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获取老年痴呆症的早期预警

商业周刊（中文版） 2010年第9期 33-34页

作者：伊丽莎白·洛帕托（elizabeth Lopatto）和卡诺科·马特苏亚（Kanoko Matsuyama）黎力（译）

通用电气公司、拜耳公司（Bayer）和Avid放射性药品公司（Avid Radiophar—maceutieals）都在竞相为医生们提供一件医学界已为之求索百年的东西，这便是针对老年痴呆症（即阿尔茨海默氏病）的早期检测。如果通过这一快速诊断使病情获得... 详细信息

通用电气公司、拜耳公司（Bayer）和Avid放射性药品公司（Avid Radiophar—maceutieals）都在竞相为医生们提供一件医学界已为之求索百年的东西，这便是针对老年痴呆症（即阿尔茨海默氏病）的早期检测。如果通过这一快速诊断使病情获得确诊，那么患者不仅能及早采用药物治疗、参加实验药品的临床测试，还可以对自己未来的生活做一番规划。

关键词：老年痴呆症早期预警通用电气公司实验药品拜耳公司药物治疗放射性

Blueberry and cranberry pangenomes as a resource for future genetic studies and breeding efforts

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Horticulture Research 2023年第11期10卷 96-105页

作者： Alan E.Yocca Adrian Platts elizabeth Alger Scott Teresi Molla F.Mengist Juliana Benevenuto Luis Felipe V.Ferrão MacKenzie Jacobs Michal Babinski Maria Magallanes-Lundback Philipp Bayer Agnieszka Golicz Jodi L.Humann Dorrie Main Richard V.Espley David Chagné Nick W.Albert Sara Montanari Nicholi Vorsa James Polashock Luis Díaz-Garcia Juan Zalapa Nahla V.Bassil Patricio R.Munoz Massimo Iorizzo Patrick P.Edger Department of Horticulture Michigan State UniversityEast LansingMI48824United States Department of Plant Biology Michigan State UniversityEast LansingMI48824United States Genetics and Genome Sciences Michigan State UniversityEast LansingMI48824United States Plants for Human Health Institute North Carolina State UniversityKannapolisNC United States Horticultural Sciences Department University of FloridaGainesvilleFL 32611United States Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI48824United States University of Western Australia Perth 6009 Australia Justus Liebig University Giessen35390 Germany Department of Horticulture Washington State UniversityPullmanWA99163United States The New Zealand Institute for Plant and Food Research Limited(PFR) AucklandNew Zealand The New Zealand Institute for Plant and Food Research Limited(PFR) PalmerstonNew Zealand The New Zealand Institute for Plant and Food Research Limited(PFR) MotuekaNew Zealand SEBS Plant BiologyRutgers UniversityNew Brunswick NJ 01019 United States Department of Viticulture and Enology University of CaliforniaDavisDavisCA 95616United States National Clonal Germplasm Repository USDA-ARSCorvallisOR 97333United States Department of Horticulture North Carolina State UniversityKannapolisNC United States MSU AgBioResearch Michigan State UniversityEast LansingMI48824United States

Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed *** industry continues to face a wide variety of production challenges(*** pressures),as well as a demand for higher-yielding cultivars with improved fruit quality ***,molecular tools to help guide breeding efforts for these species have been relatively limited compared with those for other high-value ***,we describe the construction and analysis of the first pangenome for both blueberry and *** analysis of these pangenomes revealed both crops exhibit great genetic diversity,including the presence-absence variation of 48.4%genes in highbush blueberry and 47.0%genes in *** genes,those not shared by all cultivars,are significantly enriched with molecular functions associated with disease resistance and the biosynthesis of specialized metabolites,including compounds previously associated with improving fruit quality *** discovery of thousands of genes,not present in the previous reference genomes for blueberry and cranberry,will serve as the basis of future research and as potential targets for future breeding *** pangenome,as a multiple-sequence alignment,as well as individual annotated genomes,are publicly available for analysis on the Genome Database for Vaccinium-a curated and integrated web-based relational ***,the core-gene predictions from the pangenomes will serve useful to develop a community genotyping platform to guide future molecular breeding efforts across the family.

