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Biliary complications in recipients of living donor liver transplantation:A single-centre study

World Journal of Hepatology 2021年第12期13卷 2081-2103页

作者： Reginia Nabil Guirguis ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim Shereen A Saleh Mohamed Bahaa Mahmoud el-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Biliary complications(BCs)after liver transplantation(LT)remain a considerable cause of morbidity,mortality,increased cost,and graft *** To investigate the impact of BCs on chronic graft rejection,graft failure and *** From 2011 to 2016,215 adult recipients underwent right-lobe living-donor liver transplantation(RT-LDLT)at our *** excluded 46 recipients who met the exclusion criteria,and 169 recipients were included in the final ***’and recipients’demographic data,clinical data,operative details and postoperative course information were *** also reviewed the management and outcomes of *** were followed for at least 12 mo post-LT until December 2017 or graft or patient *** The overall incidence rate of BCs including biliary leakage,biliary infection and biliary stricture was 57.4%.Twenty-seven(16%)patients experienced chronic graft *** failure developed in 20(11.8%)patients.A total of 28(16.6%)deaths occurred during *** were a risk factor for the occurrence of chronic graft rejection and failure;however,mortality was determined by recurrent hepatitis C virus *** Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure;nonetheless,effective management of these complications can improve patient and graft survival.

关键词： Biliary complications Living donor liver transplantation Retrospective analysis Bile leak Biliary stricture Risk factors Mortality Graft rejection

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Impact of biliary complications on quality of life in live-donor liver transplant recipients

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World Journal of Hepatology 2021年第10期13卷 1405-1416页

作者： Reginia Nabil Guirguis ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim Shereen A Saleh Mohamed Bahaa Mahmoud el-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Despite significant advancements in liver transplantation(LT)surgical procedures and perioperative care,post-LT biliary complications(BCs)remain a significant source of morbidity,mortality,and graft *** addition,data are conflicting regarding the health-related quality of life(HRQoL)of LT ***,the success of LT should be considered in terms of both the survival and recovery of *** To assess the impact of BCs on the HRQoL of live-donor LT recipients(LDLT-Rs).METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our *** Short Form 12 version 2(SF 12v2)health survey was used to assess their *** also included 25 LDLT-Rs without any post-LT complications as a control *** The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning(P=0.003),role-physical(Pelopment of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

关键词： Live-donor liver transplantation Quality of life The Short Form 12 version 2 Cirrhosis Biliary complications Mental health

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Screening for hepatocellular carcinoma by Egyptian physicians

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World Journal of Gastrointestinal Oncology 2015年第9期7卷 161-171页

作者： Sahar M Hassany ehab F Abdou Moustafa Mohamed el Taher Afaf Adel Abdeltwab Hubert E Blum Department of Tropical Medicine and Gastroenterology Assiut University Assiut Hospital for Febrile Illnesses Department of Internal Medicine Ⅱ Freiburg University

AIM: To assess the practice of Egyptian physicians in screening patients for hepatocellular carcinoma(HCC). METHODS: The study included 154 physicians from all over Egypt caring for patients at risk for HCC. The study was based on a questionnaire with 20 items. Each questionnaire consisted of two parts:(1) personal information regarding the physician(name, age, specialty and type of health care setting); and(2) professional experience in the care of patients at risk for HCC development(screening, knowledge about the cause and natural course of liver diseases and HCC risk). RESULTS: Sixty-eight percent of doctors with an MD degree, 48% of doctors with a master degree or a diploma and 40% of doctors with a Bachelor of Medicine, Bachelor of Surgery certificate considered the hepatitis C virus(HCV) genotype as risk factor for HCC development(P ell as liver cirrhosis(P < 0.05). Eighty-six percent of doctors in University Hospitals and 69% of Ministry of Health(MOH) doctors consider HCV infection as the leading cause of HCC in Egypt(P < 0.05). Seventy-two percent of doctors with an MD degree, 55% of doctors with a master degree or a diploma, 56% of doctors with an MBBCH certificate, 74% of doctors in University Hospitals and 46% of MOH hospital doctors consider abdominal ultrasonography as the most important investigation in HCC screening(P < 0.05). Sixty-five percent of physicians in tropical medicine, internal medicine or gastroenterology and 37% of physicians in other specialties recommend as HCC screening interval of 3 mo(P < 0.05). Seventy-one percent of doctors with an MD degree, 50% of doctors with a master degree or diploma and 60% of doctors with an MBBCH certificate follow the same ***: In Egypt, physicians spe

