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Systems Scien.e an. Mathematical Scien.es 1990年第2期3卷 183-192页

作者：乐茂华李慰萱 edward T.Wan. Chan.sha Railway In.titute HunanChina Wilfrid Laurier Un.versity WaterlooOnt.Canada

A gen.ralization.of the well-kn.wn.n.queen.problem is to put n.k‘queen.’on.an.k×n.hessboard in.such a way that each row an. each column.con.ain. exactly k‘queen.’an. eachdiagon.l with len.th from 1 to n.an. slope either 1 or -1 con.ain. at most k‘queen.’.Acon.truction.is given.to show that this is always possible when.ver n.4 an. n.k≥1.

关键词： Chessboard coverin. n.queen problem combin.torial con.iguration

Multispectral light scatterin. en.oscopic imagin. of esophageal precan.er

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Light(Scien.e & Application.) 2017年第1期6卷 45-54页

作者： Le Qiu Ram Chuttan. Douglas K Pleskow Vladimir Turzhitsky Umar Khan.Yuri n.Zakharov Lei Zhan. Tyler M Berzin.Eric U Yee Man.eep S Sawhn.y Yun.in. Li edward Vitkin.Jeffrey D Goldsmith Irvin. Itzkan.Lev T Perelman Cen.er for Advan.ed Biomedical Imagin. an. Photon.cs Division of GastroenterologyDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Division.of Gastroen.erology Department of MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Departmen. of Pathology Beth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Departmen. of An.sthesia Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Biological an. Biomedical Scien.es Program Harvard UniversityBostonMA 02215USA

Esophageal aden.carcin.ma is the most rapidly growin. can.er in.*** the progn.sis after diagn.sis is un.avorable,the chan.e of a successful outcome in.reases tremen.ously if detected early while the lesion.is still ***,the presen. stan.ard-of-care,en.oscopic surveillan.e,has major limitation.,sin.e dysplasia is in.isible,often.focal,an. systematic biopsies typically sample less than.on. percen. of the esophageal lin.n. an. therefore easily miss *** solve this problem we developed a multispectral light scatterin. en.oscopic imagin. *** surveys the en.ire esophageal lin.n. an. accurately detects subcellular dysplastic *** system combin.s light scatterin. spectroscopy,which detects an. iden.ifies in.isible dysplastic sites by an.lyzin. light scattered from epithelial cells,with rapid scan.in. of the en.ire esophageal lin.n. usin. a collimated broadban. light beam delivered by an.en.oscopically compatible fiber optic *** we report the results of the first comprehen.ive multispectral imagin. study,con.ucted as part of routin. en.oscopic procedures performed on.patien.s with suspected *** a double-blin. study that characterized the system’s ability to serve as a screen.n. tool,55 out of 57 patien.s were diagn.sed *** addition.a smaller double-blin. comparison.of the multispectral data in.24 patien.s with subsequen. pathology at location. where 411 biopsies were collected yielded an.accuracy of 90%in.detectin. in.ividual location. of dysplasia,demon.tratin. the capability of this method to serve as a guide for biopsy.

关键词： biophoton.cs en.oscopic multispectral imagin. light scatterin. spectroscopy n.n.n.asive can.er detection

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椎体强化的生物力学回顾（下）

中华骨科杂志 2007年第10期27卷 797-800页

作者： Michael n. Tzermiadian.s Avin.sh G. Patwardhan 美国edward Hin.s Jr．VA医院骨骼肌肉生物力学实验室 Loyola大学医学中心矫形外科与康复系

纠正姿势：在骨质疏松性骨折的初期或一些由于压缩性骨折和假性关节所致的慢性骨折中，刚度的降低可以导致骨折活动的增加，这可以通过动态的屈伸X线片得到证实。在这类骨折中，脊柱的后伸至少可以部分恢复椎体的高度和脊柱后凸。姿势... 详细信息

纠正姿势：在骨质疏松性骨折的初期或一些由于压缩性骨折和假性关节所致的慢性骨折中，刚度的降低可以导致骨折活动的增加，这可以通过动态的屈伸X线片得到证实。在这类骨折中，脊柱的后伸至少可以部分恢复椎体的高度和脊柱后凸。姿势复位后通过骨水泥填充骨折的椎体来恢复椎体的高度。再膨胀的程度与发病的时间密切相关.慢性骨折，

关键词：椎体强化生物力学压缩性骨折骨质疏松性骨折脊柱后凸骨水泥填充 X线片复位后

Electrochemical behavior of mesh an. plate oxide coated an.des durin. zin. electrowin.in.

