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Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut EA Lundin Ciaran P Kelly David S Sanders Kristina chen Sheena Kayaniyil Sisi Wang Rajvi J Wani Caitlin Barrett Shakira Yoosuf ellen S Pettersen Robert Sambrook Daniel A Leffler K.G.Jebsen Coeliac Disease Research Centre University of OsloOslo 0450Norway Department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel Deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence Strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence Strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUND Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United States,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before December 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of December 31,2017).RESULTS A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(SD)17.2].Patients were followed-up for a mean of 29.9 mo(SD 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in Norway and patients in the United States had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

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Outcomes of pregnancy in patients with known Budd-Chiari syndrome

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World Journal of Hepatology 2017年第21期9卷 945-952页

作者： Faisal Khan Ian Rowe Bill Martin ellen Knox Tracey Johnston Charlie Elliot Will Lester Frederick chen Simon Olliff Homoyon Mehrzad Zergham Zia Dhiraj Tripathi Liver Unit Queen Elizabeth Hospital Birmingham Women’s Hospital Pulmonary Vascular Disease Unit Royal Hallamshire Hospital Haematology and Thrombophilia Centre Queen Elizabeth Hospital Interventional Radiology Queen Elizabeth Hospital

AIM To analyse the risk of pregnancy(a prothrombotic state) in patients with Budd-Chiari Syndrome(BCS). METHODS Retrospective study of pregnancy in women with known BCS at single center from January 2001 to December 2015. RESULTS Out of 53 females with BCS, 7 women had 16 pregnancies. Median age at diagnosis of BCS in these women was 25 years(range 21-34 years). At least one causal factor for BCS was identified in 6 women(86%). Six women had undergone radiological decompressive treatment. All patients had anticoagulation. Six fetuses were lost before 20 wk gestation in 2 women. There were 9 deliveries over 32 wk gestation and one delivery at 27 wk. All infants did well. Seven babies were born by emergency caesarean section. There were no cases of thrombosis. Two patients had notable vaginal(PV) bleeding in 3 pregnancies. None of the patients had variceal haemorrhage. Two patients were diagnosed with pulmonary hypertension, one during pregnancyand the other in the post-partum period. There was no maternal *** Maternal outcomes in patients with treated BCS are favourable and fetal outcomes beyond 20 wk gestation are good. There has been increased rate of caesarean section. Pulmonary hypertension is an important finding that needs further validation. These patients should be managed in centers experienced in treating high-risk pregnancies.

关键词： Budd-Chiari syndrome Pregnancy Portal hypertension Pulmonary hypertension Thrombophilia

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欧洲渔业政策、社会科学研究:21世纪面临的挑战

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中国渔业经济 2011年第2期29卷 42-50页

作者： David Symes ellen Hoefnagel 陈自荣（译） Department of Geography University of Hull Hull HU6 7RX UK. LEI/Wageningen UR PO Box 29703 2502 LS The Hague The Netherlands 中国水产科学研究院渔业工程研究所渔港与渔场工程研究室 100141

本文为英国赫尔大学地理学院David Symes发表在Maine Policy 2010年第34卷268-275页文章的中译文。在扩展欧洲渔业政策的科学基础过程中,尽管生态系统方法和经济建模得到显著运用,社会科学对于政策有关的研究作用仍不甚明显。在有关体... 详细信息

本文为英国赫尔大学地理学院David Symes发表在Maine Policy 2010年第34卷268-275页文章的中译文。在扩展欧洲渔业政策的科学基础过程中,尽管生态系统方法和经济建模得到显著运用,社会科学对于政策有关的研究作用仍不甚明显。在有关体制结构和渔业管理理论的理解方面虽有进展,但对欧盟第六次研发与技术发展架构(2002～2006年)的分析指出,在多学科项目领域以外,社会科学的运用仍然不足。渔业社会科学的流散性和渔业政策明显缺乏社会目标的特点合理解释了社会科学难以运用到渔业政策的原因。CFP(共同渔业政策)改革预计将在2012年展开,包括中央和区域机构之间责任的重新分配,为跨学科和专业领域的政策相关研究提供更多的机会。为应对这一挑战,将需要在社会科学和跨自然和经济科学界限构建强大的网络建设。

关键词：社会科学 CFP(共同渔业政策)改革研究议程

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卵泡微环境中外泌体对IVF-ET妊娠结局的影响

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实用妇科内分泌电子杂志 2022年第18期9卷 1-3页

作者：陈秀娟杜琛赵杰张艳兵爱伦高娃内蒙古医科大学附属医院妇产科内蒙古呼和浩特010010

目的分析卵泡微环境中外泌体对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选取96例卵巢功能正常的不孕患者,均给予IVF-ET助孕治疗,根据患者是否妊娠分为妊娠组(45例)与未妊娠组(51例)。观察卵泡微环境中外泌体对IVF-ET妊娠结局。... 详细信息

