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Accommodation and peristalsis are functional responses to obstruction in rat hypertrophic ileum

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World Journal of Gastroenterology 2013年第6期19卷 846-854页

作者： Simona Bertoni Francesca Saccani Rita Gatti Alberto Rapalli Lisa Flammini Vigilio Ballabeni elisabetta Barocelli Department of Pharmacological Biological and Applied Chemical SciencesUniversity of Parma Department of Experimental Medicine University of Parma

AIM:To investigate the effects of chronic obstruction on enteric reflexes evoked by electrical stimulation (EFS) or intraluminal distension of the rat hypertrophic ***:Motor responses to EFS and to intraluminal distension were studied in the absence and in the presence of various inhibitors of enteric *** segments from operated (chronic ileal obstruction),sham-operated (control) and normal rats were horizontally mounted,connected to a pressure transducer and intraluminally *** effects of selective serotonin receptor (5-HTR) blockers were investigated on distension-induced *** cellular localization of 5-HT3Rs was also examined in control and hypertrophic tissues through confocal ***:In non-obstructed segments,EFS elicited tetrodotoxin (TTX)-sensitive responses with high am-plitude contraction followed by weak *** hypertrophic tissues,EFS lowered the baseline pressure and evoked TTX-sensitive contractions significantly larger than normal (P < 0.01) or control (P < 0.05),and devoid of any relaxation phase (P < 0.01 vs normal).Incubation with atropine and guanethidine [nonadrenergic non-cholinergic (NANC) conditions] did not modify intestinal tone in normal and control preparations,but reversed the accommodation produced by EFS in hypertrophic tissues,and depressed the amplitude of contractions in all types of tissues.L-NAME and α-chymotrypsin blocked residual NANC motility in all tissues and augmented intraluminal pressure in hypertrophic segments (P < 0.05 vs NANC conditions).Intraluminal distension of the intestinal wall evoked non-propulsive cycles of contractions and relaxations in non-obstructed *** all hypertrophic segments,strong propulsive strokes,markedly wider (P < 0.001),and larger than normal (P < 0.001) or control (P < 0.05) were *** motor patterns were blocked under NANC conditions and with simultaneous incubation with L-NAME and α-*** all types of tissues,incub

关键词： 5-HT3 receptor Intestinal obstruction Peristalsis Rat intestinal motility Serotonin

Overlap of orthorexia,eating attitude and psychological distress in some Italian and Spanish university students

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World Journal of Psychiatry 2022年第10期12卷 1298-1312页

作者： Paola Aiello elisabetta Toti Débora Villaño Anna Raguzzini Ilaria Peluso Department of Physiology and Pharmacology“V.Erspamer” Sapienza UniversityRome 00185Italy Research Centre for Food and Nutrition Council for Agricultural Research and EconomicsRome 00178Italy Food Science and Technology Department UCAMMurcia 30107Spain

BACKGROUND Orthorexia nervosa(ON)is the persistent concern of maintaining the self-imposed diet to improve one's *** factors have been associated to ON in university *** To assess the prevalence of ON in Italian and Spanish university students in relation to eating attitude and psychological distress,and the possible overlaps between ON(evaluated with different scored questionnaires from the originally proposed ORTO-15),distress and risk of eating *** This study was carried out on 160 students recruited at La Sapienza University of Rome and at the Catholic University of *** were administered to evaluate ON(ORTO-15 and sub-scores),body concerns(Multidimensional Body-Self Relations Questionnaire,MBSRQ,and Body Uneasiness test,BUT),psychological distress(Kessler Psychological Distress Scale,K10),physical activity(International Physical Activity Questionnaire,IPAQ),eating attitude(Eating Attitudes Test,EAT-26)and malnutrition(Starvation Symptom Inventory,SSI).Sex differences,within the same country,and differences between Italian and Spanish students,within the same sex,were *** The ORTO-15 positive subjects,assessed with the originally proposed cut-off,were above 70%in both Italian and Spanish students,with a higher prevalence in the Spanish sample(Italian females 76.3%,Italian males 70.7%;Spanish females 97.0%,Spanish males 96.3%).According to ORTO-7,about 30%of Italian and 48%of Spanish students were positive to ON with no significant sex *** excluding students underweight(UW),overweight(OW)or obese(OB),as well as those potentially at risk of eating disorders or presenting mild,moderate and severe distress,in the resultant normal weight(NW)-K10neg-EAT-26neg subgroup,we did not find many correlations observed in the whole sample,including those between ORTO scores and BUT,SSI,Total MBSRQ and some of its ***,ORTO-7 resulted in the only ON score unrelated with Body Mass Index,MBS

