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Hydrogels for the management of second-degree burns:currently available options and future promise

Burns & Trauma 2022年第1期10卷 71-87页

作者： katherine A.Cook Edith Martinez-Lozano Robert Sheridan edward k.rodriguez Ara Nazarian Mark W.Grinstaff Department of Chemistry Biomedical Engineeringand MedicineBoston UniversityBostonMA02215USA Musculoskeletal Translational Innovation Initiative Carl J.ShapiroDepartment of Orthopaedic SurgeryBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA02215USA Shriners Hospitals for Children and Burns Service Department of SurgeryMassachusetts General HospitalBostonMA02214USA Department of Orthopaedic Surgery Yerevan State Medical UniversityYerevanArmenia

Burn wounds result from exposure to hot liquids,chemicals,fire,electric discharge or *** severity ranges from first-degree injury,which is superficial,to fourth-degree injury,which exposes bone,tendons and *** assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the *** progression is of particular pertinence to second-degree burns,which are the most common form of thermal *** our understanding of wound healing advances,treatment options and technologies for second-degree burn management also *** hydrogels are a class of burn wound dressings that adhere to tissue,absorb wound exudate,protect from the environment,can be transparent facilitating serial wound evaluation and,in some cases,enable facile removal for dressing *** review briefly describes the burn level classification and common,commercially available dressings used to treat second-degree burns,and then focuses on new polymeric hydrogel burn dressings under preclinical development analyzing their design,structure and *** review presents the follow key learning points:(1)introduction to the integument system and the wound-healing process;(2)classification of burns according to severity and clinical appearance;(3)available dressings currently used for second-degree burns;(4)introduction to hydrogels and their preparation and characterization techniques;and(5)pre-clinical hydrogel burn wound dressings currently being developed.

关键词： Burn Wound Hydrogel Dressing Second-degree

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A Stakeholder-Guided Collaborative Approach to Improve Water Quality in a Nutrient Surplus Watershed

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Journal of Water Resource and Protection 2014年第6期6卷 571-582页

作者： Hector German rodriguez Jennie Popp edward Gbur John Pennington Agricultural Statistics Laboratory University of Arkansas Fayetteville USA Beaver Watershed Alliance Fayetteville USA Department of Agricultural Economics and Agribusiness University of Arkansas Fayetteville USA

The need for water quality improvement in nutrient surplus watersheds is a pressing issue on the agenda of some government agencies and environmental organizations. Including the water quality perceptions of different affected stakeholder groups in the decision-making process may help in addressing this issue. Unfortunately, there is a lack of published research focusing specifically on understanding how Arkansas stakeholders’ perceptions of water quality issues can be used to build and implement comprehensive and workable water quality management plans. Therefore, the objective of this study was to use a stakeholder-guided collaborative approach to help research and outreach personnel to understand water quality perceptions of key stakeholders and to integrate stakeholder engagement in both the decision-making process and in the implementation of water quality management strategies within the Lincoln Lake Watershed in northwest Arkansas. Two key stakeholder groups (i.e., Locals—residents and agricultural producers—and Outsiders—water quality specialist across the state) were surveyed to assess their perceptions regarding: 1) causes of watershed water quality problems, 2) parties responsible for water quality improvement, 3) effectiveness and affordability of best management practices to reduce water quality degradation, and 4) the stakeholders’ interactions with county, state and federal government. A total of 209 complete surveys (49% response rate) were received. Survey responses were compared to determine if significant differences existed between the two stakeholder groups’ perceptions of water quality performing Fisher’s exact tests. Results from the study showed that water quality is still perceived as an issue in the Lincoln Lake Watershed. Significant differences were found between the two stakeholder groups’ perceptions regarding: 1) different groups’ contributions to water degradation, 2) groups’ responsibilities for cleanup, 3) effectiveness of five best

关键词： Stakeholders’ Perceptions Environmental Decision Making Best Management Practices Nutrient Surplus Watershed Watershed Management

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Evaluation of MODIS Products in the Great Australian Bight and Adjacent Coastal Waters

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Open Journal of Marine Science 2018年第4期8卷 431-449页

作者： Ana Redondo rodriguez edward king Mark Doubell Paul van Ruth South Australian Research and Development Institute West Beach SA Australia CSIRO Oceans and Atmosphere Flagship CSIRO Hobart Australia

