检索结果-南通市图书馆

Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis:A rat model

World Journal of Gastroenterology 2015年第44期21卷 12576-12585页

作者： Gozde Dervis Hakim Mujde Soyturk Mehtat Unlu Pinar Ataca Meral Karaman Ozgul Sagol elif borekci Osman Yilmaz Department of Gastroenterology School of Medicine Dokuz Eylul University Department of Pathology School of Medicine Dokuz Eylul University Department of Internal Medicine School of Medicine Dokuz Eylul University Department of Laboratory Animal Science School of Medicine Dokuz Eylul University

AIM: To investigate the effects of nilotinib in a rat model of indomethacin-induced ***: Twenty-one Wistar albino female rats obtained from Dokuz Eylul University Department of Laboratory Animal Science were divided into the following three groups: control(n = 7), indomethacin(n = 7) and nilotinib(n = 7). A volume of 0.25 m L of physiological serum placebo was administered to the control and indomethacin groups through an orogastric tube for 13 d. To induce enterocolitis, the indomethacin and nilotinib groups received 7.5 m L/kg indomethacin dissolved in 5% sodium bicarbonate and administered subcutaneously in a volume of 0.5 m L twice daily for three days. Nilotinib was administered 20 mg/kg/d in two divided doses to the nilotinib group of rats for 13 d through an orogastric tube, beginning on the same day as indomethacin administration. For 13 d, the rats werefed a standard diet, and their weights were monitored daily. After the rats were sacrificed, the intestinal and colonic tissue samples were examined. The macroscopic and microscopic pathology scores were evaluated. The pathologist stained all tissue samples using terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick-end labeling method. Mucosal crypts and apoptotic cells were quantified. The plateletderived growth factor receptor(PDGFR) α and β scores assessed by immunohistochemical staining method and tissue and serum tumor necrosis factor(TNF) α levels were determined by enzyme-linked immunosorbent assay. RESULTS: Between days 1 and 13, the rats in the nilotinib and indomethacin groups lost significantly more weight than the controls(-11 g vs +14.14 g, P = 0.013;-30 g vs +14.14 g, P = 0.003). In the small intestinal and colonic tissues, the macroscopic scores were significantly lower in the nilotinib group than in the indomethacin group(1.14 ± 0.38 and 7.29 ± 2.98, P = 0.005; 1.14 ± 0.38 and 7.43 ± 2.64, P = 0.001, respectively), but the values of the nilotinib and indomethacin

关键词： Inflammatory bowel disease Enterocolitis Platelet-

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of gamification applications on success of dentistry students

引用

World Journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen Deniz elif Polat Balkan Burak İncebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** To evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).There was a statistically significant difference in average success scores between students of different groups(P=0.003<0.05)and grades(P=0.036<0.05).The average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCLUSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education Dentistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between the use of smart medical services and mental health status

引用

World Journal of Psychiatry 2025年第1期15卷 21-25页

作者： elif Sarac Ministry of National Defense General Directorate of Management ServicesAnkara 06000Türkiye

In this editorial,I comment on the article by Zhang et *** emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental *** medical services have the potential to positively influence mental health by providing monitoring,insights,and ***,they also come with challenges that need to be *** the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.

关键词： Smart devices Medical service Usage People Relationship Mental health status

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ISOTROPIC WEYL MANIFOLD WITH A SEMI-SYMMETRIC CONNECTION

引用

Acta Mathematica Scientia 2009年第1期29卷 176-180页

作者： elif zkara Canfes Department of Mathematics Technical University of Istanbul

In this work,it is proved that every isotropic Weyl manifold with a semi- symmetric connection is locally conformal to an Einstein manifold with a semi-symmetric connection.

关键词： Weyl manifold semi-symmetric connection Einstein manifold isotropic manifold sectional curvature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deep neural network ensembles for remote sensing land cover and land use classification

引用

International Journal of Digital Earth 2021年第12期14卷 1868-1881页

作者： Burak Ekim elif Sertel Institute of Informatics Satellite Communication and Remote Sensing ProgramIstanbul Technical UniversityIstanbulTurkey Department of Geomatics Engineering Istanbul Technical UniversityIstanbulTurkey

