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Rapid Multi-Wav.length Optical Assessment of Circulating Blood v.lume Without a Priori Data

Photonic Sensors 2016年第1期6卷 42-57页

作者： ekaterina v. loginova Tatyana v. ZHIDKOv. Mikhail A. PROSKURNIN v.adimir E ZHAROv M. v. Lomonosov.Moscow State Univ.rsity Chemistry Department Moscow 119991 Russia Agilent Technologies Partner Laboratory / M.v. Lomonosov.Moscow State Univ.rsity Analytical Center Moscow 119991 Russia philips Classic Laser Laboratories University of Arkansas for Medical Sciences Little Rock Arkansas 72205 USA

The measurement of circulating blood v.lume （CBv. is crucial in v.rious medical conditions including surgery, iatrogenic problems, rapid fluid administration, transfusion of red blood ceils, or trauma with extensiv. blood loss including battlefield injuries and other emergencies. Currently, av.ilable commercial techniques are inv.siv. and time-consuming for trauma situations. Recently, we hav. proposed high-speed multi-wav.length photoacoustic/photothermal （PA/PT） flow cytometry for in v.v. CBv.assessment with multiple dyes as PA contrast agents （labels）. As the first step, we hav. characterized the capability of this technique to monitor the clearance of three dyes （indocyanine green, methylene blue, and trypan blue） in an animal model. Howev.r, there are strong demands on improv.ments in PA/PT flow cytometry. As additional v.rification of our proof-of-concept of this technique, we performed optical photometric CBv.measurements in v.tro. Three label dyes--methylene blue, crystal v.olet simultaneous photometric determination of the and, partially, brilliant green--were selected for components of their two-dye mixtures in the circulating blood in v.tro without any extra data （like hemoglobin absorption） known a priori. The tests of single dyes and their mixtures in a flow system simulating a blood transfusion system showed a negligible difference between the sensitiv.ties of the determination of these dyes under batch and flow conditions. For indiv.dual dyes, the limits of detection of 3×10-6M-3×10-5M in blood were achiev.d, which prov.ded their continuous determination at a lev.l of 10-SM for the CBv.assessment without a priori data on the matrix. The CBv.assessment with errors no higher than 4% were obtained, and the possibility to apply the dev.loped procedure for optical photometric （flow cytometry） with laser sources was shown.

关键词： Circulating blood v.lume assessment spectrophotometry methylene blue crystal v.olet

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Morphology of crater and caldera lakes in the Far Eastern region of Russia and the features of their dev.lopment

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Journal of Mountain Science 2024年第4期21卷 1246-1258页

作者： Dmitrii N.KOZLOv.ekaterina v.LEBEDEv. Institute of Marine Geology and Geophysics Far Eastern Branch of the Russian Academy of SciencesYuzhno-Sakhalinsk 693022Russia Institute of Geography Russian Academy of SciencesMoscow 119017Russia

v.lcanic lakes in the Kuril-Kamchatka region are difficult to access,and for this reason,they remain poorly studied,with only scattered and brief data *** authors hav. conducted a study of 10 lake basins using modern digital echolocation surv.y techniques and hav. also compiled and summarized published data for 15 lakes in the region,calculating their main morphometric *** has been established that many caldera lake basins are modified by young explosiv. funnels,extrusiv. or effusiv. domes,and exhibit traces of hydrothermal *** lakes of the same genetic type in the Kuril-Kamchatka region are similar in depth and depression forms,the group of caldera lakes shows less homogeneity across all morphometric *** was found that the absolute heights of the reserv.irs on Kamchatka Peninsula are generally greater than those on the Kuril Islands,as is often the case with the size of their *** v.lcanic lakes under study can rapidly change their v.lume and shape under the influence of endogenous *** the first time for this region,on the base of repeated observ.tions,underwater extrusiv. dome rate growth and the approximate rates of 2 lake lev.l changes were *** observ.tions of lakes in the Ksudach calderas(Kamchatka)and on Simushir Island indicate approximate rates of lev.l changes:a decrease ranging within 0.5-0.6 m per year(ov.r a 27-year observ.tion interv.l)and an increase reaching up to 0.26 m per year(ov.r a 48-year interv.l).The growth rate of the underwater extrusiv. dome in Lake Shtyubel has av.raged 1-1.6 m per year ov.r the past 25 *** analysis has facilitated the first generalization regarding the morphology and dev.lopmental features of crater and caldera lakes in the Kuril-Kamchatka region of Russia,representing an important step in their *** results obtained will prov.de a solid foundation for subsequent research in this region and may be of interest to researchers studying

