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Thermogenic protein UCP1 and UCP3 expression in non- small cell lung cancer： relation with glycolysis and anaerobic metabolism

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Cancer Biology & Medicine 2017年第4期14卷 396-404页

作者： Alexandra Giatromanolaki Konstantina Balaska Dimitra Kalamida Christos Kakouratos efthimios sivridis Michael I. Koukourakis Department of Pathology Department of Radiotherapy/Oncology Democritus University of Thrace University Hospital ofAlexandroupolis Alexandroupolis 68100 Greece

Uncoupling protein 1(UCP1)is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat *** immunohistochemistry,we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer(NSCLC)treated with *** patterns were correlated with histopathological variables,prognosis,and the expression of enzymes/proteins related to cell *** epithelium did not express UCP1 or UCP3,while alveolar cells strongly expressed *** tumors,strong expression of UCP1 and UCP3 was recorded in43/98(43.8%)and 27/98(27.6%)cases,***1 was significantly associated with squamous cell histology(P=0.05),whilst UCP3 was more frequently overexpressed in large cell carcinomas(P=0.08),and was inversely related to necrosis(P=0.009).In linear regression analysis,UCP1 was directly related to markers of glycolysis[hexokinase(HXKII)and phosphofructokinase(PFK1)]and anaerobic glucose metabolism[pyruvate dehydrogenase kinase(PDK1)and lactate dehydrogenase(LDH5)].UCP3 was directly linked with a glucose transporter(GLUT2),monocarboxylate transporter(MCT2),glycolysis markers(PFK1 and aldolase),and with the phosphorylation of pyruvate dehydrogenase(p PDH).Kaplan-Meier survival analysis showed that UCP3 was significantly related to poor prognosis in squamous cell carcinomas(P=0.04).UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption,intensified glycolysis,and anaerobic glucose *** UCPs are targets for therapeutic interventions in lung cancer is a hypothesis that demands further investigation.

关键词： Lung cancer thermogenesis UCP1 UCP3 glycolysis anaerobic metabolism

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Cryoablation of osteoid osteomas:Is it a valid treatment option?

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World Journal of Radiology 2024年第9期16卷 389-397页

作者： Antonios Michailidis Athanasios Panos efthimios Samoladas Georgios Dimou Georgia Mingou Panagiotis Kosmoliaptsis Maria Arvaniti Christos Giankoulof Evangelos Petsatodis Department of Interventional Radiology Georgios Papanikolaou General Hospital of ThessalonikiThessaloniki 57010Greece Department of 1st Orthopaedic Clinic Georgios Papanikolaou General Hospital of ThessalonikiAristotle University of ThessalonikiThessaloniki 57010Greece Dental School EKPAAthens 15773Greece

BACKGROUND Osteoid osteoma is a benign bone tumor with characteristic clinical *** selected method for its treatment is percutaneous radiofrequency ***,percutaneous cryoablation is an alternative method with certain *** To evaluate percutaneous computed tomography(CT)-guided cryoablation for the treatment of osteoid osteoma in young patients and *** A total of 25 patients were treated with percutaneous CT-guided cryoablation for osteoid osteomas between October 2020 and March 2023 at a single *** patients were above 14-years-old(mean age,24-years-old),and all procedures were performed under local *** the 25 patients,8 were female and 17 were *** sites included the femur(n=9),medial malleolus(n=4),sacral ala(n=4),facets(n=4),humerus(n=3),and tibia(n=1).One cryoprobe was used in each procedure and,when possible,the lesion was covered by the ice-ball using an extraosseous position without penetrating the *** necessary thermal protective techniques were used depending on the anatomical structure at *** All patients treated had complete response(100%clinical success rate)starting on the day of the *** success was achieved in all *** analog scale(VAS)scores at 1 year were 0,compared to a mean VAS score of 8.5±1(SD)before the *** recurrences were reported at the 1-year follow-up and no complications were *** 11/25 cases,an extraosseous position of the cryoprobe was used with less procedural time achieving technical and clinical success and no complications with less patient *** patients were discharged from the hospital on the same day as the *** Cryoablation of osteoid osteomas is an efficacious and safe procedure with durable clinical *** greatest advantage is that the procedure can be performed under local anesthesia using an extraosseous position of the cryoprobe when possible.

