The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

作     者：Hengwei Zhang Jane LLiesveld Laura MCalvi Brea CLipe Lianping Xing Michael WBecker Edward MSchwarz Shu-Chi A.Yeh Hengwei Zhang;Jane L.Liesveld;Laura M.Calvi;Brea C.Lipe;Lianping Xing;Michael W.Becker;Edward M.Schwarz;Shu-Chi A.Yeh

作者机构：Center for Musculoskeletal ResearchUniversity of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory MedicineUniversity of Rochester Medical CenterRochesterNYUSA Wilmot Cancer CenterUniversity of Rochester Medical CenterRochesterNYUSA Department of MedicineDivision of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of MedicineDivision of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of OrthopaedicsUniversity of Rochester Medical CenterRochesterNYUSA Department of MedicineDivision of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical EngineeringUniversity of RochesterNYUSA Department of Physiology/PharmacologyUniversity of Rochester Medical CenterRochesterNYUSA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2023年第11卷第2期

页      面：273-291页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by awards from the National Institute of Health R21AR069789&R01 AG059775(to LX),R01 AG076786&R01 AG079556 The Henry and Marilyn Taub Foundation the Edward P.Evans Foundation the Mangurian Foundation the National Aeronautics and Space Administration(to LMC) NIH R21 AR081050,R01 AR056702,P30 AR069655&P50 AR072000(to EMS) University of Rochester Aging Institute and the Dresner MDS foundation(to SY) 

主　　题：remodeling homeostasis likely 

摘      要：Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.