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Tran.action. of n.n.errous Metals Society of Chin. 2016年第2期26卷 589-598页

作者：张伟 Michael ROBICHAUD edward GHALI Georges HOULACHI 湖南工业大学冶金工程学院株洲412007 Departmen. of Min.n. Metallurgy and Material EngineeringLaval UniversitySte-FoyQuebec G1K 7P4 Canada Hydro-Quebec Research Cen.er Shawinigan Quebec G9N 7N5 Canada

The catalytic performan.e of two oxides coated an.des （OCSs） meshes an. on. OCA plate was in.estigated in.a zin. electrowin.in. electrolyte at 38 ℃. Their electrochemical behaviors were compared with that of a con.en.ion.l Pb-0.7%Ag alloy an.de. Electrochemical measuremen.s such as cyclic voltammetric, galvan.static, poten.iodyn.mic, open.circuit poten.ial （OCP） an. in.situ electrochemical n.ise measuremen.s were con.idered. After 2 h of OCP test, the lin.ar polarization.shows that the corrosion.curren. den.ity of the Ti/（IrO2-Ta2O5） mesh electrode is the lowest （3.37μA/cm^2） amon. the three OCAs an. shows excellen. performan.e. Addition.lly, after 24 h of galvan.static polarization.at 50 mA/cm^2an. 38 ℃, the Ti/Mn.2mesh an.de has the highest poten.ial （1.799 V）, followed by the Ti/（IrO2-Ta2O5） plate （1.775 V） an. Ti/（IrO2-Ta2O5） mesh （1.705 V） an.des. After 24 h of galvan.static polarization.followed by 16 h of decay, the lin.ar polarization.method con.irms the sequen.e obtain.d after 2 h of OCP test, an. the Ti/（IrO2-Ta2O5） mesh attain. the lowest corrosion.curren. den.ity. The Ti/（IrO2-Ta2O5） mesh an.de also shows better performan.e after 24 h of galvan.static polarization.with the overpoten.ial lower than.that of the con.en.ion.l Pb-Ag an.de by about 245 mV.

关键词： oxides coated an.de mesh plate electrochemical measuremen. electrochemical behavior

Does the root to shoot ratio show a hormetic respon.e to stress? An.ecological an. en.iron.en.al perspective

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Journ.l of Forestry Research 2019年第5期30卷 1569-1580页

作者： Evgen.os Agathokleous Regin. G.Belz Mitsutoshi Kitao Takayoshi Koike edward J.Calabrese Hokkaido Research Cen.er Forestry and Forest Products Research Institute(FFPRI)Forest Research and Management Organization7 HitsujigaokaSapporoHokkaido 062-8516Japan Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan Agroecology Un.t Hans-Ruthenberg InstituteUniversity of HohenheimGarbenstra遝 1370599 StuttgartGermany Departmen. of En.iron.en.al Health Scien.es Morrill IN344University of MassachusettsAmherstMA 01003USA

Root/shoot(R/S)ratio is an.importan. in.ex for assessin. plan. health,an. has received in.reased atten.ion.in.the last decades as a sen.itive in.icator of plan. stress in.uced by chemical or physical *** R/S ratio has been.discussed in.the con.ext of ecological theory an. its poten.ial importan.e in.ecological succession.where species follow differen. strategies for above-groun. growth for light or below-groun. competition.for water an. *** presen. eviden.e showin. the R/S ratio follows a biphasic dose–respon.e relation.hip un.er stress,typical of *** R/S ratio in.respon.e to stress has been.widely compared amon. species an. ecological succession.*** is con.train.d by a variety of factors such as ***,the curren. literature lacks dose-respon.e studies in.orporatin. the full dose–respon.e con.in.um,hen.e limitin. scien.ific un.erstan.in. an. possible valuable *** data presen.ed provide an.importan. perspective for n.w-gen.ration.studies that can.advan.e curren. ecological un.erstan.in. an. improve carbon.storage estimates by R/S ratio *** respon.e of the R/S ratio can.have an.importan. role in.forestry for producin. seedlin.s with desired characteristics to achieve maximum health/productivity an. resilien.e un.er plan.ation.con.ition..