关键词： Cryoablation Osteoid osteoma Computed tomography guidance Interventional radiology Orthopedics Bone tumors

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Gut microbiome in alcohol use disorder:Implications for health outcomes and therapeutic strategies-a literature review

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World Journal of Methodology 2024年第1期14卷 33-44页

作者： Ilias Koutromanos Evangelia Legaki Maria Gazouli efthimios Vasilopoulos Anastasios Kouzoupis Elias Tzavellas First Department of Psychiatry "Aiginition"HospitalSchool of MedicineNational and Kapodistrian University of AthensSchool of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Department of Basic Biological Science School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Department of Basic Medical Sciences Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Alcohol use disorder(AUD)represents a major public health issue which affects millions of people globally and consist a chronic relapsing condition associated with substantial morbidity and *** gut microbiome plays a crucial role in maintaining overall health and has emerged as a significant contributor to the pathophysiology of various psychiatric *** evidence suggests that the gut microbiome is intimately linked to the development and progression of AUD,with alcohol consumption directly impacting its composition and *** review article aims to explore the intricate relationship between the gut microbiome and AUD,focusing on the implications for mental health outcomes and potential therapeutic *** discuss the bidirectional communication between the gut microbiome and the brain,highlighting the role of microbiotaderived metabolites in neuroinflammation,neurotransmission,and mood ***,we examine the influence of AUD-related factors,such as alcohol-induced gut dysbiosis and increased intestinal permeability,on mental health ***,we explore emerging therapeutic avenues targeting the gut microbiome in the management of AUD,including prebiotics,probiotics,and fecal microbiota *** the complex interplay between the gut microbiome and AUD holds promise for developing novel interventions that could improve mental health outcomes in individuals with AUD.

关键词： Alcohol use disorder Gut microbiome Dysbiosis

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Late Quaternary rates of stream incision in Northeast Peloponnese, Greece

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Frontiers of Earth Science 2016年第3期10卷 455-478页

作者： efthimios KARYMBALIS Dimitrios PAPANASTASSIOU GAKI-PAPANASTASSIOU Maria FERENTINOU Christos CHALKIAS Department of Geography Harokopio University Athens 17671 Greece Institute of Geodynamics National Observatory of Athens Athens 11810 Greece Department of Geography and Climatology Faculty of Geology and Geoenvironment National and Kapodistrian University of Athens Athens 15784 Greece Department of Geology School of Agricultural Earth and Environmental Sciences University of KwaZulu-Natal WestviUe Campus Private Bag X54001 Durban 4000 South Africa

This study focuses on defining rates of fluvial incision for the last 580±5 kyr along valley systems of eight streams that drain the eastern part of the northern Peloponnese. The streams are developed on the uplifted block of the offshore-running Xylokastro normal fault, one of the main faults bounding the southern edge of the Gulf of Corinth half-graben, and have incised a set of ten uplifted marine terraces having an amphitheatric shape. These terraces range in age from 60±5 kyr to 580±5 kyr and have been mapped in detail and correlated with late Pleistocene oxygen-isotope stages of high sea-level stands by previous studies. The terraces were used in this paper as reference surfaces in order to define fluvial incision rates at the lower reaches of the studied streams. To evaluate incision rates, thirty-three topographic valley cross-sec- tions were drawn using fieldwork measurements as well as using a highly accurate （2×2 cell size） Digital Elevation Model （DEM） at specific locations where streams cut down the inner edges of the marine terraces. For each cross-section the ratio of valley floor width to valley height （Vf） and long-term mean stream incision rates were estimated for the last 580±5 kyr, while rock uplift rates were estimated for the last 330±5 kyr. The geomorphic evolution of the valleys on the uplifted block of the Xylokastro fault has been mainly driven by the lithology of the bedrock, sea level fluctuations during the late Quaternary, and incision of the channels due to the tectonic uplift. Stream incision rates range from 0.10±0.1 mm/yr for the last 123±7 kyr to 1.14±0.1 mm/yr for the last 310±5 kyr and are gradually greater from east to west depending on the distance from the trace of the *** rates are comparable with the rock uplift rates, which range from 0.4±0.02 mm/yr to 1.49±0.12 mm/yr, over the last 330±5 kyr.

关键词： fluvial incision tectonic uplift marine ter-races Peloponnese Greece

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Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation

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Neuroscience Bulletin 2019年第6期35卷 979-995页

作者： Athanasios Tzortzopoulos Dimitra Thomaidou Maria Gaitanou Rebecca Matsas efthimios Skoulakis Department of Clinical Biochemistry Aghia Sophia Children's Hospital11527 AthensGreece Laboratory of Cellular and Molecular Neurobiology Hellenic Pasteur Institute11521 AthensGreece "Alexander Fleming"Biomedical Sciences Research Centre 16672 AthensGreece

