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Effects of molybdenum on nutrition, quality, and flavour compounds of strawberry (Fragaria×ananassa Duch. Cv. Akihime) fruit

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Journal of Integrative Agriculture 2017年第7期16卷 1502-1512页

作者： LIU Li XIAO Wei JI Mei-ling YANG Chao LI ling GAO Dong-sheng FU Xi-ling Sta.e Key Laboratory of Crop Biology College of Horticulture Science and Engineering Shandong Agricultural University

Molybdenum （Mo） is an essential trace element in plant nutrition and physiology. It affects photosynthesis and photosyn- thate accumulation, therefore also affecting fruit quality and nutritional content. This study assessed the effects of different sodium molybdate （Na2MoO4） concentrations on strawberry. Five different Mo concentrations were applied in this experi- ment, including 0, 67.5, 135, 168.75, 202.5 g ha-1, respectively. The mineral concentration, including nitrogen （N）, Mo, iron （Fe）, copper （Cu）, and selenium （Se） was assessed in strawberry fruit, as well as chlorophyll content, nutrition quality, ta.te and aroma. Results showed that net photosynthetic rate （Pn） and chlorophyll content for the strawberry plants increased with an increase in Mo concentration; and the contents of N, Mo, Fe, Cu, tota. soluble solids （TSS）, titrata.le acidity （ta., sweetness, some sugars, organic acids, and some volatile compounds in the fruit all increased, as well. However, the Mo concentration did not significantly affect the concentrations of Se, sucrose, lactic acid, acetic acid, and some aroma compounds. Fruit sprayed with 135 g ha-1 Mo exhibited the highest TSS and sweetness values, as well as the highest N and Fe concentrations among all the treatments. P value and chlorophyll content, fructose, glucose, sorbitol and tota. sugar contents in fruit supplied with 135 g ha-1 Mo were also higher than that in other treatments. Fruit sprayed with a Mo concentration of 67.5 g ha-1 exhibited significantly higher ascorbic acid （AsA） values than that of control. Ninety-seven volatile compounds were identified in fruit extracted by head-space solid-phase microextraction （HS-SPME） coupled with gas chromatography-mass spectrometry （GC-MS）. Fruits sprayed with 135 g ha-1 Mo had the highest concentrations of six characteristic aroma compounds, including methyl buta.oate, y-decalactone, ethyl buta.oate, methyl hexanoate, y-do- decalactone, and ethyl caproate.

关键词： strawberry molybdenum nutrition volatile compounds flavour

Distribution and seasonal variation of estrogenic endocrine disrupting compounds,N-nitrosodimethylamine, and N-nitrosodimethylamine formation potential in the Huangpu River, China

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Journal of Environmenta. Sciences 2014年第5期26卷 1023-1033页

作者： Ai Zhang Yongmei Li ling Chen Sta.e Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and Engineering Tongji University

Detection of estrogenic endocrine disrupting compounds （EDCs） and N-nitrosodimethylamine （NDMA） in drinking water has led to rising concerns. There are, however, a paucity of studies on the distribution and seasonal variation of NDMA and NDMA formation potential （NDMA-FP） in natural waters, especially in China. For EDCs, limited studies have investigated the distribution and seasonal variation of estrone （El）, 1713-estradiol （E2）, estriol （E3）, 17a-ethinylestradiol （ee2）, technical-nonylphenols （t-NP）, and bisphenol A （BPA） in Shanghai. In this study, water samples were collected from 11 sampling sites along the Huangpu River in 2012. The distribution and seasonal variation of EDCs, NDMA, and NDMA-FP were investigated. The results showed that all of the 11 sampling sites were conta.inated by the ta.get compounds. Compared with E2 and ee2, higher E1 and E3 concentrations were usually detected in the Huangpu River. The values of 17β- estradiol equivalents （eeQ） suggest a high possibility of endocrine effects on exposed organisms in the Huangpu River. NDMA-FP and t-NP were the dominant conta.inants among the eight ta.get compounds. The detection rates of the ta.get compounds and their concentrations were both higher in dry seasons than in wet seasons. Higher concentrations of ta.get compounds were observed in urban sampling sites near drainage outlets, and also in suburban sampling sites where intensive livestock farming and farmlands were located.

关键词： EDCs NDMA NDMA-FP seasonal variation spatial distribution

Meta.olomic alterations and chromosomal insta.ility sta.us in gastric cancer

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World Journal of Gastroenterology 2018年第33期24卷 3760-3769页

作者： Cheng-Kun Tsai ta.Sen Yeh Ren-Chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu Cheng-Yu Hung Hung-Yao Ho Mei-ling Cheng Gigin Lin Clinical Meta.olomics Core Lab Chang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Imaging and Intervention Imaging Core LabInstitute for Radiological ResearchChang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Chang Gung Memorial Hospita. at Linkou and Chang Gung University Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Biotechnology and Laboratory Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Biomedical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan

