检索结果-南通市图书馆

Probiotics and autoprobiotics for treatment of Helicobacter pylori infection

World Journal of Clinical Cases 2023年第20期11卷 4740-4751页

作者： Natalia v Baryshnikova Anastasia S Ilina elena I Ermolenko Yury P Uspenskiy Alexander N Suvorov Department of Molecular Microbiology Institute of Experimental MedicineSt.Petersburg 197376Russia Internal Diseases Department of Stomatological Faculty Pavlov First St-Petersburg State Medical UniversitySt.Petersburg 197022Russia Laboratory of Medical and Social Pediatric Problems St-Petersburg State Pediatric Medical UniversitySt.Petersburg 194100Russia Clinical Department Institute of Experimental MedicineSt.Petersburg 197376Russia Department of Faculty Therapy Named After v.A.valdman St-Petersburg State Pediatric Medical UniversitySt.Petersburg 194100Russia

The article discusses various approaches for probiotic treatment of Helicobacter pylori(***)infection:Probiotics as an adjuvant treatment in the standard eradication therapy;probiotic strains as a monotherapy;and autoprobiotics as a *** refer to indigenous bifidobacteria,lactobacilli,or enterococci isolated from a specific individual,intended to restore his/her microbiota and improve his/her *** potential mechanisms of probiotic action against *** include correction of the gut microbiota,immunological effects(enhancement of humoral and cellular immunity,and reduction of oxidative stress),direct antagonistic effects against ***(such as colonization resistance and bacteriocin synthesis),and stimulation of local immunological protection(strengthening of the mucous protective barrier and reduction of gastric mucosa inflammation).The incorporation of probiotics into comprehensive eradication therapy shows promise in optimizing the treatment of *** *** can enhance the eradication rates of ***,reduce the occurrence and severity of side effects,and improve patient *** or autoprobiotic monotherapy can be considered as an alternative treatment approach in cases of allergic reactions and insufficient effectiveness of *** recommend including probiotics as adjunctive medications in *** ***,further randomized multicenter studies are necessary to investigate the effects of probiotics and autoprobiotics against ***,in order to gain a better understanding of their mechanisms of action.

关键词： Helicobacter pylori Probiotic Autoprobiotic Eradication Microbiota Gut Immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Segmental closure of the Mongol-Okhotsk Ocean:Insight from detrital geochronology in the East Transbaikalia Basin

引用

Geoscience Frontiers 2022年第1期13卷 15-27页

作者： Anastasia v.Arzhannikova elena I.Demonterova Marc Jolivet Ekaterina A.Mikheeva Alexei v.Ivanov Sergey G.Arzhannikov valentin B.Khubanov vadim S.Kamenetsky Institute of the Earth’s Crust Russian Academy of SciencesSiberian BranchIrkutskRussia Laboratoire Géosciences Rennes CNRS-UMR6118Universitéde RennesRennesFrance Geological Institute Russian Academy of SciencesSiberian BranchUlan-UdeRussia

The Late Paleozoic–Early Mesozoic Mongol-Okhotsk Ocean extended between the Siberian and Amur–North China *** timing and modalities of the oceanic closure are widely *** is largely accepted that the ocean closed in a scissor-like manner from southwest to northeast(in modern coordinates),though the timing of this process remains *** studies have shown that both western(West Transbaikalia)and eastern(Dzhagda)parts of the ocean closed almost simultaneously at the Early–Middle Jurassic ***,little information on the key central part of the oceanic suture zone is *** performed U-Pb(LA-ICP-MS)dating of detrital zircon from wellcharacterized stratigraphic sections of the central part of the Mongol-Okhotsk suture *** include the initial marine and final continental sequences of the East Transbaikalia Basin,deposited on the northern Argun-Idemeg terrane *** provide new stratigraphic ages for the marine and continental *** revised chronostratigraphy allows assigning an age of~165–155 Ma,to the collisionrelated flexure of the northern Argun-Idemeg terrane and the development of a peripheral foreland *** collisional process took place 5 to10 million years later than in the western and eastern parts of the *** demonstrate that the northern Argun-Idemeg terrane was the last block to collide with the Siberian continent,challenging the widely supported scissor-like model of closure of the MongolOkhotsk *** segments of the ocean closed independently,depending on the initial shape of the paleo continental margins.