We used Drosophila melanogaster as an experimental model to express mouse and pig BM88/CEND1(cell cycle exit and neuronal differentiation 1) in order to investigate its potential functional effects on Drosophila neurogenesis. BM88/CEND1 is a neuron-specific protein whose function is implicated in triggering cells to exit from the cell cycle and differentiate towards a neuronal phenotype. Transgenic flies expressing either mouse or pig BM88/CEND1 in the nervous system had severe neuronal phenotypes with variable expressivity at various stages of embryonic development. In early embryonic stage 10,BM88/CEND1 expression led to an increase in the neuralspecific antigenicity of neuroectoderm at the expense of precursor cells [neuroblasts(Nbs) and ganglion mother cells(GMCs)] including the defective formation and differentiation of the MP2 precursors, whereas at later stages(12–15), protein accumulation induced gross morphological defects primarily in the CNS accompanied by a reduction of Nb and GMC markers. Furthermore, the neuronal precursor cells of embryos expressing BM88/CEND1 failed to carry out proper cell-cycle progression as revealed by the disorganized expression patterns of specific cell-cycle markers. BM88/CEND1 accumulation in the Drosophila eye affected normal eye disc development by disrupting the ommatidia. Finally, we demonstrated that expression of BM88/CEND1 modified/reduced the levels of activated MAP kinase indicating a functional effect of BM88/CEND1 on the MAPK signaling pathway. Our findings suggest that the expression of mammalian BM88/CEND1 in Drosophila exerts specific functional effects associated with neuronal precursor cell formation during embryonic neurogenesis and proper eye disc *** study also validates the use of Drosophila as a powerful model system in which to investigate gene function and the underlying molecular mechanisms.

关键词： Drosophila Neurogenesis BM88/CEND1 Nervous system Protein function

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Multiscale Hemodynamics Using GPU Clusters

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Communications in Computational Physics 2012年第1期11卷 48-64页

作者： Mauro Bisson Massimo Bernaschi Simone Melchionna Sauro Succi efthimios Kaxiras Department of Computer Science University of Rome“Sapienza”Italy Istituto Applicazioni Calcolo Consiglio Nazionale delle RicercheRomeItaly Istituto Processi Chimico-Fisici Consiglio Nazionale delle RicercheRomeItaly Institute of Material Sciences and Engineering ´Ecole Polytechnique F´ed´erale de LausanneSwitzerland Freiburg Institute for Advanced Studies School of Soft Matter ResearchAlbertstr.1979104 FreiburgGermany Department of Physics and School of Engineering and Applied Sciences Harvard UniversityCambridgeMAUSA

The parallel implementation of MUPHY,a concurrent multiscale code for large-scale hemodynamic simulations in anatomically realistic geometries,for multi-GPU platforms is *** tests show excellent results,with a nearly linear parallel speed-up on up to 32GPUs and a more than tenfold GPU/CPU acceleration,all across the range of *** basic MUPHY scheme combines a hydrokinetic(Lattice Boltzmann)representation of the blood plasma,with a Particle Dynamics treatment of suspended biological bodies,such as red blood *** the best of our knowledge,this represents the first effort in the direction of laying down general design principles for multiscale/physics parallel Particle Dynamics applications in non-ideal *** configures the present multi-GPU version of MUPHY as one of the first examples of a high-performance parallel code for multiscale/physics biofluidic applications in realistically complex geometries.

关键词： Multi-GPU computing hemodynamics molecular dynamics irregular domain

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A systematic approach to generating accurate neural network potentials:the case of carbon

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npj Computational Materials 2021年第1期7卷 463-475页

作者： Yusuf Shaidu Emine Küçükbenli Ruggero Lot Franco Pellegrini efthimios Kaxiras Stefano de Gironcoli Scuola Internazionale Superiore di Studi Avanzati TriesteItaly The Abdus Salam International Centre for Theoretical Physics TriesteItaly John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMAUSA Laboratoire de Physique de l’École Normale Supérieure UniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisParisFrance Department of Physics Harvard UniversityCambridgeMAUSA CNR-IOM DEMOCRITOS Istituto Officina dei MaterialiTriesteItaly

Availability of affordable and widely applicable interatomic potentials is the key needed to unlock the riches of modern materials *** neural network-based approaches for generating potentials are promising;however,neural network training requires large amounts of data,sampled adequately from an often unknown potential energy *** we propose a selfconsistent approach that is based on crystal structure prediction formalism and is guided by unsupervised data analysis,to construct an accurate,inexpensive,and transferable artificial neural network *** this approach,we construct an interatomic potential for carbon and demonstrate its ability to reproduce first principles results on elastic and vibrational properties for diamond,graphite,and graphene,as well as energy ordering and structural properties of a wide range of crystalline and amorphous phases.