AIM To explore the correlation of meta.olomics profiles ofgastric cancer(GC) with its chromosomal insta.ility(CIN) *** Nineteen GC patients were classified as CIN and nonCIN type by The Cancer Genome Atlas Research Group system, based on 409 oncogenes and tumor suppressor genes sequenced. The aqueous meta.olites of the GC tumor and its surrounding adjacent healthy tissues were identified through liquid chromatographymass spectrometry. Groups were compared by defining variable importa.ce in projection score of > 1.2, a fold change value or its reciprocal of > 1.2, and a P value of ta.,twelve men and seven women were enrolled, with a median age of 66 years(range, 47-87 years). The numbers of gene alterations in the CIN GC group were significantly higher than those in the non-CIN GC(32-218 vs 2-17; P ta.ic acid, oxidized gluta.hione, succinyladenosine, and uridine diphosphate-Nacetylglucosamine levels, but significantly lower butyrylcarnitine, gluta.hione hydroxyhexanoycarnitine, inosinic acid, isovalerylcarnitine, and threonine levels(all P ta.ned significantly higher phosphocholine and uridine 5'-monophosphate levels but significantly lower beta.citryl-L-gluta.ic acid levels than did non-CIN tumors(all P ta.e, and gluta.ate meta.olism, glyoxylate and dicarboxylate meta.olism, histidine meta.olism, and phenylalanine, tyrosine, and tryptophan *** Meta.olomic profiles of GC tumors and the adjacent healthy tissue are distinct, and the CIN sta.us is associated with downstream meta.olic alterations in GC.

关键词： Gastric cancer Meta.olomics Oncogene Copy-number Chromosomal insta.ility Liquid chromatography-mass spectrometry

Glycerophospholipids pathways and chromosomal insta.ility in gastric cancer: Global lipidomics analysis

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World Journal of Gastrointestinal Oncology 2019年第3期11卷 181-194页

作者： Cheng-Yu Hung ta.Sen Yeh Cheng-Kun Tsai Ren-Chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu Chia-Ni Lin Mei-ling Cheng Gigin Lin Molecular Medicine Research Center Chang Gung University Clinical Meta.olomics Core Lab Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Medical Imaging and Intervention Imaging Core Lab Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Surgery Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Pathology Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Laboratory Medicine Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Biomedical Science College of Medicine Chang Gung University

BACKGROUND Based on the breakthrough of genomics analysis, The Cancer Genome Atlas Research Group recently proposed an integrative genomic analysis, dividing gastric cancer(GC) into four subtypes, characterized by the chromosomal insta.ility(CIN) sta.us. However, the CIN sta.us of GC is still vaguely characterized and lacking the valuable easy-to-use CIN markers to diagnosis in molecular and histological *** To explore the associations of CIN with downstream lipidomics *** We collected cancerous and noncancerous tissue samples from 18 patients with GC; the samples were divided into CIN and non-CIN types based on the system of The Cancer Genome Atlas Research Group and 409 sequenced oncogenes and tumor suppressor genes. We identified the lipidomics profiles of the GC samples and samples of their adjacent noncancerous tissues by using liquid chromatography–mass spectrometry. Furthermore, we selected leading meta.olites based on variable importa.ce in projection scores of > 1.0 and P ta.us of GC is primarily associated with downstream lipidomics in the glycerophospholipid pathway.

关键词： Chromosomal insta.ility Gastric cancer Glycerophospholipids Meta.olomics Lipidomics profile

Case Report:ta.ayasu's arteritis associated with Crohn's disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 631-634页

作者： You-shi LIU You-hong FANG ling-xiang RUAN You-ming LI Lin LI ling-ling JIANG Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Children 's Hospita. of Zhejiang University Hangzhou 310003 China Department of Radiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

ta.ayasu's arteritis(ta.,also known as the "pulseless disease," is a chronic vasculitis of the aorta.and aortic *** with Crohn's disease is rare and has not been documented in China *** this paper we report on a case of ta.ayasu's arteritis associated with concurrent Crohn's disease.A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue,and his upper limb pulses were *** was diagnosed with ta.and underwent an axillary artery bypass with autologous great saphenous vein on the left subclavian *** the surgery,he regained the normal blood *** patient also had years of diarrhea and developed an anal canal ulcer,and was diagnosed with inflammatory bowel disease and ulcerative colitis *** months after the ta.surgery,he was hospita.ized for severe stomachache and diarrhea and was finally diagnosed with Crohn's *** possible pathophysiological mechanisms responsible for concurrent existence of ta.and Crohn's disease may be associated with immune disorders,especially autoimmunity.

关键词： ta.ayasu's arteritis Crohn's disease Inflammatory bowel disease Immune disorders

Optimal AP Deployment in Cell-Free Massive MIMO Systems with LoS/NLoS Transmissions:A Stochastic Geometry Approach

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China Communications 2024年第9期21卷 146-158页

作者： Jiang ling Zhang Qi Zhu Hongbo Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Cell-free massive multiple-input multipleoutput(MIMO)is a promising technology for future wireless communications,where a large number of distributed access points(APs)simulta.eously serve all users over the same time-frequency *** users and APs may locate close to each other,the line-of-sight(Lo S)transmission occurs more frequently in cell-free massive MIMO ***,in this paper,we investigate the cell-free massive MIMO system with Lo S and non-line-of-sight(NLo S)transmissions,where APs and users are both distributed according to Poisson point *** tools from stochastic geometry,we derive a tight lower bound for the user downlink achievable rate and we further obta.n the energy efficiency(ee)by considering the power consumption on downlink payload transmissions and circuitry *** on the analysis,the optimal AP density and AP antenna number that maximize the ee are *** is found that compared with the previous work that only considers NLo S transmissions,the actual optimal AP density should be much smaller,and the maximized ee is actually much higher.

