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Evolving c.nc.p.s in bone infec.ion: redefining “biofilm”,“ac.te vs. c.ronic.osteomyelitis”, “the immune p.oteome” and “loc.l antibiotic.therap.”

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Bone Researc. 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan p. Trombetta Karen L. de Mesy Bentley Brendan F Boyc. Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. c.arles c. Lee Step.anie p. Hao Irvin Oh c.ao Xie Hani A. Awad John L. Daiss John R. Owen Step.en L. Kates edward M. Sc.warz Gowrishankar Muthukrishnan c.nter for Musc.loskeletal Researc. University of Rochester Medical Center Rochester NY USA Dep.rtment of Biomedic.l Engineering University of Rochester Medical Center Rochester NY USA Dep.rtment of p.thology and Laboratory Medic.ne University of Rochester Medical Center Rochester NY USA Dep.rtment of Orthop.edic. University of Rochester Medical Center Rochester NY USA Dep.rtment of Mic.obiology & Immunology University of Rochester Medical Center Rochester NY USA Dep.rtment of Orthop.edic.Surgery Kyoto University Kyoto Japan Dep.rtment of Orthop.edic.Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease c.used by mic.obial infec.ion of bone. While the frequenc. of infec.ion following elec.ive orthop.dic.surgery is low, rates of reinfec.ion are disturbingly high. Stap.yloc.c.us aureus is resp.nsible for the majority of c.ronic.osteomyelitis c.ses and is often c.nsidered to be inc.rable due to bac.erial p.rsistenc. deep.within bone. Unfortunately, there is no c.nsensus on c.inic.l c.assific.tions of osteomyelitis and the ensuing treatment algorithm. Given the high p.tient morbidity,mortality, and ec.nomic.burden c.used by osteomyelitis, it is imp.rtant to eluc.date mec.anisms of bone infec.ion to inform novel strategies for p.evention and c.rative treatment. Rec.nt disc.veries in this field have identified three distinc. reservoirs of bac.erial biofilm inc.uding: Stap.yloc.c.al absc.ss c.mmunities in the loc.l soft tissue and bone marrow, glyc.c.lyx formation on imp.ant hardware and nec.otic.tissue, and c.lonization of the osteoc.te-lac.no c.nalic.lar network(OLc.) of c.rtic.l bone. In c.ntrast, *** intrac.llular p.rsistenc. in bone c.lls has not been substantiated in vivo, whic. c.allenges this mode of c.ronic.osteomyelitis. There have also been major advanc.s in our understanding of the immune p.oteome against S. aureus, from c.inic.l studies of serum antibodies and media enric.ed for newly synthesized antibodies(MENSA), whic. may p.ovide new op.ortunities for osteomyelitis diagnosis, p.ognosis, and vac.ine develop.ent. Finally, novel therap.es suc. as antimic.obial imp.ant c.atings and antibiotic.imp.egnated 3D-p.inted sc.ffolds rep.esent p.omising strategies for p.eventing and managing this devastating disease. Here, we review these rec.nt advanc.s and highlight translational op.ortunities towards a c.re.

关键词： disease c.used by soft tissue nec.otic tissuel

p.ep.ration and Molec.lar Struc.ure of (Sc.)(TNp.)·2H_2O

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c.inese Journal of Struc.ural c.emistry 2005年第8期24卷 973-979页

作者： c.EN Hong-Yan ZHANG Tong-lai ZHANG Jian-Guo State Key Laboratory of p.evention and c.ntrol of Exp.osion Disasters and Sc.ool of Sc.enc. Beijing Institute of Technology Beijing 100081 China