关键词： breeding cultivar crops

在组织切片中肥大细胞的证明及迅速记数的简单方法

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动物学杂志 1960年第5期 199-199页

作者： Smith,elizabeth ,W.Atkinson,W.B. ,艾民康

肥大细胞的选择性染色法如下:1)薄片新鲜组织(3—5毫米厚)于下液固定18—24小时,但标本置于此液至少一周尚无显明害处。配法:福尔马林液10毫升;95%酒精90毫升;醋酸钙1克。2)组织以95%酒精洗2次,每次1小时。3)以常法制做石蜡切片(8—12... 详细信息

肥大细胞的选择性染色法如下:1)薄片新鲜组织(3—5毫米厚)于下液固定18—24小时,但标本置于此液至少一周尚无显明害处。配法:福尔马林液10毫升;95%酒精90毫升;醋酸钙1克。2)组织以95%酒精洗2次,每次1小时。3)以常法制做石蜡切片(8—12微米厚),粘片,脱蜡,经纯酒精至95%酒精。4)在室温于下液内染1小时。配法:甲苯胺蓝(toluidine blue)0.25克;70%酒精100毫升;浓盐酸

关键词：组织切片肥大细胞福尔马林液石蜡切片醋酸钙粘片周尚甲苯胺蓝复染以常

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搜寻人才

商业周刊（中文版） 2007年第11期 46-46,48页

作者：伊丽莎白·沃伊克（elizabeth Woyke）马哈·阿塔尔（Maha Atal）杨鸣娟（译者）

设计院校正在打造新一代创意型经理在辛辛那提大学的校园里，宝洁公司的员工与设计专业的学生坐在了一起，他们集思广益，共同创建一个虚拟的三口环保之家，他们居住在节能住宅里，发电依靠太阳能。“我们设想了一个家庭模型，他们住在... 详细信息

设计院校正在打造新一代创意型经理在辛辛那提大学的校园里，宝洁公司的员工与设计专业的学生坐在了一起，他们集思广益，共同创建一个虚拟的三口环保之家，他们居住在节能住宅里，发电依靠太阳能。“我们设想了一个家庭模型，他们住在这样的房子里，而且希望按照可持续的方式生活，”宝洁公司全球设计组织（Global Design Organization）的副主任鲍伯·舒瓦茨说，“什么产品可以24小时不间断地支持这样的生活方式呢？”

关键词：人才搜寻宝洁公司生活方式设计专业集思广益节能住宅设计组织

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抑郁,孤独感和自杀风险:社会心理交互模型

抑郁,孤独感和自杀风险:社会心理交互模型

CD36 expression and lipid metabolism following an oral glucose challenge in South Asians

第二十一届全国心理学学术会议

作者： Edward C.Chang Abigael G.Lucas 李明崎 Collin B.Beavan Rachel S.Eisner Brianna M.McManamon Natalia S.Rodriguez Olivia M.Katamanin Eliza C.Bourke Amaia de la Fuente Olga Carde?oso Kaidi Wu elizabeth A.Yu elizabeth L.Jeglic Jameson K. Hirsch 王若茜高芯芸 Zimeng Li Xin Wang Olivia D.Chang 密歇根大学心理学系斯基德莫尔学院巴斯克大学

美国的拉丁裔人群自杀风险颇高,但目前的自杀研究对象大多是白人群体,针对拉丁裔人群自杀风险的影响因素的研究尚且不足。以往研究证明,抑郁是自杀风险重要的预测因子。拉丁文化中的集体主义思想也显示,当个体被社会孤立后,产生的孤独... 详细信息

美国的拉丁裔人群自杀风险颇高,但目前的自杀研究对象大多是白人群体,针对拉丁裔人群自杀风险的影响因素的研究尚且不足。以往研究证明,抑郁是自杀风险重要的预测因子。拉丁文化中的集体主义思想也显示,当个体被社会孤立后,产生的孤独感会预测其自杀风险。因此,本研究根据社会心理易损模型,同时考虑个体心理和环境变量对自杀风险的预测作用。本研究采用问卷法探究分别抑郁,孤独感,以及两者的交互作用对自杀风险(绝望和自杀行为)的预测作用。研究样本包括156名拉丁裔大学生,使用分层回归的方法,第一层控制年龄和性别,第二层放入抑郁和孤独感,第三层放入两者交互项,因变量是大学生的绝望和自杀行为。分层回归结果表明,抑郁和孤独感都能独立显著预测绝望和自杀行为。同时,抑郁和孤独感对预测自杀风险的交互效应显著,低孤独感可以缓冲抑郁对自杀风险的预测:随着抑郁增强,相比于被社会孤立的个体,没有被孤立的个体的自杀风险的上升速率显著较低。本研究首次探索了拉丁裔人群的抑郁和孤独感对自杀风险的预测作用,表明减少社会心理的受损能减少自杀风险。与以往研究模式一致,抑郁的对自杀的预测力大约是孤独感的两倍。此外,抑郁和孤独感对自杀风险的影响也存在交互作用,减少个体的孤独感能缓冲抑郁对自杀风险的影响。因此,集体主义文化下的拉丁裔群体(甚至文化相似的东亚群体),未来针对自杀的干预,不仅应关注个体的心理抑郁心境,还可以通过加强社会联结减少孤独感,以降低人群的自杀风险。