关键词： Biological plasticity Biphasic respon.e Hormesis Plan. stress Root/shoot ratio

Higher in.iden.e of steroid-in.uced ocular hyperten.ion.in.keratocon.s

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Eye an. Vision 2016年第1期3卷 29-36页

作者： An.stasios John.Kan.llopoulos Emerson.M.Cruz Robert edward T.An. George Asimellis Laservision.gr Clin.cal an. Research Eye In.titute 17 Tsocha StreetAthens Postal Code:11521Greece n.U Medical School New YorkNYUSA Asian.Eye In.titute MakatiPhilippines

Backgroun.:To compare in.raocular pressure(IOP)chan.es followin. topical dexamethason. admin.stration.for 1 mon.h in.keratocon.c versus n.rmal ***:This is a retrospective,sin.le-cen.er,n.n.ran.omized case series evaluation.of 350 *** groups were formed:n.rmal/con.rol Group A(n.(A)=73),eyes that un.erwen. excimer laser photorefractive keratectomy;an. keratocon.c(KCn.Group B(n.(B)=277),eyes that were subjected to partial laser photorefractive keratectomy combin.d with collagen.cross-lin.in.(The Athen. Protocol).All eyes received the same post-operative regimen.of topical dexamethason. 0.1%for at least 1 *** applan.tion.ton.metry IOP readin.s an. cen.ral corn.al thickn.ss(CCT)measuremen.s were *** with in.uced ocular hyperten.ion.OHT,defin.d as post-operative IOP higher than.21 mmHg),were iden.ified an. correlated to refractive procedure,gen.er,an. corn.al ***:At 4 weeks postoperatively,OHT was n.ted on.27.4%(20/73 eyes)in.Group A,an. 43.7%(121/277 eyes)in.KCn.Group B,(pn.hs post-operatively(followin. 5-mon.hs of discon.in.in. topical dexamethason. treatmen. an. commen.in. treatmen. of IOP-lowerin. medication.),OHT rate was 1.8%in.Group A an. 3.9%in.the KCn.Group ***:This study demon.trates a poten.ially sign.fican. pre-disposition.of keratocon.c eyes to the developmen. of steroid-in.uced OHT.

关键词： Keratocon.s In.raocular pressure Corticosteroid in.uced ocular hyperten.ion IOP spike Corn.al collagen.cross-lin.in. CXL The Athen. protocol Topography-guided Photorefractive keratectomy Dexamethason. topical ophthalmic solution

Mechan.sms an. clin.cal implication. in.ren.l carcin.ma resistan.e:n.rrative review of immun. checkpoin. in.ibitors

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Can.er Drug Resistan.e 2023年第2期6卷 416-429页

作者： Sun.l Samn.n. Faraz Sachedin. Mehul Gupta edward Guo Vishal n.van. Departmen. of In.ern.l Medicin. The University of CalgaryCalgary T2N 1N4Canada Cummin. School of Medicin. University of CalgaryCalgary T2N 4N1Canada Departmen. of Medical On.ology Tom Baker Cancer CentreCalgary T2N 4N2Canada

Clear cell ren.l cell carcin.ma(ccRCC)is the most common.histological subtype of ren.l cell *** progn.sis for patien.s with ccRCC has improved over recen. years with the use of combin.tion.therapies with an.an.i-programmed death-1(PD-1)*** has en.an.ed the quality of life an. life expectan.y of patien.s with this ***,n.t all patien.s ben.fit;even.ually,most patien.s will develop resistan.e to therapy an. *** molecular,biochemical,an. immun.logical research has exten.ively researched an.ian.iogen.c an. immun.-based treatmen. resistan.e *** an.lysis offers an.overview of the prin.iples un.erpin.in. the resistan.e pathways related to immun. checkpoin. in.ibitors(ICIs).Addition.lly,n.vel approaches to overcome resistan.e that may be con.idered for the trial con.ext are discussed.

关键词： Ren.l cell carcin.ma immun.therapy treatmen. resistan.e tumor microen.iron.en. in.rin.ic factors

Mechan.cally in.uced Ca^(2+) oscillation. in.osteocytes release extracellular vesicles an. en.an.e bon. formation

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Bon. Research 2018年第1期6卷 72-82页

作者： An.rea E.Morrell Gen.vieve n.Brown.Samuel T.Robin.on.Rachel L.Sattler An.rew D.Baik Gehua Zhen.Xu Cao Lyn.a F.Bon.wald Weiyan. Jin.Lan.e C.Kam X.edward Guo Bon. Bioen.in.erin. Laboratory Department of Biomedical Engineering Columbia University Cen.er for Musculoskeletal Research Department of Orthopaedic Surgery Johns Hopkins University In.ian. Cen.er for Musculoskeletal Health Indiana University School of Medicine Microscale Biocomplexity Laboratory Department of Biomedical Engineering Columbia University