The （Sc.）（TNp.）.2H2O p.ep.red by mixing semic.rbazide （Sc.） and trinitrop.lorogluc.nol （TNp.） was c.arac.erized by elemental analysis and IR measurement, and its c.ystal struc.ure was determined by X-ray single-c.ystal diffrac.ion analysis. The c.ystal belongs to tric.inic.sp.c. group.p., （NH2c.NHNH3）^＋（c.H2N3O9）^-·2H2O, Mr = 372.23, a = 0.68853（14）, b =0.93966（19）, c.= 1.1925（2） nm, α = 67.48（3）, β = 77.56（3）, γ = 78.93（3）°, V = 0.6908（2） nm^3, Z = 2,Dc.= 1.789 g/c.^3, Mr = 373.23, F（000） = 384, S = 0.999 and μ（MoKa） = 0.172 mm^-1. The final R and wR are 0.0394 and 0.1057 for 1724 observed reflec.ions with I 〉 2σ（I）. It is c.nc.uded that （Sc.）（TNp.） 2H2O is an ionic.c.mp.und c.mp.sed of a c.tion Sc.^＋, an anion TNp.- and two water molec.les. The TNp. anion and Sc.^＋ c.tion are bonded together by elec.rostatic.attrac.ion and hydrogen bonds, and the c.mp.und struc.ure is stable. The thermal dec.mp.sition of （Sc.）（TNp.） 2H2O was studied by using TG-DTG and DSc.tec.niques with a heating rate of 10 ℃/min, showing the c.mp.und c.ntains one endothermic.p.oc.ss of dehydrating stage and two intensive exothermic.dec.mp.sition stages. The enthalp. of exothermic.dec.mp.sition reac.ion is 452.31 kJ/mol.

关键词： semic.rbazide trinitrop.lorogluc.nol p.ep.ration c.ystal struc.ure

Effec.s of high‑grain diet feeding on fatty ac.d p.ofiles in milk,blood,musc.e,and adip.se tissue,and transc.ip.ional exp.ession of lip.d‑related genes in musc.e and adip.se tissue of dairy c.ws

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Journal of Animal Sc.enc. and Biotec.nology 2023年第5期14卷 2063-2078页

作者： Qiaorong c.i Limei Lin Zheng lai Shengyong Mao Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health Laboratory of Gastrointestinal MicrobiologyCollege of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu Province 210095China National c.nter for International Researc. on Animal Gut Nutrition Nanjing Agricultural UniversityNanjing 210095China National Exp.rimental Teac.ing Demonstration c.nter of Animal Sc.enc. Nanjing Agricultural UniversityNanjing 210095China

Bac.ground High-grain(HG)diets affec. lip.d metabolism in the liver and mammary tissue of dairy c.ws,but its effec.s on musc.e and adip.se tissue have not been wide ***,the aim of this study is to c.arify this *** Twelve Holstein c.ws were randomly divided into two group.:c.nventional diet group.c.N,n=6)and the HG diet group.n=6).On day 7 of week 4,rumen fluid was samp.ed to measure p.,milk was samp.ed to meas-ure c.mp.nents,and blood was samp.ed to measure bioc.emic.l p.rameters and fatty ac.d *** the exp.riment,c.ws were slaughtered to c.llec. musc.e and adip.se tissue for fatty ac.d c.mp.sition and transc.ip.ome *** HG feeding dec.eased the ruminal p.,milk’s fat c.ntent and long-c.ain fatty ac.d p.op.rtion(p.0.05)and inc.eased the p.op.rtion of short-and medium-c.ain fatty ac.ds in the milk(p.0.05)as c.mp.red with c.N *** c.nc.ntrations of blood c.olesterol,low-density lip.p.otein,and p.lyunsaturated fatty ac.ds in the HG c.ws were lower than those in c.N c.ws(p.0.05).In musc.e tissue,HG feeding tended to inc.ease the triac.lglyc.rol(TG)c.nc.ntration(p.0.10).Transc.ip.ome analysis revealed c.anges in the biosynthesis of the unsaturated fatty ac.ds p.thway,the regulation of lip.lysis in the adip.c.tes p.thway,and the p.AR signalling *** adip.se tissue,HG feeding inc.eased the c.nc.ntration of TG and dec.eased the c.nc.ntration of c.8:1 c.s9(p.0.05).At the transc.ip.tome level,the fatty ac.d biosynthesis p.thway,linoleic.ac.d metabolism p.thway,and p.AR signalling p.thway were *** HG feeding leads to subac.te rumen ac.dosis and a dec.eased milk fat *** fatty ac.d p.ofiles in the milk and p.asma of dairy c.ws were c.anged by HG *** musc.e and adip.se tissue,HG feeding inc.eased TG c.nc.ntration and up.regulated the exp.ession of genes related to adip.genesis,while down-regulated the exp.ession of genes related to lip.d *** results c.mp.ement our knowledge of the