关键词： v.lcanic lakes Echolocation surv.y v.lcanism Gashydrotherms Kamchatka Kuril Islands

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Photoluminescence,structural and antibacterial properties of co-dopedβ-Ca_(3)(PO_(4))_(2)-type phosphates Ca_(8)CuRE(PO_(4))_(7)(RE=Eu-Er)

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Journal of Rare Earths 2024年第9期42卷 1658-1668,I0002页

作者： Iv.n v.Nikiforov.ekaterina v.Iliin Bogdan I.Lazoryak Sergey M.Aksenov.Pav.l v.Slukin Dina v.Deyneko Department of Chemistry Lomonosov Moscow State University119991MoscowRussia Laboratory of Arctic Mineralogy and Material Sciences Kola Science CentreRussian Academy of Sciences184209ApatityRussia Geological Institute Kola Science CentreRussian Academy of Sciences184209ApatityRussia State Scientific Center of Applied Microbiology and Biotechnology of Rospotrebnadzor 24 Block A142279ObolenskRussia

Nov.l Ca_(8)CuRE(PO_(4))_(7)where RE^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Ho^(3+)and Er^(3+)were synthesized by a solid-state method in *** structures of the samples were characterized by powder X-ray diffraction using Rietv.ld refinement to determine the occupation of crystal *** samples are found to hav. a centrosymmetric structure with space group R3c,as shown by dielectric *** synthesized Ca_(8)CuRE(PO_(4))_(7)samples hav. multifunctional *** Cu^(2+)ions prov.de antibacterial properties,while the rare earth elements ions exhibit luminescence properties,and theβ-Ca_3(PO_(4))_(2)-type host is *** photoluminescence properties of RE^(3+)ions were studied and compared with other simmilar Ca_(8)MRE(PO_(4))_(7)phosphates,where M is a div.lent *** photoluminescence intensity quenching in terms of energy transfer from RE^(3+)to Cu^(2+)is *** bioactiv. properties were studied in relation to antibacterial activ.ty against *** and *** syntesized Ca_(8)CuRE(PO_(4))_(7)samples demonstrate v.ry high and stable inhibition of bacteria *** correlation between crystal structure and properties is *** combining multiple approaches to the directio nal design of such materials,sev.ral important properties within a single chemical compound to achiev. biov.sualization and bioactiv. properties simultaneously can be combined.

关键词： β-Ca_(3)(PO_(4))_(2) Whitlockite-type structure Bioactiv. phosphates TCP Photoluminescence Rare earths

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Selection of shaped charges parameters for producing aluminum particles with v.locities in the range of 2.5-16 km/s

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Defence Technology（防务技术） 2024年第8期38卷 126-135页

作者： v.adimir I.Kolpakov.Sergey v.Fedorov.ekaterina P.v.nogradov. Irina A.Bolotina Bauman Moscow State Technical Univ.rsity Moscow 105005Russia

Testing rocket and space technology objects in ground conditions for resistance to the impact of meteoroids and fragments of space debris can be carried out using shaped charges. To substantiate the design parameters of shaped charges that ensure the formation of aluminum particles in a wide v.locity range(from 2.5 to 16 km/s), numerical modeling of the formation process was carried out within the framework of a two-dimensional axisymmetric problem of continuum mechanics using three different computing codes to increase the reliability of the results. The calculations consider shaped charges with a diameter of 20-100 mm with aluminum liners of v.rious shapes. It is shown that the formation of particles with v.locities close to the lower limit of the considered range is ensured by gently sloping segmental liners of degressiv. thickness. To form higher-v.locity particles with v.locities ov.r 5 km/s, it is proposed to use combined liners, the jet-forming part of which has the shape of a hemisphere of constant thickness or the shape of a semi-ellipsoid or semi-superellipsoid of rotation of degressiv. thickness.

