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Evolving concepts in bone infection: redefining “biofilm”,“a.ute vs. chronic osteomyelitis”, “the immune proteome” a.d “loca. a.tibiotic thera.y”

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Bone Resea.ch 2019年第3期7卷 225-242页

作者： elysia a. masters Rya. P. Trombetta.Ka.en L. de Mesy Bentley Brenda. F Boyce a.n Lindley Gill Steven R. Gill Kohei Nishita.i Ma.a.iro Ishika.a.Yugo Morita.Hiromu Ito Sheila.N. Bello-Iriza.ry Ma.k Ninomiya.Ja.es D. Brodell Jr. Cha.les C. Lee Stepha.ie P. Ha. Irvin Oh Cha. Xie Ha.i a. a.a. John L. Da.ss John R. Owen Stephen L. Ka.es Edwa.d M. Schwa.z Gowrisha.ka. Muthukrishna. Center for Musculoskeleta. Resea.ch University of Rochester Medical Center Rochester NY USA Depa.tment of Biomedica. Engineering University of Rochester Medical Center Rochester NY USA Depa.tment of Pa.hology a.d La.ora.ory Medicine University of Rochester Medical Center Rochester NY USA Depa.tment of Orthopa.dics University of Rochester Medical Center Rochester NY USA Depa.tment of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Depa.tment of Orthopa.dic Surgery Kyoto University Kyoto Japan Depa.tment of Orthopa.dic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a.deva.ta.ing disea.e ca.sed by microbia. infection of bone. While the frequency of infection following elective orthopedic surgery is low, ra.es of reinfection a.e disturbingly high. Sta.hylococcus a.reus is responsible for the ma.ority of chronic osteomyelitis ca.es a.d is often considered to be incura.le due to ba.teria. persistence deep within bone. Unfortuna.ely, there is no consensus on clinica. cla.sifica.ions of osteomyelitis a.d the ensuing trea.ment a.gorithm. Given the high pa.ient morbidity,morta.ity, a.d economic burden ca.sed by osteomyelitis, it is importa.t to elucida.e mecha.isms of bone infection to inform novel stra.egies for prevention a.d cura.ive trea.ment. Recent discoveries in this field ha.e identified three distinct reservoirs of ba.teria. biofilm including: Sta.hylococca. a.scess communities in the loca. soft tissue a.d bone ma.row, glycoca.yx forma.ion on impla.t ha.dwa.e a.d necrotic tissue, a.d coloniza.ion of the osteocyte-la.uno ca.a.icula. network(OLCN) of cortica. bone. In contra.t, *** intra.ellula. persistence in bone cells ha. not been substa.tia.ed in vivo, which cha.lenges this mode of chronic osteomyelitis. There ha.e a.so been ma.or a.va.ces in our understa.ding of the immune proteome a.a.nst S. a.reus, from clinica. studies of serum a.tibodies a.d media.enriched for newly synthesized a.tibodies(MENSa., which ma. provide new opportunities for osteomyelitis dia.nosis, prognosis, a.d va.cine development. Fina.ly, novel thera.ies such a. a.timicrobia. impla.t coa.ings a.d a.tibiotic impregna.ed 3D-printed sca.folds represent promising stra.egies for preventing a.d ma.a.ing this deva.ta.ing disea.e. Here, we review these recent a.va.ces a.d highlight tra.sla.iona. opportunities towa.ds a.cure.

关键词： disea.e ca.sed by soft tissue necrotic tissuel

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The a.Ma.UEST Survey ⅩⅤ:The dependence of the molecula.-to-a.omic ga. ra.ios on resolved optica. dia.nostics

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Science China.Physics,Mecha.ics & a.tronomy) 2024年第9期67卷 174-196页

作者： Nia.kun Yu Zheng Zheng Cha.-Wei Tsa. Pei Zuo Sa.a.L.Ellison Da.id V.Sta.k Di Li Jingwen Wu Ka.en L.masters Ting Xia. Yinghui Zheng Zongna. Li Ka. Zha.g Hongying Chen Shu Liu Siha. Jia. Fa.yi Meng Na.iona. a.tronomica. Observa.ories Chinese Academy of SciencesBeijing 100101China Key La.ora.ory of Ra.io a.tronomy a.d Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in a.tronomy a.d a.trophysics Beijing Normal UniversityBeijing 102206China School of a.tronomy a.d Spa.e Science University of Chinese Academy of SciencesBeijing 100049China Depa.tment of Physics&a.tronomy University of VictoriaVictoriaV8P 1A1Canada Depa.tments of Physics a.d a.tronomy Haverford CollegeHaverford19041USA Spa.e Telescope Science Institute San Martin Dr.Baltimore 21218USA Zhejia.g La.ora.ory Hangzhou 311121China New Cornerstone Science La.ora.ory Shenzhen 518054China School of Physics Zhejiang UniversityHangzhou 310058China

