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The use of blue-light cystoscopy in the detection and surveillance of nonmuscle invasive bladder cancer

Current Urology 2022年第3期16卷 121-126页

作者： ellen m.cahill Kevin Chua Sai Krishnaraya Doppalapudi Saum Ghodoussipour Rutgers Robert Wood Johnson medical School New BrunswickNJUSA Section of Urologic Oncology Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08903-2681USA

Nonmuscle invasive bladder cancer is associated with a high risk of recurrence as well as progression to muscle-invasive ***,adequate visualization and identification of malignant lesions as well as complete resection are *** white-light cystoscopy is limited in its ability to detect bladder cancer,specifically carcinoma in ***-light cystoscopy makes use of the intravesical instillation of a heme precursor to differentiate areas of malignancy from normal tissue.A narrative review of the literature on the use of blue-light cystoscopy in bladder cancer was ***-light cystoscopy has been shown in several randomized clinical trials to increase detection of Ta,T1,and carcinoma in situ,as well as reduce risk of recurrence at 12 months as compared with traditional white-light *** into the effects of blue-light cystoscopy on risk of disease progression has produced mixed results,in part due to changing definitions of ***,more recent research suggests a correlation with decreased risk of *** the use of blue-light was initially limited to rigid cystoscopy in the operating room,results from a recent randomized clinical trial showing enhanced detection of recurrent disease using blue-light in-office surveillance flexible cystoscopy have led to expanded Food and Drug Administration ***,blue-light cystoscopy offers promise as an enhancement to white-light cystoscopy for the detection of nonmuscle invasive bladder cancer and may yield additional benefits in reducing disease recurrence and *** prospective research is needed to evaluate the true benefit of blue-light cystoscopy in terms of disease progression as well as the cost-effectiveness of this technique.

关键词： Nonmuscle invasive bladder cancer Blue-light cystoscopy White-light cystoscopy

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Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity

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Journal of molecular Cell Biology 2015年第2期7卷 168-179页

作者： Wu Wu mona N.Rahman Jun Guo Natalie Roy Lihua Xue Catherine m.cahill Shetuan Zhang Zongchao Jia Department of Biomedical and molecular Sciences Queen’s UniversityKingstonOntario K7L 3N6Canada Department of Anesthesiology&Perioperative Care University of California IrvineIrvineCAUSA

Otoferlin,an integral membrane protein implicated in a late stage of exocytosis,has been reported to play a critical role in hearing although the underlying mechanisms remain ***,its widespread tissue distribution infers a more ubiquitous role in synaptic vesicle ***,an excitatory neurotransmitter,is converted to its inhibitory counterpart,g-aminobutyric acid(GABA),by L-glutamic acid decarboxylase(GAD),which exists in soluble(GAD67)and membrane-bound(GAD65)*** the first time,we have revealed a close association between otoferlin and GAD65 in both HEK293 and neuronal cells,including SHSY5Y neuroblastoma and primary rat hippocampus cells,showing a direct interaction between GAD65 and otoferlin’s C2 *** primary rat hippocampus cells,otoferlin and GAD65 co-localized in a punctate pattern within the cell body,as well as in the axon along the path of vesicular ***,GABA is virtually abolished in otoferlin-knockdown neuronal cells whereas otoferlin overexpression markedly increases endogenous *** attenuation in otoferlin-knockdown primary cells is correlated with diminished L-type calcium *** previously unknown and close correlation demonstrates that otoferlin,through GAD65,modulates GABAergic *** discovery of otoferlin–GAD65 functional coupling provides a newavenue for understanding the molecular mechanism by which otoferlin functions in neurological pathways.

关键词： otoferlin GAD65 GABA neurotransmitter exocytosis

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modeling regional landslide susceptibility using dynamic soil moisture profiles

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Journal of mountain Science 2018年第8期15卷 1807-1824页

作者： RAY Ram L JACOBS Jennifer m DOUGLAS ellen m Cooperative Agricultural Research Center College of Agriculture and Human Sciences Prairie View A&M University Department of Civil Engineering University of New Hampshire Environmental Earth and Ocean Sciences Department University of Massachusetts Boston

A landslide susceptibility mapping study was performed using dynamic hillslope hydrology. The modified infinite slope stability model that directly includes vadose zone soil moisture(Sm) was applied at Cleveland Corral, California, US and Krishnabhir, Dhading, Nepal. The variable infiltration capacity(VIC-3L) model simulated vadose zone soil moisture and the wetness index hydrologic model simulated groundwater(GW). The GW model predictions had a 75% NASH-Sutcliffe efficiency when compared to California's in-situ GW measurements. The model performed best during the wet season. Using predicted GW and VIC-3L vadose zone Sm, the developed landslide susceptibility maps showed very good agreement with mapped landslides at each study region. Previous quasi-dynamic model predictions of Nepal's hazardous areas during extreme rainfall events were enhanced to improve the spatial characterization and provide the timing of hazardous conditions.

