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产业用纺织品 2007年第1期25卷 39-39,43页

作者： c.edward Hayes 金磊

2005年全球地毯装运量已达到46亿m2,货值335亿美元.1998～2004年间地毯装运量和货值的年均增长率均为2%,2005年的装运量和货值年增长率分别为3%和5%.

关键词：增长趋势地毯世界年均增长率年增长率运量

In-situ characterization of metal nanoparticles and their organic coatings using laser-vaporization aerosol mass spectrometry

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Nano Research 2015年第12期8卷 3780-3795页

作者： Patrik T. Nilsson Axel c. Eriksson Linus Ludvigsson Maria E. Messing Erik Z. Nordin Anders Gudmundsson Bengt O. Meuller Knut Deppert edward c. Fortner Timothy B. Onasch Joakim H. Pagels Ergonomics and Aerosol Technology Lund University P.O. Box 118 Lund SE-22100 Sweden Nuclear Physics Lund University P.O. Box 118 LundSE-22100 Sweden Solid State Physics Lund University P.O. Box 118 Lund SE-22100 Sweden Synchrotron Radiation Research Lund University P.O. Box 118 Lund SE-22100 Sweden Aerodyne Research Inc. Billefica MA 01821-3976 USA

The development of methods to produce nanoparticles with unique properties via the aerosol route is progressing rapidly. Typical characterization techniques extract particles from the synthesis process for subsequent offiine analysis, which may alter the particle characteristics. In this work, we use laser-vaporization aerosol mass spectrometry （LV-AMS） with 70-eV electron ionization for real-time, in-situ nanoparticle characterization. The particle characteristics are examined for various aerosol synthesis methods, degrees of sintering, and for controlled condensation of organic material to simulate surface coating/functionalization. The LV-AMS is used to characterize several types of metal nanoparticles （Ag, Au, Pd, PdAg, Fe, Ni, and cu）. The degree of oxidation of the Fe and Ni nanoparticles is found to increase with increased sintering temperature, while the surface organic-impurity content of the metal particles decreases with increased sintering temperature. For aggregate metal particles, the organic-impurity content is found to be similar to that of a monolayer. By comparing different equivalent-diameter measurements, we demonstrate that the LV-AMS can be used in tandem with a differential mobility analyzer to determine the compactness of synthesized metal particles, both during sintering and during material addition for surface functionalization. Further, materials supplied to the particle production line downstream of the particle generators are found to reach the generators as contaminants. The capacity for such in-situ observations is important, as it facilitates rapid response to undesired behavior within the particle production process. This study demonstrates the utility of real-time, in-situ aerosol mass spectrometric measurements to characterize metal nanoparticles obtained directly from the synthesis process line, including their chemical composition, shape, and contamination, providing the potential for effective optimization of process operating p

关键词： metal aeroso1 organic surface coating contamination morphology alloy spark discharge

Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses

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cellular & Molecular Immunology 2017年第5期14卷 412-422页

作者： Renfang Mao Riyun Yang Xia chen edward W Harhaj Xiaoying Wang Yihui Fan Basic Medical Research center School of Medicine Nantong University Nantong Jiangsu 226001 People's Republic of China Department of Oncology Sidney Kimmel Comprehensive Cancer Center Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Immunology School of Medicine Nantong University Nantong Jiangsu 226001 People's Republic of China

RNA-binding proteins （RBPs） are central players in post-transcriptional regulation and immune homeostasis. The ribonuclease and RBP Regnase-1 exerts critical roles in both immune cells and non-immune cells. Its expression is rapidly induced under diverse conditions including microbial infections, treatment with inflammatory cytokines and chemical or mechanical stimulation. Regnase-1 activation is transient and is subject to negative feedback mechanisms including proteasome-mediated degradation or mucosa-associated lymphoid tissue 1 （MALT1） mediated cleavage. The major function of Regnase-1 is promoting mRNA decay via its ribonuclease activity by specifically targeting a subset of genes in different cell types. In monocytes, Regnase-1 downregulates IL-6 and IL-12B mRNAs, thus mitigating inflammation, whereas in T cells, it restricts T-cell activation by targeting c-Rel, Ox40 and 11-2 transcripts. In cancer cells, Regnase-1 promotes apoptosis by inhibiting anti-apoptotic genes including Bcl2L1, Bcl2A1, RelB and Bcl3. Together with up-frameshift protein-1 （UPF1）, Regnase-1 specifically cleaves mRNAs that are active during translation by recognizing a stem-loop （SL） structure within the 3＇UTRs of these genes in endoplasmic reticulum-bound ribosomes. Through this mechanism, Regnase-1 rapidly shapes mRNA profiles and associated protein expression, restricts inflammation and maintains immune homeostasis. Dysregulation of Regnase-1 has been described in a multitude of pathological states including autoimmune diseases, cancer and cardiovascular diseases. Here, we provide a comprehensive update on the function, regulation and molecular mechanisms of Regnase-1, and we propose that Regnase-1 may function as a master rapid response gene for cellular adaption triggered by microenvironmental changes.