With the advancement of satellite technology,a considerable amount of very high-resolution imagery has become available to be used for the Land Cover and Land Use(LCLU)classification task aiming to categorize remotely sensed images based on their semantic ***,Deep Neural Networks(DNNs)have been widely used for different applications in the field of remote sensing and they have profound impacts;however,improvement of the generalizability and robustness of the DNNs needs to be progressed further to achieve higher accuracy for a variety of sensing geometries and *** address this problem by deploying three different Deep Neural Network Ensemble(DNNE)methods and creating a comparative analysis for the LCLU classification *** enables improvement of the performance of DNNs by ensuring the diversity of the models that are ***,enhances the generalizability of the models and produces more robust and generalizable outcomes for LCLU classification *** experimental results on NWPU-RESISC45 and AID datasets demonstrate that utilizing the aggregated information from multiple DNNs leads to an increase in classification performance,achieves state-of-the-art,and promotes researchers to make use of DNNE.

关键词： Classification convolutional neural networks(CNN) deep neural network ensembles(DNNE) land cover and land use(LCLU) remote sensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibiotic ciprofloxacin removal from aqueous solutions by electrochemically activated persulfate process:Optimization,degradation pathways,and toxicology assessment

引用

Journal of Environmental Sciences 2024年第9期143卷 85-98页

作者： elif Yakamercan Ahmet Aygün Halis Simsek Environmental Engineering Department Bursa Technical UniversityBursaTurkey Agricultural and Biological Engineering Department Purdue UniversityWest LafayetteINUSA

Ciprofloxacin(CIP)is a commonly used antibiotic in the fluoroquinolone group and is widely used in medical and veterinary medicine disciplines to treat bacterial *** CIP is discharged into the sewage system,it cannot be removed by a conventional wastewater treatment plant because of its recalcitrant *** this study,boron-doped diamond anode and persulfate were used to degrade CIP in an aquatic solution by creating an electrochemically activated persulfate(EAP)*** added to the system as a coactivator and the process was called EAP+*** effects of independent variables,including pH,Fe^(2+),persulfate concentration,and electrolysis time on the systemwere optimized using the response surface *** results showed that the EAP+Fe process removed 94%of CIP under the following optimum conditions:A pH of 3,persulfate/Fe^(2+)concentration of 0.4 mmol/L,initial CIP concentration 30 mg/L,and electrolysis time of 12.64 *** removal efficiency was increased from 65.10%to 94.35%by adding Fe^(2+)as a transition *** degradation products,7 pathways,and 78 intermediates of CIP were studied,and three of those intermediates(m/z 298,498,and 505)were *** toxicological analysis based on toxicity estimation software results indicated that some degradation products of CIP were toxic to targeted animals,including fathead minnow,Daphnia magna,Tetrahymena pyriformis,and *** optimumoperation costswere similar in EAP and EAP+Fe processes,approximately 0.54€/m^(3).

关键词： Ciprofloxacin Response surface methodology Electrochemically activated persulfate Electrooxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Towards overcoming data scarcity in materials science:unifying models and datasets with a mixture of experts framework

引用

npj Computational Materials 2022年第1期8卷 2322-2330页

作者： Rees Chang Yu-Xiong Wang elif Ertekin Department of Materials Science and Engineering University of Illinois at Urbana-Champaign1304 West Green StreetUrbana61801ILUSA Department of Computer Science University of Illinois at Urbana-Champaign201 North Goodwin AvenueUrbana61801ILUSA Materials Research Laboratory University of Illinois at Urbana-Champaign104 South Goodwin AvenueUrbana61801ILUSA Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign1206 West Green StreetUrbana61801ILUSA

While machine learning has emerged in recent years as a useful tool for the rapid prediction of materials properties,generating sufficient data to reliably train models without overfitting is often *** overcoming this limitation,we present a general framework for leveraging complementary information across different models and datasets for accurate prediction of data-scarce materials *** approach,based on a machine learning paradigm called mixture of experts,outperforms pairwise transfer learning on 14 of 19 materials property regression tasks,performing comparably on four of the remaining *** approach is interpretable,model-agnostic,and scalable to combining an arbitrary number of pre-trained models and datasets to any downstream property prediction *** anticipate the performance of our framework will further improve as better model architectures,new pre-training tasks,and larger materials datasets are developed by the community.

