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Frailty Prevalence and Characteristics in Older Patients with Type 2 Diabetes

Journal of Diabetes Mellitus 2019年第2期9卷 31-38页

作者： Takahisa Tanikawa Sayuri Sable-Morita Haruhiko Tokuda Hidenori arai Department of Endocrinology National Center for Geriatrics and Gerontology Obu Japan Nursing Department National Center for Geriatrics and Gerontology Obu Japan Department of Clinical Laboratory National Center for Geriatrics and Gerontology Obu Japan National Center for Geriatrics and Gerontology Obu Japan

Background: Older diabetic patients are more likely to be frail than those who do not have diabetes. Frailty is an important risk factor for both mortality and disability in older patients with type 2 diabetes. However, the mechanism of frailty in diabetes mellitus is not fully understood. Aims: The aim of this study was to identify the prevalence of frailty and associated factors in older patients with type 2 diabetes in Japan. Methods: A cross-sectional study was conducted with a total of 178 outpatients who were over 65 years old with type 2 diabetes. We used the Obu Study Health Promotion for the Elderly definition of frailty to divided subjects into a non-frail and a frail group. We investigated the association between frailty and various patient characteristics. Results: In the study, 21.4% of the older patients with type 2 diabetes were considered frail. There were no significant differences in the duration of diabetes, BMI, proportion of microvascular complications, or HbA1c values between the frail and non-frail group. However, serum albumin and IGF-1 levels were lower in the frail group than the non-frail group as were the Mini-Mental State Examination scores. The frail group had a higher number of medications than the non-frail group. In a multivariable analysis, frailty was positively associated with the number of medications and, lower levels of both serum albumin and IGF-1. Conclusion: Our study suggests that diabetes accelerates the aging process and frailty is associated with low albumin, polypharmacy and low levels of IGF-1.

关键词： Frailty Albumin Insulin-Like Growth Factor-1 Polypharmacy

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In Vivo Interaction of Morphine and Diclofenac

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Pharmacology & Pharmacy 2016年第12期7卷 493-503页

作者： Yoshiaki Kimura Koki Muryoi Mika Shibata Noriyuki Ozaki Kunizo arai Faculty of Pharmacy Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan Suisen Pharmacy Fukui Pharmaceutical Association Fukui Japan Department of Functional Anatomy Graduate School of Medical Sciences Kanazawa University Kanazawa Japan

The number of studies on possible pharmacokinetic interactions between opioid analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used in combination for the treatment of chronic pain, is limited. In rats, the major metabolic pathway of morphine is glucuronidation to morphine-3-glucuronide (M3G) by UDP-glucuronosyltransferase. In this study, we investigated the influence of diclofenac (NSAID) on the formation of M3G in vitro using rat liver tissue homogenates. Competitive inhibition of M3G formation by diclofenac was observed with an average Ki of 19.9 μM. Because these in vitro findings suggested that a pharmacokinetic interaction occurs in vitro , we investigated whether diclofenac inhibits the glucuronidation of morphine in rats. A single dose of diclofenac increased serum concentrations of both morphine and M3G and showed a higher analgesic efficacy in the Von Frey test. Furthermore, diclofenac caused a net decrease in morphine urine concentrations, but the excretion of M3G through biliary and urinary routes was unchanged. These results demonstrated that in contrast to in vitro data a single dose of diclofenac did not alter the glucuronidation of morphine in vitro .

关键词： Morphine Diclofenac Udp-Glucuronosyltransferase Von Frey Test

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STUDY ON DAMPING FACTOR OF THE LONG SPAN HISTORICAL WOODEN BUILDING WITH SEISMIC MUD WALL

STUDY ON DAMPING FACTOR OF THE LONG SPAN HISTORICAL WOODEN B...

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International Symposium on New Olympics New Shell and Spatial Structures

作者： Koichi Matsuno Shingo arai Kenji HORI Asuka KONDO Dep. of Architecture Toyo University 2100 Kujirai Kawagoe-shi Saitama JAPAN Professor Dr. Eng. Graduate School of Engineering Toyo University 2100 Kujirai Kawagoe-shi Saitama JAPAN Graduate Student Graduate School of Engineering Toyo University 2100 Kujirai Kawagoe-shi Saitama JAPAN Graduate Student Graduate School of Engineering Toyo University 2100 Kujirai Kawagoe-shi Saitama JAPAN Graduate Student

＜正＞The wood spatial structure was adopted in the pavilion such as expositions that had been held in Japan. There are reports of the loading experiment and the vibration experiment that executed at construction or the demolition work of the pavilion. The few one is current states in a systematic research for the damping performance. At present, a theoretical method of forecasting the damping performance in the building accurately doesn’t exist, and the evaluation relies on the measurement so far. In this paper, among the damping performances, it introduces the damping factor presumed from the microtremor measured data of the comparatively large-scale traditional wooden building. Six targeted large warehouses are wooden buildings with a Japanese traditional roof frame though the building scale, the planar shape, and the section shape are different it. Table 1 shows the outline of the building and structure of six large warehouses that executes the microtremor measurement. The building is as shown in Photo 1 to 4.