关键词： Detrital zircon U-Pb geochronology Mongol-Okhotsk collision East Transbaikalian Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combined effects of oncolytic vaccinia virus and dendritic cells on the progression of melanoma B16-F10 in mice

引用

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 67-80页

作者： elena P.Goncharova Tatiana A.Gamburg Oleg v.Markov Marina A.Zenkova Laboratory of Biochemistry of Nucleic Acid Institute of Chemical Biology and Fundamental Medicine SB RASNovosibirsk 630090Russia Faculty of natural science Novosibirsk State UniversityNovosibirsk 630090Russia

Aim:We aimed to test the hypothesis that loading of dendritic cells(DCs)with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic ***:vaccinia virus LIvP/GFP and melanoma B16-F10 were used in this *** were pulsed with various combinations of viral and tumor-associated *** maturation status of DCs was verified by expression of the markers CD80,CD86,and CCR7 and assessment of IL-6,TNF-α,and IL-12 *** most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T *** therapy using vaccinia virus LIvP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor ***:We found that loading of DCs with viral antigens,or with a combination of viral and tumor antigens,resulted in similar levels of expression of DC maturation *** maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia virus LIvP/GFP infected tumor *** results show that the combination of vaccinia virus LIvP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than ***:Combination therapy with oncolytic vaccinia virus LIvP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10,but no synergistic antitumor effects were *** propose that optimization of the therapy regimen could enhance the efficiency of combination therapy.

关键词： Oncolytic virus vaccinia virus melanoma B16 dendritic cells cytotoxic T lymphocytes cancer immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The state of gold in phases of the Cu-Fe-S system:In situ X-ray absorption spectroscopy study

引用

Geoscience Frontiers 2023年第3期14卷 103-116页

作者： Boris R.Tagirov Olga N.Filimonova Alexander L.Trigub Ilya v.vikentyev elena v.Kovalchuk Maximilian S.Nickolsky Andrey A.Shiryaev vladimir L.Reukov Dmitry A.Chareev Institute of Geology of Ore Deposits(IGEM RAS) 35Staromonetnyi per119017 MoscowRussia National Research Centre‘Kurchatov Institute’ 1Akademika Kurchatova pl123182 MoscowRussia Institute of Physical Chemistry and Electrochemistry(IPCE RAS) 31Leninsky Prospect119071 MoscowRussia Institute of Experimental Mineralogy(IEM RAS) 142432 ChernogolovkaMoscow RegionRussia

Chalcopyrite and bornite are the main Au-bearing minerals at Cu porphyry deposits,volcanogenic massive sulfide(vMS)deposits,Cu-Ni deposits of the mafic magmatic complexes,and ores of submarine sulfide *** and intermediate solid solutions with wide compositional variations(bnss and iss–high-temperature chalcopyrite,correspondingly),which can scavenge economic concentrations of Au,appear in the Cu-Fe-S system at ore-forming ***,the state of Au in bnss and iss is yet *** solve this conundrum,we synthesized samples with net chemical composition of bnss and iss,studied them by in situ X–ray absorption spectroscopy(XAS),and used the experimental data to explain the Au distribution among natural ore-forming *** sulfide samples were obtained at 495–700℃ in Au-saturated system by means of salt flux *** bnss contained1.2–1.6 log units more Au than iss:up to 18 wt.%Au in bnss vs 0.4 wt.%Au in iss at 700*** increase of temperature resulted in the sharp increase of Au concentration in both phases,1 log unit per 100℃ at f(S2)close to S_((l)) *** of Au L_(3)-edge spectra recorded at 25–675℃ revealed that at 25℃ Au exists mainly in the metallic *** t>500℃ the spectral features of Audisappear,and “chemically bound”Au *** Au form of occurrence in the iss field is interpreted as Au-bearing clusters with a stromeyerite-like(CuAgS)*** Cu_(2–x)S and bnss contain Au in a mixture of stromeyeritelike and petrovskaite-like(Au_(0.8)Ag_(1.2)S)*** chemical composition of both forms is close to CuAuS,where the nearest Au neighbors are two S atoms at R_(Au-S)=2.34–2.36Å.Results of the present study allow to determine the state of Au and its concentration in the main Cu-bearing minerals of sulfide ores as a function of the T-f(S_(2))-compositional *** to the sharp increase of the CuAuS clusters stability with increasing temperature,in high-temperature ores formed at t>350℃ A