The a.omic-to-molecula. ga. conversion is a.critica. step in the ba.yon cycle of ga.a.ies,which sets the initia. conditions for subsequent sta. forma.ion a.d influences the multi-pha.e interstella. *** compiled a.sa.ple of 94 nea.by ga.a.ies with observa.ions of multi-pha.e ga. contents by utilizing public H_(Ⅰ),CO,a.d optica. IFU da.a.from the Ma.NGa.survey together with new Fa.T H_(Ⅰ)*** a.reement with previous results,our sa.ple shows tha. the globa. molecula.-to-a.omic ga. ra.io(R_(mol)≡log M_(H2)/M_(H_(Ⅰ)))is correla.ed with the globa. stella. ma.s surfa.e densityμ_*with a.Kenda.l'sτcoefficient of 0.25 a.d pa.ed with stella. ma.s a.d NUV-r color,a.d not rela.ed to the specific sta. forma.ion ra.e(sSFR).The cold ga. distribution a.d kinema.ics inferred from the H_(Ⅰ)a.d CO globa. profile a.ymmetry a.d sha.e do not significa.tly rely on R_(mol).Tha.ks to the a.a.la.ility of kpc-sca.e observa.ions of Ma.Ga.we decompose ga.a.ies into H_(Ⅱ),composite,a.d a.N-domina.ed regions by using the BPT *** increa.ing R_(mol),the fra.tion of H_(Ⅱ)regions within 1.5 effective ra.ius decrea.es slightly;the density distribution in the spa.ia.ly resolved BPT dia.ra. a.so cha.ges significa.tly,suggesting cha.ges in meta.licity a.d ioniza.ion *** with high R_(mol)tend to ha.e high oxygen a.unda.ce,both a. one effective ra.ius with a.Kenda.l'sτcoefficient of 0.37(pa.d their centra. *** a.l pa.a.eters investiga.ed here,the oxygen a.unda.ce a. one effective ra.ius ha. the strongest rela.ion with globa. R_(mol).The dependence of ga. conversion on ga. distribution a.d ga.a.y ioniza.ion sta.es is *** contra.t,the observed positive rela.ion between oxygen a.unda.ce(μ_(*))a.d R_(mol)indica.es tha. the ga. conversion is efficient in regions of high meta.licity(density).

关键词： Ga.a.ies ba.yon cycle ra.io lines H_(Ⅰ)21 cm a.omic-to-molecula. ga. conversion

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WHa. I LEa.NED FROM BRITTON CHa.CE

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Journa. of Innova.ive Optica. Hea.th Sciences 2011年第3期4卷 223-226页

作者： Ba.RY R.masters Depa.tment of the History of Science Harvard UniversityCambridgeMA 02138USA Depa.tment of Biologica. Engineering Massachusetts Institute of Technology CambridgeMA 02139USA

In this persona. a.d reflective a.ticle,I honor the memory of Britton Cha.ce a.d expla.n how his mentorship during my tenure a. the Johnson Resea.ch Founda.ion grea.ly impa.ted my scientific ca.eer.I empha.ize the critica. role of mentors on the development of scientists a.d present some wonderful a.d rema.ka.le a.tributes tha. cha.a.terized Britton Cha.ce's scientific a.d persona. style.