关键词： Autoimmune diseases Regnase-1 ribonuclease RNA-binding proteins microenvironment

Thermal conversion of Biomass by Microwave Energy- First Results with Wood

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Thermal Conversion of Biomass by Microwave Energy- First Res...

Safety and effectiveness of the SUPRAcOR presbyopic LASIK algorithm on hyperopic patients

The 18th European Biomass conference and Exhibition

作者： Schrammel G. Paisler c. krug H. Rauch R. Hofbauer H.

By using a microwave generator as energy source wood gets converted into three products:（1） condensate（"product oil"）,（2） product gas and（3） charcoal（"material residue"）. In this microwave-based specific kind of pyrolysis process wood is used as standard input material in order to have the possibility to compare the three generated products either with products of already established conventional pyrolysis processes [1] or other processes like gasification within thermo-chemical conversion [2]. Therefore, a discontinuous microwave apparatus of technical standard size（magnetron power: 6 k W, magnetron frequency: 2.45 GHz） is used.

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Eye and Vision 2016年第1期3卷 253-262页

作者： Robert edward T.Ang Emerson M.cruz Alex U.Pisig Maria Luisa Patricia c.Solis Rosalie Mae M.Reyes Gerhard Youssefi Asian Eye Institute 8th Floor PHINMA PlazaRockwell CenterMakati City 1200Philippines Department of Ophthalmology Cardinal Santos Medical Center10 Wilson St.Greenhills WestSan Juan CityPhilippines TEcHNOLAS PerfectVision GmbH A Bausch&Lomb CompanyMesserschmittstrasse 1-3Munich 80992Germany

Background:To evaluate the safety and effectiveness of the Supracor excimer laser algorithm to treat hyperopic presbyopic patients using laser in-situ keratomileusis(LASIK).Methods:This is a retrospective case review of patients diagnosed with hyperopia(Sphere≥+0.0 D and presbyopia reading add≥1.0 D)who underwent Supracor excimer laser treatment on at least one eye for presbyopia correction from year May 2011 to May *** vision was further analyzed after patients were subdivided into three groups:Group A(n=22 eyes,11 patients)had Supracor on both eyes;Group B(n=18 eyes,18 patients)had Supracor in one eye and hyperopic LASIK on fellow eye;and Group c(n=29 eyes,29 patients)had Supracor in one eye and no treatment on the fellow ***:This study evaluated 58 patients wherein 69 eyes underwent Supracor presbyopic ***,mean manifest refraction spherical equivalent(MRSE)of all eyes that underwent Supracor was+1.37±0.72 D with mean uncorrected distance visual acuity(UDVA),uncorrected intermediate visual acuity(UIVA),and uncorrected near visual acuity(UNVA)of 20/50(0.35 logMAR),20/50(0.35 logMAR),and J9(0.61 logMAR),*** 6 months postoperatively,mean MRSE was−0.43±0.59 D with mean UDVA,UIVA and UNVA of 20/25(0.13 logMAR),20/20(0.01 logMAR),and J1(0.05 logMAR),*** of two lines of best-corrected distance visual acuity(BcDVA)was seen in 6%of *** corneal steepening of 1.0 D at the 3 mm zone and 0.7 D in the 5 mm zone was *** vertical coma increased from−0.02 to+0.10 while mean 4th order spherical aberration became more negative from 0.20 to−*** binocular UDVA,UIVA,and UNVA are 20/20,20/20 and J1,respectively,in all treatment groups at the 6 month postoperative *** significant differences in binocular UDVA(p≥0.36),UIVA(p≥0.19)and UNVA(p≥0.56)among groups were ***:Supracor excimer laser algorithm is safe and effective for the treatment of presbyopia in *** and bil

关键词： Presbyopia LASIK Supracor Hyperopia

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

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Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang Jane LLiesveld Laura Mcalvi Brea cLipe Lianping Xing Michael WBecker edward MSchwarz Shu-chi A.Yeh center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot cancer center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HScs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

Herbal formula enhances 5-fluorouracil activity through suppression of thymidylate synthase

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中国药理学与毒理学杂志 2019年第9期33卷 644-645页

作者： LIU Hai-zhou LIU Hui ZHOU Zhi-yi Robert A.PARISE edward cHU John c.ScHMITZ cancer Therapeutics Program UPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPennsylvaniaUSA Department of Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200000China