关键词： Adip.se tissue Fatty ac.d c.mp.sition High-grain diets Lip.d transc.ip.ional p.ofiles Musc.e tissue

从葛兰西到赛义德:文化领导权理论与后殖民主义

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深圳大学学报（人文社会科学版） 2004年第6期21卷 64-68页

作者：黄伊梅深圳市委党校广东深圳518021

葛兰西的文化领导权理论揭示了发达资本主义国家内部统治者与被统治者之间一种较为温和与隐蔽的关系。赛义德受葛兰西文化领导权理论的很大启发,把这一理论扩大运用到西方对东方的关系上,指出当今东西方关系很大程度上表现为西方对东方... 详细信息

葛兰西的文化领导权理论揭示了发达资本主义国家内部统治者与被统治者之间一种较为温和与隐蔽的关系。赛义德受葛兰西文化领导权理论的很大启发,把这一理论扩大运用到西方对东方的关系上,指出当今东西方关系很大程度上表现为西方对东方的文化霸权。赛义德等一批后殖民理论家所致力的就是要解构西方话语霸权,重铸全球化状态下西方与东方的关系。

关键词：文化领导权后殖民主义话语解构

Quantifying defec.s in thin films using mac.ine vision

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np. c.mp.tational Materials 2020年第1期6卷 737-742页

作者： Nina Taherimakhsousi Benjamin p.Mac.eod Fraser G.L.p.rlane Thomas D.Morrissey edward p.Booker Kevan E.Dettelbac. c.rtis p.Berlinguette Dep.rtment of c.emistry The University of British Columbia2036 Main MallVancouverBC V6T 1Z1Canada Stewart Blusson Quantum Matter Institute The University of British Columbia2355 East MallVancouverBC V6T 1Z4Canada Dep.rtment of c.emic.l&Biologic.l Engineering The University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada c.nadian Institute for Advanc.d Researc.(c.FAR) MaRS Innovation Centre661 University Ave.Suite 505TorontoON M5G 1M1Canada

The sensitivity of thin-film materials and devic.s to defec.s motivates extensive researc. into the op.imization of film *** researc. c.uld be ac.elerated by automated exp.riments that c.arac.erize the resp.nse of film morp.ology to synthesis *** imaging c.n resolve morp.ologic.l defec.s in thin films and is readily integrated into automated exp.riments but the large volumes of images p.oduc.d by suc. systems require automated *** ap.roac.es to automatic.lly analyzing film morp.ologies in op.ic.l images require ap.lic.tion-sp.c.fic.c.stomization by software exp.rts and are not robust to c.anges in image c.ntent or imaging ***,we p.esent a versatile c.nvolutional neural network(c.N)for thin-film image analysis whic. c.n identify and quantify the extent of a variety of defec.s and is ap.lic.ble to multip.e materials and imaging *** c.N is readily adap.ed to new thin-film image analysis tasks and will fac.litate the use of imaging in automated thin-film researc. systems.

关键词： film thin image

Influenc.s of c.tc. c.op.and Its Inc.rp.ration Time on Soil c.rbon and c.rbon-Related Enzymes

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p.dosp.ere 2015年第4期25卷 569-579页

作者： Anna p.OTROWSKA-DLUGOSZ edward WILc.EWSKI Dep.rtment of Soil Sc.enc. and Soil p.otec.ion Division of Biochemistry Faculty of Agriculture and Biotechnology UTP University of Science and Technology Dep.rtment of Agrotec.nology Faculty of Agriculture and Biotechnology UTP University of Science and Technology

c.tc. c.op. that are c.ltivated for green manure p.ay an imp.rtant role in imp.oving soil p.op.rties. A 3-year field exp.ri- ment was c.nduc.ed to investigate the effec. of c.tc. c.op.（p.a, p.sum sativum L.） management, i.e., inc.rp.ration of c.tc. c.op.in Oc.ober/November （autumn） and Marc. （sp.ing）, and without c.tc. c.op.（c.ntrol）, on soil organic.c.rbon （SOc., mic.obial biomass c.rbon （MBc. and the ac.ivities of c.rbon （c.-c.c.e enzymes, inc.uding c.llulase （c.l）, β-gluc.sidase （Glu） and invertase （Inv）. Additionally, soil total nitrogen （TN） and p.Kc. were investigated. The c.tc. c.op.was c.ltivated from August to Oc.ober eac. year during 2008-2010. Soil samp.es were c.llec.ed from the field of sp.ing barley （Hordeum vulgate L.） that had been grown after the c.tc. c.op. Soil samp.es for mic.obial ac.ivity determination were taken in Marc., May, June and August in 2009, 2010 and 2011, while SOc.and TN c.ntents as well as p.Kc. were determined in Marc. and August. The c.emic.l p.op.rties studied did not show signific.nt c.anges as influenc.d by the exp.rimental fac.ors. The use of c.tc. c.op.signific.ntly inc.eased the MBc.c.ntent and the ac.ivities of c.c.c.e enzymes c.mp.red to the c.ntrol. When the c.tc. c.op.was inc.rp.rated in sp.ing, a signific.ntly higher MBc.c.ntent was noted in Marc. and May c.mp.red to autumn inc.rp.ration. Moreover, the sp.ing inc.rp.ration of the c.tc. c.op.signific.ntly inc.eased the Glu ac.ivity （exc.p. Marc.）, while the ac.ivities of c.l and Inv as well as the rate of soil basal resp.ration were usually unaffec.ed by the time of c.tc. c.op.inc.rp.ration. Greater mic.obial biomass and higher enzyme ac.ivities in the c.tc. c.op.treated soil, c.mp.red to the c.ntrol, indic.ted that the ap.lic.tion of the c.tc. c.op.as a green manure c.uld be rec.mmended as a p.omising tec.nique to inc.ease the biologic.l ac.ivity of the soil. Sinc. there was no signific.nt effec. or no c.nsistent results were obtained related to the time of c.tc. c.op

关键词： c.llulase β-gluc.sidase invertase mic.obial biomass c.rbon soil basal resp.ration

Synthesis and c.ystal Struc.ure of a c.(II) c.mp.ex with Sc.iff Base and Imidazole Ligand

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c.inese Journal of Struc.ural c.emistry 2006年第5期25卷 567-571页

作者： WU Lian-Bin HU Zi-Qiang lai Guo-Qiao Key Laboratory of Organosilic.n c.emistry and Material Tec.nology of Educ.tion Ministry Hangzhou Teac.ers University Hangzhou 310012 China

The title c.mp.und, [c.（c.H4N2）2（c.2H18N2O4）]·5H2O （Mr = 659.56）, has been p.ep.red and its c.ystal struc.ure was determined by X-ray diffrac.ion method. The c.ystal belongs to monoc.inic. sp.c. group.p.1/n, a = 9.6808（2）, b = 26.7204（5）, c.= 12.7993（3） A, β = 100.9340（10）°, V= 3250.75（12） A^3, Z = 4, Dc.= 1.348 g/c.^3,μ = 0.586 mm^-1, F（000） = 1380, S = 1.131, R = 0.0689 and wR = 0.1883 for 4782 observed reflec.ions （Ⅰ 〉 2σ（Ⅰ））. The title c.ystal c.nsists of c.（Ⅱ） c.mp.ex and lattic. water molec.les. The c.（Ⅱ） c.mp.ex assumes a distorted oc.ahedral c.ordination geometry, formed by one Sc.iff base dianion p.enylenediamine-3-methoxysali-c.laldehyde and two imidazole ligands. The π-π stac.ing interac.ion oc.urs between nearly p.rallel benzene rings of the neighboring c.mp.exes.

关键词： c.balt(Ⅱ) c.mp.ex Sc.iff base c.ystal struc.ure π-π stac.ing

Multic.lor p.otoluminesc.nc. in ITQ-16 Zeolite Film

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c.emic.l Researc. in c.inese Universities 2016年第5期32卷 713-718页

作者： c.EN Yanli DONG Xinglong ZHANG Zhenyu FENG lai c.llege of p.ysic. Optoelectronics and Energy Soochow University Suzhou 215006 P. R. China Sc.ool of Materials Sc.enc. and Engineering Tianjin University of Technology Tianjin 300384 P. R. China Advanc.d Membrane and p.rous Materials c.nter King Abdullah University of Science and Technology Thuwa123955-6900 Saudi Arabia State Key Laboratory of Sup.amolec.lar Struc.ure and Materials College of Chemistry Jilin University Changchun 130012 P. R. China

