检索结果-南通市图书馆

环球科学 2024年第3期 50-57页

作者：伊丽莎白·斯沃博达张胜楠(译) 不详中国科学院心理研究所

当埃丝特·奥拉德乔(Esther Oladejo)连续好几天都想不起来吃饭时,她意识到自已已经越过了一条无形的边界。作为一名颇有天赋的橄榄球运动员,忙碌的学校日程也不曾停下她成长的脚步。

关键词：橄榄球运动员青少年抑郁发病前

Cell adhesion in renal tubular epithelial cells:Biochemistry,biophysics or both

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第4期46卷 937-940页

作者： CLAIrE elizabeth HILLS ELEFTHErIOS SIAMANTOUrAS PAUL EDWArD SQUIrES Diabetes Metabolism&Inflammation GroupSchool of Life SciencesJoseph Banks LaboratoriesUniversity of LincolnLincolnLN67DLUK

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and ***,these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix,as well as the biophysical and mechanical properties orchestrated by cytoskeletal,membrane and matrix *** fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function,it is important to consider both biochemical and biophysical attributes of the system being *** this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

关键词： Cell-adhesion Cadherin Cytoskeleton AFM Kidney Epithelium

Thrombosis after SArS-CoV2 infection or COVID-19 vaccination:will a nonpathologic anti-PF4 antibody be a solution?—A narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bio-X research 2022年第3期5卷 97-103页

作者： elizabeth rao Payal Grover Hongtao Zhang Department of Pathology and Laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

The coronavirus disease 2019(COVID-19)pandemic was triggered by severe acute respiratory syndrome coronavirus 2(SArS-CoV-2),a previously unknown strain of *** fully understand the consequences and complications of SArS-CoV-2 infections,we have reviewed current literature on coagulation dysfunctions that are related to the disease and *** COVID-19 is more commonly considered as a respiratory illness,studies indicate that,in addition to respiratory illness,a coagulation dysfunction may develop in individuals after the initial infection,placing them at the risk of developing thrombotic *** who died of COVID-19 had higher levels of D-dimer,a biomarker for blood clot formation and *** treatments for coagulation dysfunctions are critically needed to improve patient *** the other hand,antibodies against platelet factor 4(PF4)/heparin may be found in patients with rare instances of vaccine-induced immunological thrombotic thrombocytopenia(VITT)following vaccination with adenovirus-based *** is characterized by atypical thrombosis and thrombocytopenia,similar to immune-mediated heparin-induced thrombocytopenia(HIT),but with no need for heparin to trigger the immune *** both adenovirus-based and mrNA-based vaccines express the Spike protein of SArS-CoV-2,VITT is exclusively related to adenovirus-based *** to the resemblance with HIT,the use of heparin is highly discouraged against treating patients with thrombotic thrombocytopenia after SArS-CoV-2 infection or with VITT after *** immunoglobulin therapy coupled with anticoagulation is recommended *** well-studied anti-PF4 monoclonal antibody rTO,which does not induce pathologic immune complexes in the presence of heparin and has been humanized for a potential treatment modality for HIT,may provide a nonanticoagulant HIT-specific solution to the problem of increased blood coagulation after SArS-CoV-2 infecti

关键词： antibody coagulation dysfunctions COVID-19 PF4 vaccine-induced immunological thrombotic thrombocytopenia

Telehealth interventions for alcohol use disorder:A systematic review

在线全文

学校读者我要写书评

暂无评论

Liver research 2022年第3期6卷 146-154页

作者： Arpad Kelemen elizabeth Minarcik Christopher Steets Yulan Liang Department of Organizational Systems and Adult Health University of MarylandBaltimoreMDUSA Department of Family and Community Health University of MarylandBaltimoreMDUSA

Alcohol use disorder(AUD)is a worldwide problem for individuals of varying ages and backgrounds and is associated with the underlying cause of alcoholic liver disease,liver cirrhosis,liver cancer,or many other common diseases and health *** treatments such as cognitive behavioral therapy(CBT)have been demonstrated as an evidence-based treatment to aid individuals struggling with ***,these treatments have excessive costs and time demand with trained *** this paper,we examine the efficacy and long-term impacts of digitally delivered CBT and other online telehealth tools and apps for AUD *** show the effectiveness in the ability of digitally delivered CBT to decrease alcohol use in AUD *** additional use of online technologies and smartphone apps for post-CBT care demonstrates that such computer-aided apps could have long-term effects when it is continually employed,which opens the door for AUD patients who were not seeking treatment *** longitudinal examination research is needed to evaluate the lasting effects in liver health and other chronic diseases associated with digitally delivered alcohol reduction for AUD patients.