关键词： Space debris Meteoric impact Explosion Shaped charge High-v.locity aluminum element Segmental liner Combined liner Numerical simulation

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ChatGPT: Application in Chemistry Education and Challenges

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Journal of Computer and Communications 2024年第3期12卷 196-206页

作者： v.adimir L. Kodkin ekaterina v. Artem’ev. Power Engineering Faculty South Ural State University Chelyabinsk Russia Department of Chemistry Institute of Natural Sciences South Ural State University Chelyabinsk Russia

The paper discusses the adv.ncements and applications of neural networks, specifically ChatGPT, in v.rious fields, including chemistry education and research. It examines the benefits of AI and ChatGPT, such as their ability to process and analyze large amounts of data, create personalized training systems, and offer problem-solv.ng recommendations. The paper delv.s into practical applications, showcasing how ChatGPT can be utilised to augment chemistry learning. It prov.des examples of using ChatGPT for creating tests, generating multiple-choice questions, and studying chemistry in general. Concerns are v.iced about the ethical and societal impact of AI dev.lopment. In conclusion, it explores the exciting potential of AI to tackle challenges that may exceed human capabilities alone, pav.ng the way for further exploration and collaboration between humans and intelligent machines.

关键词： ChatGPT 3.5 Artificial Intelligence AI for Education Computer-Based Learning

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A rened analytical model for reconstruction problems in diuse reectance spectroscopy

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Journal of Innov.tiv. Optical Health Sciences 2024年第5期17卷 33-51页

作者： ekaterina Sergeev. Daria Kurakina Ilya Turchin and Mikhail Kirillin A.v.gaponov.grekhov.institute of applied physics of the russian academy of sciences ulyanov.st.46 603950nizhny novgorodrussia

A rened analytical model of spatially resolv.d diffuse reectance with small source-detector separations(SDSs)for the in v.v. skin studies is *** to the conv.ntional model dev.loped by Farrell et al.,it accounts for the limited acceptance angle of the *** rened model is v.lidated in the wide range of optical parameters by Monte Carlo simulations of skin diffuse reectance at SDSs of units of *** of uniform dermis and two-layered epidermis-dermis structures are *** accuracy of the rened model compared to the conv.ntional one is demonstrated in the separate,constraint-free reconstruction of absorption and reduced scattering spectra of uniform dermis from the Monte Carlo simulated *** the case of epidermis-dermis geometry,the recov.red v.lues of reduced scattering in dermis are ov.restimated and the recov.red v.lues of absorption are underestimated for both analytical ***,in the presence of a thin mismatched topical layer,only the effectiv. attenuation coe±cient of the bottom layer can be accurately recov.red using a diffusion theorybased analytical model while separate reconstruction of absorption and reduced scattering fails due to the inapplicability of the method of ***-ndings require implementation of more sophisticated models of light transfer in inhomogeneous media in the recov.ry algorithms.

关键词： Diffuse reffectance spectroscopy in v.v. skin studies optical properties reconstruction diffuse approximation Monte Carlo simulations method of images

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Specificity of electrophysical and gas-sensitiv. properties of nanocomposite ZnO–TiO_(2) films formed by solid-phase pyrolysis

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ChemPhysMater 2024年第3期3卷 314-319页

作者： v.ctor v.Petrov.Maria G.v.lkov. Alexsandra P.Iv.nishchev. Gleb v.Tolstyak ekaterina M.Bayanb Institute of Nanotechnologies Electronicsand Equipment EngineeringSouthern Federal UniversityTaganrog 347922Russia Faculty of Chemistry Southern Federal UniversityRostov-on-Don 344090Russia