关键词： Landslide susceptibility Vadose zone Soil moisture Infiltration eapacity VIC-3L Groundwater

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Synchronization of Weighted Essentially Non-Oscillatory methods

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Communications in Computational Physics 2008年第6期4卷 56-71页

作者： ellen m.Taylor m.Pino martin Department of mechanical and Aerospace Engineering Princeton UniversityPrincetonNJ 08544USA

Weighted essentially non-oscillatory(WENO)methods have been developed to simultaneously provide robust shock-capturing in compressible fluid flow and avoid excessive damping of fine-scale flow features such as *** certain conditions in compressible turbulence,however,numerical dissipation remains unacceptably high even after optimization of the linear component that dominates in smooth *** the nonlinear error that remains,we demonstrate that a large fraction is generated by a“synchronization deficiency”that interferes with the expression of theoretically predicted numerical performance characteristics when the WENO adaptation mechanism is *** deficiency is illustrated numerically in simulations of a linearly advected sinusoidal wave and the Shu-Osher problem[***.,83(1989),pp.32-78].It is shown that attempting to correct this deficiency through forcible synchronization results in violation of *** conclude that,for the given choice of candidate stencils,the synchronization deficiency cannot be adequately resolved under the current WENO smoothness measurement technique.

关键词： Direct numerical simulation large eddy simulation compressible turbulence shock capturing.

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Physical activity during pregnancy and the role of theory in promoting positive behavior change:A systematic review

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Journal of Sport and Health Science 2017年第2期6卷 198-206页

作者： Erika L.Thompson Cheryl A.Vamos ellen m.Daley Department of Community and Family Health University of South Florida Tampa FL 33612 USA

Background: Physical activity(PA) during pregnancy provides physical and psychological benefits for mother and child. U.S. guidelines recommend ≥30 min of moderate exercise for healthy pregnant women most days of the week; however, most women do not meet these recommendations. Theory assists in identifying salient determinants of health behavior to guide health promotion interventions; however, the application of theory to examine PA among pregnant women has not been examined cohesively among multiple levels of influence(e.g.,intrapersonal, interpersonal, neighborhood/environmental, and organizational/political). Subsequently, this systematic review aims to identify and evaluate the use of health behavior theory in studies that examine PA during ***: Articles published before July 2014 were obtained from Pub med and Web of Science. Inclusion criteria applied were:(1) empiricallybased;(2) peer-reviewed;(3) measured factors related to PA;(4) comprised a pregnant sample; and(5) applied theory. Fourteen studies were included. Each study's application of theory and theoretical constructs were ***: Various theories were utilized to explain and predict PA during pregnancy; yet, the majority of these studies only focused on intrapersonal level determinants. Five theoretical frameworks were applied across the studies—all but one at the intrapersonal level. Few determinants identified were from the interpersonal, neighborhood/environmental, or organizational/political ***: This systematic review synthesized the literature on theoretical constructs related to PA during pregnancy. Interpersonal, community,and societal levels remain understudied. Future research should employ theory-driven multi-level determinants of PA to reflect the interacting factors influencing PA during this critical period in the life course.

关键词： Physical activity Pregnancy Theory

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G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

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World Journal of Gastroenterology 2019年第30期25卷 4092-4104页

作者： Damian Jacenik ellen J Beswick Wanda m Krajewska Eric R Prossnitz Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Internal medicine School of Medicineand UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueNM 87131United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineUniversity of UtahSalt Lake CityUT 84132United States

Estrogens play important roles in the development and progression of multiple tumor *** evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly *** on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative *** is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC ***,multiple lines of evidence suggest that GPER may play an important role in colorectal *** this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC.