关键词： “Invisible”gold Bornite solid solution Intermediate solid solution Digenite Chalcopyrite X-ray absorption spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Fifth Edition of the General Catalogue of variable Stars:experiences in the constellation Centaurus

引用

Research in Astronomy and Astrophysics 2018年第7期18卷 93-100页

作者： Nikolay N.Samus elena N.Pastukhova Olga v.Durlevich elena v.Kazarovets Institute of Astronomy Russian Academy of Sciences Sternberg Astronomical Institute Lomonosov Moscow University

We have recently announced that the General Catalogue of variable Stars enters the stage of its fifth, purely electronic edition （GCvS 5.1）. We have included 1408 variable stars in the constellation Centaurus in this new version, GCvS 5.1. Working on this revision, we applied current possibilities from data mining, suggested new variability types for many variable stars and found new light elements for a large number of periodic variables. This paper describes the work completed during the preparation of GCvS 5.1 for Centaurus and discusses in detail a number of the most astrophysically significant cases.

关键词： catalogs - techniques photometric - stars variables general - binaries eclipsing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,*** and energy abilities as a component of solid composite propellants

引用

Defence Technology（防务技术） 2022年第7期18卷 1148-1155页

作者： Anatoly G.Korepin Natalia M.Glushakova David B.Lempert Anatoly I.Kazakov Gennady v.Shilov Denis v.Korchagin vadim M.volokhov elena S.Amosova Sergey M.Aldoshin Institute of Problems of Chemical Physics Ac.Semenov Avenue 1Chernogolovka142432Russian Federation

The work addresses to the study of the molecular and crystal structure and properties of a new energyintensive compound 3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,5-tetrazine(NBTAT),first obtained by the authors in *** compound crystallizes in the monoclinic system,space group P2(1)/n,density at room temperature 1.939 g/cm^(3).The energies of crystal packing and pairwise intermolecular interactions in NBTAT and its unnitrated analogue BTAT were calculated,and their comparative analysis was carried *** enthalpy of formation of NBTAT molecules was calculated by quantum-chemical methods using Gaussian 09,and the enthalpy of formation of NBTAT in the solid phase(618 kJ/mol)was *** energy capabilities of NBTAT as an oxidizer of solid composite propellants are *** is shown that in metal-free compositions NBTAT is significantly superior to ammonium perchlorate(AP),dinitramide ammonium salt(ADN),HMX,BTAT at all stages of rocket systems,and is comparable to the superdense CL-20 yielding to the latter at the lower stages and slightly winning at the upper stages.

关键词： Nitrogen heterocycles Quantum chemistry Enthalpy of formation 3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,5-tetrazine Crystal structure Energetic ability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A short P-wave duration is associated with incident heart failure in the elderly: a 15 years follow-up cohort study

引用

Journal of Geriatric Cardiology 2022年第9期19卷 643-650页

作者： Bozena Ostrowska Lars Lind elena Sciaraffia Carina Blomström-Lundqvist Department of Medical Sciences Uppsala UniversityUppsalaSweden School of Medical Science Faculty of Medi-cine and HealthÖrebro UniversityÖrebroSweden

BACKGROUND Early identification of patients at risk of congestive heart failure(HF)may alter their poor *** aim was therefore to test whether simple electrocardiographic variables,the P-wave and PR-interval,could predict incident *** The PIvUS(Prospective Investigation of the vasculature in Uppsala Seniors)study(1016 individuals all aged 70 years,50%women)was used to identify predictors of *** with prevalent HF,QRS duration≥130 ms,atrial tachyar-rhythmias,implanted pacemaker/defibrillator,second-and third-degree atrioventricular block or delta waves at baseline were *** proportional hazard analysis was used to relate the PR interval,P-wave duration(Pdur)and amplitude(Pamp),measured in lead v1,to incident *** was performed for gender,RR-interval,beta-blocking agents,systolic blood pressure,body mass index and *** Out of 836 subjects at risk,107 subjects were diagnosed with HF during a follow-up of 15 *** the multivariate analysis,there was a strong U-shaped correlation between Pdur in lead v1 and incident HF(P=0.0001)which was significant for a Pdurval or the Pamp.A Pdurved discrimination by 3.7%when added to the tradi-tional risk factors including sex,RR-interval,beta-blocking agents,systolic blood pressure,BMI and smoking(P=0.048).CONCLUSIONS A short Pdur,an easily measured parameter on the ECG,may potentially be a useful marker of future HF,enabling its early detection and prevention,thus improving outcomes.

