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Bergamottin reduces liver damage by suppressing inflammation, endoplasmic reticulum and oxidative stress in cafeteria diet-fed mice

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Food Bioscience 2023年第2期52卷 290-297页

作者： Ebru Yazıcı elif sahin elif Alvuroglu Esin Yulug Ahmet Mentese Deparment of Obesity Diabetes and Atherosclerosis MetabolismGraduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical Biochemistry Graduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Histology ad Embrylogy Faculty of MedicineKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical Biochemistry Karadeniz Technical University61080TrabzonTurkiye

Cafeteria diet is known to induce excessive endoplasmic reticulum stress(ERS),oxidative stress(OS),and inflammation that could cause metabolic changes and liver ***(BGM)is a natural furanocoumarin that is known to have various biological *** present study,for the first time,assessed the reducing effect of BGM on the development of liver damage in cafeteria diet fed mice.48 male C57BL/6 mice were fed an experimental diets diet for 16 weeks and BGM(0.05 mg/kg and 0.22 mg/kg)was administered for the last four *** serum samples and liver homogenates were assessed for markers of ERS,OS,and ***,histopathological analyzes were *** study demonstrated that the CAF diet caused metabolic changes,ERS,OS,and inflammation in serum and liver ***,BGM exerts anti-oxidant,anti-ER stress anti-inflammatory effects in CAF-induced liver ***,BGM may potentially be a novel therapeutic compound to ameliorate liver damage.

关键词： Bergamottin Cafeteria diet ER stress Inflammation Liver damage Oxidative stress

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Effect of the COVID-19 pandemic on patients with presumed diagnosis of acute appendicitis

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World Journal of Clinical Cases 2022年第29期10卷 10487-10500页

作者： Sami Akbulut Adem Tuncer Zeki Ogut Tevfik Tolga sahin Cemalettin Koc Emek Guldogan Ertugrul Karabulut elif Seren Tanriverdi Ali Ozer Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey Department of Public Health Inonu University Faculty of MedicineMalatya 44280Turkey Department of Surgery Inonu University Faculty of MedicineMalatya 44280Turkey Department of Medical Microbiology Inonu University Medical FacultyMalatya 44280Turkey

BACKGROUND Acute appendicitis(AAp) is the most frequent cause of acute abdominal pain,and appendectomy is the most frequent emergency procedure that is performed *** coronavirus disease 2019(COVID-19) pandemic has caused delays in managing diseases requiring emergency approaches such as AAp and *** To compare the demographic,clinical,and histopathological outcomes of patients with AAp who underwent appendectomy during pre-COVID-19 and COVID-19 *** The demographic,clinical,biochemical,and histopathological parameters were evaluated and compared in patients who underwent appendectomy with the presumed diagnosis of AAp in the pre-COVID-19(October 2018-March 2020) and COVID-19(March 2020-July 2021) *** Admissions to our tertiary care hospital for AAp increased 44.8% in the COVID-19 ***-19(n = 154) and COVID-19(n = 223) periods were compared for various parameters,and we found that there were statistically significant differences in terms of variables such as procedures performed on the weekdays or weekends [odds ratio(OR):1.76;P = 0.018],presence of AAp findings on ultrasonography(OR:15.4;P < 0.001),confirmation of AAp in the histopathologic analysis(OR:2.6;P = 0.003),determination of perforation in the appendectomy specimen(OR:2.2;P = 0.004),the diameter of the appendix(P < 0.001),and hospital stay(P = 0.003).There was no statistically significant difference in terms of interval between the initiation of symptoms and admission to the hospital between the pre-COVID-19(median:24 h;interquartile range:34) and COVID-19(median:36 h;interquartile range:60) periods(P = 0.348).The interval between the initiation of symptoms until the hospital admission was significantly longer in patients with perforated AAp regardless of the COVID-19 or pre-COVID-19 status(P < 0.001).CONCLUSION The present study showed that in the COVID-19 period,the ultrasonographic determination rate of AAp,perforation rate of AAp,and duration of hospital

关键词： SARS-CoV-2 COVID-19 pandemic Acute appendicitis Perforated appendicitis Negative appendectomy

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