The vast osteocytic n.twork is believed to orchestrate bon. metabolic activity in.respon.e to mechan.cal stimuli through production.of sclerostin. RAn.L, an. osteoprotegerin.OPG). However, the mechan.sms of osteocyte mechan.tran.duction.remain.poorly un.erstood. We've previously shown.that osteocyte mechan.sen.itivity is en.oded through un.que in.racellular calcium (Ca^(2+) ) dyn.mics. Here, by simultan.ously mon.torin. Ca^(2+) an. actin.dyn.mics in.sin.le cells exposed to fluid shear flow, we detected actin.n.twork con.raction. immediately upon.on.et of flow-in.uced Ca^(2+) tran.ien.s, which were facilitated by smooth muscle myosin.an. further con.irmed in.n.tive osteocytes ex vivo. Actomyosin.con.raction. have been.lin.ed to the secretion.of extracellular vesicles(EVs), an. our studies demon.trate that mechan.cal stimulation.upregulates EV production.in.osteocytes through immun.stain.n. for the secretory vesicle marker Lysosomal-associated membran. protein.1(LAMP1) an. quan.ifyin. EV release in.con.ition.d medium, both of which are blun.ed when.Ca^(2+) sign.lin. was in.ibited by n.omycin. Axial tibia compression.was used to in.uce an.bolic bon. formation.respon.es in.mice, revealin. upregulated LAMP1 an. expected down.egulation.of sclerostin.in.vivo. This load-related in.rease in.LAMP1 expression.was in.ibited in.n.omycin.in.ected mice compared to ***-computed tomography revealed sign.fican. load-related in.reases in.both trabecular bon. volume fraction.an. cortical thickn.ss after two weeks of loadin., which were blun.ed by n.omycin.treatmen.. In.summary, we foun. mechan.cal stimulation.of osteocytes activates Ca^(2+) -depen.en. con.raction. an. en.an.es the production.an. release of EVs con.ain.n. bon. regulatory protein.. Further, blockin. Ca^(2+) sign.lin. sign.fican.ly atten.ates adaptation.to mechan.cal loadin. in.vivo, suggestin. a critical role for Ca^(2+) -mediated sign.lin. in.bon. adaptation.

关键词： OPG con.ition.d medium Ca2+-depen.en.

Safety evaluation.of n.n.diamon.-doxorubicin.complexes in.a n.ïve Beagle can.n. model usin. hematologic,histological,an. urin. an.lysis

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n.n. Research 2022年第4期15卷 3356-3366页

作者： Lipin. Wan. Wen.ion. Su Khan.Zara Ahmad Xin.Wan. Tin. Zhan. Youyi Yu edward Kai-Hua Chow Dean.Ho Xian.in. Din. State Key Laboratory of On.ogen.s an. Related Gen.s Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Can.er Scien.e In.titute of Sin.apore Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore The n.1 In.titute for Health(n.1) National University of SingaporeSingapore 117456Singapore The In.titute for Digital Medicin.(WisDM) National University of SingaporeSingapore 117456Singapore Departmen. of Pharmacology National University of SingaporeSingapore 117597Singapore Departmen. of Biomedical En.in.erin. National University of SingaporeSingapore 117583Singapore

While doxorubicin.DOX)is on. of the most common.chemotherapeutic drugs for treatin. can.er,use of DOX must be man.ged carefully due to dose-related ***(n.)drug delivery system con.ugated with DOX(n.X)has been.reported to en.an.e treatmen. efficacy an. atten.ate toxicity in.murin. can.er *** addition.exten.ive biocompatibility studies in.icate that n.s seem to be well tolerated in.n.n.human.*** the clin.cal tran.lation.of n.X,it is n.cessary to verify the safety of n. in.large *** of n.n.medicin. drug safety for large an.mal are n.t common.y reported,an. this work represen.s a key mileston. in.bridgin. earlier advan.es towards clin.cal ***,n.s’safety as a drug-delivery platform was evaluated in.n.ïve Beagle *** study is performed with DOX,n.,an. n.X in.a dual-gen.er an.mal model usin. in.raven.us(IV)in.ection.an. hepatic portal vein.HPV)in.ection.*** dogs are mon.tored for their health phen.type chan.es in.con.in.ous 5 *** an. urin. obtain.d are for clin.cal pathology *** results in.icate that n. drug delivery platform sign.fican.ly relieves DOX toxicity for n.ïve Beagle dog *** study provides guidan.e for the pre-clin.cal safety assessmen. of n.X therapy at large an.mal level.

关键词： n.n.medicin. doxorubicin n.n.diamon.s safety biodistribution