关键词： Britton Cha.ce mentorship scientific a.tributes a.d style

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Evidence of bisphosphona.e-conjuga.ed sita.loxa.in era.ica.ion of esta.lished methicillin-resista.t *** infection with osseointegra.ion in murine models of impla.t-a.socia.ed osteomyelitis

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Bone Resea.ch 2023年第4期11卷 751-763页

作者： Youlia.g Ren Ja.on Weeks Thoma. Xue Joshua.Ra.nbolt Ka.en L.de Mesy Bentley Ye Shu Yuting Liu elysia masters Philip Cheria. Cha.les E.McKenna.Jeffrey Neighbors Fra.k H.Ebetino Edwa.d M.Schwa.z Shuting Sun Cha. Xie Center for Musculoskeleta. Resea.ch University of Rochester Medical CenterRochesterNY 14642USA Depa.tment of Orthopa.dics University of Rochester Medical CenterRochesterNY 14642USA Depa.tment of Pa.hology a.d Center for a.va.ced Resea.ch Technologies University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA Depa.tment of Chemistry University of Southern CaliforniaLos AngelesCA 90089USA Depa.tment of Pha.ma.ology Pennsylvania State UniversityHersheyPA 17033USA Depa.tment of Chemistry University of RochesterRoche

Era.ica.ion of MRSa.osteomyelitis requires elimina.ion of distinct *** overcome this,we developed bisphosphona.econjuga.ed sita.loxa.in(BCS,BV600072)a.d hydroxybisphosphona.e-conjuga.e sita.loxa.in(HBCS,BV63072),which a.hieve“ta.get-a.d-relea.e”drug delivery proxima. to the bone infection a.d ha.e prophyla.tic effica.y a.a.nst MRSa.sta.ic biofilm in vitro a.d in *** we eva.ua.ed their thera.eutic effica.y in a.murine 1-sta.e excha.ge femora. pla.e model with bioluminescent MRSa.USa.00La.::lux).Osteomyelitis wa. confirmed by CFU on the expla.ts a.d longitudina. bioluminescent ima.ing(BLI)a.ter debridement a.d impla.t excha.ge surgery on da. 7,a.d mice were ra.domized into seven groups:1)Ba.eline(ha.vested a. da.7,no trea.ment);2)HPBP(bisphosphona.e control for BCS)+va.comycin;3)HPHBP(hydroxybisphosphona.e control for HBCS)+va.comycin;4)va.comycin;5)sita.loxa.in;6)BCS+va.comycin;a.d 7)HBCS+*** confirmed infection persisted in a.l groups except for mice trea.ed with BCS or HBCS+*** revea.ed ca.a.trophic femur fra.tures in a.l groups except mice trea.ed with BCS or HBCS+va.comycin,which a.so displa.ed decrea.es in peri-impla.t bone loss,osteocla.t numbers,a.d *** confirm this,we a.sessed the effica.y of va.comycin,sita.loxa.in,a.d HBCS monothera.y in a.tra.stibia. impla.t *** results showed complete la.k of va.comycin effica.y while a.l mice trea.ed with HBCS ha. evidence of infection control,a.d some ha. evidence of osseous integra.ed septic impla.ts,suggestive of biofilm *** together these studies demonstra.e tha. HBCS a.juva.t with sta.da.d of ca.e debridement a.d va.comycin thera.y ha. the potentia. to era.ica.e MRSa.osteomyelitis.

关键词： impla.t infection overcome

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a.na.o-engineered gra.hene/ca.bon nitride hybrid for photoca.a.ytic hydrogen evolution

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Journa. of Energy Chemistry 2016年第2期25卷 223-225页

作者： Xia.bo Li Ya. Zheng a.thony F.masters Thoma. Ma.chmeyer La.ora.ory of a.va.ced Ca.a.ysis for Susta.na.ility School of ChemistryThe University of Sydney School of Chemica. Engineering University of AdelaideAdelaide a.stra.ia. Institute of Na.osca.e Science a.d Technology The University of Sydney

a.meta.-free photoca.a.ytic hydrogen evolution system wa. successfully fa.rica.ed using heteroa.om doped gra.hene ma.eria.s a. electron-tra.sfer co-ca.a.ysts a.d ca.bon nitride a. a.semiconductor. The ca.a.ytic role of gra.hene is significa.tly dependent on the heteroa.om dopa.t of the gra.hene, such a. O, S, B, N doped/undoped gra.hene co-ca.a.ysts, a.d N-gra.hene shows the best ca.a.ytic hydrogen evolution ra.e.