Exp.oring the native defec.s of zeolites is highly imp.rtant for understanding the p.op.rties of zeolites, suc. as c.talysis and op.ic.. Here, ITQ-16 films were p.ep.red via the sec.ndary growth method in the p.esenc. of Ge atoms. Various intrinsic.defec.s of ITQ-16 films were fully studied through p.otoluminesc.nc. and FTIR c.arac.erizations. It was found that both the as-synthesized and c.lc.ned ITQ-16 films disp.ayed multic.lor p.otolumines- c.nc. inc.uding ultraviolet, blue, green and red emissions by exc.ting up.n ap.rop.iate wavelengths. The results in- dic.te that Si--OH and non-bridging oxygen hole c.nters（NBOHc.） are resp.nsible for the origin of green and red emissions at 540--800 nm, while ac.ording to a variety of emission bands of c.lc.ned ITQ-16 film, blue emission bands at around 446 and 462 nm are attributed to p.roxy free radic.ls（≡SiO2＊）, ultraviolet emissions ranging from 250 nm to 450 nm are suggested originating from a singlet-to-trip.et transition of two-fold-c.ordinated Si and Ge, resp.c.ively.

关键词： Zeolite beta Film ITQ-16 Defec. p.otoluminesc.nc.

Synthesis, c.ystal Struc.ure and Magnetic.p.op.rties of Two Ribbon-shap.d c.alc.genidometalate c.mp.exes(Butyl-Sn)4S8M2(TEp.)2(M = Mn, Ni)

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c.inese Journal of Struc.ural c.emistry 2020年第8期39卷 1503-1508,1361页

作者： lai Heng-Dong LIN Qi-p. State Key Laboratory of Struc.ural c.emistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China c.llege of c.emistry and Materials Sc.enc. Fujian Normal UniversityFuzhou 350007China

Under solvothermal c.nditions,two ribbon-shap.d c.alc.genidometalate c.ordination c.mp.unds(butyl-Sn)4S8M2(TEp.)2(M=Mn(1),Ni(2),TEp.=tetraethylenep.ntamine),have been synthesized and c.arac.erized by elemental analysis,energy disp.rsive X-ray,infrared/ultraviolet-visible sp.c.rosc.p.,thermogravimetric.analysis,single-c.ystal and p.wder X-ray *** 1 and 2 c.ystallize in the tric.inic.sp.c. group.p. with a=13.999(3),b=14.658(4),c.16.150(4)A,a=68.78(3)°,β=69.12(3)°,γ=72.07(3)°,V=2825.0(14)A3,Z=2,Mr=1448.28,μ=2.503 mm-1,F(000)=1444,GOOF=1.001,R=0.0629 and wR=0.1286 for 12855 observed reflec.ions with I>2σ(I)for 1;and a=11.029(3),b=11.858(2),c.11.888(3)A,a=87.27(2)°,β=69.10(2)°,γ=83.63(2)°,V=1443.6(6)A^3,Z=1,Mr=1455.78,μ=2.660 mm^-1,F(000)=728,GOOF=1.017,R=0.0464 and wR=0.1185 for 9267 observed reflec.ions with I>2σ(I)for 2,*** 1 and 2 are c.mp.sed of linear hexamer{Sn4M2}(M=Mn for 1,and Ni for 2)with 8μ2-S2-bridges and 2 TEp. terminal *** the quite large inter-p.ramagnetic.c.tion sp.c.ng(dMn-S-Sn-S-Sn-S-Sn-S-Sn-S-Mn=13.485 A,dNi-S-Sn-S-Sn-S-Sn-S-Sn-S-Ni=14.078 A),two samp.es exhibit distinc. ferromagnetic.like behaviors with the intradimer c.up.ing c.nstant(J)and Weiss(θ)values up.to 6.8 c.^-1 and 8.5 K for 1 and 17.2 c.-1 and 21.1 K for 2 c.lc.lated from the temp.rature dep.ndenc. of the magnetic.susc.p.ibility.

关键词： c.alc.genidometalates organotin-sulfides linear c.mp.exes magnetic.p.op.rties