关键词： Hepatocellular carcinoma Egyptian physicians Scree

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Plasma D-dimer level in early and late-onset neonatal sepsis

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World Journal of Critical Care Medicine 2022年第3期11卷 139-148页

作者： Mohammed Al-Biltagi ehab M Hantash Mohammed Ramadan el-Shanshory Enayat Aly Badr Mohamed Zahra Manar Hany Anwar Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt Department of Pediatrics University Medical CenterArabian Gulf UniversityManama 26671ManamaBahrain Department of Pediatrics University Medical CenterBahrainDr.Sulaiman Al Habib Medical GroupKSAManama 26671ManamaBahrain Department of Anatomy Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Neonatology Unit Department of PediatricsDr.Sulaiman Al Habib Medical GroupRiyadh 11636RiyadhSaudi Arabia Department of Pediatrics Hematol UnitTanta UniversityFaculty of MedicineTanta 31511AlgharbiaEgypt Department of Clinical Pathology Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Clinical Pathology Ministry of HealthEgyptTanta 31511AlghrabiaEgypt

BACKGROUND Neonatal sepsis is a life-threatening *** diagnosis is essential,but no single marker of infection has been *** activates a coagulation cascade with simultaneous production of the D-dimers due to lysis of *** test reflects the activation of the coagulation *** To assess the D-dimer plasma level,elaborating its clinicopathological value in neonates with early-onset and late-onset neonatal *** The study was a prospective cross-sectional study that included ninety neonates;divided into three groups:Group I:Early-onset sepsis(EOS);Group II:Late-onset sepsis(LOS);and GroupⅢ:Control *** diagnosed neonatal sepsis according to our protocol.C-reactive protein(CRP)and D-dimer assays were compared between EOS and LOS and correlated to the causative microbiological *** D-dimer was significantly higher in septic groups with a considerably higher number of cases with positive *** with LOS had substantially higher levels of D-dimer than EOS,with no significant differences in *** with LOS had a significantly longer hospitalization duration and higher gram-negative bacteriemia and mortality rates than EOS(Pels(Acinetobacter,Klebsiella,and Pseudomonas)and CRP(Serratia,Klebsiella,and Pseudomonas);while gram-positive sepsis was associated with relatively lower levels.D-dimer had a significant negative correlation with hemoglobin level and platelet count;and a significant positive correlation with CRP,hospitalization duration,and mortality *** best-suggested cut-off point for D-dimer in neonatal sepsis was 0.75 mg/L,giving a sensitivity of 72.7%and specificity of 86.7%.The D-dimer assay has specificity and sensitivity comparable to CRP in the current *** The current study revealed a significant diagnostic value for D-dimer in neonatal sepsis.D-dimer can be used as an adjunct to other sepsis markers to increase th

关键词： Early-onset neonatal sepsis Late-onset neonatal sepsis C-reactive protein D-dimer

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Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study

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World Journal of Gastroenterology 2021年第40期27卷 6951-6966页

作者： Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem Eman Fouad ehab F Mostafa Mohammed A Medhat Amr Abdalazeem Hazem elmorsy Miriam M Aziz Rateba S Mohammed Mohamed Ibrahem Hassan elgarem Dalia Omran Mohamed Hassany Bassem elsayed Ahmed Y Abdelaziz Mohamed el Kassas Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt Gastroenterology Department National Hepatology&Tropical Medicine Research InstituteCairo 11563Egypt Hepatology Department Students HospitalCairo UniversityGiza 12566Egypt The Public Health Department Faculty of MedicineCairo UniversityCairo 11562Egypt Egyptian Ministry of Health and PopulationCairo 11567Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 15655Egypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairo 13544Egypt Internal Medicine 15 Mayo Smart HospitalMinistry of Health and PopulationCairo 13488Egypt Pediatrics Department Faculty of MedicineCairo UniversityCairo 11562Egypt Occupational and Environmental Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Clinical Biochemistry Department Faculty of medicineCairo UniversityCairo 11562Egypt Endemic Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Urology Department Cairo UniversityCairo 11562Egypt

BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable *** studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is *** To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,*** polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of *** information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal ***-ups were conducted until discharge or *** analyses were performed to determine the independent factors affecting *** This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his ***’mean age was 45.04±17.61 years,and 21.98%had severe or critical *** aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,*** total,26%and 32%of patients had elevated ALT and AST,*** liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,*** gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or *** was elevated in 50%of patients over ***-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and *** independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI

关键词： COVID-19 Egypt Liver injury Gastrointestinal symptoms Fibrosis-4 Liver enzymes

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Nutritional Status of Mothers and Its Determinants in Alemtidad Area, Khartoum

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Food and Nutrition Sciences 2014年第22期5卷 2203-2208页

作者： Waled Amen Mohammed Ahmed Eiman Abdalla Ahmed Khalid Ahmad Omar Arafa ehab Ibrahim Salih el-Amin Ziad M. Alostaz Khalid eltahir Khalid Nursing Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Altaiseer Medical Complex Khartoum Sudan Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Basic Sciences Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia

Background: Nutritional status of mothers is considered one of the major problems facing mothers in the world. The nutrition plays a major role in mothers and child health. Objective: This study aims to assess mothers’ nutritional status and its determinants in Alemtidad area, Khartoum. Methods: A descriptive community based survey was conducted in the Alemtidad area of Khartoum between November 2012 and December 2012. One hundred and eighty mothers were selected by simple randomization. Data were collected by using structured designed questionnaire which was then analyzed by (SPSS) program version 20. Results: The study conducted among mothers in Alemtidad area;their age ranged between 19 and 86 years with the mean age 38 ± 12 years. From those mothers about half were unemployed, and having mainly primary and secondary educational level. 81.1% of mothers were not able to select the proper food according to age and nutrients and about 71.1% of mothers took two meals per day and 23.3% one meals per day, and only 5.6 take three meals per day. The Body Mass Index (BMI) was calculated to measure the nutrition status of mothers;this study shows that mothers in Alemtidad are mainly overweight and obese, 45.6% and 18% respectively and only 35% within normal range of Body Mass Index (BMI). Conclusion: The study concludes that mothers are either overweight or obese (45.6%, 17.7% respectively). Compared to national and international statistics the findings of this study reflect high Body Mass Index (BMI) of mothers in Alemtidad.

关键词： Nutritional Status Determinant of Nutritional Status Food Consumption Mothers

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Evaluation of the systematic set-up errors using electronic portal image device in the radiotherapy procedures

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The Chinese-German Journal of Clinical Oncology 2013年第9期12卷 439-442页

作者： ehab M. Attalla Rizk Abd el Moneam Aida R. Tolba Maha H.Mokhtar Medhat W. Ismail Children Cancer Hospital Department of Radiotherapy and Nuclear Medicine National Cancer Institute Cairo University Faculty of Science Helwan University

Objective： The aim of this work was to quantify the extent of set-up errors to conduct a quality assurance （QA） aspect of treatment delivery, verification of the treatment field＇s position on different days using electronic portal. Methods： This study was carried out on 12 patients, treated for pelvis tumor; and total of 240 images obtained by electronic portal image device （EPID） were analyzed. The EPIs acquire using EPID attached to the Siemens linear accelerator. The anatomy match- ing software （Theraview） was used and displacement in two dimensions were noted for each treatment field to study patient setup errors. Results： The percentages of mean deviations less than 5 mm in X direction were 65% ＆ 92%, from 5-10 mm were 31% ＆ 19% and more than 10 mm were 11% ＆ 9% forNP and lateral direction respectively. The percentages of mean deviations less than 5 mm in Y direction were 65% ＆ 63%, from 5-10 mm were 33% ＆ 28% and more than 10 mm were 22% ＆ 29%. The mean deviations in 2D-vector errors were 〈 5 mm in 47% and 46%, 5-10 mm in 36% and 37% and 〉 10 mm in 37% and 37% of images in the NP and lateral direction respectively. Conclusion： The results revealed that the ranges of set up errors are immobilization method to improve reproducibility. The observed variations were not within the limits..