关键词： neural artificial network

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Conduction abnormalities after transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2018年第1期15卷 105-112页

作者： Panagiotis Karyofillis Anna Kostopoulou Sofia Thomopoulou Martha Habibi efthimios Livanis George Karavolias Vassilis Voudris Department of Invasive Cardiology Onassis Cardiac Surgery Centre Athens Greece

In the last few years, transcatheter aortic valve implantation （TAVI） has become an alternative procedure in patients with severe aortic stenosis and high risk for surgical aortic replacement. Due to the anatomic correlation between aortic valve structure and conduction system of the heart, one of the most common complications after TAVI is conduction system disturbances which including bundle branch block, complete heart block and need for permanent pacemaker implantation. Although these disturbances are usually not lethal, they may have a great influence on patients＇ state and long term-survival. Several risk factors for conduction disturbances have been identified which including age, anatomy of the heart, periprocedural factors, type of implanted valve, preexisting abnormalities and comorbidities. As this technique becomes more familiar to physicians, patients should be carefully screened for risk factors for the development of conduction abnormalities after TAVI in order to provide effective prevention and proper treatment.

关键词： Atrioventricular block Bundle branch block Pacemaker Transcatheter aortic valve implantation

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Identifying the occurrence time of an impending major earthquake:a review

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Earthquake Science 2017年第4期30卷 209-218页

作者： Panayiotis A.Varotsos Nicholas V.Sarlis efthimios S.Skordas Department of Physics Section of Solid State Physics and Solid Earth Physics InstituteNational and Kapodistrian University of AthensPanepistimiopolisZografos157 84 AthensGreece

The procedure through which the occurrence time of an impending major earthquake can be determined is reviewed in the light of the recent advances. This can be achieved by analyzing in natural time the seismicity in the candidate area. To apply this general procedure, we need two important elements： first, to know when we should start the analysis, i.e., set the natural time equal to zero. This is the time at which the system enters the critical stage. Second a reliable estimation of the candidate epicentral area. If geoelectrical measurements are taken and the VAN method （after the initials of the three researchers Varotsos, Alexopoulos and Nomicos）is applied, both these elements become available upon the recording of a precursory Seismic Electric Signals （SES） activity, because its initiation marks the time when the system enters the critical stage, and in addition the SES data enable the determination of the epicentral area of the impending mainshock. On the other hand, if geoelectrical data are lacking, we make use of the following two recent findings by means of natural time analysis： First, the fluctuations of the order parameter of seismicity in a large area exhibit a minimum a few months before a major earthquake almost simultaneously with the initiation of an SES activity. Second, a spatiotemporal study of this minimum unveils an estimate of the epicentral area of the impending major earthquake. Two examples are given that refer to the strongest earthquakes that occurred in Greece and Japan during the last 3 decades, i.e., the Mw6.9 earthquake in southwestern Greece on 14 February 2008 and the Mw9.0 Tohoku earthquake in Japan on 11 March 2011.

关键词： Seismic Electric Signals VAN method Natural time analysis Earthquake prediction

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Seasonal variation in the biochemical composition,condition index,and meat yield of the non-indigenous pearl oyster Pinctada imbricata radiata(Leach,1814)from the West of the Aegean Sea,Greece

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Aquaculture and Fisheries 2023年第4期8卷 451-456页

作者： John A.Theodorou Maria Makri Xanthi Douvi Alexis Ramfos efthimios Spinos Department of Animal Production Fisheries&AquacultureUniversity of PatrasMesolongi30200Greece Fisheries Department of Directorate of Agricultural Economy Region of Western GreecePatras26443Greece

The average values of the seasonal flesh biochemical composition(%)of the pearl oyster Pinctada imbricata radiata originated form 2 sampling sites,the gulfs of Evoikos(E)and Saronikos(S)in the Western Aegean Sea,showed that is rich in proteins(64.00±1.86-(E),64.67±2.95-(S))with low fat content(10.96±1.04-(E),11.86±1.13-(S))and carbohydrates(13.29±2.48-(E),9.94±4.32(S)).The condition index ranged from 26.16%±5.04 in the autumn in(E),to 44.73%±7.50 in the summer in(S).The meat yield varied from 20.49%±3.20%in the summer in(E)to 30.73%±3.47%in the summer in(S).Both results demonstrate the high nutritional profile of the pearl oyster,supporting its suitability as a potential new Mediterranean seafood source for human consumption.

关键词： Pearl oyster Condition index Meat yield Biochemical composition Aegean

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