关键词： Alcohol use disorder(AUD) Liver disease Cognitive behavioral therapy(CBT) Telehealth Digitally delivered Systematic review

Importance of Standardizing Analytical Characterization Methodology for Improved reliability of the Nanomedicine Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第11期14卷 18-32页

作者： Shahriar Sharifi Nouf N.Mahmoud elizabeth Voke Markita P.Landry Morteza Mahmoudi Department of radiology and Precision Health Program Michigan State UniversityEast LansingMIUSA Faculty of Pharmacy Al-Zaytoonah University of JordanAmman 11733Jordan Department of Biomedical Sciences College of Health SciencesQU HealthQatar University2713 DohaQatar Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyBerkeleyCAUSA Innovative Genomics Institute BerkeleyCAUSA California Institute for Quantitative Biosciences University of CaliforniaBerkeleyCAUSA Chan Zuckerberg Biohub San FranciscoCAUSA

Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine *** lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine *** such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical ***,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as *** also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical ***,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.

关键词： Characterization Nanomedicine Standard protocols reproducibility Nanomedicine devices

recent Ventures in Interdisciplinary Arctic research:The ArCPATH Project

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KING Noel KEENLYSIDE François COUNILLON Brynhildur DAVIÐSDÓTTIr Níels EINArSSON Sergey GULEV Ke FAN Torben KOENIGK James r.MCGOODWIN Marianne H.rASMUSSON Shuting YANG Institute of Arctic and Alpine research(INSTAAr) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland royal roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and Hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to resilient Sustainable Societies-ArCPATH(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ArCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ArCPATH was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ArCPATH served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： recent Ventures in Interdisciplinary Arctic research:The ArCPATH Project

Closed-loop superconducting materials discovery

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 471-478页

作者： elizabeth A.Pogue Alexander New Kyle McElroy Nam Q.Le Michael J.Pekala Ian McCue Eddie Gienger Janna Domenico elizabeth Hedrick Tyrel M.McQueen Brandon Wilfong Christine D.Piatko Christopher r.ratto Andrew Lennon Christine Chung Timothy Montalbano Gregory Bassen Christopher D.Stiles research and Exploratory Development Department Johns Hopkins University Applied Physics Laboratory11100 Johns Hopkins RoadLaurel 20723 MDUSA Department of Materials Science and Engineering Northwestern University2220 Campus DriveEvanston 60208 ILUSA Department of Materials Science and Engineering Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Department of Chemistry Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Institute for Quantum Matter William H.Miller III Department of Physics and AstronomyJohns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA

Discovery of novel materials is slow but necessary for societal ***,we demonstrate a closed-loop machine learning(ML)approach to rapidly explore a large materials search space,accelerating the intentional discovery of superconducting *** experimentally validating the results of the ML-generated superconductivity predictions and feeding those data back into the ML model to refine,we demonstrate that success rates for superconductor discovery can be more than *** four closed-loop cycles,we report discovery of a superconductor in the Zr-In-Ni system,re-discovery of five superconductors unknown in the training datasets,and identification of two additional phase diagrams of interest for new superconducting *** work demonstrates the critical role experimental feedback provides in ML-driven discovery,and provides a blueprint for how to accelerate materials progress.