关键词： electronic portal imaging device (EPID) setup errors tumor control probability

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Strain Rate Effect on the Response of Blast Loaded Reinforced Concrete Slabs

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World Journal of Engineering and Technology 2014年第4期2卷 260-268页

作者： Kamel S. Kandil Mouhamad T. Nemir ehab A. ellobody Ramy I. Shahin Department of Civil Engineering Faculty of Engineering Menoufiya University Shibin El Kom Egypt Department of Structural Engineering Faculty of Engineering Tanta University Tanta Egypt

Dynamic Increase Factor (DIF) due to strain rate effect was examined with documented experimental work done by Razaqpur, et al. In the experiment work, two 1000 × 1000 × 70 mm reinforced concrete slabs were constructed. The slabs were subjected to blast loads generated by the detonation of either 22.4 kg or 33.4 kg of ANFO located at a 3.0 m standoff. Blast wave characteristics, including incident and reflected pressures and reflected impulses were measured. The slabs were modeled by explicit analysis with or without strain rate effect to study their behavior under blast load to compare their predicted and observed behavior. The predicted post-blast damage and mode of failure for each model is compared with the observed damage of experimental work. It was concluded that when the dynamic increase factor added to concrete and reinforcement materials due to strain rate effect, the behavior of model under blast load become closer to experimental work.

关键词： Explicit Analysis Strain Rate Blast Load Ls-Dyna Scaled Distance

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Implicit and Explicit Analysis of the Response of Blast Loaded Reinforced Concrete Slabs

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World Journal of Engineering and Technology 2014年第3期2卷 211-221页

Implicit and explicit analyses were examined with experimental work done by Razaqpur et al. In the experiment work, two 1000 × 1000 × 70 mm reinforced concrete slabs were constructed. The slabs were subjected to blast loads generated by the detonation of either 22.4 kg or 33.4 kg of ANFO located at a 3.0 m standoff. Blast wave characteristics, including incident and reflected pressures and reflected impulses were measured. The slabs were modeled by implicit and explicit analysis to study their behavior under blast load to compare their predicted and observed behavior. The post-blast damage and mode of failure of each slab were observed. It was concluded that explicit analysis provides better modeling than implicit analysis.

关键词： Implicit Analysis Explicit Analysis Strain Rate Blast Load Ansys Ls-Dyna Scaled Distance

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How does epidemiological and clinicopathological features affect survival after gastrectomy for gastric cancer patientssingle Egyptian center experience

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World Journal of Gastrointestinal Surgery 2016年第6期8卷 444-451页

作者： ehab el Hanafy Ayman el Nakeeb Helmy Ezzat Emad Hamdy ehab Atif Tharwat Kandil Amgad Fouad Mohamed Abdel Wahab Ahmed Monier Gastroenterology Surgical Center Mansoura University

AIM:To investigate the clinicopathological features and the significance of different prognostic factors which predict surgical overall survival in patients with gastric ***:This retrospective study includes 80 patients diagnosed and treated at gastroenterology surgical center,Mansoura University,Egypt between February 2009 to February *** factors were assessed by cox proportional hazard ***:There were 57 male and 23 *** median age was 57 years(24-83).One,3 and 5 years survival rates were 71%,69% and 46% *** median survival was 69.96 *** the follow-up period,13 patients died(16%).Hospital morbidity was reported in 10 patients(12.5%).The median number of lymph nodes removed was 22(4-41).Lymph node(LN) involvement was found in 91% of *** R0 resection,depth of wall invasion,LN involvement and the number(> 15) of retrieved LN,LN ratio and tumor differentiation predict *** multivariable analysis,tumor differentiation,curability of resection and a number of resected LN superior to 15 were found to beindependent prognostic ***:Surgery remains the cornerstone of *** differentiation,curability of resection and a number of resected LN superior to 15 were found to be independent prognostic *** LN dissection does not increase the morbidity or mortality rate but markedly improves long term survival.

关键词： Cancer stomach Prognostic factors Lymph node metastasis Recurrence after gastrectomy Lymph node ratio

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