Multispectral light scattering endoscopic imaging of esophageal precancer

作     者：Le Qiu Ram Chuttani Douglas K Pleskow Vladimir Turzhitsky Umar Khan Yuri N Zakharov Lei Zhang Tyler M Berzin Eric U Yee Mandeep S Sawhney Yunping Li Edward Vitkin Jeffrey D Goldsmith Irving Itzkan Lev T Perelman 

作者机构：Center for Advanced Biomedical Imaging and PhotonicsDivision of GastroenterologyDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Division of GastroenterologyDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Department of PathologyBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Department of AnesthesiaCritical Care and Pain MedicineBeth Israel Deaconess Medical CenterHarvard UniversityBostonMA 02215USA Biological and Biomedical Sciences ProgramHarvard UniversityBostonMA 02215USA 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2017年第6卷第1期

页      面：45-54页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the US National Institutes of Health grants R01 EB003472,R01 EB025173 and R01 CA205431 the US National Science Foundation grants EFRI-1240410,CBET-1402926 and CBET-1605116 

主　　题：biophotonics endoscopic multispectral imaging light scattering spectroscopy noninvasive cancer detection 

摘      要：Esophageal adenocarcinoma is the most rapidly growing cancer in *** the prognosis after diagnosis is unfavorable,the chance of a successful outcome increases tremendously if detected early while the lesion is still ***,the present standard-of-care,endoscopic surveillance,has major limitations,since dysplasia is invisible,often focal,and systematic biopsies typically sample less than one percent of the esophageal lining and therefore easily miss *** solve this problem we developed a multispectral light scattering endoscopic imaging *** surveys the entire esophageal lining and accurately detects subcellular dysplastic *** system combines light scattering spectroscopy,which detects and identifies invisible dysplastic sites by analyzing light scattered from epithelial cells,with rapid scanning of the entire esophageal lining using a collimated broadband light beam delivered by an endoscopically compatible fiber optic *** we report the results of the first comprehensive multispectral imaging study,conducted as part of routine endoscopic procedures performed on patients with suspected *** a double-blind study that characterized the system’s ability to serve as a screening tool,55 out of 57 patients were diagnosed *** addition,a smaller double-blind comparison of the multispectral data in 24 patients with subsequent pathology at locations where 411 biopsies were collected yielded an accuracy of 90%in detecting individual locations of dysplasia,demonstrating the capability of this method to serve as a guide for biopsy.