目的分析卵泡微环境中外泌体对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选取96例卵巢功能正常的不孕患者,均给予IVF-ET助孕治疗,根据患者是否妊娠分为妊娠组(45例)与未妊娠组(51例)。观察卵泡微环境中外泌体对IVF-ET妊娠结局。结果妊娠组外泌体浓度、BCA蛋白浓度高于未妊娠组(P0.05);血清FSH、卵泡液中外泌体浓度与卵子质量有关(P<0.05),为影响卵子质量的独立危险因素;基础AFC、卵泡液中外泌体浓度为影响妊娠结局的独立危险因素(P<0.05)。结论卵泡微环境中外泌体可影响IVF-ET妊娠结局。

关键词：卵泡微环境外泌体体外受精-胚胎移植妊娠结局

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A new prognostic histopathologic classification of nasopharyngeal carcinoma

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Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng ellen T.Chang chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan chen Gang chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

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熟男魅力全新升级

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旅游休闲 2017年第9期 98-106页

作者： ellen 李欧文

他是《终极一班》里的土龙帮太子爷王亚瑟,他是《爱情闯进门》里温柔体贴的秦雨江。辰亦儒,那个飞轮海里阳光帅气的大男孩,华丽转身之后,多了一份硬朗与坚实。

关键词：辰亦儒飞轮海华丽转身铁板烧

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乳腺癌患者配偶夫妻沟通干预方案的修订与实施

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中国护理管理 2016年第2期16卷 202-206页

作者：李智刘均娥陈双琴 Frances Marcus Lewis ellen H.Zahlis 首都医科大学护理学院北京市100069 华盛顿大学护理学院

不良的沟通方式会影响乳腺癌夫妻关系的调适。本文详细介绍了乳腺癌患者配偶夫妻沟通干预方案的本土化修订过程、内容、实施方法及效果的初步评价,旨在帮助配偶学会良好的夫妻沟通方法,为乳腺癌家庭支持研究提供参考。

关键词：乳腺肿瘤配偶夫妻沟通干预

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小说·性别·历史文化--美国汉学家魏爱莲教授访谈录

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浙江大学学报（人文社会科学版） 2018年第2期48卷 194-201页

作者：赵红娟 [美]魏爱莲浙江外国语学院中文学院浙江杭州310023 维斯理学院东亚系马萨诸塞州维斯理02481

《水浒后传》虽然不足以列入一流经典,但在探讨中国小说批评在金圣叹等人影响下是如何形成的这一问题时,此书无疑具有作为例证的价值。《水浒后传》被作者陈忱用来表达对政治的疏离和不满,书中引入了小说可以表达个人感情的观念,这使作... 详细信息

《水浒后传》虽然不足以列入一流经典,但在探讨中国小说批评在金圣叹等人影响下是如何形成的这一问题时,此书无疑具有作为例证的价值。《水浒后传》被作者陈忱用来表达对政治的疏离和不满,书中引入了小说可以表达个人感情的观念,这使作者站在时代的前沿。中国妇女文化经历了明末清初以及18世纪末至19世纪末这两个时期的发展,在第二个时期,女性可以是读者、评论者甚至作者。女性读者推动了小说的发展,到《红楼梦》续书时表现尤为突出。各种《红楼梦》续书显示出女性可以是值得尊敬的小说批评家,续书的情节经常回应女性的关切。出版、传教和妇女之间有一定关联。出版文化与妇女文化在19世纪末以前有所发展,中西小说在19世纪都拥有了更多的读者。这一方面是因为中国读者不断增长的兴趣;另一方面是书商们敏锐地意识到小说能带来更多利润。就传教士而言,他们意识到小说能改变读者的观念。

关键词：魏爱莲小说性别《水浒后传》《红楼梦》续书出版

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现行版ISO 704标准及其未来

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术语标准化与信息技术 2007年第3期 13-15,26页

作者：苏.怀特周长青陈兵美国肯特州大学中国标准化研究院

ISO 704:2000标准简明介绍了术语管理的原则和工作方法,适用于标准化工作者。其新的修订草案受到了来自ISO/TC37技术委员会中新的、面向元数据思想的成员们的强烈反对。本文描述了特定的新用户群体,产生意见的原因,并且提出了解决的办法。

关键词：术语学原则术语工作者知识管理元数据

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Angel and Enchantress:An Analysis of the Images of May Welland and ellen Olenska in The Age of Innocence

语言与文化研究

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语言与文化研究 2013年第1期11卷 206-210页

作者：张建春 chen Huilai School of Foreign Languages Honghe University

Edith Wharton was one of the famous female writers of America in the late nineteenth century and early twentieth *** studied main characters,psychologies of characters and the marriage system in *** author of this paper will analyze two different images between May Welland and ellen *** analyzing the times,social background in the nineteenth century and the reasons that caused their differences,the author of this paper will try to reveal women’s suffering and depression in traditional patriarchal society.

关键词： angel enchantress patriarchal society feminine consciousness

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