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Preparation of Light-Emitting Ytterbium-Doped Tantalum-Oxide Thin Films Using a Simple Co-Sputtering Method

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Materials Sciences and Applications 2015年第2期6卷 209-213页

作者： Kenta Miura Kazusa Kano Yuki arai Osamu Hanaizumi Graduate School of Science and Technology Gunma University Kiryu Japan

Light-emitting ytterbium-doped tantalum-oxide thin films were prepared using a simple co-sputtering method for the first time. Sharp photoluminescence peaks having a wavelength of around 980 nm were observed from films annealed from 700°C to 1000°C for 10 to 40 min. The strongest intensity of the 980-nm peak was obtained from a film deposited using three ytterbium-oxide pellets and annealed at 800°C for 20 min. Such rare-earth doped tantalum-oxide sputtered films can be used as high-refractive-index materials of autocloned photonic crystals that can be applied to novel light-emitting devices, and they will also be used as both anti-reflection and down-conversion layers for realizing high-efficiency silicon solar cells.

关键词： Tantalum Oxide Ytterbium Co-Sputtering Annealing Photoluminescence

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DRUG RESISTANT AND BIOACTIVE E COLI IN BeijiNG

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中华医学杂志(英文版) 1984年第11期97卷 824-824页

作者： Toshihiko arai Sadao Komatsu Md. Alshad Ullah Department of Microbiotogy Keio University School of Medicine Japan

We surveyed antibiotic resistant and various bioactive Escherichia coli strains isolated in the Capital Hospital in Beijing in 1981. It was found that most of the clinical strains in Beijing were antibiotic resistant. Tetracycline resistant strains were most prevalent (92%), and incidences of resistant strains to streptomycin, sulfonamides, chloramphenicol, ampicillin and kanamycin decreased in this order, suggesting that tetracycline derivatives were widely used in Beijing. Incidence of conjugative R plasmids in Beiijng (38%) was same as that in Tokyo and lower than that in Moscow. We examined hemagglutination, the common antigens with small intestine adhesive bacteria, colicin production, enterotoxin production, DNase production, invading ability into intestinal epithelial cells, active iron incorporating ability and capsules of the collected strains and found that incidences of these bioactive strains were not so different from those in Tokyo, although minor differences were found in many characters. None of the genes for these bioactive characters were found on the highly conjugative plasmids. This lower incidences of bioactive as well as conjugative R plasmids in Beiijng and Tokyo than those in Moscow suggested that plasmids in E coli strains in Beijing were similar to those in Tokyo but different from those in Moscow.

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Fabrication of Erbium and Ytterbium Co-Doped Tantalum-Oxide Thin Films Using Radio-Frequency Co-Sputtering

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Materials Sciences and Applications 2015年第5期6卷 343-347页

作者： Kenta Miura Yuki arai Kazusa Kano Osamu Hanaizumi Graduate School of Science and Technology Gunma University Kiryu Japan

An erbium and ytterbium co-doped tantalum-oxide (Ta2 O5:Er, Yb) thin film was fabricated using a simple co-sputtering method for the first time, and its photoluminescence (PL) spectrum was evaluated. Energy transfers between Er3+ and Yb3+ in the Ta2 O5:Er, Yb co-sputtered thin film were discussed by comparing between PL spectra of the Ta2 O5:Er, Yb film and Ta2 O5:Er or Ta2 O5:Yb films reported in our previous works. Such a Ta2 O5:Er, Yb co-sputtered film can be used as a high-refractive- index and light-emitting material of a multilayered photonic crystal that can be applied to a novel light-emitting device, and it will also be used as a multi-functional coating film having both anti-reflection and down-conversion effects for realizing a high-efficiency silicon solar cell.

关键词： Tantalum Oxide Erbium Ytterbium Co-Sputtering Photoluminescence

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江口凤鲚耳石中微量元素的环境“指纹”

江口凤鲚耳石中微量元素的环境“指纹”

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中国水产学会第五届青年学术年会

作者：杨健 Takaomi arai Nobuyuki Miyazaki 刘洪波中国水产科学研究院淡水渔业研究中心内陆渔业环境和资源重点开放实验室日本东京大学海洋研究所

洄游性鱼类在不同的生活史阶段栖息环境可能截然不同,而准确了解这些鱼类生活史过程中的生境变化非常困难。因为传统的调查法无法解决"多种类泛用"、"全生活史监测"和"不增加外部负荷"等难题。本研究利用微量元素电子探针分析技术研究...