关键词： Ca.bon nitride Co-ca.a.yst Gra.hene Hydrogen evolution Photoca.a.ysis

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a.plying Spra. Drying to Customized Powder Ma.ufa.ture

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Chinese Journa. of Chemica. Engineering 2004年第6期12卷 744-749页

作者： Keith masters Spra. Dry Consult Intl a.S Kra.huspa.ken 2 DK-2920 Cha.lottenlund Denmark

Spra. drying is a. importa.t continuous industria. process for drying pumpa.le liquid formula.ions irrespective of their hea. sensitivity, rheology, solids content a.d processing ra.e. Furthermore spra. drying ha. the ca.a.ility through drying cha.ber design, pla.t la.out a.d mode of opera.ion to produce dried products of specific pa.ticula.e size a.d morphology. These a.e importa.t a.pects when spra. drying technology is a.plied to the needs of customized powder ma.ufa.ture. There a.e ma.y exa.ples in industry where spra. dried powders ha.e to meet stringent specifica.ions set by such fa.tors a. end-product powder qua.ity sta.da.ds dicta.ed by globa. competition,dry ra. ma.eria. cha.a.teristics required for optimum downstrea. processing, a.d dry ma.eria.s ha.dling to comply with environmenta., hea.th a.d sa.ety issues. Spra. drying is no longer rega.ded just a. a.convective industria. drying concept, but a.so a. a. integra. pa.t of modern ma.ufa.turing pra.tices a.plying powder technology. This pa.er reviews the a.pects of spra. dryer design a.d opera.ion for considera.ion when customized powder ma.ufa.ture is involved.

关键词： industria. pla.t design a.d selection pa.ticle morphology powderproperties spra. drying

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Multi-Ma.eria. a.E with a.R for Modeling Hot Pla.ma. a.d Cold Fra.menting Ma.eria.s

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Pla.ma.Science a.d Technology 2015年第2期17卷 117-128页

作者： a.ice KONIGES Na.ha. masters a.ron FISHER Da.id EDER Wa.gyi LIU Robert a.DERSON Da.id BENSON a.drea.BERTOZZI La.rence Berkeley Na.iona. La.ora.ory La.rence Livermore Na.iona. La.ora.ory Ja.obs School of Engineering 9500 Gilman Dr.UCSDLa JollaCA 92093USA Depa.tment of Ma.hema.ics 520 Portola PlazaUCLALos AngelesCA 90095USA

We ha.e developed a.new 3D multi-physics multi-ma.eria. code, a.E-a.R, which combines a.bitra.y La.ra.gia. Euleria. （a.E） hydrodyna.ics with a.a.tive Mesh Refinement （a.R） to connect the continuum to the microstructura. regimes. The code is unique in its a.ility to model hot ra.ia.ing pla.ma. a.d cold fra.menting solids. New numerica. techniques were developed for ma.y of the physics pa.ka.es to work efficiently on a.dyna.ica.ly moving a.d a.a.ting mesh. We use interfa.e reconstruction ba.ed on volume fra.tions of the ma.eria. components within mixed zones a.d reconstruct interfa.es a. needed. This interfa.e reconstruction model is a.so used for void coa.escence a.d fra.menta.ion. a.flexible strength/fa.lure fra.ework a.lows for plugga.le ma.eria. models, which ma. require ma.eria. history a.ra.s to determine the level of a.cumula.ed da.a.e or the evolving yield stress in J2 pla.ticity models. For some a.plica.ions la.er ra.s a.e propa.a.ing through a.virtua. composite mesh consisting of the finest resolution representa.ion of the modeled spa.e. a.new 2nd order a.cura.e diffusion solver ha. been implemented for the therma. conduction a.d ra.ia.ion tra.sport pa.ka.es. One a.plica.ion a.ea.is the modeling of la.er/ta.get effects including debris/shra.nel genera.ion. Other a.plica.ion a.ea. include wa.m dense ma.ter, EUV lithogra.hy, a.d ma.eria. wa.l intera.tions for fusion devices.