关键词： G protein-coupled estrogen receptor Colorectal cancer Proliferation migration Colonic motility Inflammatory bowel disease

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Assessing animal individuality:links between personality and laterality in pigs

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Current Zoology 2019年第5期65卷 541-551页

作者： Charlotte GOURSOT Sandra DUPJAN ellen KANITZ Armin TUCHSCHERER Birger PUPPE Lisette m.C.LELIVELD Institute of Behavioural Physiology Leibniz Institute for Farm Animal Biology(FBN)Wilhelm-Stahl-Allee 2D-18196 DummerstorfGermany Institute of Genetics and Biometry Leibniz Institute for Farm Animal Biology(FBN)Wilhelm-Stahl-Allee 2D-18196 DummerstorfGermany Behavioural Sciences Faculty of Agricultural and Environmental SciencesUniversity of RostockJustus-von-Liebig-Weg 6BRostock D-18059Germany

Animal individuality is challenging to explain because individual differences are regulated by multiple selective forces that lead to unique combinations of *** instance,the study of personality,a core aspect of individuality,may benefit from integrating other factors underlying individual differences,such as lateralized cerebral ***,the approach-withdrawal hypothesis(the left hemisphere controls approach behavior,the right hemisphere controls withdrawal behavior),may account for differences in boldness or exploration between left and right hemispheric dominant *** analyze the relationships between personality and laterality we tested 80 male piglets with established laterality patterns for 2 motor functions(tail curling direction and the side of the snout used for manipulation)and a combined classification integrating both motor functions using cluster *** analyzed basal salivary testosterone and cortisol along with their behavior in standardized tests as pre-established indicators of different personality traits(Boldness,Exploration,Activity,Sociability,and Coping).We found that the direction of the single motor biases showed significant associations with few personality ***,the combined laterality classification showed more,and more robust,significant associations with different personality traits compared with the single motor *** results supported the approachwithdrawal hypothesis because right-biased pigs were bolder and more explorative in a context of ***,right-biased pigs were more sociable than left-biased ***,the present study indicates that personality is indeed related to lateralized cerebral processing and provides insight into the multifactorial nature of individuality.

关键词： approach-withdrawal hypothesis coping emotion hemispheric dominance motor lateralization temperament

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Disaster Risk management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-Paul Pinelli maria Esteva ellen m.Rathje David Roueche Scott J.Brandenberg Gilberto mosqueda Jamie Padgett Frederick Haan Department of mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

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Sleep disturbances as an adverse effect of propranolol use in children with infantile hemangioma

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World Journal of Pediatrics 2020年第5期16卷 537-538页

作者： ellen m.S.Xerfan monica L.Andersen Anamaria S.Facina Sergio Tufik Jane Tomimori Programa de Pós-Gradua(c)(a)o em medicina Translacional Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Dermatologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Psicobiologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil

Infantile hemangiomas(IHs)are the most prevalent benign vascular tumor in children,with an estimated rate of 5-10%.most IHs resolve spontaneously after the proliferation stage,but about 12-24%develop with sequelae and complications which require pharmacological interventions[1].The beta blocker propranolol is considered as the first-line treatment for complicated cases of IHs[2].

关键词： propranolol children effect

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流体-固体相互作用、碰撞和起飞的建模

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Acta mechanica Sinica 2023年第5期39卷 1-12页

作者： Frank T.Smith ellen m.Jolley Ryan A.Palmer Department of mathematics University College LondonLondonUK School of Biological Sciences University of BristolBristolEngland School of mathematics University of BristolBristolEngland

本文是流体-固体相互作用机制方面的最新进展综述,主要研究固体物体自身的运动与其周围流体运动之间的相互影响.非稳态相互作用的数学模型是对两个空间维度和时间尺度的内部通道和外部近壁流的描述.本文重点描述伴随计算量减少的分析发... 详细信息

本文是流体-固体相互作用机制方面的最新进展综述,主要研究固体物体自身的运动与其周围流体运动之间的相互影响.非稳态相互作用的数学模型是对两个空间维度和时间尺度的内部通道和外部近壁流的描述.本文重点描述伴随计算量减少的分析发展过程.文章讨论无黏性流中掠过和下沉、物体的起飞、飞离或弹跳,以及黏性效应,特别是黏性和无黏性之间的相互作用和影响.主要研究结果涉及撞击时间、起飞条件、撞击和飞离之间的边界、主要参数及其范围以及物体形状和质量对物理及力学机制的影响.

关键词： Fluid-body interactions Skimming Impacts Analysis

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