洄游性鱼类在不同的生活史阶段栖息环境可能截然不同,而准确了解这些鱼类生活史过程中的生境变化非常困难。因为传统的调查法无法解决"多种类泛用"、"全生活史监测"和"不增加外部负荷"等难题。本研究利用微量元素电子探针分析技术研究了长江口风鲚耳石中Sr和Ca的环境"指纹"。结果表明,长江口凤鲚不像迄今所报道的不进入淡水域。在其产卵、孵化、发育和生长等生活史过程中风鲚所需环境的变化,远比目前所了解的要复杂.其洄游类型和群体构成可能存在着多样性。该水域的风鲚繁殖群体可能由淡水-河口半咸水、淡水-河口半咸水-海水、海水-河口半成水洄游的群体混合构成。耳石微量元素环境"指纹"的研究,是一种极具潜力的可较为准确地了解鱼类的洄游生态学的新途径。

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A sensitive homogeneous non-competitive immunoassay using β-galactosidase complementation for the detection of small haptens

A sensitive homogeneous non-competitive immunoassay using β...

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The Seventh China-Japan Joint Symposium on Enzyme Engineering

作者： Teruyuki Nagamune Tomoichi Yokozeki Ryouichi arai Hiroshi Ueda Department of Chemistry and Biotechnology Graduate School of EngineeringThe University of Tokyo

＜正＞Introduction The needs for the high throughput analysis of small molecular substances such as pesticides and hormones in the environment are becoming *** such analyses,homogeneous immunological assays rather than heterogeneous ones are preferred due to their simplicity,easiness to automation,and higher ***,the sensitivity of

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A Low Profile Four-Way Directional Antenna with Dual Polarization

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Journal of Electromagnetic Analysis and Applications 2015年第5期7卷 178-187页

作者： Rohani Bakar Shumpei Fuse Hiroyuki arai Yuki Inoue Keizo Cho Department of Electrical and Computer Engineering Yokohama National University Yokohama Japan Research Laboratories NTT DOCOMO INC Yokosuka Japan Department of Electrical Electronics and Computer Engineering Chiba Institute of Technology Chiba Japan

This paper presents a low profile dual polarized directional antenna composed of loop and dipole arrays mounted on a ground plane with each loops and dipoles being fed independently. Each loop antenna is paired with a reflector while each dipole antenna is paired with a director and a reflector. The proposed antenna is intended for an indoor base station (BS) with resonance frequency of 2.4 GHz and capable of producing four orthogonal directional pattern with downward elevation angle equals to 30°;and half power bandwidth (HPBW) less than 80°;in both vertical and horizontal polarization. The reflection characteristics of the loop and dipole arrays are less than -10 dB and the mutual coupling between the vertical and horizontal polarization elements is nearly less than -20 dB. In later progress, the dipole antenna was substituted with printed dipole antenna to achieve a better performance. Both the calculated and measured results demonstrated that the desired radiation patterns were achieved, and the measured results agreed well with the calculated ones. Consequently, a low profile antenna with a thickness of 0.16 λ (20 mm) having the expected radiation pattern is successfully designed.

关键词： Directional Antenna Dual Polarization Dipole Antenna Loop Antenna Reflector

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Inferior mesenteric arteriovenous fistula during treatment with bevacizumab in colorectal cancer patient: A case report

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1364-1371页

作者： Ayako Doi Hiroyuki Takeda Kumiko Umemoto Ryosuke Oumi Shinji Wada Shingo Hamaguchi Hidefumi Mimura Hiroyuki arai Yoshiki Horie Takuro Mizukami Naoki Izawa Takashi Ogura Takako EguchiNakajima Yu Sunakawa Department of Clinical Oncology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Gastroenterology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Radiology St.Marianna University School of MedicineKanagawa 216-8511Japan Innovation Center for Next Generation Clinical Trials and iPS Cell Therapy Kyoto University HospitalKyoto 606-8507Japan

BACKGROUND Fistula formation is a severe adverse event related to antiangiogenetic agents such as bevacizumab and inferior mesenteric arteriovenous fistula(IMAVF) is a result of acquired factor, especially colon surgery. However, IMAVF occurs very rarely and there are few reports in patients during chemotherapy. We report a case of a patient who developed IMAVF during treatment with bevacizumab in metastatic colorectal cancer(mCRC) after colon *** SUMMARY An 81-year-old man was diagnosed with descending colon cancer and underwent left hemicolectomy without any complications. He was definitely diagnosed with high-risk stage 2 and received tegafur-uracil plus leucovorin as adjuvant chemotherapy. Three years and 6 mo after the operation, the cancer relapsed with peritoneal dissemination. The patient underwent CyberKnife radiosurgery targeting the recurrent tumor and received chemotherapy with S-1 plus bevacizumab. At 1 year after chemotherapy, he complained of severe diarrhea, which is suspected drug-induced colitis. As diarrhea worsened despite the termination of treatment, he underwent colonoscopy and computed tomography (CT) scans that revealed edematous change from sigmoid to rectosigmoid colon. CT scans also revealed an aneurysm adjacent to the inferior mesenteric vein and multidetector CT angiography showed the IMAVF. Elective angiography confirmed the diagnosis of an IMAVF and it was successfully treated by arterial embolization. The patient resumed chemotherapy with only S-1 6 mo after *** Clinicians should keep in mind the probability of severe diarrhea arose from IMAVF in mCRC patients treated with bevacizumab.

关键词： Metastatic cancer Colon surgery Chemotherapy Fistula formation Inferior mesenteric artery Interventional radiology Case report

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