ZnO–TiO_(2) thin films containing 0.5 mol%,1.0 mol%,and 5.0 mol%ZnO were synthesized by oxidativ. solidphase *** materials contained anatase and rutile phases with particle size of 6–13 nm,as confirmed using X-ray phase analysis and scanning electron *** a certain number of ZnO crystallites appeared in the TiO_(2) film structure in the temperature range of room temperature to 220℃,a two-lev.l response of the film resistance was observ.d,differing by approximately 10%,as obtained by electrophysical *** two-lev.l response correlates with the formation of two donor energy lev.ls of 0.28 and 0.33 ev.in the band structure of the ZnO–TiO_(2) *** donor lev.l with a higher activ.tion energy corresponded to the Ti v.cancy(v.Ti),and that with a lower activ.tion energy corresponded to the Zn v.cancy(v.Zn).Two lev.ls of gas-sensitiv. properties were noted for 0.5ZnO–TiO_(2),1ZnO–TiO_(2),and 5ZnO–TiO_(2) under the influence of 50 ppm NO_(2) at 250℃.Such two-lev.l responses can be ascribed to the pinning of the Fermi lev.l on ZnO and TiO_(2) *** mechanism of the beak-shaped and two-lev.l responses of sensors based on composite nanomaterials when exposed to v.rious gases was elucidated.

关键词： Thin film ZnO TiO_(2) Nanocomposites Pyrolysis Gas sensors

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PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv.ALISA D.INESHINA TATIANA A.ARISTOv. v.RA v.DENISOv. Sv.TLANA A.SIZIKOv. DARIA S.BATOROv. GALINA Y.USHAKOv. ekaterina Y.SHEv.LA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,prev.ous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in v.tro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activ.tor of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparativ.ly assessed with flow cytometry in PD-1-and TIM-3-negativ. and positiv. T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positiv. T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negativ. and positiv. CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusiv. regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negativ. T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to allev.ate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

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Age of maturation and behav.oral tactics in male yellow ground squirrel Spermophilus fulv.s during mating season

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Current Zoology 2014年第6期60卷 700-711页

作者： Nina A. v.SILIEv. ekaterina v. PAv.Ov. Sergey v. NAIDENKO Andrey v.TCHABOv.KY A.N. Sev.rtsov.Institute of Ecology and Ev.lution Russian Academy of Sciences 33 Leninsky pr. Moscow 119071 Russia

Life-history theory predicts that in hibemators age of maturation is related positiv.ly to body size and negativ.ly to the duration of activ. season abov.ground. Yellow souslik is a large-sized ground squirrel with long hibernation, which suggests late maturation. We used four-year field observ.tions of marked indiv.duals to determine the age of maturation in males through analysis of age-dependent v.riation in body size, mass, androgen status, timing of spring emergence, ranging patterns and social behav.or during the mating season. Yearling males were smaller, lighter, had lower lev.l of fecal testosterone, emerged later and had smaller home ranges than older males. Social activ.ty and the number of females encountered did not differ between age classes. After the second hibernation none of the studied parameters v.ried with age. Cluster analysis rev.aled two behav.oral tactics：＂activ.＂ males （adults only） emerged earlier, ranged more widely, initiated more contacts, encountered more females and were heav.er than ＂passiv.＂ males （both yearling and adult）. Thus, males of S. fulv.s reached adult size and matured after two hibernations, which is relativ.ly fast for such a big species with short activ. period. Indirect ev.dence for copulations and high v.riation among yearlings in all parameters suggest that some of them might successfully compete with adults. Activ. tactic of wandering and searching for females is energetically costly, and probably only adult males in good physical condition can afford it, whereas passiv. tactic of residing is energy sav.ng and good for adults in poor condition and for yearlings that are continuing to grow.

关键词： Age of maturation Mating system Reproductiv. tactics Ground squirrel Spermophilusfulv.s

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Inv.stigation of electrophysical, photo- and gas-sensitiv. properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Adv.nced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaev. Alexandra P.Iv.nishev. Maria G.v.lkov. v.ctoria Yu.Storozhenko Soslan A.Khubezhov.ekaterina M.Bayan v.ctor v.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal Univ.rsity Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensiv.ly studied by atomic force and Kelv.n probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductiv.ty parameters on exposure to light with a wav.length of 470 nm were also *** study of the photosensitiv.ty kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum v.lue of the charge carrier generation time *** of the activ.tion energy of the conductiv.ty,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters hav. maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response v.lues when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitiv. properties surface potential potential barrier conduction activ.tion energy

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