关键词： cell-free massive MIMO energy efficiency LoS/NLoS transmissions stochastic geometry

甲状腺相关性眼病伴眼外肌肌腱受累1例(英文)

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国际眼科杂志 2012年第3期12卷 394-396页

作者： Ng Guan Fook Dinesh Kumar Ang ee ling Liza-Sharmini AT 马来西亚理科大学医学院眼科马来西亚吉兰丹马来西亚槟城总医院眼科

目的:报告1例甲状腺相关性眼病的非典型CT扫描表现。方法:一位64岁的中国女性出现复视3mo,无视力模糊。14a前她曾患甲状腺功能亢进症伴多结节甲状腺肿并行甲状腺切除术。眼科检查发现双眼下斜视并向上注视受限。左眼red desaturation并... 详细信息

目的:报告1例甲状腺相关性眼病的非典型CT扫描表现。方法:一位64岁的中国女性出现复视3mo,无视力模糊。14a前她曾患甲状腺功能亢进症伴多结节甲状腺肿并行甲状腺切除术。眼科检查发现双眼下斜视并向上注视受限。左眼red desaturation并Ⅰ级相对性瞳孔传入障碍。T3,T4和促甲状腺激素(thyroid stimulating hormone,TSH)正常。TSH受体、抗体水平高,与Graves'病一致。磁共振成像(magnetic resonance imaging,MRI)显示双下直肌弥漫性增大,肌腱受累。结果:给予几周期静脉注射甲基强的松龙继之以口服强的松后视力无提高,反之继续下降。行左眼眼眶减压术,术后其左眼视力有所改善。结论:有肌腱受累的眼外肌增大不能排除甲状腺相关性眼眶病(thyroid assciated orbitopathy,ta.)的可能。

关键词：甲状腺眼病甲状腺相关性眼眶病 CT扫描肌腱

Improved method for analyzing the degradation of estrogens in water by solid-phase extraction coupled with ultra performance liquid chromatography-ultraviolet detection

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Journal of Environmenta. Sciences 2011年第4期23卷 693-698页

作者： Minggang Zheng ling Wang Yuandui Bi Feng Liu College of Chemistry and Chemical Engineering and Environment Qingdao University Qingdao 266071 China The First Institute of Oceanography Qingdao 266101 China.

We esta.lished an improved method for the determination of four estrogens including estriol （E3）, 17β-estradiol （E2）, 17α-ethynyl- estrodiol （ee2） and estrone （E1） in water. The method consisted of solid-phase extraction （0.5 L water） and subsequent analysis of analytes by ultra-performance liquid chromatography （UPLC） with an ultraviolet detector （UVD）. Base-line separation was achieved for all studied estrogens using a column （50 mm × 2.1 mm） packed with 1.7 μm particle size sta.ionary phase. Recovery was higher than 88% and detection limits ranged between 12.5–23.7 ng/L for the four estrogens, with the RSD ranging from 7% to 11%. The method was successfully applied to determine E2 and ee2 in simulated natural water, which found that about 70% of E2 was degraded （with a half-life of about 30 hr） within 48 hr and about 55% of ee2 was degraded （with a half-life of about 36 hr）. Low levels of E1 were found, however E3 was undetecta.le during the process.

关键词： estrogens base-lined separation half-life degradation

Evaluation of vibration stress of ta.1 tita.ium alloy blade by quantita.ive fractography

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Rare Meta.s 2014年第3期33卷 263-269页

作者： Xin-ling Liu Yuan-Ming Xu Chun-Hu ta. Beijing Institute of Aeronautical Materials Aviation Industries of China Key Laboratory of Aeronautical Materials Testing and Evaluation Chinata. Failure Analysis Center of Aviation Industries of China School of Aeronautical Science and Engineering Beijing University of Aeronautics and Astronautics Beijing Key Laboratory of Aeronautical Materials Testing and Evaluation

Vibration fatigue is the main failure mode of compressor blade. Evaluating the vibration stress of blade that leads to cracking is very useful for analysis of vibration fatigue. In this paper, fatigue stress estimation methods by quantita.ive fractography were studied through experimenta. blade and in-service first-sta.e compressor blade in order to evaluate the initiation vibration stress of in-service blade. The analysis process of initiation vibration stress was esta.lished. The evaluating result of vibration stress of in-service blade subjected to centrifugal force and bending vibration stress agrees with aero engine test result. It is shown that the evaluation method can not only evaluate the equivalent fatigue stresses of different crack depths but also yield the initiation equivalent fatigue stress.

关键词： Compressor blade Bending vibration Stress evaluate Quantita.ive fractography