关键词： prediction mixture property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bergamottin reduces liver damage by suppressing inflammation, endoplasmic reticulum and oxidative stress in cafeteria diet-fed mice

引用

Food Bioscience 2023年第2期52卷 290-297页

作者： Ebru Yazıcı elif Sahin elif Alvuroglu Esin Yulug Ahmet Mentese Deparment of Obesity Diabetes and Atherosclerosis MetabolismGraduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical Biochemistry Graduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Histology ad Embrylogy Faculty of MedicineKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical Biochemistry Karadeniz Technical University61080TrabzonTurkiye

Cafeteria diet is known to induce excessive endoplasmic reticulum stress(ERS),oxidative stress(OS),and inflammation that could cause metabolic changes and liver ***(BGM)is a natural furanocoumarin that is known to have various biological *** present study,for the first time,assessed the reducing effect of BGM on the development of liver damage in cafeteria diet fed mice.48 male C57BL/6 mice were fed an experimental diets diet for 16 weeks and BGM(0.05 mg/kg and 0.22 mg/kg)was administered for the last four *** serum samples and liver homogenates were assessed for markers of ERS,OS,and ***,histopathological analyzes were *** study demonstrated that the CAF diet caused metabolic changes,ERS,OS,and inflammation in serum and liver ***,BGM exerts anti-oxidant,anti-ER stress anti-inflammatory effects in CAF-induced liver ***,BGM may potentially be a novel therapeutic compound to ameliorate liver damage.

关键词： Bergamottin Cafeteria diet ER stress Inflammation Liver damage Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensitive Spectrofluorimetric Method of Analysis for Gabapentin in Pure and Pharmaceutical Preparations

引用

Chinese Journal of Chemistry 2011年第3期29卷 562-566页

作者： Ulu, Sevgi Tatar Kel, elif Department of Analytical Chemistry Faculty of Pharmacy Istanbul University 34416 Istanbul Turkey

Highly sensitive spectrofluorimetric method was developed and validated for the determination of gabapentin in pure and pharmaceutical preparations. The method was based on nucleophilic substitution reaction of gabapentin with 4-fluoro-7-nitrobenzofurazan （NBD-F） in an alkaline medium （pH 9.5） to form a highly fluorescent derivative that was measured at 521 nm after excitation at 458 rim. The factors affecting the reaction was carefully studied and optimized. The method was successfully validated for linearity, limit of detection, limit of quantification, accuracy, precision, robustness and specificity. Under the optimized conditions, linear relationship with good correlation coefficient （0.9998） was found between the relative fluorescence intensity and gabapentin concentration in the range of 10--100 ng·mL^-1. The limit of detection and limit of quantification were 0.43 and 1.30 ng·mL ^-1, respectively. The proposed method was successfully applied to the determination of gabapentin in its pharmaceutical capsules. The results obtained by the proposed method were comparable with those obtained by the official method. Statistical comparison by t- and F- tests revealed that there was no significant difference between the results of the two methods with respect to mean values and standard deviations at the 95% confidence level.

关键词： gabapentin NBD-F spectrofluorimetric method derivatization determination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling of sage (Salvia fruticosa Miller) phenolics diffusion in meat cubes during ultrasound assisted vacuum impregnation

引用

FOOD BIOSCIENCE 2023年第3期53卷 2302-2311页

作者： Aykin-Dincer, elif Dincer, Cuneyt Akdeniz Univ Engn Fac Dept Food Engn TR-07058 Antalya Turkiye Akdeniz Univ Food Safety & Agr Res Ctr TR-07058 Antalya Turkiye Akdeniz Univ Finike Vocat Sch Dept Food Proc TR-07740 Antalya Turkiye

This study aimed to investigate the modelling of the transport of sage phenolics into meat cubes under various vacuum impregnation (VI) conditions (Control, VI-100, VI-250, and VI-500 mbar;ultrasound-assisted (UA) VI -100, VI-250, and VI-500 mbar). Azuara model from five different models has been proposed as a model that can be used successfully in describing kinetic parameters. After 180 min of treatment, the phenolic contents of the samples were determined between 462.7 and 639.8 mg/kg. Although the highest phenolic content (639.8 mg/kg) was obtained in the samples applied UAVI-100, the highest equilibrium phenolic content was calculated in the samples applied VI-100 in the calculations performed with the Azuara model. In addition, the diffusion coefficients calculated for the samples varied between 8.5 x 10-6 and 11.4 x 10-6 m2/s.

关键词： Beef meat cubes Marination Sage Phenolic extracts Enrichment Azuara model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：