关键词： discovery materials loop

Immune response differences in degradable and non-degradable alloy implants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第6期24卷 153-170页

作者： Taravat Khodaei elizabeth Schmitzer Abhirami P.Suresh Abhinav P.Acharya Biomedical Engineering School of Biological and Health System EngineeringArizona StateUniversityTempeAZ85281USA Biological Design Arizona State UniversityTempeAZ85281USA Chemical Engineering School for the Engineering of MatterTransportand EnergyArizona StateUniversityTempeAZ85281USA Materials Science and Engineering School for the Engineering of MatterTransportand EnergyArizona State UniversityTempeAZ85281USA Center for Immunotherapy Vaccines and VirotherapyArizona State UniversityTempeAZ85281USA

Alloy based implants have made a great impact in the clinic and in preclinical *** responses are one of the major causes of failure of these implants in the *** the immune responses toward non-degradable alloy implants are well documented,there is a poor understanding of the immune responses against degradable alloy ***,there have been several reports suggesting that degradable implants may develop substantial immune *** phenomenon needs to be further studied in detail to make the case for the degradable implants to be utilized in ***,we review these new recent reports suggesting the role of innate and potentially adaptive immune cells in inducing immune responses against degradable ***,we discussed immune responses to allergen components of non-degradable implants to give a better overview on differences in the immune response between non-degradable and degradable ***,we also provide potential areas of research that can be undertaken that may shed light on the local and global immune responses that are generated in response to degradable implants.

关键词： alloy utilized implants

Prospective associations between joint categories of physical activity and insomnia symptoms with onset of poor mental health in a population-based cohort

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2023年第3期12卷 295-303页

作者： Mitch J Duncan elizabeth G Holliday Nicola W Burton Nicholas Glozier Stina Oftedal School of Medicine and Public Health College of HealthMedicineand WellbeingThe University of NewcastleCallaghanNSW 2308Australia Priority research Centre for Physical Activity and Nutrition The University of NewcastleCallaghanNSW 2308Australia School of Applied Psychology Griffith UniversityBrisbaneQLD 4122Australia Menzies Health Institute Queensland Griffith UniversityBrisbaneQLD 4122Australia Brain and Mind Centre Central Clinical SchoolThe University of SydneyNSW 2050Australia

Background:Physical inactivity and insomnia symptoms are independently associated with increased risk of depression and anxiety;however,few studies jointly examine these risk *** study aimed to prospectively examine the joint association of physical activity(PA)and insomnia symptoms with onset of poor mental health in ***:Participants from the 2013 to 2018 annnual waves of the Household Income and Labour Dynamics in Australia panel study who had good mental health(Mental Health Inventory-5>54)in 2013,and who completed at least 1 follow-up survey(2014-2018),were included(n=10,977).Poor mental health(Mental Health Inventory-5≤54)was assessed ***(2013)PA was classified as high/moderate/low,and insomnia symptoms(i.e.,trouble sleeping)were classified as no insomnia symptoms/insomnia symptoms,with 6 mutually exclusive PAinsomnia symptom groups *** of PA-insomnia symptom groups with onset of poor mental health were examined using discrete-time proportional-hazards logit-hazard ***:There were 2322 new cases of poor mental health(21.2%).relative to the high PA/no insomnia symptoms group,there were higher odds(odds ratio and 95%confidence interval(95%CI))of poor mental health among the high PA/insomnia symptoms(Or=1.87,95%CI:1.57-2.23),moderate PA/insomnia symptoms(Or=1.93,95%CI:1.61-2.31),low PA/insomnia symptoms(Or=2.33,95%CI:1.96-2.78),and low PA/no insomnia symptoms(Or=1.14,95%CI:1.01-1.29)*** level of PA combined with insomnia symptoms was associated with increased odds of poor mental health,with the odds increasing as PA ***:The se findings highlight the potential benefit of interventions targeting both PA and insomnia symptoms for promoting mental health.

关键词： Depression Physical activity Sleep quality

Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2022年第6期17卷 1286-1292页

作者： Joshua D.rieskamp Patricia Sarchet Bryon M.Smith elizabeth D.Kirby Neuroscience Graduate Program The Ohio State UniversityColumbusOHUSA Department of Psychology The Ohio State UniversityColumbusOHUSA Department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immediate progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by CD31^(+)endothelia,GFAP-SOX2^(+)intermediate progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)radial glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology