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岭南心血管病杂志 2001年第6期7卷 413-413页

作者： edward l.kaplan 刘小青 Universityof Minnesota Medical SchoolMinneapolis Minnesota USA

虽然对A组β溶血性链球菌与风湿热的关系已认识半个多世纪,但对这个关系的许多重要的问题尚未完全确定。

关键词：风湿热风湿性心脏病链球菌宿主

Accelerated intermetallic phase amorphization in a Mg-based high-entropy alloy powder

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Journal of Magnesium and Alloys 2024年第5期12卷 1792-1798页

作者： Prince Sharma Purvam Mehulkumar Gandhi Kerri-lee Chintersingh Mirko Schoenitz edward l.Dreizin Sz-Chian liou Ganesh Balasubramanian Institute for Functional Materials&Devices Lehigh UniversityBethlehemPA 18015USA Center of Materials for Advanced Energetics New Jersey Institute of TechnologyNewarkNJ 07102USA

We describe a novel mechanism for the synthesis of a stable high-entropy alloy powder from an otherwise immiscible Mg-Ti rich metallic mixture by employing high-energy mechanical *** presented methodology expedites the synthesis of amorphous alloy powder by strategically injecting entropic disorder through the inclusion of multi-principal elements in the alloy *** from first principles and materials theory corroborate the results from microscopic characterizations that reveal a transition of the amorphous phase from a precursor intermetallic *** transformation,characterized by the emergence of antisite disorder,lattice expansion,and the presence of nanograin boundaries,signifies a departure from the precursor intermetallic ***,this phase transformation is accelerated by the presence of multiple principal elements that induce severe lattice distortion and a higher configurational *** atomic size mismatch of the dissimilar elements present in the alloy produces a stable amorphous phase that resists reverting to an ordered lattice even on annealing.

关键词： High-entropy alloy High-energy milling Antisite disorder Amorphous Intermetallic

Weight regain after intragastric balloon for pre-surgical weight loss

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt Kevin Choy Alexandra Kovar Teresa S Jones Krzysztof J Wikiel edward l Jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： Vladislav V Tsukanov Julia l Tonkikh edward V Kasparov Alexander V Vasyutin Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages(TAM)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,M2 TAM polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAM and the differentiation of the functions of M1 and M2 phagocytes are of great importance for the progression of *** is assumed that M2 TAM promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： liver cancer Treatment Calculus bovis Tumor-associated macrophages M2 tumor Macrophage polarization Wnt/β-catenin pathway

High association strengths are linked to phenotypic similarity,including plumage color and patterns,of participants in mixed-species bird flocks of southwestern China

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Current Zoology 2024年第1期70卷 34-44页

作者： liping Zhou Christos Mammides Youfang Chen Wenyi Zhou Wenzhang Dai edward l.Braun Rebecca T.Kimball Yang liu Scott K.Robinson Eben Goodale Guangxi Key laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Kunming Natural History Museum of Zoology Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Nature Conservation Unit Frederick University7Yianni Frederickou StreetPallouriotissaNicosia 1036Cyprus State Key laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Florida Museum of Natural History University of FloridaGainesvilleFL 34201USA Department of Biology University of FloridaGainesvilleFL 34201USA School of life Science and Institute of Wetland Ecology Nanjing UniversityNanjing 210000China State Key laboratory of Biocontrol School of EcologySun-Yatsen UniversityGuangzhou 510275China Department of Health and Environmental Science Xi'an Jiaotong Liverpool UniversitySuzhou 215123China

Participants in mixed-species bird flocks(MSFs)have been shown to associate with species that are similar in body size,diet,and evolutionary history,suggesting that facilitation structures these *** addition,several studies have suggested that species in MsFs resemble each other in their plumage,but this question has not been systematically investigated for any MsF *** the nonbreeding season of 2020 and 2021,we sampled 585 MSFs on 14 transects in 2 habitats of Tongbiguang Nature Reserve in western Yunnan Province,*** performed social network analysis and the Multiple Regression Quadratic Assignment Procedure to evaluate the effect of 4 species traits(body size,overall plumage color,distinctive plumage patterns,and diet)and evolutionary history on species association strength at the whole-MSF and within-MSF *** 41 significant relationships showed that species with stronger associations were more similar in their various *** size had the strongest effect on association strength,followed by phylogeny,plumage patterns,and plumage color;diet had the weakest *** results are consistent with the hypotheses that the benefits of associating with phenotypically similar species outweigh the potential costs of interspecific competition,and that trait matching can occur in plumage characteristics,albeit more weakly than in other *** explanations exist as to why similarities in plumage may occur in MSFs,including that they could reduce predators'ability to target phenotypically"odd"*** trait matching in plumage occurs through assortative processes in ecological time or is influenced by co-evolution requires furtherstudy.

关键词： co-evolution interaction networks mixed-species animal groups phenotypic similarity trait convergence

Ten misconceptions regarding decision-making in critical care

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World Journal of Critical Care Medicine 2024年第2期13卷 72-82页

作者： Tara Ramaswamy Jamie l Sparling Marvin G Chang edward A Bittner Department of Anesthesiology Perioperative and Pain MedicineStanford University School of MedicineStanfordCA 94305United States Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States

Diagnostic errors are prevalent in critical care practice and are associated with patient harm and costs for providers and the healthcare *** complexity,illness severity,and the urgency in initiating proper treatment all contribute to decision-making ***-related factors such as fatigue,cognitive overload,and inexperience further interfere with effective *** science has provided insight into the clinical decision-making process that can be used to reduce *** evidence-based review discusses ten common misconceptions regarding critical care *** understanding how practitioners make clinical decisions and examining how errors occur,strategies may be developed and implemented to decrease errors in Decision-making and improve patient outcomes.

关键词： Clinical reasoning Cognitive bias Critical care Debiasing strategies decision making Diagnostic reasoning Diagnostic error Heuristics Medical knowledge Patient safety

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翻译中国经典文献的三点心得

文史哲 2024年第2期 39-54,166页

作者：夏含夷叶芊(译) 芝加哥大学宾夕法尼亚州立大学

透过作者自身已出版的相关译作,在翻译中国经典文献时,有三个既各自独立又彼此相连的方面需要关注,那就是词源、古文字和声韵。结合《老子》《周易》《礼记·缁衣》《诗经》等文本的翻译可见,词源既包括中文原文字词的出处,也包括作为... 详细信息

透过作者自身已出版的相关译作,在翻译中国经典文献时,有三个既各自独立又彼此相连的方面需要关注,那就是词源、古文字和声韵。结合《老子》《周易》《礼记·缁衣》《诗经》等文本的翻译可见,词源既包括中文原文字词的出处,也包括作为目标语言的英文文字的词源。古文字问题则只限于古汉语;就文中的举例而言,这一方面还时常涉及新出土的早期中国文字材料。关于声韵,翻译时至少应当尝试模仿原文文字的发音。当然,英文与中文的发音不可能一模一样,并不需要照搬原文的韵律,然而模仿原文的节奏经常会有助于翻译。

关键词：老子周易诗经经典文献翻译

Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems

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Science China(life Sciences) 2024年第1期67卷 188-203页