关键词：抑郁孤独感自杀风险拉丁裔大学生

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World Journal of Diabetes 2015年第7期6卷 983-989页

作者： Jeetesh V Patel Amitava Banerjee Silvia Montoro-Garcia Eduard Shantsila Mushfique Alam Paul Flinders Kathleen AL Houlton elizabeth A Hughes Gregory YH Lip Paramjit S Gill University of Birmingham Centre for Cardiovascular Sciences Sandwell and West Birmingham Hospitals NHS Trust Sandwell Medical Research Unit Sandwell General Hospital Primary Care Clinical Sciences University of Birmingham Medical School University of Nottingham

AIM:To investigate lipid metabolism and the relationship with monocyte expression of the fatty acid translocase CD36 in South ***:An observational study of South Asians whom as an ethnic group have-a higher risk of developing *** susceptibility to diabetes is coupled with an earlier and more rapid progression of micro-,and macro-vascular *** healthy South Asian participants [mean age 34.6(8.9) years,76.2% male,mean body-mass index 25.0(5.2) kg/m2] were recruited from an urban residential area of central Birmingham(United Kingdom).The main outcomes measured were post prandial(30 min) and post absorptive(120 min) changes from fasting(0 min) in circulating lipoproteins,lipds and hormones,andmonocyte expression of CD36 post injection of a 75 g oral glucose *** inducements of variations of monocyte CD36 expression were ***:Our results showed evident changes in monocyte CD36 expression following the glucose challenge(P < 0.001).Non-esterified fatty acids(NEFA) levels decreased progressively during the challenge(P < 0.001),in contrast to increased cholesterol(but not triglyceride) concentrations within very low density lipoprotein(VLDL) and low density lipoprotein subfractions(P < 0.01).Levels of,glucose,serum triglycerides and high density lipoprotein cholesterol remained largely *** of monocyte CD36 were negatively(r =-0.47,P = 0.04) associated to fat from the diet and positively to carbohydrate from the diet(r = 0.65,P < 0.001).CONCLUSION:These data suggest that the initiation of VLDL genesis follows the consumption of glucose within this population,inferring that the sequestration of NEFA from these particles happens due to the increased availability of CD36 *** these are preliminary results,it would appear that lifestyle exposures have a role in moderating the expression of CD36.

关键词： CD36 Lipoprotein Glucose South Asians Diabetes Micro-vascular Macro-vascular

13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

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13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

2015中国遗传学会大会

作者：贾仲林 elizabeth J.Leslie Margaret E.Cooper Azeez Butali Jennifer Standley Jennifer Rigdon Satoshi Suzukil Ayana Gongorjav T.Enkhtur Shonkhuuz Nagato Natsume 石冰 Mary L.Marazita Jeffrey C.Murray 四川大学华西口腔医学院口腔疾病国家重点实验室 Department of Pediatrics University of Iowa 四川大学华西口腔医院唇腭裂外科 Center for Craniofacial and Dental Genetics Department of Oral BiologySchool of Dental MedicineUniversity of Pittsburgh Department of Oral Pathology Radiologyand MedicineCollege of DentistryUniversity of Iowa Divisionof Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of DentistryAichi-Gakuin University

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验... 详细信息

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验证唇腭裂全基因组关联研究Meta分析发现的6个显著相关的位点:rs742071(1p36),rs7590268(2p21),rs7632427(3p11.1),rs12543318(8q21.3),rs8001641(13q31.1)和rs7179658(15q22.2);同时对来自美国,蒙古,和菲律宾三个人群的713个病例,438个正常对照及485个核心家系在SPRY2基因下游200Kb的三个非编码保守区进行直接测序。我们发现rs8001641位点显著与欧洲人群非综合征型唇裂伴腭裂的发生相关((p=4 x 10-5,ORtransmission=1.86和95%CI:1.38-2.52)。我们还在亚洲和欧洲的病例中发现了一些位于保守区域的遗传变异,它们可帮助定位与唇腭裂发生风险相关的常见遗传变异。这项研究进一步证实了先前报道的rs8001641和欧洲人群唇腭裂之间的关联。