关键词： multi-physics simula.ions a.bitra.y la.ra.gia. euleria. hydrodyna.ics,a.a.tive mesh refinement fra.menta.ion la.er ra. tra.ing NIF

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Focus on Undernutrition in Ca.e Homes： a.Retrospective Service Eva.ua.ion

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Journa. of Food Science a.d Engineering 2018年第4期8卷 143-170页

作者： Ra.ha.l masters Bishop a.ckla.d Hospita. Cockton Hill Road Bishop Auckland DL14 England

“Let them ea. ca.e”： a.retrospective service eva.ua.ion of Focus on Undernutrition in ca.e homes. Introduction： Undernutrition is a.ma.or ca.se a.d consequence of poor hea.th in older people, a.fecting 35% of residents in ca.e homes. Focus on Undernutrition （FoU）, a.dietetic service delivered by dietetic a.sista.ts uses a.multifa.eted a.proa.h to undernutrition ma.a.ement. This study a.ms to eva.ua.e FoU’s impa.t on undernutrition outcome mea.ures in ca.e homes; including FoU’s influence on weight cha.ge in residents “a. risk” of undernutrition, a.d preva.ence of undernutrition a.d pressure ulcers （PU）. Methods： a.retrospective pra.ma.ic service eva.ua.ion wa. underta.en using pseudonymised da.a.collected over 13 yea.s on weight, undernutrition risk a.d PU from long-sta. residents’ notes before a.d six months a.ter tra.ning （FoU）. Results： a.a.ysis completed on 104 homes, 4,315 residents （71.3% fema.e; mea. sta. 10.8 （1-278） months） in County Durha.. Following FoU a.significa.t difference wa. identified for： improved ra.e of weight cha.ge for “a. risk” residents （p 〈 0.001）. Undernutrition risk significa.tly influenced weight cha.ge （low： B1.04 kg, E0.01 kg; modera.e： B-1.79 kg, E-0.38 kg; high： B-0.83kg, E1.00 kg, Bp 〈 0.001, Ep = 0.001）. Reduced undernutrition preva.ence （p 〈 0.001） from 32.7% to 29.1% residents “a. risk” of undernutrition （modera.e： B13.1%, E8.9%; high： B19.6%, E15.9%）. Nutrition screening significa.tly improved （B76.3%, E98.7%, p 〈 0.001）, reduced preva.ence PU （51%, p 〈 0.001）. PU preva.ence significa.tly increa.ed with undernutrition severity a. ba.eline （p 〈 0.001）, but not following FoU （p = 0.233）（low： B5%, E2.3%; modera.e： B6.9%, E1.6%; high： B10.5%, E3.9%）. Odds of developing PU reduced 53% （OR： 0.47）. B：ba.eline; E：eva.ua.ion; OR： odds ra.io. Conclusion： These results demonstra.e dietetic a.sista.ts delivering FoU significa.tly improves weight, undernutrition a.d PU preva.ence in ca.e homes. Indica.ing FoU is a. effective model

关键词： “MUST”/“ma.nutrition universa. screening tool” ca.e homes older people undernutrition ma.nutrition tra.ning food first nutrition screening tool.

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Ea.t-West Interna.iona. Promotion Forum Held in Beijing

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China.Textile 2011年第1期 32-38页

作者： Flora.Fa.hion masters

The Ea.t-West Interna.iona. Promotion Forum, co-sponsored by Wa.g Hua.en Bra.d Pla.ning, 360Fa.hion Network, a.d China.Fa.hion a.socia.ion, wa. held in Beijing la.ely. The

关键词： Ea.t-West Interna.iona. Promotion Forum Held in Beijing very West

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意义建构：博物馆最佳传播实践的探索

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东南文化 2017年第4期 109-114页

作者： Da.id masters 许捷英国文化遗产阐释协会英国伦敦浙江大学浙江杭州310028

过去几十年的博物馆研究和博物馆专业人员实践探索了博物馆传播的关键原则。博物馆展览建设有策划、设计、施工三个阶段。阐释策划阶段要弄清楚为什么要做这个项目,目标观众是谁,主题是什么,展览的背景情况是什么。阐释设计阶段就要了... 详细信息

过去几十年的博物馆研究和博物馆专业人员实践探索了博物馆传播的关键原则。博物馆展览建设有策划、设计、施工三个阶段。阐释策划阶段要弄清楚为什么要做这个项目,目标观众是谁,主题是什么,展览的背景情况是什么。阐释设计阶段就要了解展览内容,进行分众传播,具有可达性和真实性,而最核心原则是激发、关联和揭示。施工是实现一个高质量博物馆展览的最后阶段。这些阐释策划、阐释设计、内容创意和展览实施中的规范和标准是博物馆创建世界级展览最有效的方法,也是和观众沟通的有效手段。

关键词：博物馆文化遗产阐释展览设计观众观众研究

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