作者： Xuan Dong Cixiu li Yiting Wang Tao Hu Fan Zhang Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwynck edward CHolmes Patrick Sorgeloos liying Sui Jie Huang Weifeng Shi State Key laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesLaboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of Mariculture Epidemiology and BiosecurityQingdao 266071China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021China Key laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China Dalian Ocean University Dalian 116023China Asian Regional Artemia Reference Center Tianjin University of Science&TechnologyTianjin 300457China Ghent University Ghent 9000Belgium Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydney 2006Australia Network of Aquaculture Centres in Asia-Pacific Bangkok 10900Thailand School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ecological importance in hypersaline *** a crucial live food in aquaculture,brine shrimp cysts have become one of the most important aquatic products traded ***,our understanding of the biodiversity,prevalence and global connectedness of viruses in brine shrimp is still very limited.A total of 143 batches of brine shrimp(belonging to seven species)cysts were collected from six continents including 21 countries and more than 100 geographic locations worldwide during 1977–*** total,55 novel RNA viruses were identified,which could be assigned to 18 different viral families and related *** viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA *** analyses of the RNA-directed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and ***,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ecological niche.A notable case was the novel brine shrimp noda-like virus 3,which shared 79.25%(RdRp)and 63.88%(capsid proteins)amino acid identity with covert mortality nodavirus(CMNV)that may cause losses in *** addition,both virome composition and phylogenetic analyses revealed global connectedness in certain brine shrimp viruses,particularly among Asia and Northern *** highlights the incredible species diversity of viruses in these ancient species and provides essential data for the prevalence of RNA viruses in the global aquaculture *** broadly,these findings provide novel insights into the previously unrecognized RNA virosphere in hypersaline ecosystems worldwide and demonstrate that human activity might have driven the global connectedness of brine shrimp viruses.

关键词： brine shrimp Artemia virus diversity novel virus discovery global connectedness hypersaline ecosystem

Identification of novel mammalian viruses in tree shrews(Tupaia belangeri chinensis)

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Zoological Research 2024年第2期45卷 429-438页

作者： Hong Zhou Ren-Rong Tian Xiu-Rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-liang Zhao Xu-Dong Zhang Yu-Hua Ma long-Bao lv edward CHolmes Yong-Tang Zheng Wei-Feng Shi School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China Key laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University and Shandong Academy of Medical SciencesTaianShandong 271000China Key laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China National Resource Center for Non-Human Primates Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydneyNew South Wales 2006Australia Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Virology Shanghai Jiao Tong University School of MedicineShanghai 200025China

The Chinese tree shrew(Tupaia belangeri chinensis),a member of the mammalian order Scandentia,exhibits considerable similarities with primates,including humans,in aspects of its nervous,immune,and metabolic *** similarities have established the tree shrew as a promising experimental model for biomedical research on cancer,infectious diseases,metabolic disorders,and mental health ***,we used metatranscriptomic sequencing to analyze plasma,as well as oral and anal swab samples,from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic *** total,eight mammalian viruses with complete genomes were identified,belonging to six viral families,including Flaviviridae,Hepeviridae,Parvovirinae,Picornaviridae,Sedoreoviridae,and ***,the presence of rotavirus was recorded in tree shrews for the first *** viruses-hepacivirus 1,parvovirus,and picornavirus-exhibited low genetic similarity(ly reported viruses at the whole-genome scale,indicating ***,three other viruses-hepacivirus 2,hepatovirus A and hepevirus-exhibited high similarity(>94%)to known viral *** analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel *** findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews,highlighting the necessity for further research into their potential for crossspecies transmission.

关键词： Tree shrew(Tupaia belangeri chinensis) Meta-transcriptomic sequencing Mammalian viruses Genomic analysis

Clinical features and management of autoimmune hepatitis

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World Journal of Gastroenterology 2008年第21期14卷 3301-3305页

作者： edward l Krawitt Departments of Medicine University of VermontBurlingtonVermontand Dartmouth CollegeHanoverNew HampshireVermont 05405-0068United States

Autoimmune hepatitis(AIH) is a chronic hepatitis of unknown etiology which can progress to *** clinical manifestations are highly variable and some-times follow a fluctuating *** is based on characteristic histologic,clinical,biochemical and sero-logical ***-inflammatory/immunosuppressive treatment frequently induces remission but long-term maintenance therapy is often *** transplan-tation is generally successful in patients with decompen-sated cirrhosis unresponsive to or intolerant of medical therapy.

关键词： Autoimmunity Autoimmune hepatitis Chronic hepatitis Cirrhosis liver disease