Satellite remote sensing data can produce global environmental data and is easily accessible and widely used by the scientific and non-scientific community. However, to use satellite data, it is important to know its limitations and how it validates against in situ measurements for the different regions. Here, field measurements of chlorophyll-a concentration and euphotic depth within the Great Australian Bight, Gulf St Vincent and Spencer Gulf were used to validate ocean colour products derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) onboard the Aqua satellite. The field data include in situ and in vivo chlorophyll-a concentration, which were compared against MODIS chlorophyll-a products derived from three algorithms (OC3M, Carder, and Garver-Siegel-Maritorena (GSM)), as well as euphotic depth measurements derived from photosynthetically active radiation (PAR) profiles, which were compared against two MODIS euphotic depth products (derived semi-analytically and from surface chlorophyll-a). The OC3M product performed well in open waters, with errors below the 35% NASA accepted limit, but it overestimated chlorophyll-a values in shallow (ker or no significant relationships to in situ measurements in the Eastern Great Australian Bight. This is thought to be due to the summertime subsurface upwelling pool that is characteristic of the area. Based on these results, the OC3M product provides the most reliable estimates of chlorophyll-a, and is recommended for further applications of MODIS imagery, if the limitations in shallow waters are taken into account. Alternatively, the GSM product could be a better option if the algorithm

关键词： Great Australian Bight MODIS Remote Sensing Ocean Color Chlorophyll Euphotic Depth

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Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

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Journal of Animal Science and Biotechnology 2017年第2期8卷 378-390页

作者： Samuel M.Waititu Fugui Yin Rob Patterson Juan C.rodriguez-Lecompte Charles M.Nyachoti Department of Animal Science University of Manitoba201-12 Dafoe RoadWinnipegM6 R3T 2N2Canada Canadian Bio-systems Inc. CalgaryAB T2C OJTCanada Atlantic Veterinary College University of Prince Edward IslandCharlottetownPE C1A 4P3Canada

Background： This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter（AGP） on performance, immune status and gut structure after an E. coli lipopolysaccharide（LPS） challenge. Thirty-six pigs were allotted to six treatments including： a non-challenged control（NCC）; LPS-challenged control（CC）; CC ＋ AGP; CC ＋ yeast extract; CC ＋ enzymes; and CC ＋ enzymes ＋ yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal ***： Overall（d 1 to 11）, compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG（P = 0.004）,ADFI（P = 0.03） and gain/feed ratio（P = 0.01）. At 6 h post-challenge, AGP pigs had lower plasma urea N（PUN; P = 0.02）and serum TNF-α concentration（P = 0.07）, and higher platelet count（P = 0.04） and serum IL-10 concentration（P = 0.02） than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN（P = 0.02） than CC pigs, whereas enzymes ＋ yeast extract interacted non-additively（P = 0.001） to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN（P = 0.02）and higher duodenal（P = 0.03）, jejunal（P = 0.01） and ileal（P = 0.07） villus height than CC pigs. In addition, enzymes ＋yeast extract interacted additively and non-additively to reduce ileal IFN-γ（P 0.10） were observed between AGP and enzymes ＋ yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ（P ＆lt; 0.0001） and TNF-α（P = 0.003） in enzymes ＋ yeast extract pigs at 96 h ***： The LPS challenged piglets receiving enzymes ＋ yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance.

关键词： Antimicrobial growth promoter Feed enzymes Growth performance Immunity Nucleotides Piglets

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抑郁,孤独感和自杀风险:社会心理交互模型

抑郁,孤独感和自杀风险:社会心理交互模型

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第二十一届全国心理学学术会议

作者： edward C.Chang Abigael G.Lucas 李明崎 Collin B.Beavan Rachel S.Eisner Brianna M.McManamon Natalia S.rodriguez Olivia M.katamanin Eliza C.Bourke Amaia de la Fuente Olga Carde?oso kaidi Wu Elizabeth A.Yu Elizabeth L.Jeglic Jameson k. Hirsch 王若茜高芯芸 Zimeng Li Xin Wang Olivia D.Chang 密歇根大学心理学系斯基德莫尔学院巴斯克大学

美国的拉丁裔人群自杀风险颇高,但目前的自杀研究对象大多是白人群体,针对拉丁裔人群自杀风险的影响因素的研究尚且不足。以往研究证明,抑郁是自杀风险重要的预测因子。拉丁文化中的集体主义思想也显示,当个体被社会孤立后,产生的孤独... 详细信息