关键词： Diet Exercise Food avoidance Other Specified Feeding and Eating Disorder Lifestyle

Characterization and catalytic activity of soft-templated Ni0-CeO_(2) mixed oxides for CO and CO_(2) co-methanation

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 251-268页

作者： Luciano Atzori Maria Giorgia Cutrufello Daniela Meloni Barbara Onida Delia Gazzoli Andrea Ardu Roberto Monaci Maria Franca Sini elisabetta Rombi Department of Chemical and Geological Sciences University of Cagliari09042 Monserrato(CA)Italy Department of Materials Science and Chemical Engineering CR-INSTM for Materials with Controlled PorosityPolytechnic of Turin10129 TurinItaly Department of Chemistry University of Rome“La Sapienza”00185 RomeItaly

Nanosized NiO,CeO_(2) and NiO-CeO_(2) mixed oxides with different Ni/Ce molar ratios were prepared by the soft template *** the samples were characterized by different techniques as to their chemical composition,structure,morphology and *** the catalysts submitted to the same reduction pretreatment adopted for the activity tests the surface basic properties and specific metal surface area were also *** and CeO_(2) nanocrystals of about 4 nm in size were obtained,regardless of the Ni/Ce molar *** Raman and X-ray photoelectron spectroscopy results proved the formation of defective sites at the NiO-CeO_(2) interface,where Ni species are in strong interaction with the *** microcalorimetric and Fourier transform infrared analyses of the reduced samples highlighted that,unlike metallic nickel,CeO_(2) is able to effectively adsorb CO_(2),forming carbonates and hydrogen *** reduction in H2 at 400°C for 1 h,the catalytic performance was studied in the CO and CO_(2) co-methanation *** tests were performed at atmospheric pressure and 300°C,using CO/CO_(2)/H_(2) molar compositions of 1/1/7 or 1/1/5,and space velocities equal to 72000 or 450000 cm^(3)∙h^(-1)∙gcat^(-1).Whereas CO was almost completely hydrogenated in any investigated experimental conditions,CO_(2) conversion was strongly affected by both the CO/CO_(2)/H_(2) ratio and the space *** faster and definitely preferred CO hydrogenation was explained in the light of the different mechanisms of CO and CO_(2) *** a selected sample,the influence of the reaction temperature and of a higher number of space velocity values,as well as the stability,were also *** that the Ni content is optimized,the NiCe system investigated was very promising,being highly active for the CO_(x) co-methanation reaction in a wide range of operating conditions and stable(up to 50 h)also when submitted to thermal stress.

关键词： soft template method Ni0-CeO_(2)catalystss CO and CO_(2)co-mtharation synthetic natural gas production

Hepatitis A:Epidemiology and prevention in developing countries

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World Journal of Hepatology 2012年第3期4卷 68-73页

作者： elisabetta Franco Cristina Meleleo Laura Serino Debora Sorbara Laura Zaratti Department of Public HealthUniversity Tor Vergata Specialization School for Hygiene and Preventive Medicine University Tor Vergata