Traditional chinese herbal medicine(TcM)has been shown to enhance the efficacy of standard anticancer ***,there are only a limited number of well-controlled preclinical and clinical studies documenting the potential benefit of *** To identify biologically active formulas that were effective against colorectal cancer(cRc)by screening TcM formulas in in vitro and in vivo animal *** cell growth assays,cell cycle analysis,immunoblot analysis and qRT-PcR were performed to investigate the mechanism(s)of action of the formulason human cRc *** vivo animal models were used to evaluate the antitumor activity of formulasalone and in combination with *** We identified Huangqin Gegen Tang(HQGGT)which suppressed the in vivo growth of human cRc HT-29 *** significantly inhibited the growth of cRc cell *** enhanced the cytotoxicity of 5-FU against human 5-FU-resistant cells(H630R1)and mouse colon cancer cells(Mc38).This synergy was the result of suppression of thymidylate synthase expression by *** significantly enhanced the antitumor effect of 5-FU in mice bearing Mc38 *** studies have identified Huangqin as the herb responsible for TS inhibi⁃*** These findings provide support for the potential role of HQGGT as a novel modulator of fluoropyrim⁃idine chemotherapy for cRc treatment.

关键词： colorectal cancer thymidylate synthase 5-fluorouracil

Behavioral primary prevention of cardiovascular diseases

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 34-37页

作者： Andrew Elagizi edward Archer carl J.Lavie Department of Internal Medicine Leonard J Chabert Medical CenterHoumaLAUSA EnduringFX ColumbiaSCUSA Department of cardiovascular Diseases John Ochsner Heart and Vascular InstituteOchsner Clinical School-The University of Queensland School of MedicineNew OrleansLAUSA

The 2012 grade c recommendation from the United States Preventive Service Task Force(USPSTF)is that clinicians may choose to selectively counsel adults about healthful diet and physical activity(PA)for cardiovascular ... 详细信息

关键词： prevention cardiovascular diseases

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对描述流域酸化影响常用方法的评价

环境科学与管理 1987年第4期 18-22页

作者： E.c.krug 刘海桥

亨利克森模型在评价酸雨的酸性影响时,使用了近年来的水化学数据,模型基于用阳离子代替酸化前的碱度,用非海洋产生的 SO;代替人为排放的酸,这两种假设都会产生对酸雨酸性影响估价偏高的倾向,对“敏感”水体评价的误差也特别大。离子交换... 详细信息

亨利克森模型在评价酸雨的酸性影响时,使用了近年来的水化学数据,模型基于用阳离子代替酸化前的碱度,用非海洋产生的 SO;代替人为排放的酸,这两种假设都会产生对酸雨酸性影响估价偏高的倾向,对“敏感”水体评价的误差也特别大。离子交换和 SO;溶解模型在描述产生

关键词：酸化离子交换交换反应酸性土壤酸性土酸雨酸性降水降雨酸中和能力腐殖质流域湖泊水质有机质迪朗酸化作用

Microstructural evolution of a silicon carbide-carbon coated nanostructured ferritic alloy composite during in-situ Kr ion irradiation at 300℃ 450℃

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Journal of Materials Science & Technology 2021年第12期71卷 75-83页

作者： Kaustubh Bawane Kathy Lu Xian-Ming Bai Jing Hu Meimei Li Peter M.Bald edward Ryan Department of Materials Science and Engineering Virginia TechBlacksburgVAUSA IVEM-Tandem Facility Argonne National LaboratoryLemontILUSA

This work focuses on irradiation behaviors of a novel silicon carbide and carbon coated nanostructured ferritic alloy(Sic-c@NFA)composite for potential applications as a cladding and structural material for next generation nuclear *** Sic-c@NFA samples were irradiated with 1 MeV Kr ions up to 10 dpa at 300 and 4500 *** and defect evolution were studied in-situ at the IVEM-Tandem facility at Argonne National *** effects of ion irradiation on various phases such asα-ferrite matrix,(Fe,cr)_(7)c_(3),and(Ti,W)c precipitates were ***α-ferrite matrix showed a continuous increase in dislocation density along with spatial ordering of dislocation loops(or loop strings)at>5 *** size of the dislocation loops at 450℃was larger than that at 300℃.The nucleation and growth of new(Ti,W)c precipitates inα-ferrite grains were enhanced with the ion dose at 450℃.This study provides new insight into the irradiation resistance of the Sic-c@NFA system.

关键词： In-situ ion irradiation Ferritic steel (Fecr)_(7)c_(3) Metal matrix composite Fuel cladding