美国的拉丁裔人群自杀风险颇高,但目前的自杀研究对象大多是白人群体,针对拉丁裔人群自杀风险的影响因素的研究尚且不足。以往研究证明,抑郁是自杀风险重要的预测因子。拉丁文化中的集体主义思想也显示,当个体被社会孤立后,产生的孤独感会预测其自杀风险。因此,本研究根据社会心理易损模型,同时考虑个体心理和环境变量对自杀风险的预测作用。本研究采用问卷法探究分别抑郁,孤独感,以及两者的交互作用对自杀风险(绝望和自杀行为)的预测作用。研究样本包括156名拉丁裔大学生,使用分层回归的方法,第一层控制年龄和性别,第二层放入抑郁和孤独感,第三层放入两者交互项,因变量是大学生的绝望和自杀行为。分层回归结果表明,抑郁和孤独感都能独立显著预测绝望和自杀行为。同时,抑郁和孤独感对预测自杀风险的交互效应显著,低孤独感可以缓冲抑郁对自杀风险的预测:随着抑郁增强,相比于被社会孤立的个体,没有被孤立的个体的自杀风险的上升速率显著较低。本研究首次探索了拉丁裔人群的抑郁和孤独感对自杀风险的预测作用,表明减少社会心理的受损能减少自杀风险。与以往研究模式一致,抑郁的对自杀的预测力大约是孤独感的两倍。此外,抑郁和孤独感对自杀风险的影响也存在交互作用,减少个体的孤独感能缓冲抑郁对自杀风险的影响。因此,集体主义文化下的拉丁裔群体(甚至文化相似的东亚群体),未来针对自杀的干预,不仅应关注个体的心理抑郁心境,还可以通过加强社会联结减少孤独感,以降低人群的自杀风险。

关键词：抑郁孤独感自杀风险拉丁裔大学生

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探究西班牙大学生孤独感与抑郁症状之间的关系:以应对策略为中介

探究西班牙大学生孤独感与抑郁症状之间的关系:以应对策略为中介

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第二十二届全国心理学学术会议

作者：梁芃伟石小轩 Brianna M.McManamon Amaiadela Fuente Olga Carde?oso Natalia S.rodriguez Olivia M.katamanin Rachel S.Eisner Collin B.Beavan Eliza C.Bourke Deesha D.Shah Abigael G.Lucas Olivia D.Chang Mingqi Li edward C.Chang 北京师范大学心理学部 Department of Psychology University of Michigan Department of Developmental and Educational Psychology University of Basque Country (UPV/EHU) Department of Psychology Skidmore College

孤独感,指受到社会孤立或与他人隔绝的感觉。研究发现,孤独感与消极的情感状况有关,尤其是与年轻人的抑郁症状有关。然而孤独和抑郁症状之间的关联机制尚不清楚。针对这一问题,有研究者提出通过应对策略来调节年轻人孤独感和抑郁症状之... 详细信息

孤独感,指受到社会孤立或与他人隔绝的感觉。研究发现,孤独感与消极的情感状况有关,尤其是与年轻人的抑郁症状有关。然而孤独和抑郁症状之间的关联机制尚不清楚。针对这一问题,有研究者提出通过应对策略来调节年轻人孤独感和抑郁症状之间的关系,应对策略是指为应对压力所做出的认知和行为上的努力。因而本研究旨在探究在西班牙大学生群体中应对策略在孤独感与抑郁症状之间的中介作用。本研究中,我们采用应对策略量表(包含积极(engagement)和消极(disengagement)两个维度,每个维度又包括应对问题(problem engagement)和应对情绪(emotion engagement)两个子维度,每个子维度下包括两种应对策略),R-UCLA孤独感量表以及Beck抑郁量表对364名西班牙大学生(275名女性)进行了抽样调查以检验孤独感、不同应对策略和抑郁症状水平。采用多重中介分析,来确定孤独感和抑郁症状之间的关系是否是由积极应对策略(如解决问题)和消极应对策略(如回避问题)起部分中介作用。结果显示1)问题解决和认知重构的间接效应显著,且与孤独感和抑郁症状均呈负相关;2)问题回避,愿望式思考,自我批评的间接效应显著,且与孤独感呈正相关。3)愿望式思考和自我批评与抑郁症状呈正相关,而问题回避与抑郁症状呈负相关。4)社会支持、情绪表达和孤独感呈负相关,情绪抑制和孤独感呈正相关,但三种应对策略均与抑郁症状无显著相关。中介模型表明,孤独感阻碍了以问题为中心的积极应对策略的使用,从而降低了高孤独感的西班牙大学生的问题解决能力,导致他们出现抑郁症状的风险增加。同时这些结果也表明,在西班牙大学生中,孤独感增加了自我批评和愿望式思考这两种应对策略的使用,使得消极应对策略的使用增加,进而增加了出现抑郁症状的风险。综上,本研究探讨了在西班牙大学生群体中,应对策略在孤独感和抑郁症状之间的中介作用。研究结果发现,减少孤独感、改善积极应对策略、避免消极应对策略、提高问题回避技能是西班牙大学生减少抑郁症状的重要措施。

关键词：孤独感抑郁症状应对策略西班牙大学生

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Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt edward F.Brown Niccolo Bucciantini Luciano Burderi edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan k.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.kaastra Emrah kalemci Oleg kargaltsev Nobuyuki kawai Laurens keek Stefanie komossa Ingo kreykenbohm Lucien kuiper Devaky kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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