关键词：全基因组关联研究非综合征型口面裂

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旧金山思科办公室

现代装饰 2014年第4期 26-37页

作者： Primo Orpilla Verda Alexander Denise Cherry Perry Stephney Clem Soga Steve Gerten elizabeth Guerrero Chase Lunt Alma Lopez Caren Currie Sarunya Wongjodsri Justin Ackerman David Hunter Jeorge Jordan Olivia Ward Kroeun Dav Chase Lunt Amie Zemlicka Maleesa Pollock Will Chu Jasper Sanidad 姜敏华

思科公司(CISCO)是一家全球知名的企业互联网方案解决商,与Google、Facebook等互联网公司一样办公氛围富有创新和活力。2012年11月,思科收购云计算网络初创公司Meraki。短短一年之后,Meraki整体搬进了位于旧金山的新办公室。面积约10,22... 详细信息

思科公司(CISCO)是一家全球知名的企业互联网方案解决商,与Google、Facebook等互联网公司一样办公氛围富有创新和活力。2012年11月,思科收购云计算网络初创公司Meraki。短短一年之后,Meraki整体搬进了位于旧金山的新办公室。面积约10,220平方米的新办公室由当地著名设计工作室Studio O+A操刀设计。整个办公环境视野开阔、光线充盈、极具活力,带给人一种轻松自由的工作氛围。

关键词：思科公司云计算视野开阔办公环境旧金山初创公司设计师旧金山湾蒙古包楼梯 Studio 大片

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Potential factors influencing lymphatic filariasis transmission in"hotspot"and"control"areas in Ghana:the importance of vectors

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Infectious Diseases of Poverty 2019年第1期8卷 45-55页

作者： Sellase Pi-Bansa Joseph Harold Nyarko Osei Kwadwo Kyeremeh Frempong elizabeth Elhassan Osei Kweku Akuoko David Agyemang Collins Ahorlu Maxwell Alexander Appawu Benjamin Guibehi Koudou Michael David Wilson Dziedzom Komi de Souza Samuel Kweku Dadzie Jurg Utzinger Daniel Adjei Boakye Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Noguchi Memorial Institute for Medical Research College of Health SciencesUniversity of GhanaLegonGhana Department of Animal Biology and Conservation Science University of GhanaLegonGhana SightSavers International Ghana OfficeAccraGhana African Regional Postgraduate Programme in Insect Science University of GhanaLegonGhana Vector Biology Department Liverpool School of Tropical MedicineLiverpoolUK Centre Suisse de Recherches Scientifiques en Cote d'Ivoire AbidjanCote d'Ivoire

Background:Mass drug administration(MDA)programmes for the control of lymphatic filariasis in Ghana,have been ongoing in some endemic districts for 16 *** current study aimed to assess factors that govern the success of MDA programmes for breaking transmission of lymphatic filariasis in ***:The study was undertaken in two"hotspot"districts(Ahanta West and Kassena Nankana West)and two control districts(Mpohor and Bongo)in *** were collected and identified using morphological and molecular tools.A proportion of the cibarial armatures of each species was *** were performed onAnopheles gambiae for filarial worm detection.A questionnaire was administered to obtain information on MDA compliance and vector control *** were compared between districts to determine factors that might explain persistent transmission of lymphatic ***:High numbers of mosquitoes were sampled in Ahanta West district compared to Mpohor district(F=16.09,P=0.002).There was no significant difference between the numbers of mosquitoes collected in Kassena Nankana West and Bongo districts(F=2.16,P=0.185).Mansonia species were predominant in Ahanta West *** mosquitoes were prevalent in all *** with infected and infective filarial worms was found only in Ahanta West *** differences were found in cibarial teeth numbers and shape for mosquito species in the surveyed *** MDA coverage was high in all *** average use of bednet and indoor residual spraying was 82.4 and 66.2%,*** was high compliance in the five preceding MDA rounds in Ahanta West and Kassena Nankana West districts,both considered hotspots of lymphatic filariasis ***:The study on persistent transmission of lymphatic filariasis in the two areas in Ghana present information that shows the importance of local understanding of factors affecting control and elimination of lymphatic

关键词： Ghana Hotspots Lymphatic filariasis Mass drug administration Microfilariae Systematic non-compliance Vector control

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