Hepatitis A is the most common form of acute viral hepatitis in the *** geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socioeconomic *** anti-hepatitis A virus(HAV)seroprevalence rate is presently decreasing in many parts of the world,but in less developed regions and in several developing countries,HAV infection is still very common in the first years of life and seroprev-alence rates approach 100%.In areas of intermediate endemicity,the delay in the exposure to the virus has generated a huge number of susceptible adolescents and adults and significantly increased the average age at *** the severity of disease increases with age,this has led to outbreaks of hepatitis *** factors contribute to the decline of the infection rate,including rising socioeconomic levels,increased access to clean water and the availability of a hepatitis A vaccine that was developed in the *** populations with a high proportion of susceptible adults,implementing vaccination programs may be *** this report,we review available epidemiological data and implementation of vaccination strategies,particularly focusing on developing countries.

关键词： Hepatitis A Developing countries Endemic-ity Seroprevalence Vaccine

Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

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Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor Francois Brisset Marie-Francoise Bernet-Camard Didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization

Ampulla of Vater carcinoma: Molecular landscape and clinical implications

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 370-380页

作者： Antonio Pea Giulio Riva Riccardo Bernasconi elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini Department of Surgery University and Hospital Trust of Verona Department of Diagnostics and Public Health Section of Pathology University and Hospital Trust of Verona ARC-Net Research Center University and Hospital Trust of Verona

Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well.

关键词： Pancreatobiliary Intestinal Mixed ELF3 TP53 KRAS Ampullary Vater Histotype

Notes for developing a molecular test for the full characterization of circulating tumor cells

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Chinese Journal of Cancer Research 2015年第5期27卷 471-478页

作者： elisabetta Rossi Antonella Facchinetti Rita Zamarchi Department of Surgery Oncology and GastroenterologyOncology SectionUniversity of Padova IOV-IRCCS

The proved association between the circulating tumor cell （CTC） levels and the patients＇ survival parameters has been growing interest to investigate the molecular profile of these neoplastic cells among which hide out precursors capable of initiating a new distant metastatic lesion. The full characterization of the tumor cells in peripheral blood of cancer patients is expected to be of help for understanding and （prospectively） for counteracting the metastatic process. The major hitch that is hampering the successful gaining of this result is the lack of a consensus onto standard operating procedures （SOPs） for performing what we generally define as the ＂liquid biopsy＂. Here we review the more recent acquisitions in the analysis of CTCs and tumor related nucleic acids, looking to the main open questions that are hampering their definitive employ in the routine clinical practice.

关键词： Circulating tumor cells (CTCs) single-cell analysis liquid biopsy

Management Accounting as a Science： From Costs and Benefits Analysis of Productions to Strategic Planning of Uncertainty

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Journal of Modern Accounting and Auditing 2016年第12期12卷 577-581页

作者： elisabetta Mafrolla University of Foggia Foggia Italy

This article discusses the role assumed by management accounting as a discipline over years. Management accounting has long lived in the shadow of financial accounting, and has been often accused of fostering productivity rather than creativity. The revolution involving the business environment in the last decades has much improved the role of creativity and innovation and the adaptability of the fn-m to the context often was a key to success. This article supports the innovative role of management accounting in the post-modem era, aimed at reducing the strategic dominance of the increasing uncertainty.

关键词： management accounting strategic planning history of accounting innovation uncertainty

Commentary on “Will male semen quality improve with environmental quality?”

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Asian Journal of Andrology 2023年第2期25卷 286-286页

作者： elisabetta Tosti Department of Biology and Evolution of Marine Organisms Stazione Zoologica Anton DohrnNaples 80121Italy

The adverse effect of environmental pollution,climate change,and bad lifestyles on human reproductive fitness and health is reported in a large body of literature and is a matter of attention from the scientific community and governments all over the *** several reproductive processes from gametogenesis up to embryo and fetal development are affected by a variety of environmental stressors,most of the data available in the literature are related to sperm physiology and quality.1 I read with interests the article by Dai et al.2 that reports an improvement of sperm quality along with environmental quality in Wenzhou,a highly populated area in the south of Zhejiang province,coastal eastern China.

关键词： China. coastal pollution