studies should be conducted in children with cancer.

关键词： children effective dose ionizing radiation

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Air leak syndrome after endoscopic retrograde cholangiopancreatography:A rare and fatal complication

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World Journal of Gastroenterology 2015年第15期21卷 4770-4772页

作者： Bulent Yilmaz emir Charles Roach Seyfettin Koklu Onur Aydin Ozan Unlu Yusuf Alper Kilic Department of Gastroenterology Hacettepe University School of Medicine Department of General Surgery Hacettepe University School of Medicine

Endoscopic retrograde cholangiopancreatography(ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air leak syndrome has rarely been reported in association with ERCP and the optimal management of this serious conditioncan be difficult to establish. Our group successfully managed a case of air leak syndrome following ERCP which was caused by a 3cm Stapfer type I perforation in the posterolateral aspect of the second part of the duodenum and was repaired surgically. Hereby, we describe the presentation and subsequent therapeutic approach.

关键词： Air leak syndrome Endoscopic retrogradecholangiopancreatography Complication Perforation Stapfer

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Reading History From Literature： July 1941

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Cultural and Religious Studies 2016年第7期4卷 452-457页

作者： Badegul CAN emir Karadeniz Technical University Trabzon Turkey

The science of history studies past events based on certain documents. A significant part of these documents consists of literary works which reveal a documentary nature by reflecting the period when they were written. Then it is safe to say that literary works play an effective role in terms of history teaching by carrying the features of a certain period in a nation＇s history with the realities depicted in them. On the contrary, depicting problems in literary works in terms of their socio-cultural and psychological effects on people and societies may produce a more effective history teaching then considering these problems in history books only in terms of their causes and effects. Especially the literary works centered on historical events generally serve as an integral part of history teaching. The best examples are the historical novels which are themed and plotted on a war-centered history. This paper undertakes to study the role of literature in communicating historical events and providing history teaching by considering one of the historical novels, namely ＂July 1941＂ by Grigory Baldanov.

关键词： history literary work Grigory Baklanov historical novel July 1941

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