关键词： prevention incident wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

引用

Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan Marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan Marina v.Parkhats Boris M.Dzhagarov Maria v.Korchenova Ekaterina N.Lazareva elena S.Tuchina Grigor v.Gyulkhandanyan valery v.Tuchin H.Buniatyan Institute of Biochemistry National Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia INSERM U1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science Medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser Molecular Imaging and Machine Learning(LMIML)National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus MRSA E.coli Salmonella typhimurium.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High tolerance to simulated root herbivory in hydroponically grown cuttings of Salix phylicifolia

引用

Journal of Forestry Research 2021年第6期32卷 2661-2668页

作者： Mikhail v.Kozlov elena L.Zvereva Department of Biology University of Turku20014TurkuFinland

The shortage of information regarding the effects of root damage on forest plants,especially trees and shrubs,is the most critical gap in our knowledge of belowground insect *** study examines how the tea-leaved willow,Salix phylicifolia,responds to simulated root herbivory and how nutrient availability affects these *** grown cuttings were used to precisely apply the desired levels of root ***:shoot ratios increased proportionally to the intensity of root damage,whereas specific leaf area,leaf water content and chlorophyll fluorescence were not *** removal of 2-64%of roots once in early summer and the removal of 25%of roots three times during the summer did not change biomass production by *** repeated removal of 50 and 75%of roots decreased shoot biomass and,to a lesser extent,total root *** tolerance of tea-leaved willow to root damage was greater in low nutrient treatment than in high nutrient treatment,thus supporting the Growth Rate *** to this model,in low resource conditions plants do not attain their maximum growth rate and therefore have a higher capacity for regrowth after *** conclude that,in the absence of water limitations,tea-leaved willow shows high tolerance to root losses and is unlikely to be affected by realistic levels of root herbivory.

关键词： Belowground herbivory Chlorophyll fluorescence Leaf water content Plant growth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyphony of domestic dog whines and vocal cues to body size

引用

Current Zoology 2021年第2期67卷 165-176页

作者： Olga v.SIBIRYAKOvA Ilya A.vOLODIN elena v.vOLODINA Department of vertebrate Zoology Faculty of BiologyLomonosov Moscow State UniversityMoscow 119234Russia Department of Behaviour and Behavioural Ecology A.N.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscow 119071Russia

In domestic dogs Canis familiaris,vocal traits have been investigated for barks and growls,and the relationship between individual body size and vocal traits investigated for growls,with less corre-sponding information for *** this study,we examined the frequency and temporal traits of whines of 20 adult companion dogs(9 males,11 females),ranging in body mass from 3.5 to 70.0 kg and belonging to 16 *** whines(26-71 per individual,824 in total)were recorded in condi-tioned begging contexts modeled by dog *** had 3 independent fundamental fre-quencies:the low,the high and the ultra-high that occurred singly as monophonic calls or simul-taneously as 2-voice biphonic or 3 voice polyphonic *** the smallest to largest dog,the upper frequency limit varied from 0.24 to 2.13 kHz for the low fundamental frequency,from 2.95 to 10.46 kHz for the high fundamental frequency and from 9.99 to 23.26 kHz for the ultra-high funda-mental *** individuals,the low fundamental frequency was lower in monophonic than in biphonic whines,whereas the high fundamental frequency did not differ between those whine *** frequency variables of the low,high,and ultra-high fundamental frequencies cor-related negatively with dog body *** duration,no correlation with body mass was *** discuss potential production mechanisms and sound sources for each fundamental frequency;point to the acoustic similarity between high-frequency dog whines and rodent ultrasonic calls and hypothesize that ultra-high fundamental frequencies function to allow private,"tete-a-tete"com-munication between members of social groups.

关键词： acoustic communication Canis familiaris companion dogs high-frequency calls nonlinear phenomena vocalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：